ID   D4ACI9_RAT              Unreviewed;       788 AA.
AC   D4ACI9;
DT   20-APR-2010, integrated into UniProtKB/TrEMBL.
DT   25-MAY-2022, sequence version 2.
DT   27-MAR-2024, entry version 109.
DE   SubName: Full=Intraflagellar transport 88 {ECO:0000313|Ensembl:ENSRNOP00000012988.5};
GN   Name=Ift88 {ECO:0000313|Ensembl:ENSRNOP00000012988.5,
GN   ECO:0000313|RGD:1309717};
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000012988.5, ECO:0000313|Proteomes:UP000002494};
RN   [1] {ECO:0000313|Ensembl:ENSRNOP00000012988.5, ECO:0000313|Proteomes:UP000002494}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000012988.5,
RC   ECO:0000313|Proteomes:UP000002494};
RX   PubMed=15057822; DOI=10.1038/nature02426;
RG   Rat Genome Sequencing Project Consortium;
RA   Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA   Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA   Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA   Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA   Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA   Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA   Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA   Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA   Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA   Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA   Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA   Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA   Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA   Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA   Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA   Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA   Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA   Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA   Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA   Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA   Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA   Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA   Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA   Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA   Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA   Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA   Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA   Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA   Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA   Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA   Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA   Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA   Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA   Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA   Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA   Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA   Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA   Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA   Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA   Mockrin S., Collins F.S.;
RT   "Genome sequence of the Brown Norway rat yields insights into mammalian
RT   evolution.";
RL   Nature 428:493-521(2004).
RN   [2] {ECO:0000313|Ensembl:ENSRNOP00000012988.5}
RP   IDENTIFICATION.
RC   STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000012988.5};
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   RefSeq; XP_006252132.1; XM_006252070.3.
DR   AlphaFoldDB; D4ACI9; -.
DR   Ensembl; ENSRNOT00000012988.8; ENSRNOP00000012988.5; ENSRNOG00000009278.8.
DR   GeneID; 305918; -.
DR   UCSC; RGD:1309717; rat.
DR   AGR; RGD:1309717; -.
DR   CTD; 8100; -.
DR   RGD; 1309717; Ift88.
DR   VEuPathDB; HostDB:ENSRNOG00000009278; -.
DR   GeneTree; ENSGT00390000015473; -.
DR   OrthoDB; 312444at2759; -.
DR   TreeFam; TF313218; -.
DR   Proteomes; UP000002494; Chromosome 15.
DR   Bgee; ENSRNOG00000009278; Expressed in testis and 19 other cell types or tissues.
DR   ExpressionAtlas; D4ACI9; baseline and differential.
DR   GO; GO:0002080; C:acrosomal membrane; ISO:RGD.
DR   GO; GO:0097541; C:axonemal basal plate; ISO:RGD.
DR   GO; GO:0005930; C:axoneme; ISO:RGD.
DR   GO; GO:0005814; C:centriole; ISO:RGD.
DR   GO; GO:0005813; C:centrosome; ISO:RGD.
DR   GO; GO:0036064; C:ciliary basal body; ISO:RGD.
DR   GO; GO:0097546; C:ciliary base; ISO:RGD.
DR   GO; GO:0097542; C:ciliary tip; ISO:RGD.
DR   GO; GO:0005929; C:cilium; ISO:RGD.
DR   GO; GO:0005737; C:cytoplasm; ISO:RGD.
DR   GO; GO:0030992; C:intraciliary transport particle B; ISO:RGD.
DR   GO; GO:0060091; C:kinocilium; ISO:RGD.
DR   GO; GO:0002177; C:manchette; ISO:RGD.
DR   GO; GO:0031514; C:motile cilium; ISO:RGD.
DR   GO; GO:0097730; C:non-motile cilium; ISO:RGD.
DR   GO; GO:0002081; C:outer acrosomal membrane; IDA:MGI.
DR   GO; GO:0032391; C:photoreceptor connecting cilium; ISO:RGD.
DR   GO; GO:0036126; C:sperm flagellum; ISO:RGD.
DR   GO; GO:0005802; C:trans-Golgi network; IDA:MGI.
DR   GO; GO:0019894; F:kinesin binding; ISO:RGD.
DR   GO; GO:0009887; P:animal organ morphogenesis; ISO:RGD.
DR   GO; GO:0009952; P:anterior/posterior pattern specification; ISO:RGD.
DR   GO; GO:0007420; P:brain development; ISO:RGD.
DR   GO; GO:0055007; P:cardiac muscle cell differentiation; ISO:RGD.
DR   GO; GO:0060411; P:cardiac septum morphogenesis; ISO:RGD.
DR   GO; GO:0060271; P:cilium assembly; ISO:RGD.
DR   GO; GO:0003341; P:cilium movement; ISO:RGD.
DR   GO; GO:0090102; P:cochlea development; ISO:RGD.
DR   GO; GO:0031122; P:cytoplasmic microtubule organization; ISO:RGD.
DR   GO; GO:0007368; P:determination of left/right symmetry; ISO:RGD.
DR   GO; GO:0009953; P:dorsal/ventral pattern formation; ISO:RGD.
DR   GO; GO:0042733; P:embryonic digit morphogenesis; ISO:RGD.
DR   GO; GO:0001886; P:endothelial cell morphogenesis; ISO:RGD.
DR   GO; GO:0036334; P:epidermal stem cell homeostasis; ISO:RGD.
DR   GO; GO:0008544; P:epidermis development; ISO:RGD.
DR   GO; GO:0001654; P:eye development; ISO:RGD.
DR   GO; GO:0030900; P:forebrain development; ISO:RGD.
DR   GO; GO:0048853; P:forebrain morphogenesis; ISO:RGD.
DR   GO; GO:0007507; P:heart development; ISO:RGD.
DR   GO; GO:0060914; P:heart formation; ISO:RGD.
DR   GO; GO:0060122; P:inner ear receptor cell stereocilium organization; ISO:RGD.
DR   GO; GO:0042073; P:intraciliary transport; IBA:GO_Central.
DR   GO; GO:0043616; P:keratinocyte proliferation; ISO:RGD.
DR   GO; GO:0001822; P:kidney development; ISO:RGD.
DR   GO; GO:0060173; P:limb development; ISO:RGD.
DR   GO; GO:0001889; P:liver development; ISO:RGD.
DR   GO; GO:0030324; P:lung development; ISO:RGD.
DR   GO; GO:0060426; P:lung vasculature development; ISO:RGD.
DR   GO; GO:0050680; P:negative regulation of epithelial cell proliferation; ISO:RGD.
DR   GO; GO:0010839; P:negative regulation of keratinocyte proliferation; ISO:RGD.
DR   GO; GO:0007399; P:nervous system development; ISO:RGD.
DR   GO; GO:0061351; P:neural precursor cell proliferation; ISO:RGD.
DR   GO; GO:1905515; P:non-motile cilium assembly; ISO:RGD.
DR   GO; GO:0007219; P:Notch signaling pathway; ISO:RGD.
DR   GO; GO:0031016; P:pancreas development; ISO:RGD.
DR   GO; GO:0045724; P:positive regulation of cilium assembly; ISO:RGD.
DR   GO; GO:0043568; P:positive regulation of insulin-like growth factor receptor signaling pathway; ISO:RGD.
DR   GO; GO:1903929; P:primary palate development; ISO:RGD.
DR   GO; GO:0008104; P:protein localization; ISO:RGD.
DR   GO; GO:2000785; P:regulation of autophagosome assembly; ISO:RGD.
DR   GO; GO:1902017; P:regulation of cilium assembly; ISO:RGD.
DR   GO; GO:0045598; P:regulation of fat cell differentiation; ISO:RGD.
DR   GO; GO:0060259; P:regulation of feeding behavior; ISO:RGD.
DR   GO; GO:0042487; P:regulation of odontogenesis of dentin-containing tooth; ISO:RGD.
DR   GO; GO:0070613; P:regulation of protein processing; ISO:RGD.
DR   GO; GO:0034405; P:response to fluid shear stress; ISO:RGD.
DR   GO; GO:0034021; P:response to silicon dioxide; IEP:RGD.
DR   GO; GO:0007224; P:smoothened signaling pathway; ISO:RGD.
DR   GO; GO:0007288; P:sperm axoneme assembly; ISO:RGD.
DR   GO; GO:0007290; P:spermatid nucleus elongation; ISO:RGD.
DR   GO; GO:0021513; P:spinal cord dorsal/ventral patterning; ISO:RGD.
DR   GO; GO:0021537; P:telencephalon development; ISO:RGD.
DR   Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 2.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR019734; TPR_repeat.
DR   PANTHER; PTHR44117; INTRAFLAGELLAR TRANSPORT PROTEIN 88 HOMOLOG; 1.
DR   PANTHER; PTHR44117:SF1; INTRAFLAGELLAR TRANSPORT PROTEIN 88 HOMOLOG; 1.
DR   Pfam; PF12895; ANAPC3; 1.
DR   Pfam; PF13424; TPR_12; 1.
DR   Pfam; PF13432; TPR_16; 1.
DR   Pfam; PF13181; TPR_8; 1.
DR   SMART; SM00028; TPR; 11.
DR   SUPFAM; SSF48452; TPR-like; 3.
DR   PROSITE; PS50005; TPR; 6.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000002494}.
FT   REGION          112..135
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          724..788
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        724..739
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   788 AA;  89176 MW;  E85317D18DF54434 CRC64;
     MMENVHLAPE TDEDDLYSGF NDYNPAYDTE ELENDTGFQQ AVRTSHGRRP PVTAKIPSTA
     VSRPIATGYG SKTSLTSSMG RPMTGTIQDG VARPMTAVRA AGFSKAALRG SAFDPLGQSR
     GPAPPLEAKN EDSPEEKIRQ LEKKVNELVE ESCIANSCGD LKLALEKAKD AGRKERVLVR
     QREQVTSPEN INLDLTYSVL FNLASQYSAN EMYAEALNTY QVIVKNKMFS NAGRLKVNMG
     NIYLKQRNYS KAIKFYRMAL DQIPSVHKEM RIKIMQNIGI TFIKTGQYSD AINSFEHIMS
     MAPSLKAGFN LILSCFAIGD REKMKKAFQK LIAVPLEIDE DDKYISPSDD PHTNLLIEAI
     KNDHLRQMER ERKAMAEKYI MTAAKLIAPV IEASFAVGYN WCVEVVKASQ YVELANDLEI
     NKAITYLRQK DFNQAVDTLK MFEKKDSRVK SAAATNLSFL YYLENEFAQA SSYADLAVSS
     DRYNPSALTN KGNTVFANGD YEKAAEFYKE ALRNDSSCTE ALYNIGLTYK KLNRLDEALD
     SFLKLHAILR NSAQVLCQIA NVYELMEDPN QAIEWLMQLI SVVPTDSQAL SKLGELYDSE
     GDKSQAFQYY YESYRYFPSN IEVIEWLGAY YIDTQFCEKA IQYFERASLI QPTQVKWQLM
     VASCFRRSGN YQKALDTYKE IHRKFPENVE CLRFLVRLCT DIGLKEVQEY ATKLKRLEKM
     KEMREQRIKS GRDSGGGSRS KREGSAGSDA SYVDPLGPQI ERPKTAARKR IDEDDFADEE
     LGDDLLPE
//