ID   D4ASS2_ARTBC            Unreviewed;       688 AA.
AC   D4ASS2;
DT   18-MAY-2010, integrated into UniProtKB/TrEMBL.
DT   18-MAY-2010, sequence version 1.
DT   27-MAR-2024, entry version 54.
DE   SubName: Full=Histone-lysine N-methyltransferase (Ash1), putative {ECO:0000313|EMBL:EFE33822.1};
GN   ORFNames=ARB_07287 {ECO:0000313|EMBL:EFE33822.1};
OS   Arthroderma benhamiae (strain ATCC MYA-4681 / CBS 112371) (Trichophyton
OS   mentagrophytes).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Arthrodermataceae; Trichophyton.
OX   NCBI_TaxID=663331 {ECO:0000313|EMBL:EFE33822.1, ECO:0000313|Proteomes:UP000008866};
RN   [1] {ECO:0000313|Proteomes:UP000008866}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-4681 / CBS 112371 {ECO:0000313|Proteomes:UP000008866};
RX   PubMed=21247460; DOI=10.1186/gb-2011-12-1-r7;
RA   Burmester A., Shelest E., Gloeckner G., Heddergott C., Schindler S.,
RA   Staib P., Heidel A., Felder M., Petzold A., Szafranski K., Feuermann M.,
RA   Pedruzzi I., Priebe S., Groth M., Winkler R., Li W., Kniemeyer O.,
RA   Schroeckh V., Hertweck C., Hube B., White T.C., Platzer M., Guthke R.,
RA   Heitman J., Woestemeyer J., Zipfel P.F., Monod M., Brakhage A.A.;
RT   "Comparative and functional genomics provide insights into the
RT   pathogenicity of dermatophytic fungi.";
RL   Genome Biol. 12:R7.1-R7.16(2011).
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EFE33822.1}.
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DR   EMBL; ABSU01000008; EFE33822.1; -; Genomic_DNA.
DR   RefSeq; XP_003014725.1; XM_003014679.1.
DR   AlphaFoldDB; D4ASS2; -.
DR   STRING; 663331.D4ASS2; -.
DR   GeneID; 9520262; -.
DR   KEGG; abe:ARB_07287; -.
DR   eggNOG; KOG1083; Eukaryota.
DR   HOGENOM; CLU_004379_3_0_1; -.
DR   OMA; NECFYLM; -.
DR   OrthoDB; 950362at2759; -.
DR   Proteomes; UP000008866; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0042054; F:histone methyltransferase activity; IEA:InterPro.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   Gene3D; 2.170.270.10; SET domain; 1.
DR   InterPro; IPR006560; AWS_dom.
DR   InterPro; IPR001214; SET_dom.
DR   InterPro; IPR046341; SET_dom_sf.
DR   PANTHER; PTHR22884:SF512; N-METHYLTRANSFERASE (ASH1), PUTATIVE (AFU_ORTHOLOGUE AFUA_3G06480)-RELATED; 1.
DR   PANTHER; PTHR22884; SET DOMAIN PROTEINS; 1.
DR   Pfam; PF17907; AWS; 1.
DR   Pfam; PF00856; SET; 1.
DR   SMART; SM00317; SET; 1.
DR   SUPFAM; SSF82199; SET domain; 1.
DR   PROSITE; PS51215; AWS; 1.
DR   PROSITE; PS50280; SET; 1.
PE   4: Predicted;
KW   Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW   ECO:0000313|EMBL:EFE33822.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008866};
KW   Transferase {ECO:0000313|EMBL:EFE33822.1}.
FT   DOMAIN          370..417
FT                   /note="AWS"
FT                   /evidence="ECO:0000259|PROSITE:PS51215"
FT   DOMAIN          428..544
FT                   /note="SET"
FT                   /evidence="ECO:0000259|PROSITE:PS50280"
FT   REGION          1..271
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          545..612
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          635..688
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..61
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        70..90
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        101..130
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        134..167
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        194..258
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        545..561
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        562..588
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        635..660
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   688 AA;  76634 MW;  D6F2146EA921E490 CRC64;
     MSRVARESTT STSITPDSDS TLLESTGHTL TPATSISETS SNVDVPVTEP VSQTKPPQTR
     RVTRAFTRGG IDNDTEHNGN KHEDALREDI SASVSEGGTV VKHEPSRRPE RRSLRGRRGL
     SARALEPCEE ETTAEIQLEN TGSSTGDEPI KEETGSRPQS STKADAAQPR RRSGRLTLLE
     KTKTVLNQVS SILGKRQRDD KEDVKSKSKS KSKVEDRRSS LRSRTVVRKE TQEESATKKR
     RVSEDVSTPP KKEKKADLPP SSAPVQTAPK RKKWLTHGLY AGPNAFAKLE LPGPQSKRKG
     TRQAPRERVL FPMPKYSGAL LLEKGRPFRL PYDIFSPLPR GQPKPDEWRK INKNIFIGDA
     AGIWKATMPT EQSTCLCTPE MGCEENCQNR HMFYECDENN CKLGEDLCRN RNFSELRKRI
     KTGGKYNIGV EVIKTESRGY GVRSNRTFEP NQIIVEYTGE ILTQIEAQRR MKTIYKKNEC
     FYLMDFDQDM IIDATRGSIA RFVNHSCEPN CKMEKWIVAG KPRIALFAGD NGIMTGEELT
     YDYNFEPKGK DSKEKSTVKP ASTGTKRKSQ GVTNSQASKK QKTAKQSSVK AGLKRVASKA
     SQGIKSQAKS IRVPKKRVGV QFNKSARTRT TAAADVSFKS VSRSSRTSRQ AASSTKLRMP
     SRSRARLAKT AVQTVLKGRG GRRTSARS
//