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Protein
Submitted name:

Adhesion G protein-coupled receptor A2

Gene

Adgra2

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptorSAAS annotation, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Submitted name:
Adhesion G protein-coupled receptor A2Imported
Submitted name:
RCG43370Imported
Gene namesi
Name:Adgra2Imported
ORF Names:rCG_43370Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 16

Organism-specific databases

RGDi2323365 Adgra2

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei769 – 790HelicalSequence analysisAdd BLAST22
Transmembranei802 – 822HelicalSequence analysisAdd BLAST21
Transmembranei884 – 904HelicalSequence analysisAdd BLAST21
Transmembranei924 – 947HelicalSequence analysisAdd BLAST24
Transmembranei1018 – 1038HelicalSequence analysisAdd BLAST21
Transmembranei1045 – 1064HelicalSequence analysisAdd BLAST20

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 33Sequence analysisAdd BLAST33
ChainiPRO_501408791634 – 1336Sequence analysisAdd BLAST1303

Keywords - PTMi

Disulfide bondSAAS annotation

Expressioni

Gene expression databases

BgeeiENSRNOG00000012991

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000017776

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini260 – 344Ig-likeInterPro annotationAdd BLAST85
Domaini327 – 421G_PROTEIN_RECEP_F2_3InterPro annotationAdd BLAST95
Domaini707 – 755GPSInterPro annotationAdd BLAST49
Domaini766 – 941G_PROTEIN_RECEP_F2_4InterPro annotationAdd BLAST176

Sequence similaritiesi

Belongs to the G-protein coupled receptor 2 family.SAAS annotation

Keywords - Domaini

Immunoglobulin domainSAAS annotation, Leucine-rich repeatSAAS annotation, RepeatSAAS annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG0619 Eukaryota
COG4886 LUCA
GeneTreeiENSGT00860000133701
OMAiRTLCAYP
OrthoDBiEOG091G03GB

Family and domain databases

Gene3Di2.60.40.10, 1 hit
3.80.10.10, 1 hit
4.10.1240.10, 1 hit
InterProiView protein in InterPro
IPR000483 Cys-rich_flank_reg_C
IPR017981 GPCR_2-like
IPR036445 GPCR_2_extracell_dom_sf
IPR001879 GPCR_2_extracellular_dom
IPR000832 GPCR_2_secretin-like
IPR017983 GPCR_2_secretin-like_CS
IPR000203 GPS
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
PfamiView protein in Pfam
PF00002 7tm_2, 1 hit
PF01825 GPS, 1 hit
PF13855 LRR_8, 1 hit
SMARTiView protein in SMART
SM00303 GPS, 1 hit
SM00409 IG, 1 hit
SM00369 LRR_TYP, 4 hits
SM00082 LRRCT, 1 hit
SUPFAMiSSF111418 SSF111418, 1 hit
SSF48726 SSF48726, 1 hit
PROSITEiView protein in PROSITE
PS00650 G_PROTEIN_RECEP_F2_2, 1 hit
PS50227 G_PROTEIN_RECEP_F2_3, 1 hit
PS50261 G_PROTEIN_RECEP_F2_4, 1 hit
PS50221 GPS, 1 hit
PS50835 IG_LIKE, 1 hit
PS51450 LRR, 3 hits

Sequencei

Sequence statusi: Complete.

D4ADC7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGAGGRRMPV RSARLLLLPL LPCLLLLAPG TRGAPGCPVP IRGCKCSGER
60 70 80 90 100
PKGLSGGAHN PARRRVVCGG GDLPEPPDPG LLPNGTITLL LSNNKITGLR
110 120 130 140 150
NGSFLGLSLL EKLDLRSNVI STVQPGAFLG LGELKRLDLS NNRIGCLTSE
160 170 180 190 200
TFQGLPRLLR LNISGNIYSS LQPGVFDELP DLKIVDFGTE FLTCDCRLRW
210 220 230 240 250
LLPWARNHSL QLSERTLCAY PSALHAHALS SLQESQLRCE GALELHTHYL
260 270 280 290 300
IPSLRQVVFQ GDRLPFQCSA SYLGNDTQIH WYHNGAPMES DEQAGIVLAE
310 320 330 340 350
NLIHDCTFIT SELTLSHIGV WASGEWECSV STVQGNTSKK VEIVVLETSA
360 370 380 390 400
SYCPAERVTN NRGDFRWPRT LAGITAYQSC LQYPFTSVPL SGGAPGTRAS
410 420 430 440 450
RRCDRAGRWE PGDYSHCLYT NDITRVLYTF VLMPINASNA LTLAHQLRVY
460 470 480 490 500
TAEAASFSDM MDVVYVAQMI QKFLGYVDQI KELVEVMVDM ASNLMLVDEH
510 520 530 540 550
LLWLAQREDK ACSGIVGALE RIGGAALSPH AQHISVNSRN VALEAYLIKP
560 570 580 590 600
HSYVGLTCTA FQRREVGVSG VQPSSPGQDV PLEPEALADQ QLRFRCTTGR
610 620 630 640 650
PNVSLSSFHI KNSVALASIQ LPPSLFSTLP AALAPPVPPD CTLQLLVFRN
660 670 680 690 700
GRLFRSHGNT SRPGTAEPSK RRGVATPVIF AGTSGCGVGN LTEPVAVSLR
710 720 730 740 750
HWAEGTDPLA AWWNQDGPGG WSSEGCKLRF SQPNVSSLYC QHLGNVAVLM
760 770 780 790 800
ELSAFPREAG GSGAGLHPVV YPCTALLLLC LFSTIITYIL NHSSIHVSRK
810 820 830 840 850
GWHMLLNLCF HMAMTSAVFV GGVTLTNYQM VCQAVGITLH YSSLSSLLWM
860 870 880 890 900
GVKARVLHKE LSWRAPPPEE GEAAPPGPRP MLRFYLIAGG IPLIICGITA
910 920 930 940 950
AVNIHNYRDH SPYCWLVWRP SLGAFYIPVA LILPITWIYF LCAGLHLRGH
960 970 980 990 1000
VAQNPKQGNS RLSLEPGEDP RGSTRLRSSG VLLSDSGSLL ATVSAGVGTP
1010 1020 1030 1040 1050
APPEESDGVY SPGVQLGALM TTHFLYLAMW ACGALAVSQR WLPRVVCSCL
1060 1070 1080 1090 1100
YGVAASALGL FVFTHHCARR RDVRASWRAC CPPASPSASH APPRALPTAA
1110 1120 1130 1140 1150
EDGSPVLGEG PASLKSSPSG SSGRAPPPPC KLTNLQVAQS QVCEASMVAR
1160 1170 1180 1190 1200
GDGEPEPTGS RSSLAPRHHN NLHHGRRVHK SRAKGHRAGE TGGKSRLKAL
1210 1220 1230 1240 1250
RAGTSPGAPE LLSSESGSLH NSPSDSYPGS SRNSPGDGLP LEGEPMLTPS
1260 1270 1280 1290 1300
EGSDTSAAQI PETGRPGQRR SASRDNLKGS GSALERESKR RSYPLNTTSL
1310 1320 1330
NGAPKGGKYE DASVTGAEAI AGGCMKTGLW KSETTV
Length:1,336
Mass (Da):143,381
Last modified:April 3, 2013 - v2
Checksum:i3B98670BDC3CA558
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07072519 Genomic DNA No translation available.
AC113785 Genomic DNA No translation available.
CH473970 Genomic DNA Translation: EDM09091.1

Genome annotation databases

EnsembliENSRNOT00000017776; ENSRNOP00000017776; ENSRNOG00000012991

Similar proteinsi

Entry informationi

Entry nameiD4ADC7_RAT
AccessioniPrimary (citable) accession number: D4ADC7
Entry historyiIntegrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 3, 2013
Last modified: March 28, 2018
This is version 71 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health