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D4APE2

- DPP4_ARTBC

UniProt

D4APE2 - DPP4_ARTBC

Protein

Probable dipeptidyl peptidase 4

Gene

DPP4

Organism
Arthroderma benhamiae (strain ATCC MYA-4681 / CBS 112371) (Trichophyton mentagrophytes)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 21 (01 Oct 2014)
      Sequence version 1 (18 May 2010)
      Previous versions | rss
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    Functioni

    Extracellular dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline. Contributes to pathogenicity By similarity.By similarity

    Catalytic activityi

    Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei616 – 6161Charge relay systemPROSITE-ProRule annotation
    Active sitei693 – 6931Charge relay systemPROSITE-ProRule annotation
    Active sitei728 – 7281Charge relay systemPROSITE-ProRule annotation

    GO - Molecular functioni

    1. aminopeptidase activity Source: UniProtKB-KW
    2. serine-type endopeptidase activity Source: InterPro

    GO - Biological processi

    1. pathogenesis Source: UniProtKB-KW

    Keywords - Molecular functioni

    Aminopeptidase, Hydrolase, Protease, Serine protease

    Keywords - Biological processi

    Virulence

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable dipeptidyl peptidase 4 (EC:3.4.14.5)
    Alternative name(s):
    Dipeptidyl peptidase IV
    Short name:
    DPP IV
    Short name:
    DppIV
    Gene namesi
    Name:DPP4
    ORF Names:ARB_06110
    OrganismiArthroderma benhamiae (strain ATCC MYA-4681 / CBS 112371) (Trichophyton mentagrophytes)
    Taxonomic identifieri663331 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesArthrodermataceaeArthroderma
    ProteomesiUP000008866: Unassembled WGS sequence

    Subcellular locationi

    Secreted 1 Publication

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell
    2. membrane Source: InterPro

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1818Sequence AnalysisAdd
    BLAST
    Chaini19 – 778760Probable dipeptidyl peptidase 4PRO_0000397808Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi84 – 841N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi114 – 1141N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi222 – 2221N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Structurei

    3D structure databases

    ProteinModelPortaliD4APE2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase S9B family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    KOiK01278.
    OrthoDBiEOG72VHFG.

    Family and domain databases

    Gene3Di2.140.10.30. 1 hit.
    3.40.50.1820. 1 hit.
    InterProiIPR029058. AB_hydrolase.
    IPR002471. Pept_S9_AS.
    IPR001375. Peptidase_S9.
    IPR002469. Peptidase_S9B.
    [Graphical view]
    PfamiPF00930. DPPIV_N. 1 hit.
    PF00326. Peptidase_S9. 1 hit.
    [Graphical view]
    SUPFAMiSSF53474. SSF53474. 1 hit.
    PROSITEiPS00708. PRO_ENDOPEP_SER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    D4APE2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKTSQFLSLL LLAGIAQAIV PPREPRPPTG GGNKLLTYKE CVPRATISPR    50
    STSLAWINSD EDGQYISQSD DGALILQNIV TNTNKTLVAA DKVPKGYYDY 100
    WFKPDLSAVL WATNYTKQYR HSYFANYFIL DIEKGSLTPL SQDQAGDIQY 150
    AQWSPMDNSI AYVRGNDLYI WNNGKTKRIT ENGGPDIFNG VPDWVYEEEI 200
    FGDRFALWFS PDGEYLAYLR FNETGVPTYT IPYYKNKQKI APAYPRELEI 250
    RYPKVSAKNP TVQFHLLNIA SSQETTIPVT AFPENDLVIG EVAWLSSGHD 300
    SVAYRAFNRV QDREKIVSVK VESKESKVIR ERDGTDGWID NLLSMSYIGD 350
    VNGKEYYVDI SDASGWAHIY LYPVDGGKEI ALTTGEWEVV AILKVDTKKK 400
    LIYFTSTKYH STTRHVYSVS YDTKVMTPLV NDKEAAYYTA SFSAKGGYYI 450
    LSYQGPNVPY QELYSTKDSK KPLKTITSND ALLEKLKEYK LPKVSFFEIK 500
    LPSGETLNVK QRLPPNFNPH KKYPVLFTPY GGPGAQEVSQ AWNSLDFKSY 550
    ITSDPELEYV TWTVDNRGTG YKGRKFRSAV AKRLGFLEPQ DQVFAAKELL 600
    KNRWADKDHI GIWGWSYGGF LTAKTLETDS GVFTFGISTA PVSDFRLYDS 650
    MYTERYMKTV ELNADGYSET AVHKVDGFKN LKGHYLIQHG TGDDNVHFQN 700
    AAVLSNTLMN GGVTADKLTT QWFTDSDHGI RYDMDSTYQY KQLAKMVYDQ 750
    KQRKPERPPM HQWSKRVLAA LFGERAEE 778
    Length:778
    Mass (Da):88,399
    Last modified:May 18, 2010 - v1
    Checksum:iCD21E4B0654123B7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    ABSU01000004 Genomic DNA. Translation: EFE35153.1.
    RefSeqiXP_003015798.1. XM_003015752.1.

    Genome annotation databases

    GeneIDi9526080.
    KEGGiabe:ARB_06110.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    ABSU01000004 Genomic DNA. Translation: EFE35153.1 .
    RefSeqi XP_003015798.1. XM_003015752.1.

    3D structure databases

    ProteinModelPortali D4APE2.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 9526080.
    KEGGi abe:ARB_06110.

    Phylogenomic databases

    KOi K01278.
    OrthoDBi EOG72VHFG.

    Family and domain databases

    Gene3Di 2.140.10.30. 1 hit.
    3.40.50.1820. 1 hit.
    InterProi IPR029058. AB_hydrolase.
    IPR002471. Pept_S9_AS.
    IPR001375. Peptidase_S9.
    IPR002469. Peptidase_S9B.
    [Graphical view ]
    Pfami PF00930. DPPIV_N. 1 hit.
    PF00326. Peptidase_S9. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53474. SSF53474. 1 hit.
    PROSITEi PS00708. PRO_ENDOPEP_SER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], IDENTIFICATION BY MASS SPECTROMETRY, SUBCELLULAR LOCATION.
      Strain: ATCC MYA-4681 / CBS 112371.

    Entry informationi

    Entry nameiDPP4_ARTBC
    AccessioniPrimary (citable) accession number: D4APE2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 5, 2010
    Last sequence update: May 18, 2010
    Last modified: October 1, 2014
    This is version 21 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3