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D4APE2

- DPP4_ARTBC

UniProt

D4APE2 - DPP4_ARTBC

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Protein

Probable dipeptidyl peptidase 4

Gene

DPP4

Organism
Arthroderma benhamiae (strain ATCC MYA-4681 / CBS 112371) (Trichophyton mentagrophytes)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Extracellular dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline. Contributes to pathogenicity (By similarity).By similarity

Catalytic activityi

Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei616 – 6161Charge relay systemPROSITE-ProRule annotation
Active sitei693 – 6931Charge relay systemPROSITE-ProRule annotation
Active sitei728 – 7281Charge relay systemPROSITE-ProRule annotation

GO - Molecular functioni

  1. aminopeptidase activity Source: UniProtKB-KW
  2. serine-type endopeptidase activity Source: InterPro

GO - Biological processi

  1. pathogenesis Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Aminopeptidase, Hydrolase, Protease, Serine protease

Keywords - Biological processi

Virulence

Names & Taxonomyi

Protein namesi
Recommended name:
Probable dipeptidyl peptidase 4 (EC:3.4.14.5)
Alternative name(s):
Dipeptidyl peptidase IV
Short name:
DPP IV
Short name:
DppIV
Gene namesi
Name:DPP4
ORF Names:ARB_06110
OrganismiArthroderma benhamiae (strain ATCC MYA-4681 / CBS 112371) (Trichophyton mentagrophytes)
Taxonomic identifieri663331 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesArthrodermataceaeArthroderma
ProteomesiUP000008866: Unassembled WGS sequence

Subcellular locationi

Secreted 1 Publication

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
  2. membrane Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence AnalysisAdd
BLAST
Chaini19 – 778760Probable dipeptidyl peptidase 4PRO_0000397808Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi84 – 841N-linked (GlcNAc...)Sequence Analysis
Glycosylationi114 – 1141N-linked (GlcNAc...)Sequence Analysis
Glycosylationi222 – 2221N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliD4APE2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S9B family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

KOiK01278.
OrthoDBiEOG72VHFG.

Family and domain databases

Gene3Di2.140.10.30. 1 hit.
3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR002471. Pept_S9_AS.
IPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B.
[Graphical view]
PfamiPF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00708. PRO_ENDOPEP_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

D4APE2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKTSQFLSLL LLAGIAQAIV PPREPRPPTG GGNKLLTYKE CVPRATISPR
60 70 80 90 100
STSLAWINSD EDGQYISQSD DGALILQNIV TNTNKTLVAA DKVPKGYYDY
110 120 130 140 150
WFKPDLSAVL WATNYTKQYR HSYFANYFIL DIEKGSLTPL SQDQAGDIQY
160 170 180 190 200
AQWSPMDNSI AYVRGNDLYI WNNGKTKRIT ENGGPDIFNG VPDWVYEEEI
210 220 230 240 250
FGDRFALWFS PDGEYLAYLR FNETGVPTYT IPYYKNKQKI APAYPRELEI
260 270 280 290 300
RYPKVSAKNP TVQFHLLNIA SSQETTIPVT AFPENDLVIG EVAWLSSGHD
310 320 330 340 350
SVAYRAFNRV QDREKIVSVK VESKESKVIR ERDGTDGWID NLLSMSYIGD
360 370 380 390 400
VNGKEYYVDI SDASGWAHIY LYPVDGGKEI ALTTGEWEVV AILKVDTKKK
410 420 430 440 450
LIYFTSTKYH STTRHVYSVS YDTKVMTPLV NDKEAAYYTA SFSAKGGYYI
460 470 480 490 500
LSYQGPNVPY QELYSTKDSK KPLKTITSND ALLEKLKEYK LPKVSFFEIK
510 520 530 540 550
LPSGETLNVK QRLPPNFNPH KKYPVLFTPY GGPGAQEVSQ AWNSLDFKSY
560 570 580 590 600
ITSDPELEYV TWTVDNRGTG YKGRKFRSAV AKRLGFLEPQ DQVFAAKELL
610 620 630 640 650
KNRWADKDHI GIWGWSYGGF LTAKTLETDS GVFTFGISTA PVSDFRLYDS
660 670 680 690 700
MYTERYMKTV ELNADGYSET AVHKVDGFKN LKGHYLIQHG TGDDNVHFQN
710 720 730 740 750
AAVLSNTLMN GGVTADKLTT QWFTDSDHGI RYDMDSTYQY KQLAKMVYDQ
760 770
KQRKPERPPM HQWSKRVLAA LFGERAEE
Length:778
Mass (Da):88,399
Last modified:May 18, 2010 - v1
Checksum:iCD21E4B0654123B7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ABSU01000004 Genomic DNA. Translation: EFE35153.1.
RefSeqiXP_003015798.1. XM_003015752.1.

Genome annotation databases

GeneIDi9526080.
KEGGiabe:ARB_06110.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ABSU01000004 Genomic DNA. Translation: EFE35153.1 .
RefSeqi XP_003015798.1. XM_003015752.1.

3D structure databases

ProteinModelPortali D4APE2.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 9526080.
KEGGi abe:ARB_06110.

Phylogenomic databases

KOi K01278.
OrthoDBi EOG72VHFG.

Family and domain databases

Gene3Di 2.140.10.30. 1 hit.
3.40.50.1820. 1 hit.
InterProi IPR029058. AB_hydrolase.
IPR002471. Pept_S9_AS.
IPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B.
[Graphical view ]
Pfami PF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view ]
SUPFAMi SSF53474. SSF53474. 1 hit.
PROSITEi PS00708. PRO_ENDOPEP_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], IDENTIFICATION BY MASS SPECTROMETRY, SUBCELLULAR LOCATION.
    Strain: ATCC MYA-4681 / CBS 112371.

Entry informationi

Entry nameiDPP4_ARTBC
AccessioniPrimary (citable) accession number: D4APE2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 5, 2010
Last sequence update: May 18, 2010
Last modified: October 29, 2014
This is version 22 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3