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Protein

DNA ligase

Gene

ARB_04383

Organism
Arthroderma benhamiae (strain ATCC MYA-4681 / CBS 112371) (Trichophyton mentagrophytes)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. DNA binding Source: InterPro
  3. DNA ligase (ATP) activity Source: UniProtKB-EC

GO - Biological processi

  1. DNA biosynthetic process Source: InterPro
  2. DNA ligation involved in DNA repair Source: InterPro
  3. DNA recombination Source: UniProtKB-KW
  4. DNA replication Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotation

Keywords - Biological processi

DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Gene namesi
ORF Names:ARB_04383Imported
OrganismiArthroderma benhamiae (strain ATCC MYA-4681 / CBS 112371) (Trichophyton mentagrophytes)Imported
Taxonomic identifieri663331 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesArthrodermataceaeArthroderma
ProteomesiUP000008866: Unassembled WGS sequence

Structurei

3D structure databases

ProteinModelPortaliD4AJD4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

KOiK10777.
OrthoDBiEOG7QC84G.

Family and domain databases

Gene3Di2.40.50.140. 1 hit.
3.40.50.10190. 2 hits.
InterProiIPR001357. BRCT_dom.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR029710. LIG4.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PANTHERiPTHR10459:SF7. PTHR10459:SF7. 1 hit.
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SMARTiSM00292. BRCT. 2 hits.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF52113. SSF52113. 2 hits.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS50172. BRCT. 2 hits.
PS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D4AJD4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPNPGGAIR ETERELDEKP RNHGQTLPFH DLFISLFNPL NDLKKKPAGP
60 70 80 90 100
PAARRKAGPT GRNNLSPHEL RRNVIERFIS RWRQQVGNDF FPAFRLIVPE
110 120 130 140 150
KDRDRAMYGL KEKAIGKLLV KVMKIDKNSE DGYNLLNWKL PGQRAATAMT
160 170 180 190 200
GDFAGRCFEV ISKRPLRTEV GDMSIADVNS RLDDLAVASK EDAQLPILAE
210 220 230 240 250
FYRRMNPEEM MWLIRIILRQ MKVGATERTF FEIWHPDAES LFNISSSLRR
260 270 280 290 300
VCWELYLPSI RLEADEARVT LMQCFQPQLA QFQMHSFQKI IERMRLAEDD
310 320 330 340 350
PEFWIEEKLD GERMQLHMET NSSIPGGKRF EFWSRKAKEY TYLYGNGFYD
360 370 380 390 400
DNGSLTRHLK NAFADGVESI ILDGEMITWD PEQDAPVPFG TLKTAALAEQ
410 420 430 440 450
RNPFSASGHR PLFRIFDIVY LNGKPLTRYT LRDRRRALEA SVIPVHRRFE
460 470 480 490 500
IHPYQVGKSA SDIEPLLRKV VAEASEGLVL KNPNSPYRLN ERNDDWMKVK
510 520 530 540 550
PDYMTEFGES LDCIVVGGYY GSGKRGGNIS SYLCGLRVDD THAEDGTNPM
560 570 580 590 600
KCYSFCKVGG GFTAADYANI RHHTDGKWHD WDPKKPPTEY IELAGGDAQH
610 620 630 640 650
ERPDVWIKPD DSIVVCVKAA AVTPSDQFRL GLTVRFPRFK RLRMDKDWQS
660 670 680 690 700
ALSVQEFMDL KAGAEQEKKE KDFQVDNSRR KKTKRSKKKE LTVAGSGEPN
710 720 730 740 750
VAYVGSKTHI FDGLSFCGLK IQALEVNYAN IFIVVMTESV KPMKKSKADL
760 770 780 790 800
EQLIKANGGK IYQTNNAAKD TYCIADRRTV KVASLQKSGL ENVIRPCWIS
810 820 830 840 850
DCISQNEHDI GESSILLPLE PRHMFFTKED QKEEISNNVD KYDDSFARDT
860 870 880 890 900
SIAELTEILH KMDAISDISG EERLDIMSDL TLDGDQGSVH SDVEGWLFKN
910 920 930 940 950
LTIFFAPCSH LSSVPGEPYV DALSIRQQLA RNITIFTGAT VTDQQKNNRI
960 970 980 990 1000
THVIVDPSAD RDPETGKAKN YTTLRSEFAT RRAIPHFVTV QWVEECWKEK
1010 1020
TLVDEERMYS MPAIALPGLC
Length:1,020
Mass (Da):116,241
Last modified:May 18, 2010 - v1
Checksum:iE34AC539D072D3A8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ABSU01000001 Genomic DNA. Translation: EFE36857.1.
RefSeqiXP_003017502.1. XM_003017456.1.

Genome annotation databases

GeneIDi9524612.
KEGGiabe:ARB_04383.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ABSU01000001 Genomic DNA. Translation: EFE36857.1.
RefSeqiXP_003017502.1. XM_003017456.1.

3D structure databases

ProteinModelPortaliD4AJD4.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi9524612.
KEGGiabe:ARB_04383.

Phylogenomic databases

KOiK10777.
OrthoDBiEOG7QC84G.

Family and domain databases

Gene3Di2.40.50.140. 1 hit.
3.40.50.10190. 2 hits.
InterProiIPR001357. BRCT_dom.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR029710. LIG4.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PANTHERiPTHR10459:SF7. PTHR10459:SF7. 1 hit.
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SMARTiSM00292. BRCT. 2 hits.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF52113. SSF52113. 2 hits.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS50172. BRCT. 2 hits.
PS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC MYA-4681 / CBS 112371Imported.

Entry informationi

Entry nameiD4AJD4_ARTBC
AccessioniPrimary (citable) accession number: D4AJD4
Entry historyi
Integrated into UniProtKB/TrEMBL: May 18, 2010
Last sequence update: May 18, 2010
Last modified: February 4, 2015
This is version 28 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.