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D4AIF1

- SCPA_ARTBC

UniProt

D4AIF1 - SCPA_ARTBC

Protein

Carboxypeptidase S1 homolog A

Gene

SCPA

Organism
Arthroderma benhamiae (strain ATCC MYA-4681 / CBS 112371) (Trichophyton mentagrophytes)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 21 (01 Oct 2014)
      Sequence version 1 (18 May 2010)
      Previous versions | rss
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    Functioni

    Extracellular serine carboxypeptidase that contributes to pathogenicity.By similarity

    Catalytic activityi

    Preferential release of a C-terminal arginine or lysine residue.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei238 – 2381PROSITE-ProRule annotation
    Active sitei458 – 4581PROSITE-ProRule annotation
    Binding sitei461 – 4611SubstrateBy similarity
    Active sitei516 – 5161PROSITE-ProRule annotation
    Binding sitei517 – 5171SubstrateBy similarity

    GO - Molecular functioni

    1. serine-type carboxypeptidase activity Source: InterPro

    GO - Biological processi

    1. pathogenesis Source: UniProtKB-KW

    Keywords - Molecular functioni

    Carboxypeptidase, Hydrolase, Protease

    Keywords - Biological processi

    Virulence

    Protein family/group databases

    MEROPSiS10.016.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Carboxypeptidase S1 homolog A (EC:3.4.16.6)
    Alternative name(s):
    Serine carboxypeptidase A
    Short name:
    SCPA
    Gene namesi
    Name:SCPA
    ORF Names:ARB_04046
    OrganismiArthroderma benhamiae (strain ATCC MYA-4681 / CBS 112371) (Trichophyton mentagrophytes)
    Taxonomic identifieri663331 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesArthrodermataceaeArthroderma
    ProteomesiUP000008866: Unassembled WGS sequence

    Subcellular locationi

    GO - Cellular componenti

    1. anchored component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1919Sequence AnalysisAdd
    BLAST
    Chaini20 – 629610Carboxypeptidase S1 homolog APRO_0000397823Add
    BLAST
    Propeptidei630 – 65223Removed in mature formSequence AnalysisPRO_0000397824Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi50 ↔ 121By similarity
    Glycosylationi77 – 771N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi132 – 1321N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi161 – 1611N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi168 – 1681N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi184 – 1841N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi202 – 2021N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi260 – 2601N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi299 – 2991N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi325 ↔ 361By similarity
    Disulfide bondi332 ↔ 354By similarity
    Glycosylationi347 – 3471N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi410 – 4101N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi474 – 4741N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi492 – 4921N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi505 – 5051N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi594 – 5941N-linked (GlcNAc...)Sequence Analysis
    Lipidationi629 – 6291GPI-anchor amidated glycineSequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase S10 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    OrthoDBiEOG7FV40C.

    Family and domain databases

    Gene3Di3.40.50.1820. 2 hits.
    InterProiIPR029058. AB_hydrolase.
    IPR001563. Peptidase_S10.
    IPR018202. Peptidase_S10_AS.
    [Graphical view]
    PANTHERiPTHR11802. PTHR11802. 1 hit.
    PfamiPF00450. Peptidase_S10. 1 hit.
    [Graphical view]
    PRINTSiPR00724. CRBOXYPTASEC.
    SUPFAMiSSF53474. SSF53474. 2 hits.
    PROSITEiPS00131. CARBOXYPEPT_SER_SER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    D4AIF1-1 [UniParc]FASTAAdd to Basket

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    MRLAASIAVA LPVIGAASAQ GFPPPVMGVT VVKSKYDENV KITYKENDIC    50
    ETTEGVRSFT GHVHLPPDND YFGVYQNYSI NTFFWFFEAR EDPKNAPLSI 100
    WLNGGPGSSS MIGLFQENGP CWINDDSKST TNNSFSWNNR VNMLYIDQPN 150
    QVGFSYDELT NITYSTINDT ISVADFSSGV PAQNLSTLVG TGSSQKPWAT 200
    ANNTVNAARS IWHFAQVWFQ EFPEHKPNNN KISIWTESYG GRYGPSFASY 250
    FQEQNEKIKN HTITKEGEMH ILNLDTLGVI NGCIDLMFQA ESYAEFPYNN 300
    TYGITAYTKE KRDAIIRDIH RPDGCFDKLA KCREAAKEGD PHFYSNNATV 350
    NAICAEANSD CDKYLMEPFQ EANLGYYDIA HPLQDPFPPP FFKGFLSQSS 400
    VLSDMGSPVN FSHYSQAVGK SFHGVGDYAR PDVRGFTGDI AYLLESGVKV 450
    ALVYGDRDYI CNWLGGEQVS LGLNYTGTEA FRKAGYADVK VNSSYVGGLV 500
    RQHGNFSFTR VFEAGHEVPG YQPETSLKIF ERIMFNKDIA TGELDIAQKQ 550
    DYGTTGTEST FQVKNEIPPS PEPTCYLLSA DGTCTPEQLN AIENGTAVVE 600
    NYIIKSPAAS KGNPPPTTTS SPTASPTAGS AMLKAPVAML AISALTVLAF 650
    YL 652
    Length:652
    Mass (Da):71,705
    Last modified:May 18, 2010 - v1
    Checksum:iFFCA2819EAC39B97
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    ABSU01000001 Genomic DNA. Translation: EFE36524.1.
    RefSeqiXP_003017169.1. XM_003017123.1.

    Genome annotation databases

    GeneIDi9527135.
    KEGGiabe:ARB_04046.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    ABSU01000001 Genomic DNA. Translation: EFE36524.1 .
    RefSeqi XP_003017169.1. XM_003017123.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi S10.016.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 9527135.
    KEGGi abe:ARB_04046.

    Phylogenomic databases

    OrthoDBi EOG7FV40C.

    Family and domain databases

    Gene3Di 3.40.50.1820. 2 hits.
    InterProi IPR029058. AB_hydrolase.
    IPR001563. Peptidase_S10.
    IPR018202. Peptidase_S10_AS.
    [Graphical view ]
    PANTHERi PTHR11802. PTHR11802. 1 hit.
    Pfami PF00450. Peptidase_S10. 1 hit.
    [Graphical view ]
    PRINTSi PR00724. CRBOXYPTASEC.
    SUPFAMi SSF53474. SSF53474. 2 hits.
    PROSITEi PS00131. CARBOXYPEPT_SER_SER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC MYA-4681 / CBS 112371.

    Entry informationi

    Entry nameiSCPA_ARTBC
    AccessioniPrimary (citable) accession number: D4AIF1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 5, 2010
    Last sequence update: May 18, 2010
    Last modified: October 1, 2014
    This is version 21 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3