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Protein
Submitted name:

GCN5 general control of amino acid synthesis-like 2 (Yeast) (Predicted)

Gene

Kat2a

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Protein predictedi

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei570Proton donor/acceptorUniRule annotation1

GO - Molecular functioni

GO - Biological processi

  • alpha-tubulin acetylation Source: RGD
  • cardiac muscle cell differentiation Source: RGD
  • cell proliferation Source: Ensembl
  • cellular response to nerve growth factor stimulus Source: RGD
  • cellular response to tumor necrosis factor Source: RGD
  • histone deubiquitination Source: Ensembl
  • histone H3-K14 acetylation Source: Ensembl
  • intracellular distribution of mitochondria Source: RGD
  • in utero embryonic development Source: Ensembl
  • metencephalon development Source: Ensembl
  • midbrain development Source: Ensembl
  • multicellular organism growth Source: Ensembl
  • neural tube closure Source: Ensembl
  • positive regulation of cell projection organization Source: RGD
  • positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  • positive regulation of histone acetylation Source: RGD
  • positive regulation of protein targeting to mitochondrion Source: Ensembl
  • positive regulation of transcription regulatory region DNA binding Source: RGD
  • regulation of mitophagy Source: Ensembl
  • regulation of protein stability Source: Ensembl
  • response to nutrient levels Source: RGD
  • response to organic cyclic compound Source: RGD
  • somitogenesis Source: Ensembl
  • telencephalon development Source: Ensembl
Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-RNO-5250924. B-WICH complex positively regulates rRNA expression.

Names & Taxonomyi

Protein namesi
Submitted name:
GCN5 general control of amino acid synthesis-like 2 (Yeast) (Predicted)Imported
Submitted name:
Protein Kat2aImported
Gene namesi
Name:Kat2aImported
Synonyms:Gcn5l2_predictedImported
ORF Names:rCG_33366Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi1307242. Kat2a.

Subcellular locationi

GO - Cellular componenti

  • Ada2/Gcn5/Ada3 transcription activator complex Source: Ensembl
  • extracellular space Source: Ensembl
  • mitotic spindle Source: Ensembl
  • nuclear chromatin Source: RGD
  • nucleus Source: RGD
  • STAGA complex Source: Ensembl
  • transcription factor TFTC complex Source: Ensembl
Complete GO annotation...

PTM / Processingi

Proteomic databases

PeptideAtlasiD4ACX5.

Expressioni

Gene expression databases

BgeeiENSRNOG00000018364.

Interactioni

GO - Molecular functioni

  • protein phosphatase binding Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000052125.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini498 – 651N-acetyltransferaseInterPro annotationAdd BLAST154
Domaini740 – 810BromoInterPro annotationAdd BLAST71

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni574 – 576Acetyl-CoA bindingUniRule annotation3
Regioni581 – 587Acetyl-CoA bindingUniRule annotation7
Regioni612 – 615Acetyl-CoA bindingUniRule annotation4

Keywords - Domaini

BromodomainSAAS annotation

Phylogenomic databases

eggNOGiKOG1472. Eukaryota.
COG5076. LUCA.
GeneTreeiENSGT00760000119099.
KOiK06062.
OMAiDYYEIIR.
OrthoDBiEOG091G03ZO.
TreeFamiTF105399.

Family and domain databases

Gene3Di1.20.920.10. 1 hit.
3.40.630.30. 1 hit.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR001487. Bromodomain.
IPR018359. Bromodomain_CS.
IPR000182. GNAT_dom.
IPR016376. Hist_acetylase_PCAF.
IPR009464. PCAF_N.
[Graphical view]
PfamiPF00583. Acetyltransf_1. 1 hit.
PF00439. Bromodomain. 1 hit.
PF06466. PCAF_N. 1 hit.
[Graphical view]
PIRSFiPIRSF003048. Histone_acetylase_PCAF. 1 hit.
PRINTSiPR00503. BROMODOMAIN.
SMARTiSM00297. BROMO. 1 hit.
[Graphical view]
SUPFAMiSSF47370. SSF47370. 1 hit.
SSF55729. SSF55729. 1 hit.
PROSITEiPS00633. BROMODOMAIN_1. 1 hit.
PS50014. BROMODOMAIN_2. 1 hit.
PS51186. GNAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D4ACX5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEPSQAPNP APAAQPRPLQ SPAPAPTSTP APSPASAPTP APTPAPAPAP
60 70 80 90 100
AAAPAGSTGT GGAGVGSGGD PARPGLSQQQ RASQRKAQVR GLPRAKKLEK
110 120 130 140 150
LGVFSACKAN ETCKCNGWKN PKPPTAPRMD LQQPAANLSE LCRSCEHPLA
160 170 180 190 200
DHVSHLENVS EDEINRLLGM VVDVENLFMS VHKEEDTDTK QVYFYLFKLL
210 220 230 240 250
RKCILQMTRP VVEGSLGSPP FEKPNIEQGV LNFVQYKFSH LAPRERQTMF
260 270 280 290 300
ELSKMFLLCL NYWKLETPAQ FRQRSQSEDV ATYKVNYTRW LCYCHVPQSC
310 320 330 340 350
DSLPRYETTH VFGRSLLRSI FTVTRRQLLE KFRVEKDKLV PEKRTLILTH
360 370 380 390 400
FPKFLSMLEE EIYGANSPIW ESGFTMPPSE GTQLVPRPAT VSATVVPSTP
410 420 430 440 450
IFSPSMGGGS NSSLSLDSTG TEPMPGEKRK LPENLTLEDA KRLRVMGDIP
460 470 480 490 500
MELVNEVMLT ITDPAAMLGP ETSLLSANAA RDETARLEER RGIIEFHVIG
510 520 530 540 550
NSLTPKANRR VLLWLVGLQN VFSHQLPRMP KEYIARLVFD PKHKTLALIK
560 570 580 590 600
DGRVIGGICF RMFPTQGFTE IVFCAVTSNE QVKGYGTHLM NHLKEYHIKH
610 620 630 640 650
SILYFLTYAD EYAIGYFKKQ GFSKDIKVPK SRYLGYIKDY EGATLMECEL
660 670 680 690 700
NPRIPYTELS HIIKKQKEII KKLIERKQAQ IRKVYPGLSC FKEGVRQIPV
710 720 730 740 750
ESVPGIRETG WKPLGKEKGK ELKDPDQLYT TLKNLLAQIK SHPSAWPFME
760 770 780 790 800
PVKKSEAPDY YEVIRFPIDL KTMTERLRSR YYVTRKLFVA DLQRVIANCR
810 820 830
EYNPPDSEYC RCASALEKFF YFKLKEGGLI DK
Length:832
Mass (Da):93,651
Last modified:April 3, 2013 - v2
Checksum:iEB9E3009F4BCE81B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07030475 Genomic DNA. No translation available.
CH473948 Genomic DNA. Translation: EDM06059.1.
RefSeqiNP_001100520.1. NM_001107050.1.
UniGeneiRn.53502.

Genome annotation databases

EnsembliENSRNOT00000055250; ENSRNOP00000052125; ENSRNOG00000018364.
GeneIDi303539.
KEGGirno:303539.
UCSCiRGD:1307242. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07030475 Genomic DNA. No translation available.
CH473948 Genomic DNA. Translation: EDM06059.1.
RefSeqiNP_001100520.1. NM_001107050.1.
UniGeneiRn.53502.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000052125.

Proteomic databases

PeptideAtlasiD4ACX5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000055250; ENSRNOP00000052125; ENSRNOG00000018364.
GeneIDi303539.
KEGGirno:303539.
UCSCiRGD:1307242. rat.

Organism-specific databases

CTDi2648.
RGDi1307242. Kat2a.

Phylogenomic databases

eggNOGiKOG1472. Eukaryota.
COG5076. LUCA.
GeneTreeiENSGT00760000119099.
KOiK06062.
OMAiDYYEIIR.
OrthoDBiEOG091G03ZO.
TreeFamiTF105399.

Enzyme and pathway databases

ReactomeiR-RNO-5250924. B-WICH complex positively regulates rRNA expression.

Gene expression databases

BgeeiENSRNOG00000018364.

Family and domain databases

Gene3Di1.20.920.10. 1 hit.
3.40.630.30. 1 hit.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR001487. Bromodomain.
IPR018359. Bromodomain_CS.
IPR000182. GNAT_dom.
IPR016376. Hist_acetylase_PCAF.
IPR009464. PCAF_N.
[Graphical view]
PfamiPF00583. Acetyltransf_1. 1 hit.
PF00439. Bromodomain. 1 hit.
PF06466. PCAF_N. 1 hit.
[Graphical view]
PIRSFiPIRSF003048. Histone_acetylase_PCAF. 1 hit.
PRINTSiPR00503. BROMODOMAIN.
SMARTiSM00297. BROMO. 1 hit.
[Graphical view]
SUPFAMiSSF47370. SSF47370. 1 hit.
SSF55729. SSF55729. 1 hit.
PROSITEiPS00633. BROMODOMAIN_1. 1 hit.
PS50014. BROMODOMAIN_2. 1 hit.
PS51186. GNAT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiD4ACX5_RAT
AccessioniPrimary (citable) accession number: D4ACX5
Entry historyi
Integrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 3, 2013
Last modified: November 30, 2016
This is version 59 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.