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Protein

Carboxypeptidase S1 homolog B

Gene

SCPB

Organism
Arthroderma benhamiae (strain ATCC MYA-4681 / CBS 112371) (Trichophyton mentagrophytes)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Extracellular serine carboxypeptidase that contributes to pathogenicity.By similarity

Catalytic activityi

Preferential release of a C-terminal arginine or lysine residue.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei234PROSITE-ProRule annotation1
Active sitei453PROSITE-ProRule annotation1
Binding sitei456SubstrateBy similarity1
Active sitei511PROSITE-ProRule annotation1
Binding sitei512SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCarboxypeptidase, Hydrolase, Protease
Biological processVirulence

Protein family/group databases

ESTHERitriru-SCPB Carboxypeptidase_S10
MEROPSiS10.016

Names & Taxonomyi

Protein namesi
Recommended name:
Carboxypeptidase S1 homolog B (EC:3.4.16.6)
Alternative name(s):
Serine carboxypeptidase B
Short name:
SPCB
Gene namesi
Name:SCPB
ORF Names:ARB_06019
OrganismiArthroderma benhamiae (strain ATCC MYA-4681 / CBS 112371) (Trichophyton mentagrophytes)
Taxonomic identifieri663331 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesArthrodermataceaeTrichophyton
Proteomesi
  • UP000008866 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000039782722 – 627Carboxypeptidase S1 homolog BAdd BLAST606
PropeptideiPRO_0000397828628 – 656Removed in mature formSequence analysisAdd BLAST29

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi51 ↔ 123By similarity
Glycosylationi130N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi157N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi180N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi194N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi256N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi296N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi305N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi322 ↔ 358By similarity
Disulfide bondi329 ↔ 351By similarity
Glycosylationi344N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi408N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi469N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi487N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi500N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi592N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi606N-linked (GlcNAc...) asparagineSequence analysis1
Lipidationi627GPI-anchor amidated glycineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PRIDEiD4AP52

Interactioni

Protein-protein interaction databases

STRINGi663331.XP_003015708.1

Structurei

3D structure databases

SMRiD4AP52
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S10 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG1282 Eukaryota
COG2939 LUCA
OrthoDBiEOG092C16XU

Family and domain databases

InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR001563 Peptidase_S10
IPR018202 Ser_caboxypep_ser_AS
PANTHERiPTHR11802 PTHR11802, 1 hit
PfamiView protein in Pfam
PF00450 Peptidase_S10, 1 hit
PRINTSiPR00724 CRBOXYPTASEC
SUPFAMiSSF53474 SSF53474, 2 hits
PROSITEiView protein in PROSITE
PS00131 CARBOXYPEPT_SER_SER, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

D4AP52-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVSFCGVAAC LLTVAGHLAQ AQFPPKPEGV TVLESKFGSG ARITYKEPGL
60 70 80 90 100
CETTEGVKSY AGYVHLPPGT LRDFGVEQDY PINTFFWFFE ARKDPENAPL
110 120 130 140 150
GIWMNGGPGS SSMFGMMTEN GPCFVNADSN STRLNPHSWN NEDQPVQVGL
160 170 180 190 200
SYDTLANFTR NLVTDEITKL EPGEPIPEQN ATFLVGTYAS RNMNTTAHGT
210 220 230 240 250
RHAAMALWHF AQVWFQEFPG YHPRNNKISI ATESYGGRYG PAFTAFFEEQ
260 270 280 290 300
NQKIKNGTWK GHEGTMHVLH LDTLMIVNGC IDRLVQWPAY PQMAYNNTYG
310 320 330 340 350
IEAVNASIHA GMLDALYRDG GCRDKINHCR SLSSVSDPEN LGINSTVNDV
360 370 380 390 400
CKDAETFCSN DVRDPYTKLS GRNYYDIGQL DPSPFPAPFY MAWLNQPHVQ
410 420 430 440 450
AALGVPLNWT QSNDVVSTAF RAIGDYPRPG WLENLAFLLE NGIKVSLVYG
460 470 480 490 500
DRDYACNWFG GELSSLGINY TDTQEFHNAG YAGIQINSSY IGGQVRQYGN
510 520 530 540 550
LSFARVYEAG HEVPSYQPET ALQIFHRALF NKDIATGTKD TSSRMDRGKF
560 570 580 590 600
YGTSGPADSF GFKNEPPPQH VHFCHILDTS TCTKEQIQSV ENGTATIRSW
610 620 630 640 650
IIVDSNSTSL FPEVVGSGEP TPTPMPGGAT TLSAHGYLYD VTLWVVLLVS

AIELVM
Length:656
Mass (Da):72,378
Last modified:May 18, 2010 - v1
Checksum:iA9DA1EA3F38BBD1B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ABSU01000004 Genomic DNA Translation: EFE35063.1
RefSeqiXP_003015708.1, XM_003015662.1

Genome annotation databases

EnsemblFungiiEFE35063; EFE35063; ARB_06019
GeneIDi9525989
KEGGiabe:ARB_06019

Similar proteinsi

Entry informationi

Entry nameiSCPB_ARTBC
AccessioniPrimary (citable) accession number: D4AP52
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 5, 2010
Last sequence update: May 18, 2010
Last modified: May 23, 2018
This is version 36 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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