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D4AZ71

- CBPYA_ARTBC

UniProt

D4AZ71 - CBPYA_ARTBC

Protein

Carboxypeptidase Y homolog A

Gene

CPYA

Organism
Arthroderma benhamiae (strain ATCC MYA-4681 / CBS 112371) (Trichophyton mentagrophytes)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 22 (01 Oct 2014)
      Sequence version 1 (18 May 2010)
      Previous versions | rss
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    Functioni

    Vacuolar carboxypeptidase involved in degradation of small peptides. Digests preferentially peptides containing an aliphatic or hydrophobic residue in P1' position, as well as methionine, leucine or phenylalanine in P1 position of ester substrate By similarity.By similarity

    Catalytic activityi

    Release of a C-terminal amino acid with broad specificity.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei266 – 2661PROSITE-ProRule annotation
    Active sitei458 – 4581PROSITE-ProRule annotation
    Active sitei520 – 5201PROSITE-ProRule annotation

    GO - Molecular functioni

    1. serine-type carboxypeptidase activity Source: InterPro

    Keywords - Molecular functioni

    Carboxypeptidase, Hydrolase, Protease

    Protein family/group databases

    MEROPSiS10.001.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Carboxypeptidase Y homolog A (EC:3.4.16.5)
    Gene namesi
    Name:CPYA
    ORF Names:ARB_01491
    OrganismiArthroderma benhamiae (strain ATCC MYA-4681 / CBS 112371) (Trichophyton mentagrophytes)
    Taxonomic identifieri663331 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesArthrodermataceaeArthroderma
    ProteomesiUP000008866: Unassembled WGS sequence

    Subcellular locationi

    Vacuole By similarity

    GO - Cellular componenti

    1. vacuole Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Vacuole

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1717Sequence AnalysisAdd
    BLAST
    Propeptidei18 – 124107By similarityPRO_0000407424Add
    BLAST
    Chaini125 – 543419Carboxypeptidase Y homolog APRO_0000407425Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi179 ↔ 419By similarity
    Glycosylationi210 – 2101N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi313 ↔ 327By similarity
    Disulfide bondi337 ↔ 360By similarity
    Disulfide bondi344 ↔ 353By similarity
    Disulfide bondi382 ↔ 389By similarity
    Glycosylationi509 – 5091N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Zymogen

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase S10 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    KOiK13289.
    OrthoDBiEOG7XDBR1.

    Family and domain databases

    Gene3Di3.40.50.1820. 2 hits.
    InterProiIPR029058. AB_hydrolase.
    IPR001563. Peptidase_S10.
    IPR018202. Peptidase_S10_AS.
    [Graphical view]
    PANTHERiPTHR11802. PTHR11802. 1 hit.
    PfamiPF00450. Peptidase_S10. 1 hit.
    [Graphical view]
    PRINTSiPR00724. CRBOXYPTASEC.
    SUPFAMiSSF53474. SSF53474. 1 hit.
    PROSITEiPS00131. CARBOXYPEPT_SER_SER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    D4AZ71-1 [UniParc]FASTAAdd to Basket

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    MKFLTTGLLA TAALAAAQEQ QVLQAEDGHG QAPQRDASIF DETLQKFQSS    50
    LEDGISHFWS EMKTNFKDYL PLISLPKKHT RRPDSEWDHV VRGADIESVW 100
    VQGADGEKRR EIDGKLHNYD LRVKAVDPSK LGVDPGVKQY SGYLDDNDAD 150
    KHLFYWFFES RNDPKNDPVV LWLNGGPGCS SLTGLFLELG PATIDKNLKV 200
    VSNPYSWNSN ASVIFLDQPV NVGFSYSGSS VSDTVAAGKD VYALLTLFFK 250
    QFPEYASQDF HISGESYAGH YIPVFAAEIL SHKNTNINLK SALIGNGLTD 300
    PLTQYPQYRP MACGEGGYPA VLDQGTCRSM DNSLERCLSL IETCYSSESA 350
    WVCVPAAMYC NSAILAPYQQ TGMNPYDVRT KCEDMASLCY PQLNAITEWL 400
    NQESVMQALG VEVQSYESCN SGINRDFLFH GDWMKPYHRL VPSVLEKIPV 450
    LIYAGDADFI CNWLGNLAWT DALEWPGHKK FAEAKLEDLK IVNNKDKGKK 500
    IGQVKSSGNF TFMRIFGAGH MVPLNQPEAS LEFFNRWLGG EWH 543
    Length:543
    Mass (Da):60,649
    Last modified:May 18, 2010 - v1
    Checksum:i8C14EB674CCD1FAC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    ABSU01000020 Genomic DNA. Translation: EFE31591.1.
    RefSeqiXP_003012231.1. XM_003012185.1.

    Genome annotation databases

    GeneIDi9519799.
    KEGGiabe:ARB_01491.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    ABSU01000020 Genomic DNA. Translation: EFE31591.1 .
    RefSeqi XP_003012231.1. XM_003012185.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi S10.001.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 9519799.
    KEGGi abe:ARB_01491.

    Phylogenomic databases

    KOi K13289.
    OrthoDBi EOG7XDBR1.

    Family and domain databases

    Gene3Di 3.40.50.1820. 2 hits.
    InterProi IPR029058. AB_hydrolase.
    IPR001563. Peptidase_S10.
    IPR018202. Peptidase_S10_AS.
    [Graphical view ]
    PANTHERi PTHR11802. PTHR11802. 1 hit.
    Pfami PF00450. Peptidase_S10. 1 hit.
    [Graphical view ]
    PRINTSi PR00724. CRBOXYPTASEC.
    SUPFAMi SSF53474. SSF53474. 1 hit.
    PROSITEi PS00131. CARBOXYPEPT_SER_SER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC MYA-4681 / CBS 112371.

    Entry informationi

    Entry nameiCBPYA_ARTBC
    AccessioniPrimary (citable) accession number: D4AZ71
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 3, 2011
    Last sequence update: May 18, 2010
    Last modified: October 1, 2014
    This is version 22 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3