D4APE2 (DPP4_ARTBC) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable dipeptidyl peptidase 4
EC=3.4.14.5

Alternative name(s):
Dipeptidyl peptidase IV
Short name=DPP IV
Short name=DppIV

Gene names

Name:	DPP4
ORF Names:	ARB_06110

Organism

Arthroderma benhamiae (strain ATCC MYA-4681 / CBS 112371) (Trichophyton mentagrophytes) [Complete proteome]

Taxonomic identifier

663331 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Pezizomycotina › leotiomyceta › Eurotiomycetes › Eurotiomycetidae › Onygenales › Arthrodermataceae › Arthroderma › Arthroderma benhamiae

Protein attributes

Sequence length	778 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Extracellular dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline. Contributes to pathogenicity By similarity.
Catalytic activity	Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.
Subcellular location	Secreted Ref.1.
Sequence similarities	Belongs to the peptidase S9B family.

Ontologies

Keywords
Biological process	Virulence
Cellular component	Secreted
Domain	Signal
Molecular function	Aminopeptidase Hydrolase Protease Serine protease
PTM	Glycoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	pathogenesis Inferred from electronic annotation. Source: UniProtKB-KW proteolysis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell membrane Inferred from electronic annotation. Source: InterPro
Molecular_function	aminopeptidase activity Inferred from electronic annotation. Source: UniProtKB-KW serine-type endopeptidase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 18	18	Potential
	Chain	19 – 778	760	Probable dipeptidyl peptidase 4		PRO_0000397808
Sites
	Active site	616	1	Charge relay system By similarity
	Active site	693	1	Charge relay system By similarity
	Active site	728	1	Charge relay system By similarity
Amino acid modifications
	Glycosylation	84	1	N-linked (GlcNAc...) Potential
	Glycosylation	114	1	N-linked (GlcNAc...) Potential
	Glycosylation	222	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	D4APE2 [UniParc]. Last modified May 18, 2010. Version 1. Checksum: CD21E4B0654123B7	FASTA	778	88,399
	10 20 30 40 50 60 MKTSQFLSLL LLAGIAQAIV PPREPRPPTG GGNKLLTYKE CVPRATISPR STSLAWINSD 70 80 90 100 110 120 EDGQYISQSD DGALILQNIV TNTNKTLVAA DKVPKGYYDY WFKPDLSAVL WATNYTKQYR 130 140 150 160 170 180 HSYFANYFIL DIEKGSLTPL SQDQAGDIQY AQWSPMDNSI AYVRGNDLYI WNNGKTKRIT 190 200 210 220 230 240 ENGGPDIFNG VPDWVYEEEI FGDRFALWFS PDGEYLAYLR FNETGVPTYT IPYYKNKQKI 250 260 270 280 290 300 APAYPRELEI RYPKVSAKNP TVQFHLLNIA SSQETTIPVT AFPENDLVIG EVAWLSSGHD 310 320 330 340 350 360 SVAYRAFNRV QDREKIVSVK VESKESKVIR ERDGTDGWID NLLSMSYIGD VNGKEYYVDI 370 380 390 400 410 420 SDASGWAHIY LYPVDGGKEI ALTTGEWEVV AILKVDTKKK LIYFTSTKYH STTRHVYSVS 430 440 450 460 470 480 YDTKVMTPLV NDKEAAYYTA SFSAKGGYYI LSYQGPNVPY QELYSTKDSK KPLKTITSND 490 500 510 520 530 540 ALLEKLKEYK LPKVSFFEIK LPSGETLNVK QRLPPNFNPH KKYPVLFTPY GGPGAQEVSQ 550 560 570 580 590 600 AWNSLDFKSY ITSDPELEYV TWTVDNRGTG YKGRKFRSAV AKRLGFLEPQ DQVFAAKELL 610 620 630 640 650 660 KNRWADKDHI GIWGWSYGGF LTAKTLETDS GVFTFGISTA PVSDFRLYDS MYTERYMKTV 670 680 690 700 710 720 ELNADGYSET AVHKVDGFKN LKGHYLIQHG TGDDNVHFQN AAVLSNTLMN GGVTADKLTT 730 740 750 760 770 QWFTDSDHGI RYDMDSTYQY KQLAKMVYDQ KQRKPERPPM HQWSKRVLAA LFGERAEE

References

[1]

"Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi." Burmester A., Shelest E., Gloeckner G., Heddergott C., Schindler S., Staib P., Heidel A., Felder M., Petzold A., Szafranski K., Feuermann M., Pedruzzi I., Priebe S., Groth M., Winkler R., Li W., Kniemeyer O., Schroeckh V. , Hertweck C., Hube B., White T.C., Platzer M., Guthke R., Heitman J., Woestemeyer J., Zipfel P.F., Monod M., Brakhage A.A. Genome Biol. 12:R7.1-R7.16(2011) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], IDENTIFICATION BY MASS SPECTROMETRY, SUBCELLULAR LOCATION. Strain: ATCC MYA-4681 / CBS 112371.

Cross-references

Sequence databases
EMBL GenBank DDBJ	ABSU01000004 Genomic DNA. Translation: EFE35153.1.
RefSeq	XP_003015798.1. XM_003015752.1.
3D structure databases
ProteinModelPortal	D4APE2.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	9526080.
KEGG	abe:ARB_06110.
Phylogenomic databases
KO	K01278.
Family and domain databases
InterPro	IPR002471. Pept_S9_AS. IPR001375. Peptidase_S9. IPR002469. Peptidase_S9B. [Graphical view]
Pfam	PF00930. DPPIV_N. 1 hit. PF00326. Peptidase_S9. 1 hit. [Graphical view]
PROSITE	PS00708. PRO_ENDOPEP_SER. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DPP4_ARTBC

Accession

Primary (citable) accession number: D4APE2

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 5, 2010
Last sequence update:	May 18, 2010
Last modified:	June 13, 2012
This is version 16 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program