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D4AQT0

- DAPB_ARTBC

UniProt

D4AQT0 - DAPB_ARTBC

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Protein

Probable dipeptidyl-aminopeptidase B

Gene
DAPB, ARB_06590
Organism
Arthroderma benhamiae (strain ATCC MYA-4681 / CBS 112371) (Trichophyton mentagrophytes)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Type IV dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline By similarity.

Catalytic activityi

Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei760 – 7601Charge relay system By similarity
Active sitei837 – 8371Charge relay system By similarity
Active sitei870 – 8701Charge relay system By similarity

GO - Molecular functioni

  1. aminopeptidase activity Source: UniProtKB-KW
  2. serine-type endopeptidase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Aminopeptidase, Hydrolase, Protease, Serine protease

Names & Taxonomyi

Protein namesi
Recommended name:
Probable dipeptidyl-aminopeptidase B (EC:3.4.14.5)
Short name:
DPAP B
Gene namesi
Name:DAPB
ORF Names:ARB_06590
OrganismiArthroderma benhamiae (strain ATCC MYA-4681 / CBS 112371) (Trichophyton mentagrophytes)
Taxonomic identifieri663331 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesArthrodermataceaeArthroderma
ProteomesiUP000008866: Unassembled WGS sequence

Subcellular locationi

Vacuole membrane; Single-pass type II membrane protein By similarity
Note: Lysosome-like vacuoles By similarity.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 9494Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei95 – 11521Helical; Signal-anchor for type II membrane protein; Reviewed predictionAdd
BLAST
Topological domaini116 – 909794Vacuolar Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. vacuolar membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 909909Probable dipeptidyl-aminopeptidase BPRO_0000412129Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi121 – 1211N-linked (GlcNAc...) Reviewed prediction
Glycosylationi207 – 2071N-linked (GlcNAc...) Reviewed prediction
Glycosylationi303 – 3031N-linked (GlcNAc...) Reviewed prediction
Glycosylationi355 – 3551N-linked (GlcNAc...) Reviewed prediction
Glycosylationi814 – 8141N-linked (GlcNAc...) Reviewed prediction
Glycosylationi819 – 8191N-linked (GlcNAc...) Reviewed prediction
Glycosylationi822 – 8221N-linked (GlcNAc...) Reviewed prediction
Glycosylationi888 – 8881N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliD4AQT0.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S9B family.

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

KOiK01282.
OrthoDBiEOG72VHFG.

Family and domain databases

Gene3Di2.140.10.30. 1 hit.
3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR002471. Pept_S9_AS.
IPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B.
[Graphical view]
PfamiPF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00708. PRO_ENDOPEP_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D4AQT0-1 [UniParc]FASTAAdd to Basket

« Hide

MRVGSRINDE EAMPLTAPES RARDSIDSSS TASISLTLVE GASHATTEPS    50
KPAHNHNGRA QGNYAEKYRD DLEEDWEEDN YIPSNGKSNQ RRTLIVFWLL 100
VALCVGGWAV AFLFFVTSPG NKTSTSPHSG SNSPEGDVTK PGIPATGKKI 150
PLDDAIGGVW SPAEHTISWI TGAKGEDGLL LQKSEGGTGP YLHVEDVRNI 200
HGTQSNNNSI VLMKESVFFV NDERISPEKV WPSPDLKTVL AMTREKKNWR 250
HSFTGLYWLF DVETQTAQPL DPDAPNGRIQ LATWSPTSDA VAFTRDNNLY 300
IRNLTSKSVK AITTDGGTNL FYGIPDWVYE EEVFEGNCAT WWSLDGKYIS 350
YLRTNETLVP EFPIDFYLSS PPGYSPKPNE ESYPYVQQIK YPKAGAPNPT 400
VNLQFYDVER EESFSVDVKD TLKDDDRLIV EVIPGSKGKV LVRETNRESY 450
IVKVAVIDAN KREGKIVRSD NIDEIDGGWV EPSHTTTYIP ADPSAGRPDD 500
GYIDTVIHEG YIHLAYFTPL ENPKPKMLTT GKWEVVAAPS GVDLKNNVVY 550
FVATKESPID RHVYSVKLDG SELQMLKDSD KSAYYDVSFS HGAGYMLLKY 600
QGPQIPWQKL ISSPSNADNY IEILEENKKL AKLSNEFSLP SLHYSTINVD 650
GFELPVVERR PPNFDETKKY PVLFQLYGGP GSQTVNKKFL VNFQTYVASS 700
LGYIVVTVDG RGTGFNGRKF KCIVRRNLGH YESHDQIQAA KAWGKKPYVD 750
KTRMAIWGWS YGGFMTLKTL EQDAGETFQY GMAVAPVTNW RYYDSVYTER 800
YMHMPQNNEG GYENASISNA TNLSQNTRFL IMHGSADDNV HFQNTLTLLD 850
KLDILGVHNY DMHVFPDSNH GIYFHHAYKM VHQRKYFNLS FLGHGFFSFY 900
SNFLPIRSF 909
Length:909
Mass (Da):102,308
Last modified:May 18, 2010 - v1
Checksum:i42AF0D1B44FB8434
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
ABSU01000005 Genomic DNA. Translation: EFE34824.1.
RefSeqiXP_003015464.1. XM_003015418.1.

Genome annotation databases

GeneIDi9521191.
KEGGiabe:ARB_06590.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
ABSU01000005 Genomic DNA. Translation: EFE34824.1 .
RefSeqi XP_003015464.1. XM_003015418.1.

3D structure databases

ProteinModelPortali D4AQT0.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 9521191.
KEGGi abe:ARB_06590.

Phylogenomic databases

KOi K01282.
OrthoDBi EOG72VHFG.

Family and domain databases

Gene3Di 2.140.10.30. 1 hit.
3.40.50.1820. 1 hit.
InterProi IPR029058. AB_hydrolase.
IPR002471. Pept_S9_AS.
IPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B.
[Graphical view ]
Pfami PF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view ]
SUPFAMi SSF53474. SSF53474. 1 hit.
PROSITEi PS00708. PRO_ENDOPEP_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC MYA-4681 / CBS 112371.

Entry informationi

Entry nameiDAPB_ARTBC
AccessioniPrimary (citable) accession number: D4AQT0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: May 18, 2010
Last modified: June 11, 2014
This is version 19 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi