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D4AP52 (SCPB_ARTBC) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 19. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Carboxypeptidase S1 homolog B

EC=3.4.16.6
Alternative name(s):
Serine carboxypeptidase B
Short name=SPCB
Gene names
Name:SCPB
ORF Names:ARB_06019
OrganismArthroderma benhamiae (strain ATCC MYA-4681 / CBS 112371) (Trichophyton mentagrophytes) [Complete proteome]
Taxonomic identifier663331 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesArthrodermataceaeArthroderma

Protein attributes

Sequence length656 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Extracellular serine carboxypeptidase that contributes to pathogenicity By similarity.

Catalytic activity

Preferential release of a C-terminal arginine or lysine residue.

Subcellular location

Cell membrane; Lipid-anchorGPI-anchor Potential.

Sequence similarities

Belongs to the peptidase S10 family.

Ontologies

Keywords
   Biological processVirulence
   Cellular componentCell membrane
Membrane
   DomainSignal
   Molecular functionCarboxypeptidase
Hydrolase
Protease
   PTMDisulfide bond
Glycoprotein
GPI-anchor
Lipoprotein
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processpathogenesis

Inferred from electronic annotation. Source: UniProtKB-KW

proteolysis

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentanchored component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionserine-type carboxypeptidase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2121 Potential
Chain22 – 627606Carboxypeptidase S1 homolog B
PRO_0000397827
Propeptide628 – 65629Removed in mature form Potential
PRO_0000397828

Sites

Active site2341 By similarity
Active site4531 By similarity
Active site5111 By similarity
Binding site4561Substrate By similarity
Binding site5121Substrate By similarity

Amino acid modifications

Lipidation6271GPI-anchor amidated glycine Potential
Glycosylation1301N-linked (GlcNAc...) Potential
Glycosylation1571N-linked (GlcNAc...) Potential
Glycosylation1801N-linked (GlcNAc...) Potential
Glycosylation1941N-linked (GlcNAc...) Potential
Glycosylation2561N-linked (GlcNAc...) Potential
Glycosylation2961N-linked (GlcNAc...) Potential
Glycosylation3051N-linked (GlcNAc...) Potential
Glycosylation3441N-linked (GlcNAc...) Potential
Glycosylation4081N-linked (GlcNAc...) Potential
Glycosylation4691N-linked (GlcNAc...) Potential
Glycosylation4871N-linked (GlcNAc...) Potential
Glycosylation5001N-linked (GlcNAc...) Potential
Glycosylation5921N-linked (GlcNAc...) Potential
Glycosylation6061N-linked (GlcNAc...) Potential
Disulfide bond51 ↔ 123 By similarity
Disulfide bond322 ↔ 358 By similarity
Disulfide bond329 ↔ 351 By similarity

Sequences

Sequence LengthMass (Da)Tools
D4AP52 [UniParc].

Last modified May 18, 2010. Version 1.
Checksum: A9DA1EA3F38BBD1B

FASTA65672,378
        10         20         30         40         50         60 
MVSFCGVAAC LLTVAGHLAQ AQFPPKPEGV TVLESKFGSG ARITYKEPGL CETTEGVKSY 

        70         80         90        100        110        120 
AGYVHLPPGT LRDFGVEQDY PINTFFWFFE ARKDPENAPL GIWMNGGPGS SSMFGMMTEN 

       130        140        150        160        170        180 
GPCFVNADSN STRLNPHSWN NEDQPVQVGL SYDTLANFTR NLVTDEITKL EPGEPIPEQN 

       190        200        210        220        230        240 
ATFLVGTYAS RNMNTTAHGT RHAAMALWHF AQVWFQEFPG YHPRNNKISI ATESYGGRYG 

       250        260        270        280        290        300 
PAFTAFFEEQ NQKIKNGTWK GHEGTMHVLH LDTLMIVNGC IDRLVQWPAY PQMAYNNTYG 

       310        320        330        340        350        360 
IEAVNASIHA GMLDALYRDG GCRDKINHCR SLSSVSDPEN LGINSTVNDV CKDAETFCSN 

       370        380        390        400        410        420 
DVRDPYTKLS GRNYYDIGQL DPSPFPAPFY MAWLNQPHVQ AALGVPLNWT QSNDVVSTAF 

       430        440        450        460        470        480 
RAIGDYPRPG WLENLAFLLE NGIKVSLVYG DRDYACNWFG GELSSLGINY TDTQEFHNAG 

       490        500        510        520        530        540 
YAGIQINSSY IGGQVRQYGN LSFARVYEAG HEVPSYQPET ALQIFHRALF NKDIATGTKD 

       550        560        570        580        590        600 
TSSRMDRGKF YGTSGPADSF GFKNEPPPQH VHFCHILDTS TCTKEQIQSV ENGTATIRSW 

       610        620        630        640        650 
IIVDSNSTSL FPEVVGSGEP TPTPMPGGAT TLSAHGYLYD VTLWVVLLVS AIELVM 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
ABSU01000004 Genomic DNA. Translation: EFE35063.1.
RefSeqXP_003015708.1. XM_003015662.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein family/group databases

MEROPSS10.016.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID9525989.
KEGGabe:ARB_06019.

Phylogenomic databases

OrthoDBEOG7FV40C.

Family and domain databases

InterProIPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
[Graphical view]
PANTHERPTHR11802. PTHR11802. 1 hit.
PfamPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSPR00724. CRBOXYPTASEC.
PROSITEPS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSCPB_ARTBC
AccessionPrimary (citable) accession number: D4AP52
Entry history
Integrated into UniProtKB/Swiss-Prot: October 5, 2010
Last sequence update: May 18, 2010
Last modified: February 19, 2014
This is version 19 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries