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Protein
Submitted name:

Calmodulin-2

Gene

Calm2

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi21 – 32PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi57 – 68PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi94 – 105PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi130 – 141PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

Keywordsi

LigandCalciumPROSITE-ProRule annotation

Enzyme and pathway databases

ReactomeiR-RNO-111932 CaMK IV-mediated phosphorylation of CREB
R-RNO-111933 Calmodulin induced events
R-RNO-111957 Cam-PDE 1 activation
R-RNO-114608 Platelet degranulation
R-RNO-1474151 Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
R-RNO-163615 PKA activation
R-RNO-1855204 Synthesis of IP3 and IP4 in the cytosol
R-RNO-203615 eNOS activation
R-RNO-2514859 Inactivation, recovery and regulation of the phototransduction cascade
R-RNO-2672351 Stimuli-sensing channels
R-RNO-2871809 FCERI mediated Ca+2 mobilization
R-RNO-4086398 Ca2+ pathway
R-RNO-418359 Reduction of cytosolic Ca++ levels
R-RNO-425561 Sodium/Calcium exchangers
R-RNO-442717 CREB phosphorylation through the activation of CaMKK
R-RNO-442729 CREB phosphorylation through the activation of CaMKII
R-RNO-442745 Activation of CaMK IV
R-RNO-442982 Ras activation upon Ca2+ influx through NMDA receptor
R-RNO-445355 Smooth Muscle Contraction
R-RNO-451308 Activation of Ca-permeable Kainate Receptor
R-RNO-5218920 VEGFR2 mediated vascular permeability
R-RNO-5576892 Phase 0 - rapid depolarisation
R-RNO-5578775 Ion homeostasis
R-RNO-5607763 CLEC7A (Dectin-1) induces NFAT activation
R-RNO-5626467 RHO GTPases activate IQGAPs
R-RNO-5627123 RHO GTPases activate PAKs
R-RNO-5673001 RAF/MAP kinase cascade
R-RNO-70221 Glycogen breakdown (glycogenolysis)
R-RNO-8876725 Protein methylation
R-RNO-936837 Ion transport by P-type ATPases

Names & Taxonomyi

Protein namesi
Submitted name:
Calmodulin-2Imported
Gene namesi
Name:Calm2Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 15

Organism-specific databases

RGDi2258 Calm2

PTM / Processingi

Proteomic databases

PaxDbiD4ABV5
PeptideAtlasiD4ABV5
PRIDEiD4ABV5

Expressioni

Gene expression databases

BgeeiENSRNOG00000030871

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000040477

Structurei

3D structure databases

ProteinModelPortaliD4ABV5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 43EF-handInterPro annotationAdd BLAST36
Domaini44 – 79EF-handInterPro annotationAdd BLAST36
Domaini81 – 116EF-handInterPro annotationAdd BLAST36
Domaini117 – 149EF-handInterPro annotationAdd BLAST33

Phylogenomic databases

eggNOGiKOG0027 Eukaryota
COG5126 LUCA
GeneTreeiENSGT00760000118901
OMAiGRRKSHC
OrthoDBiEOG091G0V73
PhylomeDBiD4ABV5
TreeFamiTF300912

Family and domain databases

CDDicd00051 EFh, 2 hits
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
PfamiView protein in Pfam
PF13499 EF-hand_7, 2 hits
SMARTiView protein in SMART
SM00054 EFh, 4 hits
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 4 hits
PS50222 EF_HAND_2, 4 hits

Sequencei

Sequence statusi: Complete.

D4ABV5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADQLTEEQI AEFKEAFSLF DKDGDGTITT KELGTVMRSL GQNPTEAELQ
60 70 80 90 100
DMINEVDADG NGTIDFPEFL TMMARKMKDT DNEEEIREAF HVFDKDGNGY
110 120 130 140
ISAAELRHVT TNLGEKLTDE EVDEMIREAD IDGDGQVNYE EFVQMMTAK
Length:149
Mass (Da):16,815
Last modified:April 20, 2010 - v1
Checksum:i9D7734F73FFA798C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07018613 Genomic DNA No translation available.

Genome annotation databases

EnsembliENSRNOT00000046240; ENSRNOP00000040477; ENSRNOG00000030871

Similar proteinsi

Entry informationi

Entry nameiD4ABV5_RAT
AccessioniPrimary (citable) accession number: D4ABV5
Entry historyiIntegrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: May 23, 2018
This is version 67 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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