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D4ACX5

- D4ACX5_RAT

UniProt

D4ACX5 - D4ACX5_RAT

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Protein
Submitted name:

GCN5 general control of amino acid synthesis-like 2 (Yeast) (Predicted)

Gene
Kat2a, Gcn5l2_predicted, rCG_33366
Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein predictedi

Functioni

GO - Molecular functioni

  1. chromatin binding Source: Ensembl
  2. H3 histone acetyltransferase activity Source: Ensembl
  3. histone acetyltransferase activity (H4-K12 specific) Source: Ensembl
  4. transcription coactivator activity Source: Ensembl

GO - Biological processi

  1. cell proliferation Source: Ensembl
  2. histone deubiquitination Source: Ensembl
  3. histone H3-K14 acetylation Source: Ensembl
  4. in utero embryonic development Source: Ensembl
  5. metencephalon development Source: Ensembl
  6. midbrain development Source: Ensembl
  7. multicellular organism growth Source: Ensembl
  8. neural tube closure Source: Ensembl
  9. regulation of protein stability Source: Ensembl
  10. regulation of transcription, DNA-templated Source: InterPro
  11. somitogenesis Source: Ensembl
  12. telencephalon development Source: Ensembl
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_198384. HATs acetylate histones.

Names & Taxonomyi

Protein namesi
Submitted name:
GCN5 general control of amino acid synthesis-like 2 (Yeast) (Predicted)Imported
Submitted name:
Protein Kat2aImported
Gene namesi
Name:Kat2aImported
Synonyms:Gcn5l2_predictedImported
ORF Names:rCG_33366Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 10

Organism-specific databases

RGDi1307242. Kat2a.

Subcellular locationi

GO - Cellular componenti

  1. Ada2/Gcn5/Ada3 transcription activator complex Source: Ensembl
  2. mitotic spindle Source: Ensembl
  3. STAGA complex Source: Ensembl
  4. transcription factor TFTC complex Source: Ensembl
Complete GO annotation...

Family & Domainsi

Keywords - Domaini

BromodomainSAAS annotations

Phylogenomic databases

GeneTreeiENSGT00740000115051.
KOiK06062.
OMAiNSPIWES.
OrthoDBiEOG7ZKS9B.
TreeFamiTF105399.

Family and domain databases

Gene3Di1.20.920.10. 1 hit.
3.40.630.30. 1 hit.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR001487. Bromodomain.
IPR018359. Bromodomain_CS.
IPR000182. GNAT_dom.
IPR016376. Hist_acetylase_PCAF.
IPR009464. PCAF_N.
[Graphical view]
PfamiPF13508. Acetyltransf_7. 1 hit.
PF00439. Bromodomain. 1 hit.
PF06466. PCAF_N. 1 hit.
[Graphical view]
PIRSFiPIRSF003048. Histone_acetylase_PCAF. 1 hit.
PRINTSiPR00503. BROMODOMAIN.
SMARTiSM00297. BROMO. 1 hit.
[Graphical view]
SUPFAMiSSF47370. SSF47370. 1 hit.
SSF55729. SSF55729. 1 hit.
PROSITEiPS00633. BROMODOMAIN_1. 1 hit.
PS50014. BROMODOMAIN_2. 1 hit.
PS51186. GNAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D4ACX5-1 [UniParc]FASTAAdd to Basket

« Hide

MAEPSQAPNP APAAQPRPLQ SPAPAPTSTP APSPASAPTP APTPAPAPAP    50
AAAPAGSTGT GGAGVGSGGD PARPGLSQQQ RASQRKAQVR GLPRAKKLEK 100
LGVFSACKAN ETCKCNGWKN PKPPTAPRMD LQQPAANLSE LCRSCEHPLA 150
DHVSHLENVS EDEINRLLGM VVDVENLFMS VHKEEDTDTK QVYFYLFKLL 200
RKCILQMTRP VVEGSLGSPP FEKPNIEQGV LNFVQYKFSH LAPRERQTMF 250
ELSKMFLLCL NYWKLETPAQ FRQRSQSEDV ATYKVNYTRW LCYCHVPQSC 300
DSLPRYETTH VFGRSLLRSI FTVTRRQLLE KFRVEKDKLV PEKRTLILTH 350
FPKFLSMLEE EIYGANSPIW ESGFTMPPSE GTQLVPRPAT VSATVVPSTP 400
IFSPSMGGGS NSSLSLDSTG TEPMPGEKRK LPENLTLEDA KRLRVMGDIP 450
MELVNEVMLT ITDPAAMLGP ETSLLSANAA RDETARLEER RGIIEFHVIG 500
NSLTPKANRR VLLWLVGLQN VFSHQLPRMP KEYIARLVFD PKHKTLALIK 550
DGRVIGGICF RMFPTQGFTE IVFCAVTSNE QVKGYGTHLM NHLKEYHIKH 600
SILYFLTYAD EYAIGYFKKQ GFSKDIKVPK SRYLGYIKDY EGATLMECEL 650
NPRIPYTELS HIIKKQKEII KKLIERKQAQ IRKVYPGLSC FKEGVRQIPV 700
ESVPGIRETG WKPLGKEKGK ELKDPDQLYT TLKNLLAQIK SHPSAWPFME 750
PVKKSEAPDY YEVIRFPIDL KTMTERLRSR YYVTRKLFVA DLQRVIANCR 800
EYNPPDSEYC RCASALEKFF YFKLKEGGLI DK 832
Length:832
Mass (Da):93,651
Last modified:April 3, 2013 - v2
Checksum:iEB9E3009F4BCE81B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AABR06065574 Genomic DNA. No translation available.
CH473948 Genomic DNA. Translation: EDM06059.1.
RefSeqiNP_001100520.1. NM_001107050.1.
UniGeneiRn.53502.

Genome annotation databases

EnsembliENSRNOT00000055250; ENSRNOP00000052125; ENSRNOG00000018364.
GeneIDi303539.
KEGGirno:303539.
UCSCiRGD:1307242. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AABR06065574 Genomic DNA. No translation available.
CH473948 Genomic DNA. Translation: EDM06059.1 .
RefSeqi NP_001100520.1. NM_001107050.1.
UniGenei Rn.53502.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000055250 ; ENSRNOP00000052125 ; ENSRNOG00000018364 .
GeneIDi 303539.
KEGGi rno:303539.
UCSCi RGD:1307242. rat.

Organism-specific databases

CTDi 2648.
RGDi 1307242. Kat2a.

Phylogenomic databases

GeneTreei ENSGT00740000115051.
KOi K06062.
OMAi NSPIWES.
OrthoDBi EOG7ZKS9B.
TreeFami TF105399.

Enzyme and pathway databases

Reactomei REACT_198384. HATs acetylate histones.

Miscellaneous databases

NextBioi 35574302.
PROi D4ACX5.

Family and domain databases

Gene3Di 1.20.920.10. 1 hit.
3.40.630.30. 1 hit.
InterProi IPR016181. Acyl_CoA_acyltransferase.
IPR001487. Bromodomain.
IPR018359. Bromodomain_CS.
IPR000182. GNAT_dom.
IPR016376. Hist_acetylase_PCAF.
IPR009464. PCAF_N.
[Graphical view ]
Pfami PF13508. Acetyltransf_7. 1 hit.
PF00439. Bromodomain. 1 hit.
PF06466. PCAF_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF003048. Histone_acetylase_PCAF. 1 hit.
PRINTSi PR00503. BROMODOMAIN.
SMARTi SM00297. BROMO. 1 hit.
[Graphical view ]
SUPFAMi SSF47370. SSF47370. 1 hit.
SSF55729. SSF55729. 1 hit.
PROSITEi PS00633. BROMODOMAIN_1. 1 hit.
PS50014. BROMODOMAIN_2. 1 hit.
PS51186. GNAT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Rat Genome Sequencing Project Consortium
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown NorwayImported.
  2. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BNImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BNImported.
  4. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: Brown NorwayImported.

Entry informationi

Entry nameiD4ACX5_RAT
AccessioniPrimary (citable) accession number: D4ACX5
Entry historyi
Integrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 3, 2013
Last modified: September 3, 2014
This is version 36 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

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