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Protein

ATP-dependent (S)-NAD(P)H-hydrate dehydratase

Gene

Naxd

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.UniRule annotation

Catalytic activityi

ATP + (6S)-6-beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide = ADP + phosphate + NADH.UniRule annotation
ATP + (6S)-6-beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide phosphate = ADP + phosphate + NADPH.

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei149NAD(P)HX; via amide nitrogenUniRule annotation1
Binding sitei271NAD(P)HXUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi242 – 246ATPUniRule annotation5
Nucleotide bindingi261 – 270ATPUniRule annotation10

GO - Molecular functioni

Keywordsi

Molecular functionLyase
LigandATP-binding, NAD, NADP, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-dependent (S)-NAD(P)H-hydrate dehydrataseUniRule annotation (EC:4.2.1.93UniRule annotation)
Alternative name(s):
ATP-dependent NAD(P)HX dehydrataseUniRule annotation
Carbohydrate kinase domain-containing proteinUniRule annotation
NAD(P)HX dehydrataseImported
Gene namesi
Name:NaxdImported
Synonyms:Carkd
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1562691 Naxd

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 42MitochondrionUniRule annotationAdd BLAST42
ChainiPRO_000041615943 – 343ATP-dependent (S)-NAD(P)H-hydrate dehydrataseAdd BLAST301

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei63N6-acetyllysineBy similarity1
Modified residuei81PhosphotyrosineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiD4AAT7
PRIDEiD4AAT7

PTM databases

SwissPalmiD4AAT7

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000060397

Structurei

3D structure databases

SMRiD4AAT7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini49 – 340YjeF C-terminalUniRule annotationAdd BLAST292

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni202 – 208NAD(P)HXUniRule annotation7

Sequence similaritiesi

Belongs to the NnrD/CARKD family.UniRule annotation

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG3974 Eukaryota
COG0063 LUCA
InParanoidiD4AAT7
PhylomeDBiD4AAT7
TreeFamiTF300116

Family and domain databases

CDDicd01171 YXKO-related, 1 hit
Gene3Di3.40.1190.20, 1 hit
HAMAPiMF_01965 NADHX_dehydratase, 1 hit
InterProiView protein in InterPro
IPR000631 CARKD
IPR029056 Ribokinase-like
PfamiView protein in Pfam
PF01256 Carb_kinase, 1 hit
SUPFAMiSSF53613 SSF53613, 1 hit
TIGRFAMsiTIGR00196 yjeF_cterm, 1 hit
PROSITEiView protein in PROSITE
PS51383 YJEF_C_3, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

D4AAT7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVCPYGAAA VVMALLSAAI AFHCSPLLAV LQRALSLHTA HATKDMDNLF
60 70 80 90 100
QLVRNIVPAL TSKKHKGQDG RIGIVGGCQE YTGAPYFAGI SALKVGADLT
110 120 130 140 150
HVFCAREAAP VIKSYSPELI VHPVLDSSDA VEEVEKWLPR LHALVVGPGL
160 170 180 190 200
GRDDLLLNNV RGILESTKAR DIPVVIDADG LWLIAQRPAL VHGYQKAVLT
210 220 230 240 250
PNHVEFSRLW DAVLSSPMDT SNHSGSVLKL SQALGNITIV QKGEQDLISN
260 270 280 290 300
GQQVLVCNQE GSSRRCGGQG DLLSGSLGVM AHWALRAGPE KTNGSSPLLV
310 320 330 340
AAWGACTLTR ECNHLAFQKY GRSTTTTDMI AEVGAAFSKL FTT
Length:343
Mass (Da):36,518
Last modified:April 20, 2010 - v1
Checksum:i7977C328ACACA40D
GO

Sequence databases

UniGeneiRn.24864

Genome annotation databases

UCSCiRGD:1562691 rat

Similar proteinsi

Entry informationi

Entry nameiNNRD_RAT
AccessioniPrimary (citable) accession number: D4AAT7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 21, 2012
Last sequence update: April 20, 2010
Last modified: May 23, 2018
This is version 46 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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