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Protein
Submitted name:

Cytochrome P450, family 39, subfamily a, polypeptide 1 (Predicted), isoform CRA_a

Gene

Cyp39a1

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Cofactori

hemeUniRule annotation

GO - Molecular functioni

  1. heme binding Source: InterPro
  2. iron ion binding Source: InterPro
  3. oxysterol 7-alpha-hydroxylase activity Source: Ensembl
  4. steroid 7-alpha-hydroxylase activity Source: Ensembl

GO - Biological processi

  1. bile acid biosynthetic process Source: Ensembl
  2. cholesterol catabolic process Source: Ensembl
Complete GO annotation...

Keywords - Ligandi

HemeUniRule annotationSAAS annotation, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_324456. Synthesis of bile acids and bile salts via 24-hydroxycholesterol.
REACT_350068. Endogenous sterols.

Names & Taxonomyi

Protein namesi
Submitted name:
Cytochrome P450, family 39, subfamily a, polypeptide 1 (Predicted), isoform CRA_aImported
Submitted name:
Protein Cyp39a1Imported
Gene namesi
Name:Cyp39a1Imported
Synonyms:Cyp39a1_predictedImported
ORF Names:rCG_43541Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Chromosome 9

Organism-specific databases

RGDi1307471. Cyp39a1.

Subcellular locationi

Endoplasmic reticulum membrane UniRule annotation

Keywords - Cellular componenti

Endoplasmic reticulumUniRule annotation, MembraneUniRule annotation

PTM / Processingi

Proteomic databases

PRIDEiD4AE09.

Structurei

3D structure databases

ProteinModelPortaliD4AE09.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.UniRule annotation

Phylogenomic databases

GeneTreeiENSGT00550000074551.
InParanoidiD4AE09.
KOiK07439.
OMAiYGLLMLW.
OrthoDBiEOG7W153H.
PhylomeDBiD4AE09.
TreeFamiTF105090.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR024204. Cyt_P450_CYP7A1-type.
IPR002403. Cyt_P450_E_grp-IV.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PIRSFiPIRSF000047. Cytochrome_CYPVIIA1. 1 hit.
PRINTSiPR00465. EP450IV.
SUPFAMiSSF48264. SSF48264. 1 hit.

Sequencei

Sequence statusi: Complete.

D4AE09-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGIMELFSPI AIAVLGSCVL FLFSRWKNLR GPPCIQGWIP WIGAGFEFGK
60 70 80 90 100
APLEFIEKAR IKYGPVFTVF AVGKRMTFVT EEEGINVLLK SKHVDFELAV
110 120 130 140 150
QRPLYHTAWI PKNIFFALHE KLYVLMKGKM GTFNTHHFTG QLTEEFHDQL
160 170 180 190 200
EGLGTHGTMD LNDFVRYLLY PATLNTLFMK GLFLTDKRKI KEFYQHFKTY
210 220 230 240 250
DEGFEYGSQL PEWLLRNWSK SKRWLLALFE KNIGDIKTHG SAGHSETLLQ
260 270 280 290 300
AVLGMVETET RLHSPNYGLV MLWASLANAA PIAFWTLAYI LSHPDLHRTI
310 320 330 340 350
VESISSVFGT AGKDKIQVSE NDLKKLLLIK WCILESIRLR APGVITRKVV
360 370 380 390 400
KPVKILNHTV PSGDLLMLSP FWLHRNPKYF PEPESFKPER WKEANLDKYI
410 420 430 440 450
FLDYFMAFGG GKFQCPGRWF ALLEIQLCII LVLYKYECSL LDPLPKQAKF
460
SSFGGCPPAS REMPN
Length:465
Mass (Da):53,339
Last modified:April 20, 2010 - v1
Checksum:i09B7E3BA9FA8C41E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR06058914 Genomic DNA. No translation available.
AABR06058915 Genomic DNA. No translation available.
AABR06058916 Genomic DNA. No translation available.
AABR06058917 Genomic DNA. No translation available.
AABR06058918 Genomic DNA. No translation available.
CH473987 Genomic DNA. Translation: EDM18705.1.
RefSeqiNP_001100363.1. NM_001106893.1.
UniGeneiRn.153360.

Genome annotation databases

EnsembliENSRNOT00000014051; ENSRNOP00000014051; ENSRNOG00000010519.
GeneIDi301264.
KEGGirno:301264.
UCSCiRGD:1307471. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR06058914 Genomic DNA. No translation available.
AABR06058915 Genomic DNA. No translation available.
AABR06058916 Genomic DNA. No translation available.
AABR06058917 Genomic DNA. No translation available.
AABR06058918 Genomic DNA. No translation available.
CH473987 Genomic DNA. Translation: EDM18705.1.
RefSeqiNP_001100363.1. NM_001106893.1.
UniGeneiRn.153360.

3D structure databases

ProteinModelPortaliD4AE09.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiD4AE09.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000014051; ENSRNOP00000014051; ENSRNOG00000010519.
GeneIDi301264.
KEGGirno:301264.
UCSCiRGD:1307471. rat.

Organism-specific databases

CTDi51302.
RGDi1307471. Cyp39a1.

Phylogenomic databases

GeneTreeiENSGT00550000074551.
InParanoidiD4AE09.
KOiK07439.
OMAiYGLLMLW.
OrthoDBiEOG7W153H.
PhylomeDBiD4AE09.
TreeFamiTF105090.

Enzyme and pathway databases

ReactomeiREACT_324456. Synthesis of bile acids and bile salts via 24-hydroxycholesterol.
REACT_350068. Endogenous sterols.

Miscellaneous databases

NextBioi648423.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR024204. Cyt_P450_CYP7A1-type.
IPR002403. Cyt_P450_E_grp-IV.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PIRSFiPIRSF000047. Cytochrome_CYPVIIA1. 1 hit.
PRINTSiPR00465. EP450IV.
SUPFAMiSSF48264. SSF48264. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Rat Genome Sequencing Project Consortium
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown NorwayImported.
  2. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BNImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BNImported.
  4. Ensembl
    Submitted (JUN-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: Brown NorwayImported.

Entry informationi

Entry nameiD4AE09_RAT
AccessioniPrimary (citable) accession number: D4AE09
Entry historyi
Integrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: April 1, 2015
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.