Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

Calmodulin-2

Gene

Calm2

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi21 – 32PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi57 – 68PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi94 – 105PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi130 – 141PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

Keywordsi

LigandCalciumPROSITE-ProRule annotation

Enzyme and pathway databases

ReactomeiR-RNO-111932. CaMK IV-mediated phosphorylation of CREB.
R-RNO-111933. Calmodulin induced events.
R-RNO-111957. Cam-PDE 1 activation.
R-RNO-114608. Platelet degranulation.
R-RNO-1474151. Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation.
R-RNO-163615. PKA activation.
R-RNO-1855204. Synthesis of IP3 and IP4 in the cytosol.
R-RNO-203615. eNOS activation.
R-RNO-2514859. Inactivation, recovery and regulation of the phototransduction cascade.
R-RNO-2672351. Stimuli-sensing channels.
R-RNO-2871809. FCERI mediated Ca+2 mobilization.
R-RNO-4086398. Ca2+ pathway.
R-RNO-418359. Reduction of cytosolic Ca++ levels.
R-RNO-425561. Sodium/Calcium exchangers.
R-RNO-442717. CREB phosphorylation through the activation of CaMKK.
R-RNO-442729. CREB phosphorylation through the activation of CaMKII.
R-RNO-442745. Activation of CaMK IV.
R-RNO-442982. Ras activation uopn Ca2+ infux through NMDA receptor.
R-RNO-445355. Smooth Muscle Contraction.
R-RNO-451308. Activation of Ca-permeable Kainate Receptor.
R-RNO-5218920. VEGFR2 mediated vascular permeability.
R-RNO-5576892. Phase 0 - rapid depolarisation.
R-RNO-5578775. Ion homeostasis.
R-RNO-5607763. CLEC7A (Dectin-1) induces NFAT activation.
R-RNO-5626467. RHO GTPases activate IQGAPs.
R-RNO-5627123. RHO GTPases activate PAKs.
R-RNO-5673001. RAF/MAP kinase cascade.
R-RNO-70221. Glycogen breakdown (glycogenolysis).
R-RNO-8876725. Protein methylation.
R-RNO-936837. Ion transport by P-type ATPases.

Names & Taxonomyi

Protein namesi
Submitted name:
Calmodulin-2Imported
Gene namesi
Name:Calm2Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 15

Organism-specific databases

RGDi2258. Calm2.

PTM / Processingi

Proteomic databases

PaxDbiD4ABV5.
PeptideAtlasiD4ABV5.
PRIDEiD4ABV5.

Expressioni

Gene expression databases

BgeeiENSRNOG00000030871.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000040477.

Structurei

3D structure databases

ProteinModelPortaliD4ABV5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 43EF-handInterPro annotationAdd BLAST36
Domaini44 – 79EF-handInterPro annotationAdd BLAST36
Domaini81 – 116EF-handInterPro annotationAdd BLAST36
Domaini117 – 149EF-handInterPro annotationAdd BLAST33

Phylogenomic databases

eggNOGiKOG0027. Eukaryota.
COG5126. LUCA.
GeneTreeiENSGT00760000118901.
OMAiGRRKSHC.
OrthoDBiEOG091G0V73.
PhylomeDBiD4ABV5.
TreeFamiTF300912.

Family and domain databases

CDDicd00051. EFh. 2 hits.
InterProiView protein in InterPro
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
PfamiView protein in Pfam
PF13499. EF-hand_7. 2 hits.
SMARTiView protein in SMART
SM00054. EFh. 4 hits.
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiView protein in PROSITE
PS00018. EF_HAND_1. 4 hits.
PS50222. EF_HAND_2. 4 hits.

Sequencei

Sequence statusi: Complete.

D4ABV5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADQLTEEQI AEFKEAFSLF DKDGDGTITT KELGTVMRSL GQNPTEAELQ
60 70 80 90 100
DMINEVDADG NGTIDFPEFL TMMARKMKDT DNEEEIREAF HVFDKDGNGY
110 120 130 140
ISAAELRHVT TNLGEKLTDE EVDEMIREAD IDGDGQVNYE EFVQMMTAK
Length:149
Mass (Da):16,815
Last modified:April 20, 2010 - v1
Checksum:i9D7734F73FFA798C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07018613 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSRNOT00000046240; ENSRNOP00000040477; ENSRNOG00000030871.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07018613 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortaliD4ABV5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000040477.

Proteomic databases

PaxDbiD4ABV5.
PeptideAtlasiD4ABV5.
PRIDEiD4ABV5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000046240; ENSRNOP00000040477; ENSRNOG00000030871.

Organism-specific databases

RGDi2258. Calm2.

Phylogenomic databases

eggNOGiKOG0027. Eukaryota.
COG5126. LUCA.
GeneTreeiENSGT00760000118901.
OMAiGRRKSHC.
OrthoDBiEOG091G0V73.
PhylomeDBiD4ABV5.
TreeFamiTF300912.

Enzyme and pathway databases

ReactomeiR-RNO-111932. CaMK IV-mediated phosphorylation of CREB.
R-RNO-111933. Calmodulin induced events.
R-RNO-111957. Cam-PDE 1 activation.
R-RNO-114608. Platelet degranulation.
R-RNO-1474151. Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation.
R-RNO-163615. PKA activation.
R-RNO-1855204. Synthesis of IP3 and IP4 in the cytosol.
R-RNO-203615. eNOS activation.
R-RNO-2514859. Inactivation, recovery and regulation of the phototransduction cascade.
R-RNO-2672351. Stimuli-sensing channels.
R-RNO-2871809. FCERI mediated Ca+2 mobilization.
R-RNO-4086398. Ca2+ pathway.
R-RNO-418359. Reduction of cytosolic Ca++ levels.
R-RNO-425561. Sodium/Calcium exchangers.
R-RNO-442717. CREB phosphorylation through the activation of CaMKK.
R-RNO-442729. CREB phosphorylation through the activation of CaMKII.
R-RNO-442745. Activation of CaMK IV.
R-RNO-442982. Ras activation uopn Ca2+ infux through NMDA receptor.
R-RNO-445355. Smooth Muscle Contraction.
R-RNO-451308. Activation of Ca-permeable Kainate Receptor.
R-RNO-5218920. VEGFR2 mediated vascular permeability.
R-RNO-5576892. Phase 0 - rapid depolarisation.
R-RNO-5578775. Ion homeostasis.
R-RNO-5607763. CLEC7A (Dectin-1) induces NFAT activation.
R-RNO-5626467. RHO GTPases activate IQGAPs.
R-RNO-5627123. RHO GTPases activate PAKs.
R-RNO-5673001. RAF/MAP kinase cascade.
R-RNO-70221. Glycogen breakdown (glycogenolysis).
R-RNO-8876725. Protein methylation.
R-RNO-936837. Ion transport by P-type ATPases.

Gene expression databases

BgeeiENSRNOG00000030871.

Family and domain databases

CDDicd00051. EFh. 2 hits.
InterProiView protein in InterPro
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
PfamiView protein in Pfam
PF13499. EF-hand_7. 2 hits.
SMARTiView protein in SMART
SM00054. EFh. 4 hits.
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiView protein in PROSITE
PS00018. EF_HAND_1. 4 hits.
PS50222. EF_HAND_2. 4 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiD4ABV5_RAT
AccessioniPrimary (citable) accession number: D4ABV5
Entry historyiIntegrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: June 7, 2017
This is version 63 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.