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Protein

F-box/LRR-repeat protein 15

Gene

Fbxl15

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of SMURF1, thereby acting as a positive regulator of the BMP signaling pathway. Required for dorsal/ventral pattern formation. Also mediates ubiquitination of SMURF2 and WWP2 (By similarity). Required for bone mass maintenance.By similarity1 Publication

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ubl conjugation pathway

Enzyme and pathway databases

ReactomeiR-RNO-983168. Antigen processing: Ubiquitination & Proteasome degradation.
UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
F-box/LRR-repeat protein 15
Gene namesi
Name:Fbxl15
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi1306444. Fbxl15.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004109051 – 300F-box/LRR-repeat protein 15Add BLAST300

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiD4ABB4.
PeptideAtlasiD4ABB4.
PRIDEiD4ABB4.

PTM databases

iPTMnetiD4ABB4.
PhosphoSitePlusiD4ABB4.

Expressioni

Gene expression databases

BgeeiENSRNOG00000019509.
GenevisibleiD4ABB4. RN.

Interactioni

Subunit structurei

Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complex SCF(FBXL15) composed of CUL1, SKP1, RBX1 and FBXL15.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000026471.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini19 – 66F-boxAdd BLAST48
Repeati141 – 162LRR 1Add BLAST22
Repeati167 – 188LRR 2Add BLAST22
Repeati194 – 215LRR 3Add BLAST22
Repeati220 – 241LRR 4Add BLAST22
Repeati246 – 267LRR 5Add BLAST22

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni113 – 269Interaction with SMURF1By similarityAdd BLAST157

Sequence similaritiesi

Belongs to the FBXL15 family.Curated
Contains 1 F-box domain.Curated
Contains 5 LRR (leucine-rich) repeats.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiENOG410IT1W. Eukaryota.
ENOG4111ZPI. LUCA.
GeneTreeiENSGT00760000119059.
InParanoidiD4ABB4.
KOiK10281.
OMAiLKVNHCH.
OrthoDBiEOG091G0UTZ.
PhylomeDBiD4ABB4.
TreeFamiTF326769.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR001810. F-box_dom.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR006553. Leu-rich_rpt_Cys-con_subtyp.
[Graphical view]
PfamiPF00646. F-box. 1 hit.
PF13516. LRR_6. 1 hit.
[Graphical view]
SMARTiSM00367. LRR_CC. 6 hits.
[Graphical view]
SUPFAMiSSF81383. SSF81383. 1 hit.

Sequencei

Sequence statusi: Complete.

D4ABB4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPPMEQSGG EQEPGAVRLL DLPWEDVLLP HVLNWVPLRQ LLRLQRVSRA
60 70 80 90 100
FRALVQLHLA RLRRFDAAQV GPQIPRAALV RLLRDAEGLQ ELALAPCHEW
110 120 130 140 150
LLDEDLVPVL ARNPQLRSVA LAGCGQLSRR ALGALAEGCP RLQRISLAHC
160 170 180 190 200
DWVDGLALRG LADRCPALEE LDLTACRQLK DEAIVYLAQR RGAGLRSLSL
210 220 230 240 250
AVNANVGDTA VQELARNCPQ LEHLDLTGCL RVGSDGVRTL AEYCPALRSL
260 270 280 290 300
RVRHCHHVAE PSLSRLRKRG VDIDVEPPLH QALVLLQDMA GFAPFVNLQV
Length:300
Mass (Da):33,180
Last modified:April 20, 2010 - v1
Checksum:i43FE513A84A5E1F0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC096363 Genomic DNA. No translation available.
CH473986 Genomic DNA. Translation: EDL94345.1.
RefSeqiNP_001101073.1. NM_001107603.1.
UniGeneiRn.49395.

Genome annotation databases

EnsembliENSRNOT00000026471; ENSRNOP00000026471; ENSRNOG00000019509.
GeneIDi309453.
KEGGirno:309453.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC096363 Genomic DNA. No translation available.
CH473986 Genomic DNA. Translation: EDL94345.1.
RefSeqiNP_001101073.1. NM_001107603.1.
UniGeneiRn.49395.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000026471.

PTM databases

iPTMnetiD4ABB4.
PhosphoSitePlusiD4ABB4.

Proteomic databases

PaxDbiD4ABB4.
PeptideAtlasiD4ABB4.
PRIDEiD4ABB4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000026471; ENSRNOP00000026471; ENSRNOG00000019509.
GeneIDi309453.
KEGGirno:309453.

Organism-specific databases

CTDi79176.
RGDi1306444. Fbxl15.

Phylogenomic databases

eggNOGiENOG410IT1W. Eukaryota.
ENOG4111ZPI. LUCA.
GeneTreeiENSGT00760000119059.
InParanoidiD4ABB4.
KOiK10281.
OMAiLKVNHCH.
OrthoDBiEOG091G0UTZ.
PhylomeDBiD4ABB4.
TreeFamiTF326769.

Enzyme and pathway databases

UniPathwayiUPA00143.
ReactomeiR-RNO-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Miscellaneous databases

PROiD4ABB4.

Gene expression databases

BgeeiENSRNOG00000019509.
GenevisibleiD4ABB4. RN.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR001810. F-box_dom.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR006553. Leu-rich_rpt_Cys-con_subtyp.
[Graphical view]
PfamiPF00646. F-box. 1 hit.
PF13516. LRR_6. 1 hit.
[Graphical view]
SMARTiSM00367. LRR_CC. 6 hits.
[Graphical view]
SUPFAMiSSF81383. SSF81383. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiFXL15_RAT
AccessioniPrimary (citable) accession number: D4ABB4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 28, 2011
Last sequence update: April 20, 2010
Last modified: November 2, 2016
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.