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Protein

Probable endochitinase ARB_07371

Gene

ARB_07371

Organism
Arthroderma benhamiae (strain ATCC MYA-4681 / CBS 112371) (Trichophyton mentagrophytes)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

GPI-anchored chitinase involved in the degradation of chitin, a component of the cell walls of fungi and exoskeletal elements of some animals (including worms and arthropods). Required to reshape the cell wall at the sites where cell wall remodeling and/or cell wall maturation actively take place such as sites of conidia formation.By similarity

Catalytic activityi

Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1->4)-beta-linkages in chitin and chitodextrins.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei35InhibitorBy similarity1
Active sitei178Proton donorPROSITE-ProRule annotation1
Binding sitei211InhibitorBy similarity1
Binding sitei325InhibitorBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosidase, Hydrolase
Biological processCarbohydrate metabolism, Chitin degradation, Polysaccharide degradation
LigandChitin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable endochitinase ARB_07371Curated (EC:3.2.1.14By similarity)
Gene namesi
ORF Names:ARB_07371
OrganismiArthroderma benhamiae (strain ATCC MYA-4681 / CBS 112371) (Trichophyton mentagrophytes)
Taxonomic identifieri663331 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesArthrodermataceaeTrichophyton
Proteomesi
  • UP000008866 Componenti: Unassembled WGS sequence

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Cell wall, Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000043441424 – 720Probable endochitinase ARB_07371Sequence analysisAdd BLAST697
PropeptideiPRO_0000434415721 – 745Removed in mature formBy similarityAdd BLAST25

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi438N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi484N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Lipidationi720GPI-anchor amidated glycineSequence analysis1

Keywords - PTMi

Glycoprotein, GPI-anchor, Lipoprotein

Interactioni

Protein-protein interaction databases

STRINGi663331.XP_003014810.1.

Structurei

3D structure databases

ProteinModelPortaliD4AT07.
SMRiD4AT07.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni174 – 178Inhibitor bindingBy similarity5
Regioni234 – 236Inhibitor bindingBy similarity3

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi357 – 662Thr-richPROSITE-ProRule annotationAdd BLAST306
Compositional biasi605 – 705Pro-richPROSITE-ProRule annotationAdd BLAST101

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG4701. Eukaryota.
ENOG4111GPA. LUCA.
KOiK01183.
OrthoDBiEOG092C4MM9.

Family and domain databases

InterProiView protein in InterPro
IPR001223. Glyco_hydro18_cat.
IPR001579. Glyco_hydro_18_chit_AS.
IPR017853. Glycoside_hydrolase_SF.
PfamiView protein in Pfam
PF00704. Glyco_hydro_18. 1 hit.
SUPFAMiSSF51445. SSF51445. 1 hit.
PROSITEiView protein in PROSITE
PS01095. CHITINASE_18. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

D4AT07-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALPKTIMAF IAFISFLVST TFAVDVFSTT NVVTYWGQGH DQKRLSHYCQ
60 70 80 90 100
QAEHDIIVIG FVNVFPDQGK GGWPGTNFGN QCFMGTYITP EGEETELLSS
110 120 130 140 150
CHKIIEDIPI CKAAGKTIML SLGGQAVDGS KTYSVKTRQS AVYFADFLWR
160 170 180 190 200
AFGPVSPEWD GPRPFGDNVI DGFDFDIEAN GGANYEYMVE RLRSNFATDS
210 220 230 240 250
SRQYYLSAAP QCVLPDGNLG NVISSSAFDF IFVQFYNTPS CSAFNWAQNP
260 270 280 290 300
SKSGFTFDSW VQFIRKGASR NAKLFIGLVG DHTRVSPHGE YTKDDSNYLA
310 320 330 340 350
LPDADKLIKA YMNKYRANFG GVMIWDALTS DENKLVTGTY SSNIKRLLLN
360 370 380 390 400
NDPSRPTTTS KTMSSTKTSM STTTSKYTVT TSTISSTSKI SSSTWSMPTM
410 420 430 440 450
TTSTRTTSST ATRSSTIVTP STSPNPTTST STTSGHQNTT ATTTEIETQT
460 470 480 490 500
SKTFITTTSI WSSGTGIGTC TGIPTITTTP RYPNATFTSD TTGSPTMSDT
510 520 530 540 550
TITLSVTSSM HQISDTTTTI PTFSTTPIQT SDISLSMPSG TTTSKHQSSG
560 570 580 590 600
ITIPGPPHMS TTIVPASPTK PGHSTTTAIV TTTFTSVCPT GITTVTTTYT
610 620 630 640 650
TIYCPEATPM PTAGNPPPPP GMEWTTIVTT CTKCASTSAI MTVTYPVTVP
660 670 680 690 700
SEPMTPTQVP GTLPPPGAPG TGSGIPPPKT PSNEPGSPGT LTGIFPPKPT
710 720 730 740
MSVPPEMGGN GGDRTPVYTG GAGVVSPSFS VVVIVLGSIV YHIMQ
Length:745
Mass (Da):79,261
Last modified:May 18, 2010 - v1
Checksum:i56BAC7C0C2DB19C6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ABSU01000008 Genomic DNA. Translation: EFE33907.1.
RefSeqiXP_003014810.1. XM_003014764.1.

Genome annotation databases

EnsemblFungiiEFE33907; EFE33907; ARB_07371.
GeneIDi9520347.
KEGGiabe:ARB_07371.

Similar proteinsi

Entry informationi

Entry nameiCHI1_ARTBC
AccessioniPrimary (citable) accession number: D4AT07
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 14, 2015
Last sequence update: May 18, 2010
Last modified: May 10, 2017
This is version 39 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families