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D4ACX5

- D4ACX5_RAT

UniProt

D4ACX5 - D4ACX5_RAT

Protein
Submitted name:

GCN5 general control of amino acid synthesis-like 2 (Yeast) (Predicted)

Gene

Kat2a

Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 3 out of 5- Protein predictedi
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    • History
      Entry version 37 (01 Oct 2014)
      Sequence version 2 (03 Apr 2013)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. chromatin binding Source: Ensembl
    2. H3 histone acetyltransferase activity Source: Ensembl
    3. histone acetyltransferase activity (H4-K12 specific) Source: Ensembl
    4. transcription coactivator activity Source: Ensembl

    GO - Biological processi

    1. cell proliferation Source: Ensembl
    2. histone deubiquitination Source: Ensembl
    3. histone H3-K14 acetylation Source: Ensembl
    4. in utero embryonic development Source: Ensembl
    5. metencephalon development Source: Ensembl
    6. midbrain development Source: Ensembl
    7. multicellular organism growth Source: Ensembl
    8. neural tube closure Source: Ensembl
    9. regulation of protein stability Source: Ensembl
    10. regulation of transcription, DNA-templated Source: InterPro
    11. somitogenesis Source: Ensembl
    12. telencephalon development Source: Ensembl

    Enzyme and pathway databases

    ReactomeiREACT_198384. HATs acetylate histones.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    GCN5 general control of amino acid synthesis-like 2 (Yeast) (Predicted)Imported
    Submitted name:
    Protein Kat2aImported
    Gene namesi
    Name:Kat2aImported
    Synonyms:Gcn5l2_predictedImported
    ORF Names:rCG_33366Imported
    OrganismiRattus norvegicus (Rat)Imported
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 10

    Organism-specific databases

    RGDi1307242. Kat2a.

    Subcellular locationi

    GO - Cellular componenti

    1. Ada2/Gcn5/Ada3 transcription activator complex Source: Ensembl
    2. mitotic spindle Source: Ensembl
    3. STAGA complex Source: Ensembl
    4. transcription factor TFTC complex Source: Ensembl

    Family & Domainsi

    Keywords - Domaini

    BromodomainSAAS annotation

    Phylogenomic databases

    GeneTreeiENSGT00740000115051.
    KOiK06062.
    OMAiNSPIWES.
    OrthoDBiEOG7ZKS9B.
    TreeFamiTF105399.

    Family and domain databases

    Gene3Di1.20.920.10. 1 hit.
    3.40.630.30. 1 hit.
    InterProiIPR016181. Acyl_CoA_acyltransferase.
    IPR001487. Bromodomain.
    IPR018359. Bromodomain_CS.
    IPR000182. GNAT_dom.
    IPR016376. Hist_acetylase_PCAF.
    IPR009464. PCAF_N.
    [Graphical view]
    PfamiPF13508. Acetyltransf_7. 1 hit.
    PF00439. Bromodomain. 1 hit.
    PF06466. PCAF_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF003048. Histone_acetylase_PCAF. 1 hit.
    PRINTSiPR00503. BROMODOMAIN.
    SMARTiSM00297. BROMO. 1 hit.
    [Graphical view]
    SUPFAMiSSF47370. SSF47370. 1 hit.
    SSF55729. SSF55729. 1 hit.
    PROSITEiPS00633. BROMODOMAIN_1. 1 hit.
    PS50014. BROMODOMAIN_2. 1 hit.
    PS51186. GNAT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    D4ACX5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAEPSQAPNP APAAQPRPLQ SPAPAPTSTP APSPASAPTP APTPAPAPAP    50
    AAAPAGSTGT GGAGVGSGGD PARPGLSQQQ RASQRKAQVR GLPRAKKLEK 100
    LGVFSACKAN ETCKCNGWKN PKPPTAPRMD LQQPAANLSE LCRSCEHPLA 150
    DHVSHLENVS EDEINRLLGM VVDVENLFMS VHKEEDTDTK QVYFYLFKLL 200
    RKCILQMTRP VVEGSLGSPP FEKPNIEQGV LNFVQYKFSH LAPRERQTMF 250
    ELSKMFLLCL NYWKLETPAQ FRQRSQSEDV ATYKVNYTRW LCYCHVPQSC 300
    DSLPRYETTH VFGRSLLRSI FTVTRRQLLE KFRVEKDKLV PEKRTLILTH 350
    FPKFLSMLEE EIYGANSPIW ESGFTMPPSE GTQLVPRPAT VSATVVPSTP 400
    IFSPSMGGGS NSSLSLDSTG TEPMPGEKRK LPENLTLEDA KRLRVMGDIP 450
    MELVNEVMLT ITDPAAMLGP ETSLLSANAA RDETARLEER RGIIEFHVIG 500
    NSLTPKANRR VLLWLVGLQN VFSHQLPRMP KEYIARLVFD PKHKTLALIK 550
    DGRVIGGICF RMFPTQGFTE IVFCAVTSNE QVKGYGTHLM NHLKEYHIKH 600
    SILYFLTYAD EYAIGYFKKQ GFSKDIKVPK SRYLGYIKDY EGATLMECEL 650
    NPRIPYTELS HIIKKQKEII KKLIERKQAQ IRKVYPGLSC FKEGVRQIPV 700
    ESVPGIRETG WKPLGKEKGK ELKDPDQLYT TLKNLLAQIK SHPSAWPFME 750
    PVKKSEAPDY YEVIRFPIDL KTMTERLRSR YYVTRKLFVA DLQRVIANCR 800
    EYNPPDSEYC RCASALEKFF YFKLKEGGLI DK 832
    Length:832
    Mass (Da):93,651
    Last modified:April 3, 2013 - v2
    Checksum:iEB9E3009F4BCE81B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR06065574 Genomic DNA. No translation available.
    CH473948 Genomic DNA. Translation: EDM06059.1.
    RefSeqiNP_001100520.1. NM_001107050.1.
    UniGeneiRn.53502.

    Genome annotation databases

    EnsembliENSRNOT00000055250; ENSRNOP00000052125; ENSRNOG00000018364.
    GeneIDi303539.
    KEGGirno:303539.
    UCSCiRGD:1307242. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR06065574 Genomic DNA. No translation available.
    CH473948 Genomic DNA. Translation: EDM06059.1 .
    RefSeqi NP_001100520.1. NM_001107050.1.
    UniGenei Rn.53502.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000055250 ; ENSRNOP00000052125 ; ENSRNOG00000018364 .
    GeneIDi 303539.
    KEGGi rno:303539.
    UCSCi RGD:1307242. rat.

    Organism-specific databases

    CTDi 2648.
    RGDi 1307242. Kat2a.

    Phylogenomic databases

    GeneTreei ENSGT00740000115051.
    KOi K06062.
    OMAi NSPIWES.
    OrthoDBi EOG7ZKS9B.
    TreeFami TF105399.

    Enzyme and pathway databases

    Reactomei REACT_198384. HATs acetylate histones.

    Miscellaneous databases

    NextBioi 35574302.
    PROi D4ACX5.

    Family and domain databases

    Gene3Di 1.20.920.10. 1 hit.
    3.40.630.30. 1 hit.
    InterProi IPR016181. Acyl_CoA_acyltransferase.
    IPR001487. Bromodomain.
    IPR018359. Bromodomain_CS.
    IPR000182. GNAT_dom.
    IPR016376. Hist_acetylase_PCAF.
    IPR009464. PCAF_N.
    [Graphical view ]
    Pfami PF13508. Acetyltransf_7. 1 hit.
    PF00439. Bromodomain. 1 hit.
    PF06466. PCAF_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF003048. Histone_acetylase_PCAF. 1 hit.
    PRINTSi PR00503. BROMODOMAIN.
    SMARTi SM00297. BROMO. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47370. SSF47370. 1 hit.
    SSF55729. SSF55729. 1 hit.
    PROSITEi PS00633. BROMODOMAIN_1. 1 hit.
    PS50014. BROMODOMAIN_2. 1 hit.
    PS51186. GNAT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
      Rat Genome Sequencing Project Consortium
      Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
      , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
      Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Brown NorwayImported.
    2. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: BNImported.
    3. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: BNImported.
    4. Ensembl
      Submitted (JUL-2011) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: Brown NorwayImported.

    Entry informationi

    Entry nameiD4ACX5_RAT
    AccessioniPrimary (citable) accession number: D4ACX5
    Entry historyi
    Integrated into UniProtKB/TrEMBL: April 20, 2010
    Last sequence update: April 3, 2013
    Last modified: October 1, 2014
    This is version 37 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3