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Protein

Actin filament-associated protein 1-like 1

Gene

Afap1l1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in podosome and invadosome formation.By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Actin filament-associated protein 1-like 1
Short name:
AFAP1-like protein 1
Gene namesi
Name:Afap1l1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 18

Organism-specific databases

RGDi1311580. Afap1l1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell projection, Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004166931 – 767Actin filament-associated protein 1-like 1Add BLAST767

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei87PhosphoserineCombined sources1
Modified residuei93PhosphoserineCombined sources1
Modified residuei97PhosphoserineCombined sources1
Modified residuei103PhosphoserineCombined sources1
Modified residuei152PhosphoserineBy similarity1
Modified residuei328PhosphoserineBy similarity1
Modified residuei342PhosphoserineBy similarity1
Modified residuei556PhosphotyrosineBy similarity1
Modified residuei746PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiD4AB98.
PRIDEiD4AB98.

PTM databases

iPTMnetiD4AB98.
PhosphoSitePlusiD4AB98.

Expressioni

Gene expression databases

BgeeiENSRNOG00000019403.
GenevisibleiD4AB98. RN.

Interactioni

Subunit structurei

Interacts with CTTN.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000026495.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini219 – 315PH 1PROSITE-ProRule annotationAdd BLAST97
Domaini417 – 511PH 2PROSITE-ProRule annotationAdd BLAST95

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili610 – 700Sequence analysisAdd BLAST91

Sequence similaritiesi

Contains 2 PH domains.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiENOG410IEU6. Eukaryota.
ENOG4111CMN. LUCA.
GeneTreeiENSGT00390000003998.
InParanoidiD4AB98.
OMAiGRRETCD.
OrthoDBiEOG091G03NB.

Family and domain databases

Gene3Di2.30.29.30. 2 hits.
InterProiIPR030113. AFAP.
IPR030112. AFAP1L1.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
[Graphical view]
PANTHERiPTHR14338. PTHR14338. 1 hit.
PTHR14338:SF1. PTHR14338:SF1. 1 hit.
PfamiPF00169. PH. 2 hits.
[Graphical view]
SMARTiSM00233. PH. 2 hits.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 3 hits.
PROSITEiPS50003. PH_DOMAIN. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D4AB98-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDRSRVLEQL IPELTRLLSL LDHEYLSDST LEKKMAVASL LQSLQPLPAK
60 70 80 90 100
EVSFLYVNTA DLHSGPSFVE SLFEEFDCDL GDLRDMSDDG ERSKEASPEP
110 120 130 140 150
IKSPSLRSTA DVPPPLPNKP PPEDYYEEAL PLGPGKSPEY ISSHNGCSPA
160 170 180 190 200
QSIVDGYYED ADSSYPTTRM NGESKSSYND SDAMSSSYES YDEEEEEEKG
210 220 230 240 250
RQPKHQWPSE EASMHLVRDC RICAFLLRKK RFGQWAKQLT VIKEEQLLCY
260 270 280 290 300
KSSKDRQPHL RLPLDVCTVV YVPKDSRHKR HELRFSQGAT EVLVLALQSR
310 320 330 340 350
EQAEEWLKVI REVSRPIGGA ESLEVPRSPV ILCKLDQDKR LSQEKQNSDS
360 370 380 390 400
DSLGMNDSSS TLSRREACEH GKGKKNSLAE LKDSMSRAAG RKITRIISFS
410 420 430 440 450
KKKALSEDLQ TFSSEDEAPC CGYLNVLVNH GWKERWCRLR CNTLYFHKDR
460 470 480 490 500
TDLHTHVNAI ALRGCEVAPG FGPRHPFAFR ILRNRQEVAI LEASCSEDMG
510 520 530 540 550
RWLGLLLVEM GSKVTPEALH YDYVDVETLT SIVSAGRNSF LYAQSCQDQW
560 570 580 590 600
PEPRIYDEVP YEKVQDEEPQ RPTGAQVKRH ASSCSEKSHR ADPQVKVKRH
610 620 630 640 650
ASSANQYKYG KNRAEEDARR YLVEKERLEK EKETIRTELT ALRQEKKELK
660 670 680 690 700
EAIRNNPGAK LKALEEAVAT LDAQCRAKEE QRIDLELKLV AVKERLQQSL
710 720 730 740 750
AGGPALGLSV SSKSKSQETT NKPQSSVPEQ SLPVNCVSEM RKRSPSIVTS
760
NQGRVLQKAK EWEMKKT
Length:767
Mass (Da):86,875
Last modified:April 20, 2010 - v1
Checksum:i15E1C7A5707AEB58
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH473971 Genomic DNA. Translation: EDM14621.1.
RefSeqiNP_001099612.1. NM_001106142.1.
UniGeneiRn.103300.
Rn.224736.

Genome annotation databases

EnsembliENSRNOT00000026495; ENSRNOP00000026495; ENSRNOG00000019403.
GeneIDi291565.
KEGGirno:291565.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH473971 Genomic DNA. Translation: EDM14621.1.
RefSeqiNP_001099612.1. NM_001106142.1.
UniGeneiRn.103300.
Rn.224736.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000026495.

PTM databases

iPTMnetiD4AB98.
PhosphoSitePlusiD4AB98.

Proteomic databases

PaxDbiD4AB98.
PRIDEiD4AB98.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000026495; ENSRNOP00000026495; ENSRNOG00000019403.
GeneIDi291565.
KEGGirno:291565.

Organism-specific databases

CTDi134265.
RGDi1311580. Afap1l1.

Phylogenomic databases

eggNOGiENOG410IEU6. Eukaryota.
ENOG4111CMN. LUCA.
GeneTreeiENSGT00390000003998.
InParanoidiD4AB98.
OMAiGRRETCD.
OrthoDBiEOG091G03NB.

Miscellaneous databases

PROiD4AB98.

Gene expression databases

BgeeiENSRNOG00000019403.
GenevisibleiD4AB98. RN.

Family and domain databases

Gene3Di2.30.29.30. 2 hits.
InterProiIPR030113. AFAP.
IPR030112. AFAP1L1.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
[Graphical view]
PANTHERiPTHR14338. PTHR14338. 1 hit.
PTHR14338:SF1. PTHR14338:SF1. 1 hit.
PfamiPF00169. PH. 2 hits.
[Graphical view]
SMARTiSM00233. PH. 2 hits.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 3 hits.
PROSITEiPS50003. PH_DOMAIN. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAF1L1_RAT
AccessioniPrimary (citable) accession number: D4AB98
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 18, 2012
Last sequence update: April 20, 2010
Last modified: November 2, 2016
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.