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D4APE2 (DPP4_ARTBC) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 18. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable dipeptidyl peptidase 4

EC=3.4.14.5
Alternative name(s):
Dipeptidyl peptidase IV
Short name=DPP IV
Short name=DppIV
Gene names
Name:DPP4
ORF Names:ARB_06110
OrganismArthroderma benhamiae (strain ATCC MYA-4681 / CBS 112371) (Trichophyton mentagrophytes) [Complete proteome]
Taxonomic identifier663331 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesArthrodermataceaeArthroderma

Protein attributes

Sequence length778 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Extracellular dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline. Contributes to pathogenicity By similarity.

Catalytic activity

Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.

Subcellular location

Secreted Ref.1.

Sequence similarities

Belongs to the peptidase S9B family.

Ontologies

Keywords
   Biological processVirulence
   Cellular componentSecreted
   DomainSignal
   Molecular functionAminopeptidase
Hydrolase
Protease
Serine protease
   PTMGlycoprotein
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processpathogenesis

Inferred from electronic annotation. Source: UniProtKB-KW

proteolysis

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

membrane

Inferred from electronic annotation. Source: InterPro

   Molecular_functionaminopeptidase activity

Inferred from electronic annotation. Source: UniProtKB-KW

serine-type endopeptidase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1818 Potential
Chain19 – 778760Probable dipeptidyl peptidase 4
PRO_0000397808

Sites

Active site6161Charge relay system By similarity
Active site6931Charge relay system By similarity
Active site7281Charge relay system By similarity

Amino acid modifications

Glycosylation841N-linked (GlcNAc...) Potential
Glycosylation1141N-linked (GlcNAc...) Potential
Glycosylation2221N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
D4APE2 [UniParc].

Last modified May 18, 2010. Version 1.
Checksum: CD21E4B0654123B7

FASTA77888,399
        10         20         30         40         50         60 
MKTSQFLSLL LLAGIAQAIV PPREPRPPTG GGNKLLTYKE CVPRATISPR STSLAWINSD 

        70         80         90        100        110        120 
EDGQYISQSD DGALILQNIV TNTNKTLVAA DKVPKGYYDY WFKPDLSAVL WATNYTKQYR 

       130        140        150        160        170        180 
HSYFANYFIL DIEKGSLTPL SQDQAGDIQY AQWSPMDNSI AYVRGNDLYI WNNGKTKRIT 

       190        200        210        220        230        240 
ENGGPDIFNG VPDWVYEEEI FGDRFALWFS PDGEYLAYLR FNETGVPTYT IPYYKNKQKI 

       250        260        270        280        290        300 
APAYPRELEI RYPKVSAKNP TVQFHLLNIA SSQETTIPVT AFPENDLVIG EVAWLSSGHD 

       310        320        330        340        350        360 
SVAYRAFNRV QDREKIVSVK VESKESKVIR ERDGTDGWID NLLSMSYIGD VNGKEYYVDI 

       370        380        390        400        410        420 
SDASGWAHIY LYPVDGGKEI ALTTGEWEVV AILKVDTKKK LIYFTSTKYH STTRHVYSVS 

       430        440        450        460        470        480 
YDTKVMTPLV NDKEAAYYTA SFSAKGGYYI LSYQGPNVPY QELYSTKDSK KPLKTITSND 

       490        500        510        520        530        540 
ALLEKLKEYK LPKVSFFEIK LPSGETLNVK QRLPPNFNPH KKYPVLFTPY GGPGAQEVSQ 

       550        560        570        580        590        600 
AWNSLDFKSY ITSDPELEYV TWTVDNRGTG YKGRKFRSAV AKRLGFLEPQ DQVFAAKELL 

       610        620        630        640        650        660 
KNRWADKDHI GIWGWSYGGF LTAKTLETDS GVFTFGISTA PVSDFRLYDS MYTERYMKTV 

       670        680        690        700        710        720 
ELNADGYSET AVHKVDGFKN LKGHYLIQHG TGDDNVHFQN AAVLSNTLMN GGVTADKLTT 

       730        740        750        760        770 
QWFTDSDHGI RYDMDSTYQY KQLAKMVYDQ KQRKPERPPM HQWSKRVLAA LFGERAEE 

« Hide

References

[1]"Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi."
Burmester A., Shelest E., Gloeckner G., Heddergott C., Schindler S., Staib P., Heidel A., Felder M., Petzold A., Szafranski K., Feuermann M., Pedruzzi I., Priebe S., Groth M., Winkler R., Li W., Kniemeyer O., Schroeckh V. expand/collapse author list , Hertweck C., Hube B., White T.C., Platzer M., Guthke R., Heitman J., Woestemeyer J., Zipfel P.F., Monod M., Brakhage A.A.
Genome Biol. 12:R7.1-R7.16(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], IDENTIFICATION BY MASS SPECTROMETRY, SUBCELLULAR LOCATION.
Strain: ATCC MYA-4681 / CBS 112371.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
ABSU01000004 Genomic DNA. Translation: EFE35153.1.
RefSeqXP_003015798.1. XM_003015752.1.

3D structure databases

ProteinModelPortalD4APE2.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID9526080.
KEGGabe:ARB_06110.

Phylogenomic databases

KOK01278.
OrthoDBEOG72VHFG.

Family and domain databases

Gene3D2.140.10.30. 1 hit.
InterProIPR002471. Pept_S9_AS.
IPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B.
[Graphical view]
PfamPF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view]
PROSITEPS00708. PRO_ENDOPEP_SER. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDPP4_ARTBC
AccessionPrimary (citable) accession number: D4APE2
Entry history
Integrated into UniProtKB/Swiss-Prot: October 5, 2010
Last sequence update: May 18, 2010
Last modified: April 16, 2014
This is version 18 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries