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D4AP52

- SCPB_ARTBC

UniProt

D4AP52 - SCPB_ARTBC

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Protein

Carboxypeptidase S1 homolog B

Gene
SCPB, ARB_06019
Organism
Arthroderma benhamiae (strain ATCC MYA-4681 / CBS 112371) (Trichophyton mentagrophytes)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Extracellular serine carboxypeptidase that contributes to pathogenicity By similarity.

Catalytic activityi

Preferential release of a C-terminal arginine or lysine residue.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei234 – 2341 By similarity
Active sitei453 – 4531 By similarity
Binding sitei456 – 4561Substrate By similarity
Active sitei511 – 5111 By similarity
Binding sitei512 – 5121Substrate By similarity

GO - Molecular functioni

  1. serine-type carboxypeptidase activity Source: InterPro

GO - Biological processi

  1. pathogenesis Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Carboxypeptidase, Hydrolase, Protease

Keywords - Biological processi

Virulence

Protein family/group databases

MEROPSiS10.016.

Names & Taxonomyi

Protein namesi
Recommended name:
Carboxypeptidase S1 homolog B (EC:3.4.16.6)
Alternative name(s):
Serine carboxypeptidase B
Short name:
SPCB
Gene namesi
Name:SCPB
ORF Names:ARB_06019
OrganismiArthroderma benhamiae (strain ATCC MYA-4681 / CBS 112371) (Trichophyton mentagrophytes)
Taxonomic identifieri663331 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesArthrodermataceaeArthroderma
ProteomesiUP000008866: Unassembled WGS sequence

Subcellular locationi

Cell membrane; Lipid-anchorGPI-anchor Reviewed prediction

GO - Cellular componenti

  1. anchored component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121 Reviewed predictionAdd
BLAST
Chaini22 – 627606Carboxypeptidase S1 homolog BPRO_0000397827Add
BLAST
Propeptidei628 – 65629Removed in mature form Reviewed predictionPRO_0000397828Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi51 ↔ 123 By similarity
Glycosylationi130 – 1301N-linked (GlcNAc...) Reviewed prediction
Glycosylationi157 – 1571N-linked (GlcNAc...) Reviewed prediction
Glycosylationi180 – 1801N-linked (GlcNAc...) Reviewed prediction
Glycosylationi194 – 1941N-linked (GlcNAc...) Reviewed prediction
Glycosylationi256 – 2561N-linked (GlcNAc...) Reviewed prediction
Glycosylationi296 – 2961N-linked (GlcNAc...) Reviewed prediction
Glycosylationi305 – 3051N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi322 ↔ 358 By similarity
Disulfide bondi329 ↔ 351 By similarity
Glycosylationi344 – 3441N-linked (GlcNAc...) Reviewed prediction
Glycosylationi408 – 4081N-linked (GlcNAc...) Reviewed prediction
Glycosylationi469 – 4691N-linked (GlcNAc...) Reviewed prediction
Glycosylationi487 – 4871N-linked (GlcNAc...) Reviewed prediction
Glycosylationi500 – 5001N-linked (GlcNAc...) Reviewed prediction
Glycosylationi592 – 5921N-linked (GlcNAc...) Reviewed prediction
Glycosylationi606 – 6061N-linked (GlcNAc...) Reviewed prediction
Lipidationi627 – 6271GPI-anchor amidated glycine Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S10 family.

Keywords - Domaini

Signal

Phylogenomic databases

OrthoDBiEOG7FV40C.

Family and domain databases

Gene3Di3.40.50.1820. 2 hits.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 2 hits.
PROSITEiPS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

D4AP52-1 [UniParc]FASTAAdd to Basket

« Hide

MVSFCGVAAC LLTVAGHLAQ AQFPPKPEGV TVLESKFGSG ARITYKEPGL    50
CETTEGVKSY AGYVHLPPGT LRDFGVEQDY PINTFFWFFE ARKDPENAPL 100
GIWMNGGPGS SSMFGMMTEN GPCFVNADSN STRLNPHSWN NEDQPVQVGL 150
SYDTLANFTR NLVTDEITKL EPGEPIPEQN ATFLVGTYAS RNMNTTAHGT 200
RHAAMALWHF AQVWFQEFPG YHPRNNKISI ATESYGGRYG PAFTAFFEEQ 250
NQKIKNGTWK GHEGTMHVLH LDTLMIVNGC IDRLVQWPAY PQMAYNNTYG 300
IEAVNASIHA GMLDALYRDG GCRDKINHCR SLSSVSDPEN LGINSTVNDV 350
CKDAETFCSN DVRDPYTKLS GRNYYDIGQL DPSPFPAPFY MAWLNQPHVQ 400
AALGVPLNWT QSNDVVSTAF RAIGDYPRPG WLENLAFLLE NGIKVSLVYG 450
DRDYACNWFG GELSSLGINY TDTQEFHNAG YAGIQINSSY IGGQVRQYGN 500
LSFARVYEAG HEVPSYQPET ALQIFHRALF NKDIATGTKD TSSRMDRGKF 550
YGTSGPADSF GFKNEPPPQH VHFCHILDTS TCTKEQIQSV ENGTATIRSW 600
IIVDSNSTSL FPEVVGSGEP TPTPMPGGAT TLSAHGYLYD VTLWVVLLVS 650
AIELVM 656
Length:656
Mass (Da):72,378
Last modified:May 18, 2010 - v1
Checksum:iA9DA1EA3F38BBD1B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
ABSU01000004 Genomic DNA. Translation: EFE35063.1.
RefSeqiXP_003015708.1. XM_003015662.1.

Genome annotation databases

GeneIDi9525989.
KEGGiabe:ARB_06019.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
ABSU01000004 Genomic DNA. Translation: EFE35063.1 .
RefSeqi XP_003015708.1. XM_003015662.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi S10.016.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 9525989.
KEGGi abe:ARB_06019.

Phylogenomic databases

OrthoDBi EOG7FV40C.

Family and domain databases

Gene3Di 3.40.50.1820. 2 hits.
InterProi IPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
[Graphical view ]
PANTHERi PTHR11802. PTHR11802. 1 hit.
Pfami PF00450. Peptidase_S10. 1 hit.
[Graphical view ]
PRINTSi PR00724. CRBOXYPTASEC.
SUPFAMi SSF53474. SSF53474. 2 hits.
PROSITEi PS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC MYA-4681 / CBS 112371.

Entry informationi

Entry nameiSCPB_ARTBC
AccessioniPrimary (citable) accession number: D4AP52
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 5, 2010
Last sequence update: May 18, 2010
Last modified: June 11, 2014
This is version 21 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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