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Protein
Submitted name:

Phosphoribosylformylglycinamidine synthase

Gene

Pfas

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei1091NucleophilePROSITE-ProRule annotation1
Active sitei1230PROSITE-ProRule annotation1
Active sitei1232PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

  • 'de novo' IMP biosynthetic process Source: InterPro
  • glutamine metabolic process Source: RGD
  • response to drug Source: RGD
  • ribonucleoside monophosphate biosynthetic process Source: RGD

Enzyme and pathway databases

ReactomeiR-RNO-73817 Purine ribonucleoside monophosphate biosynthesis

Names & Taxonomyi

Protein namesi
Submitted name:
Phosphoribosylformylglycinamidine synthaseImported
Gene namesi
Name:PfasImported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi1304926 Pfas

PTM / Processingi

Proteomic databases

PaxDbiD4AB17
PeptideAtlasiD4AB17
PRIDEiD4AB17

Expressioni

Gene expression databases

BgeeiENSRNOG00000005193
ExpressionAtlasiD4AB17 baseline and differential

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000007087

Structurei

3D structure databases

ProteinModelPortaliD4AB17
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini997 – 1269Glutamine amidotransferase type-1InterPro annotationAdd BLAST273

Keywords - Domaini

Glutamine amidotransferasePROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1907 Eukaryota
COG0046 LUCA
COG0047 LUCA
GeneTreeiENSGT00390000007600
InParanoidiD4AB17
PhylomeDBiD4AB17
TreeFamiTF106371

Family and domain databases

Gene3Di3.30.1330.10, 2 hits
3.40.50.880, 1 hit
3.90.650.10, 2 hits
HAMAPiMF_00419 PurL_1, 1 hit
InterProiView protein in InterPro
IPR029062 Class_I_gatase-like
IPR017926 GATASE
IPR010073 PRibForGlyAmidine_synth
IPR010918 PurM-like_C_dom
IPR036676 PurM-like_C_sf
IPR036921 PurM-like_N_sf
IPR036604 PurS-like_sf
PfamiView protein in Pfam
PF02769 AIRS_C, 2 hits
SUPFAMiSSF52317 SSF52317, 1 hit
SSF55326 SSF55326, 2 hits
SSF56042 SSF56042, 2 hits
SSF82697 SSF82697, 1 hit
TIGRFAMsiTIGR01735 FGAM_synt, 1 hit
PROSITEiView protein in PROSITE
PS51273 GATASE_TYPE_1, 1 hit

Sequencei

Sequence statusi: Complete.

D4AB17-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMLLGSPGWS LAPMICCWRW DPLNFSTPAS TNIVSVCQAA GLRAVDRVET
60 70 80 90 100
TRRYRLSFAK QPTAEMEAIS LAALHDRMTE QHYPDPIQSF SPQSIPAPLK
110 120 130 140 150
DSINILAEGR PALEKANQEL GLALDSWDLD FYTKRFQELQ RNPSTVEVFD
160 170 180 190 200
LAQSNSEHSR HWFFKGQLHV DGKKLARSLF ESIMSTQSSS NPNNVLKFCD
210 220 230 240 250
NSSAIQGKEV RFLRPEDSTR PSCFRQQRGL RHVVFTAETH NFPTGVAPFS
260 270 280 290 300
GATTGTGGRI RDVQCTGRGA HVVAGTAGYC FGNLHIPGYN LPWEDPSFQY
310 320 330 340 350
PGNFARPLEV AIEASNGASD YGNKFGEPVL AGFARSLGLQ LPDGQRREWI
360 370 380 390 400
KPIMFSGGIG SMEAKHVGKE PPEPGMEVVK VGGPVYRIGV GGGAASSVQV
410 420 430 440 450
QGDNTSDLDF GAVQRGDPEM EQKMNRVIRA CVEAPGGNPI CSLHDQGAGG
460 470 480 490 500
NGNVLKELSE PAGAVIYTSR FQLGDPTLNA LEIWGAEYQE SNALLLRPSD
510 520 530 540 550
RDFLSRASAR ERCPACFVGT ITGDKRIVLV DDRECLMGKS GQGDAPPTPP
560 570 580 590 600
TPVDLDLDWV LGKMPQKEFF LQRKPPVLQP LALPPDLSVG QALERVLRLP
610 620 630 640 650
AVASKRYLTN KVDRSVGGLV AQQQCVGPLQ TPLADVAVVA LSHQELVGAA
660 670 680 690 700
TALGEQPVKS LLDPKAAARL AVSEALTNLV FALVTDLRDV KCSGNWMWAA
710 720 730 740 750
KLPGEGAGLA DACEAMVTVM AALGVAVDGG KDSLSMAARV GTETVPAPGS
760 770 780 790 800
LVISAYAVCP DITATVTPDL KHPGGKGHLL YVPLSPGQHR LGGTALAQCF
810 820 830 840 850
SQLGEHPPDL DLPENLVRAF HITQGLLKGE WGPDRRLCSG HDVSDGGLVT
860 870 880 890 900
CLLEMAFAGN CGIEVDVPAP GIHALPVLFA EEPGLVLEVQ EADVAGVLQR
910 920 930 940 950
YQSAGLHCLE LGHTGEAGPQ AMVRVSVNGT VVVEEPVGQL RALWEETSFQ
960 970 980 990 1000
LDLLQAEPRC VTEEKQGLKE RIGPSYCLPP TFPVASVPCK PGGPIPRVAI
1010 1020 1030 1040 1050
LREEGSNGDR EMADAFHLAG FEVWDVTMQD LCSGAVRLDT FRGVAFVGGF
1060 1070 1080 1090 1100
SYADVLGSAK GWAAAVTFNP QAREELGRFR RRPDTFSLGV CNGCQLLALL
1110 1120 1130 1140 1150
GWVGSDPNED QVEPDHDSQP AQPGLLLRHN LSGRFESRWA TVRVEPGPAL
1160 1170 1180 1190 1200
MLRGMEGSVL PVWSAHGEGY MAFSSPELQA KIKAKGLVPL HWADDDGNPT
1210 1220 1230 1240 1250
EQYPLNPNGS PGGIAGICSP DGRHLALMPH PERAVRLWQW AWRPSPFDGL
1260 1270
STSPWLQLFI NARNWTQEDS C
Length:1,271
Mass (Da):136,894
Last modified:July 22, 2015 - v3
Checksum:i3557F7FFE9F02DA7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC126877 Genomic DNA No translation available.
AC129753 Genomic DNA No translation available.

Genome annotation databases

EnsembliENSRNOT00000007087; ENSRNOP00000007087; ENSRNOG00000005193
UCSCiRGD:1304926 rat

Similar proteinsi

Entry informationi

Entry nameiD4AB17_RAT
AccessioniPrimary (citable) accession number: D4AB17
Entry historyiIntegrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: July 22, 2015
Last modified: June 20, 2018
This is version 71 of the entry and version 3 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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