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D4AQT0

- DAPB_ARTBC

UniProt

D4AQT0 - DAPB_ARTBC

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Protein

Probable dipeptidyl-aminopeptidase B

Gene

DAPB

Organism
Arthroderma benhamiae (strain ATCC MYA-4681 / CBS 112371) (Trichophyton mentagrophytes)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Type IV dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline.By similarity

Catalytic activityi

Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei760 – 7601Charge relay systemPROSITE-ProRule annotation
Active sitei837 – 8371Charge relay systemPROSITE-ProRule annotation
Active sitei870 – 8701Charge relay systemPROSITE-ProRule annotation

GO - Molecular functioni

  1. aminopeptidase activity Source: UniProtKB-KW
  2. serine-type endopeptidase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Aminopeptidase, Hydrolase, Protease, Serine protease

Names & Taxonomyi

Protein namesi
Recommended name:
Probable dipeptidyl-aminopeptidase B (EC:3.4.14.5)
Short name:
DPAP B
Gene namesi
Name:DAPB
ORF Names:ARB_06590
OrganismiArthroderma benhamiae (strain ATCC MYA-4681 / CBS 112371) (Trichophyton mentagrophytes)
Taxonomic identifieri663331 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesArthrodermataceaeArthroderma
ProteomesiUP000008866: Unassembled WGS sequence

Subcellular locationi

Vacuole membrane By similarity; Single-pass type II membrane protein By similarity
Note: Lysosome-like vacuoles.By similarity

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. vacuole Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 909909Probable dipeptidyl-aminopeptidase BPRO_0000412129Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi121 – 1211N-linked (GlcNAc...)Sequence Analysis
Glycosylationi207 – 2071N-linked (GlcNAc...)Sequence Analysis
Glycosylationi303 – 3031N-linked (GlcNAc...)Sequence Analysis
Glycosylationi355 – 3551N-linked (GlcNAc...)Sequence Analysis
Glycosylationi814 – 8141N-linked (GlcNAc...)Sequence Analysis
Glycosylationi819 – 8191N-linked (GlcNAc...)Sequence Analysis
Glycosylationi822 – 8221N-linked (GlcNAc...)Sequence Analysis
Glycosylationi888 – 8881N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliD4AQT0.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 9494CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini116 – 909794VacuolarSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei95 – 11521Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S9B family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

KOiK01282.
OrthoDBiEOG72VHFG.

Family and domain databases

Gene3Di2.140.10.30. 1 hit.
3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR002471. Pept_S9_AS.
IPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B.
[Graphical view]
PfamiPF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00708. PRO_ENDOPEP_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D4AQT0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRVGSRINDE EAMPLTAPES RARDSIDSSS TASISLTLVE GASHATTEPS
60 70 80 90 100
KPAHNHNGRA QGNYAEKYRD DLEEDWEEDN YIPSNGKSNQ RRTLIVFWLL
110 120 130 140 150
VALCVGGWAV AFLFFVTSPG NKTSTSPHSG SNSPEGDVTK PGIPATGKKI
160 170 180 190 200
PLDDAIGGVW SPAEHTISWI TGAKGEDGLL LQKSEGGTGP YLHVEDVRNI
210 220 230 240 250
HGTQSNNNSI VLMKESVFFV NDERISPEKV WPSPDLKTVL AMTREKKNWR
260 270 280 290 300
HSFTGLYWLF DVETQTAQPL DPDAPNGRIQ LATWSPTSDA VAFTRDNNLY
310 320 330 340 350
IRNLTSKSVK AITTDGGTNL FYGIPDWVYE EEVFEGNCAT WWSLDGKYIS
360 370 380 390 400
YLRTNETLVP EFPIDFYLSS PPGYSPKPNE ESYPYVQQIK YPKAGAPNPT
410 420 430 440 450
VNLQFYDVER EESFSVDVKD TLKDDDRLIV EVIPGSKGKV LVRETNRESY
460 470 480 490 500
IVKVAVIDAN KREGKIVRSD NIDEIDGGWV EPSHTTTYIP ADPSAGRPDD
510 520 530 540 550
GYIDTVIHEG YIHLAYFTPL ENPKPKMLTT GKWEVVAAPS GVDLKNNVVY
560 570 580 590 600
FVATKESPID RHVYSVKLDG SELQMLKDSD KSAYYDVSFS HGAGYMLLKY
610 620 630 640 650
QGPQIPWQKL ISSPSNADNY IEILEENKKL AKLSNEFSLP SLHYSTINVD
660 670 680 690 700
GFELPVVERR PPNFDETKKY PVLFQLYGGP GSQTVNKKFL VNFQTYVASS
710 720 730 740 750
LGYIVVTVDG RGTGFNGRKF KCIVRRNLGH YESHDQIQAA KAWGKKPYVD
760 770 780 790 800
KTRMAIWGWS YGGFMTLKTL EQDAGETFQY GMAVAPVTNW RYYDSVYTER
810 820 830 840 850
YMHMPQNNEG GYENASISNA TNLSQNTRFL IMHGSADDNV HFQNTLTLLD
860 870 880 890 900
KLDILGVHNY DMHVFPDSNH GIYFHHAYKM VHQRKYFNLS FLGHGFFSFY

SNFLPIRSF
Length:909
Mass (Da):102,308
Last modified:May 18, 2010 - v1
Checksum:i42AF0D1B44FB8434
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
ABSU01000005 Genomic DNA. Translation: EFE34824.1.
RefSeqiXP_003015464.1. XM_003015418.1.

Genome annotation databases

GeneIDi9521191.
KEGGiabe:ARB_06590.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
ABSU01000005 Genomic DNA. Translation: EFE34824.1 .
RefSeqi XP_003015464.1. XM_003015418.1.

3D structure databases

ProteinModelPortali D4AQT0.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 9521191.
KEGGi abe:ARB_06590.

Phylogenomic databases

KOi K01282.
OrthoDBi EOG72VHFG.

Family and domain databases

Gene3Di 2.140.10.30. 1 hit.
3.40.50.1820. 1 hit.
InterProi IPR029058. AB_hydrolase.
IPR002471. Pept_S9_AS.
IPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B.
[Graphical view ]
Pfami PF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view ]
SUPFAMi SSF53474. SSF53474. 1 hit.
PROSITEi PS00708. PRO_ENDOPEP_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC MYA-4681 / CBS 112371.

Entry informationi

Entry nameiDAPB_ARTBC
AccessioniPrimary (citable) accession number: D4AQT0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: May 18, 2010
Last modified: October 29, 2014
This is version 21 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3