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Protein

Stonin-2

Gene

Ston2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Adapter protein involved in endocytic machinery. Involved in the synaptic vesicle recycling. May facilitate clathrin-coated vesicle uncoating (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Endocytosis

Names & Taxonomyi

Protein namesi
Recommended name:
Stonin-2
Gene namesi
Name:Ston2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 6

Organism-specific databases

RGDi1311502. Ston2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cytoplasm, Membrane, Synapse, Synaptosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 895895Stonin-2PRO_0000429277Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei278 – 2781PhosphoserineBy similarity
Modified residuei284 – 2841PhosphoserineBy similarity
Modified residuei299 – 2991PhosphoserineBy similarity
Modified residuei759 – 7591PhosphoserineBy similarity

Post-translational modificationi

Phosphorylated in vitro by PKD.By similarity
Neddylated and ubiquitinated; leading to its degradation and inhibited by TOR1A and COPS4.By similarity

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiD4AB66.
PeptideAtlasiD4AB66.

PTM databases

iPTMnetiD4AB66.
PhosphoSiteiD4AB66.

Expressioni

Gene expression databases

BgeeiENSRNOG00000004458.

Interactioni

Subunit structurei

Interacts with the second C2 domain of synaptotagmins SYT1 and SYT2. Interacts with EPS15, EPS15R and ITSN1. Interacts indirectly with the AP-2 adapter complex. Interacts with TOR1A and COPS4; the interaction controls STON2 protein stability.1 Publication

Protein-protein interaction databases

IntActiD4AB66. 2 interactions.
MINTiMINT-8092238.
STRINGi10116.ENSRNOP00000005881.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini424 – 557134SHDPROSITE-ProRule annotationAdd
BLAST
Domaini565 – 872308MHDPROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi310 – 3123NPF 1
Motifi326 – 3283NPF 2

Sequence similaritiesi

Belongs to the Stoned B family.Curated
Contains 1 MHD (mu homology) domain.PROSITE-ProRule annotation
Contains 1 SHD (stonin homology) domain.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG2677. Eukaryota.
ENOG410XQHF. LUCA.
GeneTreeiENSGT00830000128302.
InParanoidiD4AB66.
KOiK20067.
OMAiFNPLDAC.
OrthoDBiEOG091G0GC2.
PhylomeDBiD4AB66.
TreeFamiTF300393.

Family and domain databases

InterProiIPR028565. MHD.
IPR012320. SHD.
IPR031228. STON2.
IPR017110. Stonin.
IPR022699. Stonin2_N.
[Graphical view]
PANTHERiPTHR10529:SF246. PTHR10529:SF246. 2 hits.
PfamiPF00928. Adap_comp_sub. 1 hit.
PF12016. Stonin2_N. 1 hit.
[Graphical view]
PIRSFiPIRSF037099. Stonin. 1 hit.
SUPFAMiSSF49447. SSF49447. 2 hits.
PROSITEiPS51072. MHD. 1 hit.
PS51070. SHD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D4AB66-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTLDHVIAT HQSEWVSFSE EPLFPTPLEG GTEEHFPGLS SSSDRSESSS
60 70 80 90 100
GENHAVDEGS QDLSHSEQDD SSEKMGLISE AASPPGSPVQ PTPDLASAIS
110 120 130 140 150
NWVQFEDDTP WSNTSAPHKE TALTLTVPCW TCPSLDSLRR CPLASESSWT
160 170 180 190 200
THSEDTSSPS VAPSYTDLQL INAEEQASGR ASGTDSTDNS SSLQEDEEVE
210 220 230 240 250
METISWWAGS PAMNGHPAVP QVTTARFPSW VTFEDNEVGC PSPTVPSPKK
260 270 280 290 300
PNAPSAATAG PDVPFNSTGS FKRDRPKSTL MNLSKVQKLD ISSLNRPPSV
310 320 330 340 350
TEAPPWRATN PFLNESLQDI QPSPINPFSA FFEEQERRSQ NSSISGTSGK
360 370 380 390 400
SQRDSLIVIY QDAISFDDSG KSQSHPDAIE KLKQLQIDDP DPVGNAALPD
410 420 430 440 450
DDPTASVEPD APSPTSALSQ PRDGWPMMLR IPEKKNIMSS RHWGPIYIKL
460 470 480 490 500
TDSGYLQLYY EQGLEKPFRE FKLEICHEVS EPRLQNYDEN GRIHSLRIDR
510 520 530 540 550
VTYKEKKKYQ PKPAVAHAAE REQVIKLGTT NYDDFLSFIH AVQDRLMDLP
560 570 580 590 600
VQSMDLSTVG LNYLEEEITV DIRDEFSGTV SKGDNQILQH HVLTRIHILS
610 620 630 640 650
FLSGLAECRL GLNDILIKGN EIVSRQDIMP TTTTKWIKLH ECRFHGCVDE
660 670 680 690 700
DVFNSSRVIL FNPLDACRFE LMRFRTVFAE KTLPFTLRTA ASINGAEVEV
710 720 730 740 750
QSWLRMSPGF SSNRDPLTQV PCENVMVRYP VPSEWVKNFR RESVLGEKSL
760 770 780 790 800
KAKVNRGASF GSAGASGSEP VMRVTLGTAK YEHAFNSIVW RINRLPDKNS
810 820 830 840 850
ASGHPHCFFC HLELGSDREV PSRFANHVNV EFSMPTTSAS KAAVRSISVE
860 870 880 890
DKPDVRKWVN YSAHYSYKVE IEQKKSLKPD FEGEDLENPK ECGVQ
Length:895
Mass (Da):99,491
Last modified:April 20, 2010 - v1
Checksum:i692E1308E897F35C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR06045586 Genomic DNA. No translation available.
AABR06045587 Genomic DNA. No translation available.
AABR06045588 Genomic DNA. No translation available.
AABR06045589 Genomic DNA. No translation available.
AABR06045590 Genomic DNA. No translation available.
AABR06045591 Genomic DNA. No translation available.
AABR06045592 Genomic DNA. No translation available.
RefSeqiNP_001129346.1. NM_001135874.1.
XP_006240468.1. XM_006240406.2.
XP_006240469.1. XM_006240407.2.
UniGeneiRn.210121.

Genome annotation databases

EnsembliENSRNOT00000005881; ENSRNOP00000005881; ENSRNOG00000004458.
GeneIDi314349.
KEGGirno:314349.
UCSCiRGD:1311502. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR06045586 Genomic DNA. No translation available.
AABR06045587 Genomic DNA. No translation available.
AABR06045588 Genomic DNA. No translation available.
AABR06045589 Genomic DNA. No translation available.
AABR06045590 Genomic DNA. No translation available.
AABR06045591 Genomic DNA. No translation available.
AABR06045592 Genomic DNA. No translation available.
RefSeqiNP_001129346.1. NM_001135874.1.
XP_006240468.1. XM_006240406.2.
XP_006240469.1. XM_006240407.2.
UniGeneiRn.210121.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiD4AB66. 2 interactions.
MINTiMINT-8092238.
STRINGi10116.ENSRNOP00000005881.

PTM databases

iPTMnetiD4AB66.
PhosphoSiteiD4AB66.

Proteomic databases

PaxDbiD4AB66.
PeptideAtlasiD4AB66.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000005881; ENSRNOP00000005881; ENSRNOG00000004458.
GeneIDi314349.
KEGGirno:314349.
UCSCiRGD:1311502. rat.

Organism-specific databases

CTDi85439.
RGDi1311502. Ston2.

Phylogenomic databases

eggNOGiKOG2677. Eukaryota.
ENOG410XQHF. LUCA.
GeneTreeiENSGT00830000128302.
InParanoidiD4AB66.
KOiK20067.
OMAiFNPLDAC.
OrthoDBiEOG091G0GC2.
PhylomeDBiD4AB66.
TreeFamiTF300393.

Miscellaneous databases

PROiD4AB66.

Gene expression databases

BgeeiENSRNOG00000004458.

Family and domain databases

InterProiIPR028565. MHD.
IPR012320. SHD.
IPR031228. STON2.
IPR017110. Stonin.
IPR022699. Stonin2_N.
[Graphical view]
PANTHERiPTHR10529:SF246. PTHR10529:SF246. 2 hits.
PfamiPF00928. Adap_comp_sub. 1 hit.
PF12016. Stonin2_N. 1 hit.
[Graphical view]
PIRSFiPIRSF037099. Stonin. 1 hit.
SUPFAMiSSF49447. SSF49447. 2 hits.
PROSITEiPS51072. MHD. 1 hit.
PS51070. SHD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSTON2_RAT
AccessioniPrimary (citable) accession number: D4AB66
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 11, 2014
Last sequence update: April 20, 2010
Last modified: September 7, 2016
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.