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D4AQT0 (DAPB_ARTBC) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 19. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable dipeptidyl-aminopeptidase B

Short name=DPAP B
EC=3.4.14.5
Gene names
Name:DAPB
ORF Names:ARB_06590
OrganismArthroderma benhamiae (strain ATCC MYA-4681 / CBS 112371) (Trichophyton mentagrophytes) [Complete proteome]
Taxonomic identifier663331 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesArthrodermataceaeArthroderma

Protein attributes

Sequence length909 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Type IV dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline By similarity.

Catalytic activity

Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.

Subcellular location

Vacuole membrane; Single-pass type II membrane protein By similarity. Note: Lysosome-like vacuoles By similarity.

Sequence similarities

Belongs to the peptidase S9B family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 909909Probable dipeptidyl-aminopeptidase B
PRO_0000412129

Regions

Topological domain1 – 9494Cytoplasmic Potential
Transmembrane95 – 11521Helical; Signal-anchor for type II membrane protein; Potential
Topological domain116 – 909794Vacuolar Potential

Sites

Active site7601Charge relay system By similarity
Active site8371Charge relay system By similarity
Active site8701Charge relay system By similarity

Amino acid modifications

Glycosylation1211N-linked (GlcNAc...) Potential
Glycosylation2071N-linked (GlcNAc...) Potential
Glycosylation3031N-linked (GlcNAc...) Potential
Glycosylation3551N-linked (GlcNAc...) Potential
Glycosylation8141N-linked (GlcNAc...) Potential
Glycosylation8191N-linked (GlcNAc...) Potential
Glycosylation8221N-linked (GlcNAc...) Potential
Glycosylation8881N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
D4AQT0 [UniParc].

Last modified May 18, 2010. Version 1.
Checksum: 42AF0D1B44FB8434

FASTA909102,308
        10         20         30         40         50         60 
MRVGSRINDE EAMPLTAPES RARDSIDSSS TASISLTLVE GASHATTEPS KPAHNHNGRA 

        70         80         90        100        110        120 
QGNYAEKYRD DLEEDWEEDN YIPSNGKSNQ RRTLIVFWLL VALCVGGWAV AFLFFVTSPG 

       130        140        150        160        170        180 
NKTSTSPHSG SNSPEGDVTK PGIPATGKKI PLDDAIGGVW SPAEHTISWI TGAKGEDGLL 

       190        200        210        220        230        240 
LQKSEGGTGP YLHVEDVRNI HGTQSNNNSI VLMKESVFFV NDERISPEKV WPSPDLKTVL 

       250        260        270        280        290        300 
AMTREKKNWR HSFTGLYWLF DVETQTAQPL DPDAPNGRIQ LATWSPTSDA VAFTRDNNLY 

       310        320        330        340        350        360 
IRNLTSKSVK AITTDGGTNL FYGIPDWVYE EEVFEGNCAT WWSLDGKYIS YLRTNETLVP 

       370        380        390        400        410        420 
EFPIDFYLSS PPGYSPKPNE ESYPYVQQIK YPKAGAPNPT VNLQFYDVER EESFSVDVKD 

       430        440        450        460        470        480 
TLKDDDRLIV EVIPGSKGKV LVRETNRESY IVKVAVIDAN KREGKIVRSD NIDEIDGGWV 

       490        500        510        520        530        540 
EPSHTTTYIP ADPSAGRPDD GYIDTVIHEG YIHLAYFTPL ENPKPKMLTT GKWEVVAAPS 

       550        560        570        580        590        600 
GVDLKNNVVY FVATKESPID RHVYSVKLDG SELQMLKDSD KSAYYDVSFS HGAGYMLLKY 

       610        620        630        640        650        660 
QGPQIPWQKL ISSPSNADNY IEILEENKKL AKLSNEFSLP SLHYSTINVD GFELPVVERR 

       670        680        690        700        710        720 
PPNFDETKKY PVLFQLYGGP GSQTVNKKFL VNFQTYVASS LGYIVVTVDG RGTGFNGRKF 

       730        740        750        760        770        780 
KCIVRRNLGH YESHDQIQAA KAWGKKPYVD KTRMAIWGWS YGGFMTLKTL EQDAGETFQY 

       790        800        810        820        830        840 
GMAVAPVTNW RYYDSVYTER YMHMPQNNEG GYENASISNA TNLSQNTRFL IMHGSADDNV 

       850        860        870        880        890        900 
HFQNTLTLLD KLDILGVHNY DMHVFPDSNH GIYFHHAYKM VHQRKYFNLS FLGHGFFSFY 


SNFLPIRSF 

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ
ABSU01000005 Genomic DNA. Translation: EFE34824.1.
RefSeqXP_003015464.1. XM_003015418.1.

3D structure databases

ProteinModelPortalD4AQT0.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID9521191.
KEGGabe:ARB_06590.

Phylogenomic databases

KOK01282.
OrthoDBEOG72VHFG.

Family and domain databases

Gene3D2.140.10.30. 1 hit.
3.40.50.1820. 1 hit.
InterProIPR029058. AB_hydrolase.
IPR002471. Pept_S9_AS.
IPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B.
[Graphical view]
PfamPF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view]
SUPFAMSSF53474. SSF53474. 1 hit.
PROSITEPS00708. PRO_ENDOPEP_SER. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDAPB_ARTBC
AccessionPrimary (citable) accession number: D4AQT0
Entry history
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: May 18, 2010
Last modified: June 11, 2014
This is version 19 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries