D4AB34 (F132B_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein FAM132B

Alternative name(s):
Complement C1q tumor necrosis factor-related protein 15
Myonectin

Gene names

Name:	Fam132b
Synonyms:	C1qtnf15, Ctrp15

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	341 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Promotes lipid uptake into adipocytes and hepatocytes via transcriptional up-regulation of genes involved in fatty acid uptake. Ref.2
Subunit structure	Homodimer; disulfide-linked. May form heteromeric complexes with C1QTNF2 and FAM132A and, to a lesser extent, with C1QTNF5 and C1QTNF10 By similarity.
Subcellular location	Secreted By similarity.
Post-translational modification	N-glycosylated By similarity.
Sequence similarities	Belongs to the FAM132 family. Contains 1 C1q domain.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	positive regulation of fatty acid transport Inferred from electronic annotation. Source: Compara regulation of fatty acid metabolic process Inferred from electronic annotation. Source: Compara
Cellular_component	extracellular space Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 24	24	Potential
	Chain	25 – 341	317	Protein FAM132B		PRO_0000422122
Regions
	Domain	186 – 341	156	C1q

Sequences

	Sequence		Length	Mass (Da)
	D4AB34 [UniParc]. Last modified April 20, 2010. Version 1. Checksum: 9467635C8DEFDBBD	FASTA	341	36,369
	10 20 30 40 50 60 MASTRSPGGA RTLLACASLL AAMGLGVPES AEPVGTQARP QPPGTELPAP PAHSPPEPTI 70 80 90 100 110 120 AHAHSVDPRD AWMLFVKQSD KGINSKKRSR TKARRLKLGL PGPPGPPGPQ GPPGPFIPSE 130 140 150 160 170 180 VLLKEFQLLL KGAVRQREST EHCTRDLTTP ASGGPSRDPV TQELESQDQG AVLALLAATL 190 200 210 220 230 240 AQSPRAPRVE AAFHCRLRRD VQVERRALHE LGVYYLPEVE GAFRRGPGLN LTSGQYTAPV 250 260 270 280 290 300 AGFYALAATL HVALTKQPRK GPPQPRDRLR LLICIQSLCQ HNASLETVMG LENSSELFTI 310 320 330 340 SVNGVLYLQT GHYTSVFLDN ASGSSLTVRG GSHFSAILLG L

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"Myonectin (CTRP15), a novel myokine that links skeletal muscle to systemic lipid homeostasis." Seldin M.M., Peterson J.M., Byerly M.S., Wei Z., Wong G.W. J. Biol. Chem. 287:11968-11980(2012) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CH473997 Genomic DNA. Translation: EDL92028.1.
IPI	IPI00568611.
RefSeq	XP_001060107.2. XM_001060107.2. XP_003754598.1. XM_003754550.1.
UniGene	Rn.225751.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000051810; ENSRNOP00000045074; ENSRNOG00000024688.
GeneID	681056.
KEGG	rno:681056.
UCSC	RGD:1584688. rat.
Organism-specific databases
CTD	151176.
RGD	1584688. Fam132b.
Phylogenomic databases
GeneTree	ENSGT00390000007846.
OMA	QSLCQHN.
OrthoDB	EOG4ZW5CH.
Family and domain databases
Gene3D	2.60.120.40. 1 hit.
InterPro	IPR008983. Tumour_necrosis_fac-like_dom. [Graphical view]
SUPFAM	SSF49842. TNF_like. 1 hit.
PROSITE	PS50871. C1Q. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	720067.

Entry information

Entry name

F132B_RAT

Accession

Primary (citable) accession number: D4AB34

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 1, 2013
Last sequence update:	April 20, 2010
Last modified:	May 1, 2013
This is version 25 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program