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D4ANI5

- D4ANI5_ARTBC

UniProt

D4ANI5 - D4ANI5_ARTBC

Protein

Kynureninase

Gene

BNA5

Organism
Arthroderma benhamiae (strain ATCC MYA-4681 / CBS 112371) (Trichophyton mentagrophytes)
Status
Unreviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 29 (01 Oct 2014)
      Sequence version 1 (18 May 2010)
      Previous versions | rss
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    Functioni

    Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.UniRule annotation

    Catalytic activityi

    L-3-hydroxykynurenine + H2O = 3-hydroxyanthranilate + L-alanine.UniRule annotation
    L-kynurenine + H2O = anthranilate + L-alanine.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei133 – 1331Pyridoxal phosphate; via amide nitrogenUniRule annotation
    Binding sitei134 – 1341Pyridoxal phosphateUniRule annotation
    Binding sitei247 – 2471Pyridoxal phosphateUniRule annotation
    Binding sitei250 – 2501Pyridoxal phosphateUniRule annotation
    Binding sitei272 – 2721Pyridoxal phosphateUniRule annotation
    Binding sitei306 – 3061Pyridoxal phosphateUniRule annotation
    Binding sitei334 – 3341Pyridoxal phosphateUniRule annotation

    GO - Molecular functioni

    1. kynureninase activity Source: UniProtKB-HAMAP
    2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 'de novo' NAD biosynthetic process from tryptophan Source: UniProtKB-HAMAP
    2. anthranilate metabolic process Source: UniProtKB-HAMAP
    3. L-kynurenine catabolic process Source: UniProtKB-UniPathway
    4. quinolinate biosynthetic process Source: UniProtKB-HAMAP
    5. tryptophan catabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    HydrolaseUniRule annotation

    Keywords - Biological processi

    Pyridine nucleotide biosynthesisUniRule annotation

    Keywords - Ligandi

    Pyridoxal phosphateUniRule annotation

    Enzyme and pathway databases

    UniPathwayiUPA00253; UER00329.
    UPA00334; UER00455.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    KynureninaseUniRule annotation (EC:3.7.1.3UniRule annotation)
    Alternative name(s):
    Biosynthesis of nicotinic acid protein 5UniRule annotation
    L-kynurenine hydrolaseUniRule annotation
    Gene namesi
    Name:BNA5UniRule annotation
    ORF Names:ARB_05790Imported
    OrganismiArthroderma benhamiae (strain ATCC MYA-4681 / CBS 112371) (Trichophyton mentagrophytes)Imported
    Taxonomic identifieri663331 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesArthrodermataceaeArthroderma
    ProteomesiUP000008866: Unassembled WGS sequence

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    CytoplasmUniRule annotation

    PTM / Processingi

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei273 – 2731N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Structurei

    3D structure databases

    ProteinModelPortaliD4ANI5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni161 – 1644Pyridoxal phosphate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the kynureninase family.UniRule annotation

    Phylogenomic databases

    KOiK01556.
    OrthoDBiEOG7V1G0J.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    HAMAPiMF_01970. Kynureninase.
    InterProiIPR000192. Aminotrans_V/Cys_dSase.
    IPR010111. Kynureninase.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view]
    PANTHERiPTHR14084. PTHR14084. 1 hit.
    PfamiPF00266. Aminotran_5. 1 hit.
    [Graphical view]
    PIRSFiPIRSF038800. KYNU. 1 hit.
    SUPFAMiSSF53383. SSF53383. 1 hit.
    TIGRFAMsiTIGR01814. kynureninase. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    D4ANI5-1 [UniParc]FASTAAdd to Basket

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    MDFSKDPSSL TREYARNLDE QDPLRDFRKE FIIPSKADLT RTTLAPPTGE    50
    EERKLEESCV YLCGNSLGLQ PVSTSEHVNS YLRSWALKGV LGHTEPHTDQ 100
    LTAEWLNIDD RAPELMAPLV GAKESEVALM GTLTSNLHLL MASFYKPTKE 150
    RYKIIFEGKA FPSDHFAIES QARHHGLDPE DAMVLIEPVS EDYPVLETSQ 200
    ILSVIDAHAD TAALILLPGI QYYTGQFFDM KTITAHAHSK GLMVGWDCAH 250
    AVGNVELQFH DWDVDFAAWC SYKYLNSGAG AMAGLFVHEK HGMVTEDSFR 300
    PRLSGWWGSD KSSRFIMDNK FVPRPGAAGY QVSNPSALDL AAVTASLKVF 350
    NKATMQALRR KSVKLTAYLE YLIDREFPSK SERPFTIITP SDPDMRGAQL 400
    SLRLRAGLLD PVFSCLLRNG VVLDERRPDV IRVAPAPLYN SFEDVWLFVR 450
    ELRVACDEAT AR 462
    Length:462
    Mass (Da):51,761
    Last modified:May 18, 2010 - v1
    Checksum:iD96BAC95B3EC56B1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    ABSU01000003 Genomic DNA. Translation: EFE35746.1.
    RefSeqiXP_003016391.1. XM_003016345.1.

    Genome annotation databases

    GeneIDi9521874.
    KEGGiabe:ARB_05790.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    ABSU01000003 Genomic DNA. Translation: EFE35746.1 .
    RefSeqi XP_003016391.1. XM_003016345.1.

    3D structure databases

    ProteinModelPortali D4ANI5.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 9521874.
    KEGGi abe:ARB_05790.

    Phylogenomic databases

    KOi K01556.
    OrthoDBi EOG7V1G0J.

    Enzyme and pathway databases

    UniPathwayi UPA00253 ; UER00329 .
    UPA00334 ; UER00455 .

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    HAMAPi MF_01970. Kynureninase.
    InterProi IPR000192. Aminotrans_V/Cys_dSase.
    IPR010111. Kynureninase.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view ]
    PANTHERi PTHR14084. PTHR14084. 1 hit.
    Pfami PF00266. Aminotran_5. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF038800. KYNU. 1 hit.
    SUPFAMi SSF53383. SSF53383. 1 hit.
    TIGRFAMsi TIGR01814. kynureninase. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC MYA-4681 / CBS 112371Imported.

    Entry informationi

    Entry nameiD4ANI5_ARTBC
    AccessioniPrimary (citable) accession number: D4ANI5
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 18, 2010
    Last sequence update: May 18, 2010
    Last modified: October 1, 2014
    This is version 29 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Caution

    The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3