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Protein
Submitted name:

Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 7 (Predicted)

Gene

Psmd7

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-RNO-1169091 Activation of NF-kappaB in B cells
R-RNO-1234176 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
R-RNO-1236978 Cross-presentation of soluble exogenous antigens (endosomes)
R-RNO-174084 Autodegradation of Cdh1 by Cdh1:APC/C
R-RNO-174113 SCF-beta-TrCP mediated degradation of Emi1
R-RNO-174154 APC/C:Cdc20 mediated degradation of Securin
R-RNO-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
R-RNO-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A
R-RNO-187577 SCF(Skp2)-mediated degradation of p27/p21
R-RNO-195253 Degradation of beta-catenin by the destruction complex
R-RNO-202424 Downstream TCR signaling
R-RNO-2467813 Separation of Sister Chromatids
R-RNO-2871837 FCERI mediated NF-kB activation
R-RNO-349425 Autodegradation of the E3 ubiquitin ligase COP1
R-RNO-350562 Regulation of ornithine decarboxylase (ODC)
R-RNO-382556 ABC-family proteins mediated transport
R-RNO-450408 AUF1 (hnRNP D0) binds and destabilizes mRNA
R-RNO-4608870 Asymmetric localization of PCP proteins
R-RNO-4641257 Degradation of AXIN
R-RNO-4641258 Degradation of DVL
R-RNO-5358346 Hedgehog ligand biogenesis
R-RNO-5607761 Dectin-1 mediated noncanonical NF-kB signaling
R-RNO-5607764 CLEC7A (Dectin-1) signaling
R-RNO-5610780 Degradation of GLI1 by the proteasome
R-RNO-5610785 GLI3 is processed to GLI3R by the proteasome
R-RNO-5632684 Hedgehog 'on' state
R-RNO-5658442 Regulation of RAS by GAPs
R-RNO-5668541 TNFR2 non-canonical NF-kB pathway
R-RNO-5676590 NIK-->noncanonical NF-kB signaling
R-RNO-5687128 MAPK6/MAPK4 signaling
R-RNO-5689603 UCH proteinases
R-RNO-5689880 Ub-specific processing proteases
R-RNO-6798695 Neutrophil degranulation
R-RNO-68827 CDT1 association with the CDC6:ORC:origin complex
R-RNO-68949 Orc1 removal from chromatin
R-RNO-69017 CDK-mediated phosphorylation and removal of Cdc6
R-RNO-69229 Ubiquitin-dependent degradation of Cyclin D1
R-RNO-69481 G2/M Checkpoints
R-RNO-69601 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
R-RNO-8852276 The role of GTSE1 in G2/M progression after G2 checkpoint
R-RNO-8854050 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
R-RNO-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs
R-RNO-8939902 Regulation of RUNX2 expression and activity
R-RNO-8941858 Regulation of RUNX3 expression and activity
R-RNO-8948751 Regulation of PTEN stability and activity
R-RNO-9020702 Interleukin-1 signaling
R-RNO-983168 Antigen processing: Ubiquitination & Proteasome degradation

Names & Taxonomyi

Protein namesi
Submitted name:
Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 7 (Predicted)Imported
Submitted name:
Proteasome 26S subunit, non-ATPase 7Imported
Gene namesi
Name:Psmd7Imported
Synonyms:Psmd7_predictedImported
ORF Names:rCG_51362Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 19

Organism-specific databases

RGDi1306902 Psmd7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

ProteasomeImported

PTM / Processingi

Proteomic databases

PRIDEiD4AEH3

Expressioni

Gene expression databases

BgeeiENSRNOG00000014097

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiD4AEH3, 1 interactor
STRINGi10116.ENSRNOP00000019104

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6EPCelectron microscopy12.30U1-320[»]
6EPDelectron microscopy15.40U1-320[»]
6EPEelectron microscopy12.80U1-320[»]
6EPFelectron microscopy11.80U1-320[»]
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini9 – 144MPNInterPro annotationAdd BLAST136

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili287 – 320Sequence analysisAdd BLAST34

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG1556 Eukaryota
COG1310 LUCA
GeneTreeiENSGT00530000063075
KOiK03038
OMAiDAYFAVE
OrthoDBiEOG091G0DX6

Family and domain databases

CDDicd08062 MPN_RPN7_8, 1 hit
InterProiView protein in InterPro
IPR000555 JAMM/MPN+_dom
IPR037518 MPN
IPR033858 MPN_RPN7_8
IPR024969 Rpn11/EIF3F_C
PANTHERiPTHR10540:SF7 PTHR10540:SF7, 1 hit
PfamiView protein in Pfam
PF01398 JAB, 1 hit
PF13012 MitMem_reg, 1 hit
SMARTiView protein in SMART
SM00232 JAB_MPN, 1 hit
PROSITEiView protein in PROSITE
PS50249 MPN, 1 hit

Sequencei

Sequence statusi: Complete.

D4AEH3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPELAVQKVV VHPLVLLSVV DHFNRIGKVG NQKRVVGVLL GSWQKKVLDV
60 70 80 90 100
SNSFAVPFDE DDKDDSVWFL DHDYLENMYG MFKKVNARER IVGWYHTGPK
110 120 130 140 150
LHKNDIAINE LMKRYCPNSV LVIIDVKPKD LGLPTEAYIS VEEVHDDGTP
160 170 180 190 200
TSKTFEHVTS EIGAEEAEEV GVEHLLRDIK DTTVGTLSQR ITNQVHGLKG
210 220 230 240 250
LNSKLLDIRT YLEKVASGKL PINHHIIYQL QDVFNLLPDA SLQEFVKAFY
260 270 280 290 300
LKTNDQMVVV YLASLIRSVV ALHNLINNKI ANRDAEKKEG QEKEESKKER
310 320
KDDKEKEKSD AKKEEKKEKK
Length:320
Mass (Da):36,492
Last modified:April 20, 2010 - v1
Checksum:i2258287A7EA2AFF9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07043774 Genomic DNA No translation available.
CH473972 Genomic DNA Translation: EDL92484.1
RefSeqiNP_001100896.1, NM_001107426.1
UniGeneiRn.20659

Genome annotation databases

EnsembliENSRNOT00000019104; ENSRNOP00000019104; ENSRNOG00000014097
GeneIDi307821
KEGGirno:307821
UCSCiRGD:1306902 rat

Similar proteinsi

Entry informationi

Entry nameiD4AEH3_RAT
AccessioniPrimary (citable) accession number: D4AEH3
Entry historyiIntegrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: May 23, 2018
This is version 72 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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