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D4ADM6

- D4ADM6_RAT

UniProt

D4ADM6 - D4ADM6_RAT

Protein

Alkaline phosphatase

Gene

Alpp

Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 37 (01 Oct 2014)
      Sequence version 1 (20 Apr 2010)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    A phosphate monoester + H2O = an alcohol + phosphate.

    GO - Molecular functioni

    1. alkaline phosphatase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    HydrolaseUniRule annotation

    Keywords - Ligandi

    MagnesiumUniRule annotation, ZincUniRule annotation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alkaline phosphataseUniRule annotation (EC:3.1.3.1UniRule annotation)
    Gene namesi
    Name:AlppImported
    OrganismiRattus norvegicus (Rat)Imported
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 9

    Organism-specific databases

    RGDi2325055. Alpp.

    Subcellular locationi

    GO - Cellular componenti

    1. myofibril Source: Ensembl

    PTM / Processingi

    Keywords - PTMi

    PhosphoproteinUniRule annotation

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the alkaline phosphatase family.UniRule annotation

    Phylogenomic databases

    GeneTreeiENSGT00390000008704.
    KOiK01077.
    OMAiKTNMKVI.
    OrthoDBiEOG7SN8CH.
    PhylomeDBiD4ADM6.
    TreeFamiTF323513.

    Family and domain databases

    Gene3Di3.40.720.10. 1 hit.
    InterProiIPR017849. Alkaline_Pase-like_a/b/a.
    IPR001952. Alkaline_phosphatase.
    IPR018299. Alkaline_phosphatase_AS.
    IPR017850. Alkaline_phosphatase_core.
    [Graphical view]
    PfamiPF00245. Alk_phosphatase. 1 hit.
    [Graphical view]
    PRINTSiPR00113. ALKPHPHTASE.
    SMARTiSM00098. alkPPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF53649. SSF53649. 1 hit.
    PROSITEiPS00123. ALKALINE_PHOSPHATASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    D4ADM6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MWGACLLLLG LSLQMSLSLV PVEEENPAFW NRKAAEALEA AKKLQPIQTS    50
    ANNLIILMGD GMGVSTVTAT RILKGQQQGH LGPETPLAMD RFPHMALSKT 100
    YNTDKQVPDS AGTGTAFLCG VKTNMKVIGL SAAARFNQCN TTWGNEVVSV 150
    MHRAKKAGKS VGVVTTTSVQ HASPAGTYAH TVNRNWYSDA HMSTAALQEG 200
    CKDIAMQLIS NTDIDVILGG GRKFMFPKGT PDQEYPTDPQ QAGTRLDGRN 250
    LVQEWLAKHQ GAQYVWNRTE LIQASLNRSV THLMGLFEPN DMKYNIDRDP 300
    TQDPSLAEMT EVAVHMLSRN PKGFYLFVEG GRIDHGHHEA IAYRALTEAV 350
    MFDSAVDKAD KLTSEKDTMI IVTADHSHVF SFGGYTQREA SIFGLAPFKA 400
    GDGKSFTSIL YGNGPGYKLN NGIRADVTEE ESSNPTYQQQ AAVPLSSETH 450
    SGEDVAIFAR GPQAHLVHGV QEQNYIAHVM AFAGCLEPYT DCGLAPPAGR 500
    SSAVSPGYIS TLLCLLAGTM LMLMVSAEP 529
    Length:529
    Mass (Da):57,253
    Last modified:April 20, 2010 - v1
    Checksum:i8D145B54479A178B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR06061444 Genomic DNA. No translation available.
    RefSeqiXP_002727285.1. XM_002727239.1.
    XP_002730104.1. XM_002730058.1.

    Genome annotation databases

    EnsembliENSRNOT00000025978; ENSRNOP00000026095; ENSRNOG00000033672.
    GeneIDi100359675.
    KEGGirno:100359675.
    UCSCiRGD:2325055. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR06061444 Genomic DNA. No translation available.
    RefSeqi XP_002727285.1. XM_002727239.1.
    XP_002730104.1. XM_002730058.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000025978 ; ENSRNOP00000026095 ; ENSRNOG00000033672 .
    GeneIDi 100359675.
    KEGGi rno:100359675.
    UCSCi RGD:2325055. rat.

    Organism-specific databases

    CTDi 250.
    RGDi 2325055. Alpp.

    Phylogenomic databases

    GeneTreei ENSGT00390000008704.
    KOi K01077.
    OMAi KTNMKVI.
    OrthoDBi EOG7SN8CH.
    PhylomeDBi D4ADM6.
    TreeFami TF323513.

    Miscellaneous databases

    NextBioi 34064933.
    PROi D4ADM6.

    Family and domain databases

    Gene3Di 3.40.720.10. 1 hit.
    InterProi IPR017849. Alkaline_Pase-like_a/b/a.
    IPR001952. Alkaline_phosphatase.
    IPR018299. Alkaline_phosphatase_AS.
    IPR017850. Alkaline_phosphatase_core.
    [Graphical view ]
    Pfami PF00245. Alk_phosphatase. 1 hit.
    [Graphical view ]
    PRINTSi PR00113. ALKPHPHTASE.
    SMARTi SM00098. alkPPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53649. SSF53649. 1 hit.
    PROSITEi PS00123. ALKALINE_PHOSPHATASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
      Rat Genome Sequencing Project Consortium
      Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
      , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
      Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Brown NorwayImported.
    2. Ensembl
      Submitted (JUL-2011) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: Brown NorwayImported.

    Entry informationi

    Entry nameiD4ADM6_RAT
    AccessioniPrimary (citable) accession number: D4ADM6
    Entry historyi
    Integrated into UniProtKB/TrEMBL: April 20, 2010
    Last sequence update: April 20, 2010
    Last modified: October 1, 2014
    This is version 37 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Caution

    The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3