Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

D4AQT0

- DAPB_ARTBC

UniProt

D4AQT0 - DAPB_ARTBC

Protein

Probable dipeptidyl-aminopeptidase B

Gene

DAPB

Organism
Arthroderma benhamiae (strain ATCC MYA-4681 / CBS 112371) (Trichophyton mentagrophytes)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 20 (01 Oct 2014)
      Sequence version 1 (18 May 2010)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Type IV dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline.By similarity

    Catalytic activityi

    Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei760 – 7601Charge relay systemPROSITE-ProRule annotation
    Active sitei837 – 8371Charge relay systemPROSITE-ProRule annotation
    Active sitei870 – 8701Charge relay systemPROSITE-ProRule annotation

    GO - Molecular functioni

    1. aminopeptidase activity Source: UniProtKB-KW
    2. serine-type endopeptidase activity Source: InterPro

    Keywords - Molecular functioni

    Aminopeptidase, Hydrolase, Protease, Serine protease

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable dipeptidyl-aminopeptidase B (EC:3.4.14.5)
    Short name:
    DPAP B
    Gene namesi
    Name:DAPB
    ORF Names:ARB_06590
    OrganismiArthroderma benhamiae (strain ATCC MYA-4681 / CBS 112371) (Trichophyton mentagrophytes)
    Taxonomic identifieri663331 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesArthrodermataceaeArthroderma
    ProteomesiUP000008866: Unassembled WGS sequence

    Subcellular locationi

    Vacuole membrane By similarity; Single-pass type II membrane protein By similarity
    Note: Lysosome-like vacuoles.By similarity

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. vacuolar membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Membrane, Vacuole

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 909909Probable dipeptidyl-aminopeptidase BPRO_0000412129Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi121 – 1211N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi207 – 2071N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi303 – 3031N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi355 – 3551N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi814 – 8141N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi819 – 8191N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi822 – 8221N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi888 – 8881N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Structurei

    3D structure databases

    ProteinModelPortaliD4AQT0.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 9494CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini116 – 909794VacuolarSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei95 – 11521Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase S9B family.Curated

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    KOiK01282.
    OrthoDBiEOG72VHFG.

    Family and domain databases

    Gene3Di2.140.10.30. 1 hit.
    3.40.50.1820. 1 hit.
    InterProiIPR029058. AB_hydrolase.
    IPR002471. Pept_S9_AS.
    IPR001375. Peptidase_S9.
    IPR002469. Peptidase_S9B.
    [Graphical view]
    PfamiPF00930. DPPIV_N. 1 hit.
    PF00326. Peptidase_S9. 1 hit.
    [Graphical view]
    SUPFAMiSSF53474. SSF53474. 1 hit.
    PROSITEiPS00708. PRO_ENDOPEP_SER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    D4AQT0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRVGSRINDE EAMPLTAPES RARDSIDSSS TASISLTLVE GASHATTEPS    50
    KPAHNHNGRA QGNYAEKYRD DLEEDWEEDN YIPSNGKSNQ RRTLIVFWLL 100
    VALCVGGWAV AFLFFVTSPG NKTSTSPHSG SNSPEGDVTK PGIPATGKKI 150
    PLDDAIGGVW SPAEHTISWI TGAKGEDGLL LQKSEGGTGP YLHVEDVRNI 200
    HGTQSNNNSI VLMKESVFFV NDERISPEKV WPSPDLKTVL AMTREKKNWR 250
    HSFTGLYWLF DVETQTAQPL DPDAPNGRIQ LATWSPTSDA VAFTRDNNLY 300
    IRNLTSKSVK AITTDGGTNL FYGIPDWVYE EEVFEGNCAT WWSLDGKYIS 350
    YLRTNETLVP EFPIDFYLSS PPGYSPKPNE ESYPYVQQIK YPKAGAPNPT 400
    VNLQFYDVER EESFSVDVKD TLKDDDRLIV EVIPGSKGKV LVRETNRESY 450
    IVKVAVIDAN KREGKIVRSD NIDEIDGGWV EPSHTTTYIP ADPSAGRPDD 500
    GYIDTVIHEG YIHLAYFTPL ENPKPKMLTT GKWEVVAAPS GVDLKNNVVY 550
    FVATKESPID RHVYSVKLDG SELQMLKDSD KSAYYDVSFS HGAGYMLLKY 600
    QGPQIPWQKL ISSPSNADNY IEILEENKKL AKLSNEFSLP SLHYSTINVD 650
    GFELPVVERR PPNFDETKKY PVLFQLYGGP GSQTVNKKFL VNFQTYVASS 700
    LGYIVVTVDG RGTGFNGRKF KCIVRRNLGH YESHDQIQAA KAWGKKPYVD 750
    KTRMAIWGWS YGGFMTLKTL EQDAGETFQY GMAVAPVTNW RYYDSVYTER 800
    YMHMPQNNEG GYENASISNA TNLSQNTRFL IMHGSADDNV HFQNTLTLLD 850
    KLDILGVHNY DMHVFPDSNH GIYFHHAYKM VHQRKYFNLS FLGHGFFSFY 900
    SNFLPIRSF 909
    Length:909
    Mass (Da):102,308
    Last modified:May 18, 2010 - v1
    Checksum:i42AF0D1B44FB8434
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    ABSU01000005 Genomic DNA. Translation: EFE34824.1.
    RefSeqiXP_003015464.1. XM_003015418.1.

    Genome annotation databases

    GeneIDi9521191.
    KEGGiabe:ARB_06590.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    ABSU01000005 Genomic DNA. Translation: EFE34824.1 .
    RefSeqi XP_003015464.1. XM_003015418.1.

    3D structure databases

    ProteinModelPortali D4AQT0.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 9521191.
    KEGGi abe:ARB_06590.

    Phylogenomic databases

    KOi K01282.
    OrthoDBi EOG72VHFG.

    Family and domain databases

    Gene3Di 2.140.10.30. 1 hit.
    3.40.50.1820. 1 hit.
    InterProi IPR029058. AB_hydrolase.
    IPR002471. Pept_S9_AS.
    IPR001375. Peptidase_S9.
    IPR002469. Peptidase_S9B.
    [Graphical view ]
    Pfami PF00930. DPPIV_N. 1 hit.
    PF00326. Peptidase_S9. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53474. SSF53474. 1 hit.
    PROSITEi PS00708. PRO_ENDOPEP_SER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC MYA-4681 / CBS 112371.

    Entry informationi

    Entry nameiDAPB_ARTBC
    AccessioniPrimary (citable) accession number: D4AQT0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 27, 2011
    Last sequence update: May 18, 2010
    Last modified: October 1, 2014
    This is version 20 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3