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Protein
Submitted name:

Protein Adgra2

Gene

Adgra2

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptorSAAS annotation, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Submitted name:
Protein Adgra2Imported
Submitted name:
RCG43370Imported
Gene namesi
Name:Adgra2Imported
Synonyms:Gpr124Imported, LOC100363275Imported
ORF Names:rCG_43370Imported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 16

Organism-specific databases

RGDi2323365. Adgra2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei769 – 790HelicalSequence analysisAdd BLAST22
Transmembranei802 – 822HelicalSequence analysisAdd BLAST21
Transmembranei884 – 904HelicalSequence analysisAdd BLAST21
Transmembranei924 – 947HelicalSequence analysisAdd BLAST24
Transmembranei1018 – 1038HelicalSequence analysisAdd BLAST21
Transmembranei1045 – 1064HelicalSequence analysisAdd BLAST20

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 33Sequence analysisAdd BLAST33
ChainiPRO_500816135934 – 1336Sequence analysisAdd BLAST1303

Keywords - PTMi

Disulfide bondSAAS annotation

PTM databases

PhosphoSitePlusiD4ADC7.

Expressioni

Gene expression databases

BgeeiENSRNOG00000012991.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000017776.

Structurei

3D structure databases

ProteinModelPortaliD4ADC7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini260 – 344Ig-like (immunoglobulin-like)InterPro annotationAdd BLAST85
Domaini327 – 421G_PROTEIN_RECEP_F2_3InterPro annotationAdd BLAST95
Domaini707 – 755GPSInterPro annotationAdd BLAST49
Domaini766 – 941G_PROTEIN_RECEP_F2_4InterPro annotationAdd BLAST176

Sequence similaritiesi

Belongs to the G-protein coupled receptor 2 family.SAAS annotation

Keywords - Domaini

Immunoglobulin domainSAAS annotation, Leucine-rich repeatSAAS annotation, RepeatSAAS annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00860000133701.
OMAiRTLCAYP.
OrthoDBiEOG091G03GB.
TreeFamiTF331206.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.80.10.10. 1 hit.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR017981. GPCR_2-like.
IPR001879. GPCR_2_extracellular_dom.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
IPR000203. GPS.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
PfamiPF00002. 7tm_2. 1 hit.
PF01825. GPS. 1 hit.
PF13855. LRR_8. 1 hit.
[Graphical view]
SMARTiSM00303. GPS. 1 hit.
SM00409. IG. 1 hit.
SM00369. LRR_TYP. 4 hits.
SM00082. LRRCT. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF52058. SSF52058. 1 hit.
PROSITEiPS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
PS50221. GPS. 1 hit.
PS50835. IG_LIKE. 1 hit.
PS51450. LRR. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D4ADC7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGAGGRRMPV RSARLLLLPL LPCLLLLAPG TRGAPGCPVP IRGCKCSGER
60 70 80 90 100
PKGLSGGAHN PARRRVVCGG GDLPEPPDPG LLPNGTITLL LSNNKITGLR
110 120 130 140 150
NGSFLGLSLL EKLDLRSNVI STVQPGAFLG LGELKRLDLS NNRIGCLTSE
160 170 180 190 200
TFQGLPRLLR LNISGNIYSS LQPGVFDELP DLKIVDFGTE FLTCDCRLRW
210 220 230 240 250
LLPWARNHSL QLSERTLCAY PSALHAHALS SLQESQLRCE GALELHTHYL
260 270 280 290 300
IPSLRQVVFQ GDRLPFQCSA SYLGNDTQIH WYHNGAPMES DEQAGIVLAE
310 320 330 340 350
NLIHDCTFIT SELTLSHIGV WASGEWECSV STVQGNTSKK VEIVVLETSA
360 370 380 390 400
SYCPAERVTN NRGDFRWPRT LAGITAYQSC LQYPFTSVPL SGGAPGTRAS
410 420 430 440 450
RRCDRAGRWE PGDYSHCLYT NDITRVLYTF VLMPINASNA LTLAHQLRVY
460 470 480 490 500
TAEAASFSDM MDVVYVAQMI QKFLGYVDQI KELVEVMVDM ASNLMLVDEH
510 520 530 540 550
LLWLAQREDK ACSGIVGALE RIGGAALSPH AQHISVNSRN VALEAYLIKP
560 570 580 590 600
HSYVGLTCTA FQRREVGVSG VQPSSPGQDV PLEPEALADQ QLRFRCTTGR
610 620 630 640 650
PNVSLSSFHI KNSVALASIQ LPPSLFSTLP AALAPPVPPD CTLQLLVFRN
660 670 680 690 700
GRLFRSHGNT SRPGTAEPSK RRGVATPVIF AGTSGCGVGN LTEPVAVSLR
710 720 730 740 750
HWAEGTDPLA AWWNQDGPGG WSSEGCKLRF SQPNVSSLYC QHLGNVAVLM
760 770 780 790 800
ELSAFPREAG GSGAGLHPVV YPCTALLLLC LFSTIITYIL NHSSIHVSRK
810 820 830 840 850
GWHMLLNLCF HMAMTSAVFV GGVTLTNYQM VCQAVGITLH YSSLSSLLWM
860 870 880 890 900
GVKARVLHKE LSWRAPPPEE GEAAPPGPRP MLRFYLIAGG IPLIICGITA
910 920 930 940 950
AVNIHNYRDH SPYCWLVWRP SLGAFYIPVA LILPITWIYF LCAGLHLRGH
960 970 980 990 1000
VAQNPKQGNS RLSLEPGEDP RGSTRLRSSG VLLSDSGSLL ATVSAGVGTP
1010 1020 1030 1040 1050
APPEESDGVY SPGVQLGALM TTHFLYLAMW ACGALAVSQR WLPRVVCSCL
1060 1070 1080 1090 1100
YGVAASALGL FVFTHHCARR RDVRASWRAC CPPASPSASH APPRALPTAA
1110 1120 1130 1140 1150
EDGSPVLGEG PASLKSSPSG SSGRAPPPPC KLTNLQVAQS QVCEASMVAR
1160 1170 1180 1190 1200
GDGEPEPTGS RSSLAPRHHN NLHHGRRVHK SRAKGHRAGE TGGKSRLKAL
1210 1220 1230 1240 1250
RAGTSPGAPE LLSSESGSLH NSPSDSYPGS SRNSPGDGLP LEGEPMLTPS
1260 1270 1280 1290 1300
EGSDTSAAQI PETGRPGQRR SASRDNLKGS GSALERESKR RSYPLNTTSL
1310 1320 1330
NGAPKGGKYE DASVTGAEAI AGGCMKTGLW KSETTV
Length:1,336
Mass (Da):143,381
Last modified:April 3, 2013 - v2
Checksum:i3B98670BDC3CA558
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR06088951 Genomic DNA. No translation available.
AABR07072519 Genomic DNA. No translation available.
AC113785 Genomic DNA. No translation available.
CH473970 Genomic DNA. Translation: EDM09091.1.

Genome annotation databases

EnsembliENSRNOT00000017776; ENSRNOP00000017776; ENSRNOG00000012991.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR06088951 Genomic DNA. No translation available.
AABR07072519 Genomic DNA. No translation available.
AC113785 Genomic DNA. No translation available.
CH473970 Genomic DNA. Translation: EDM09091.1.

3D structure databases

ProteinModelPortaliD4ADC7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000017776.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSitePlusiD4ADC7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000017776; ENSRNOP00000017776; ENSRNOG00000012991.

Organism-specific databases

RGDi2323365. Adgra2.

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00860000133701.
OMAiRTLCAYP.
OrthoDBiEOG091G03GB.
TreeFamiTF331206.

Gene expression databases

BgeeiENSRNOG00000012991.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.80.10.10. 1 hit.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR017981. GPCR_2-like.
IPR001879. GPCR_2_extracellular_dom.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
IPR000203. GPS.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
PfamiPF00002. 7tm_2. 1 hit.
PF01825. GPS. 1 hit.
PF13855. LRR_8. 1 hit.
[Graphical view]
SMARTiSM00303. GPS. 1 hit.
SM00409. IG. 1 hit.
SM00369. LRR_TYP. 4 hits.
SM00082. LRRCT. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF52058. SSF52058. 1 hit.
PROSITEiPS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
PS50221. GPS. 1 hit.
PS50835. IG_LIKE. 1 hit.
PS51450. LRR. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiD4ADC7_RAT
AccessioniPrimary (citable) accession number: D4ADC7
Entry historyi
Integrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 3, 2013
Last modified: November 30, 2016
This is version 60 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.