D4AA88 (D4AA88_RAT) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Protein Tp73 Ensembl ENSRNOP00000052265

Submitted name:
Transformation related protein 73 (Predicted) EMBL EDL81259.1

Gene names

Name:	Tp73 RGD 1307083 Ensembl ENSRNOP00000052265
Synonyms:	Trp73_predicted EMBL EDL81259.1
ORF Names:	rCG_31420 EMBL EDL81259.1

Organism

Rattus norvegicus (Rat) [Reference proteome] Ensembl ENSRNOP00000052265

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	684 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Sequence similarities

Belongs to the p53 family. RuleBase RU003401

Ontologies

Keywords
Biological process	Transcription Transcription regulation SAAS SAAS012346
Cellular component	Nucleus SAAS SAAS012346 RuleBase RU003401
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator Inferred from Biological aspect of Ancestor. Source: RefGenome activation of MAPK activity Inferred from mutant phenotype PubMed 17353261. Source: RGD cell cycle arrest Inferred from electronic annotation. Source: Compara cellular response to UV Inferred from Biological aspect of Ancestor. Source: RefGenome cerebrospinal fluid secretion Inferred from electronic annotation. Source: Compara digestive tract morphogenesis Inferred from electronic annotation. Source: Compara hippocampus development Inferred from electronic annotation. Source: Compara inflammatory response Inferred from electronic annotation. Source: Compara intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator Inferred from Biological aspect of Ancestor. Source: RefGenome kidney development Inferred from expression pattern PubMed 15805112. Source: RGD mitotic G1 DNA damage checkpoint Inferred from Biological aspect of Ancestor. Source: RefGenome negative regulation of JUN kinase activity Inferred from Biological aspect of Ancestor. Source: RefGenome negative regulation of neuron apoptotic process Inferred from Biological aspect of Ancestor. Source: RefGenome negative regulation of neuron differentiation Inferred from mutant phenotype PubMed 17353261. Source: RGD negative regulation of transcription from RNA polymerase II promoter Inferred from Biological aspect of Ancestor. Source: RefGenome neuron development Inferred from electronic annotation. Source: Compara positive regulation of apoptotic process Inferred from mutant phenotype PubMed 15716325. Source: RGD positive regulation of cell size Inferred from electronic annotation. Source: Compara positive regulation of oligodendrocyte differentiation Inferred from mutant phenotype PubMed 14960496. Source: RGD positive regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: Compara post-embryonic development Inferred from electronic annotation. Source: Compara protein tetramerization Inferred from electronic annotation. Source: InterPro release of cytochrome c from mitochondria Inferred from electronic annotation. Source: Compara response to X-ray Inferred from Biological aspect of Ancestor. Source: RefGenome response to gamma radiation Inferred from Biological aspect of Ancestor. Source: RefGenome response to organic nitrogen Inferred from expression pattern PubMed 14587038. Source: RGD transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	chromatin Inferred from direct assay PubMed 15805112. Source: RGD cytosol Inferred from Biological aspect of Ancestor. Source: RefGenome transcription factor complex Inferred from Biological aspect of Ancestor. Source: RefGenome
Molecular_function	chromatin binding Inferred from Biological aspect of Ancestor. Source: RefGenome damaged DNA binding Inferred from Biological aspect of Ancestor. Source: RefGenome double-stranded DNA binding Inferred from Biological aspect of Ancestor. Source: RefGenome p53 binding Inferred from Biological aspect of Ancestor. Source: RefGenome sequence-specific DNA binding Inferred from direct assay PubMed 15805112. Source: RGD sequence-specific DNA binding transcription factor activity Inferred from Biological aspect of Ancestor. Source: RefGenome transcription regulatory region DNA binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	D4AA88 [UniParc]. Last modified April 20, 2010. Version 1. Checksum: 5DD54931B07B269B	FASTA	684	74,579
	10 20 30 40 50 60 MSSPRQLDAY ATALPLQATG PPAPLPKSTD PSRAQVQPRM SNGVGEMAQS SSSSSSSSTF 70 80 90 100 110 120 EHLWSSLEPD STYFDLPQPS QGNSEATGSE ESNMDVFHLQ GMTSSVMAQF NLLSSAMDQM 130 140 150 160 170 180 GSRAAPASPY TPEHAASAPT HSPYAQPSST FDTMSPAPVI PSNTDYPGPH HFEVTFQQSS 190 200 210 220 230 240 TAKSATWTYS PLLKKLYCQI AKTCPIQIKV STPPPPGTAI RAMPVYKKAE HVTDIVKRCP 250 260 270 280 290 300 NHELGRDFNE GQSAPASHLI RVEGNNLSQY VDDPVTGRQS VVVPYEPPQV GTEFTTILYN 310 320 330 340 350 360 FMCNSSCVGG MNRRPILVII TLETRDGQVL GRRSFEGRIC ACPGRDRKAD EDHYREQQAL 370 380 390 400 410 420 NESTTKNGAA SKRAFKQSPP AIPALGTNVK KRRHGDEDMF YMHVRGRENF EILMKVKESL 430 440 450 460 470 480 ELMELVPQPL VDSYRQQQQQ QLLQRPSHLQ PPSYGPVLSP MNKVHGGVNK LPSVNQLVGQ 490 500 510 520 530 540 PPPHSSAAGP NLGSMGSGIL NSHSHSMPAN GEMNGGHSSQ TMVSGSHCTP PPPYHADPSL 550 560 570 580 590 600 VSFLTGLGCP NCIECFTSQG LQSIYHLQNL TIEDLGALKI PDQYRMTIWR GLQDLKQSHD 610 620 630 640 650 660 CGQQLLRSSS NAATISIGGS GELQRQRVME AVHFRVRHTI TIPNRGGAGG VTGPDEWADF 670 680 GFDLPDCKSR KQPIKEEFTE TESH

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Genome sequence of the Brown Norway rat yields insights into mammalian evolution." Rat Genome Sequencing Project Consortium Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M. , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S. Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Brown Norway Ensembl ENSRNOP00000052265.
[2]	"Gene and alternative splicing annotation with AIR." Florea L., Di Francesco V., Miller J., Turner R., Yao A., Harris M., Walenz B., Mobarry C., Merkulov G.V., Charlab R., Dew I., Deng Z., Istrail S., Li P., Sutton G. Genome Res. 15:54-66(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: BN EMBL EDL81259.1.
[3]	Mural R.J., Li P.W., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S.H., Dew I., Evans C.A., Ferriera S., Flanigan M., Fosler C., Glodek A., Gu Z., Holt R.A., Jennings D., Kraft C.L., Lu F. , Nguyen T., Nusskern D.R., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Wang Z., Woodage T., Zheng X.H., Zhong F. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: BN EMBL EDL81259.1.
[4]	Ensembl Submitted (JUL-2011) to UniProtKB Cited for: IDENTIFICATION. Strain: Brown Norway Ensembl ENSRNOP00000052265.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AABR06041235 Genomic DNA. No translation available. AABR06041236 Genomic DNA. No translation available. AABR06041237 Genomic DNA. No translation available. AABR06041238 Genomic DNA. No translation available. AABR06041239 Genomic DNA. No translation available. AABR06041240 Genomic DNA. No translation available. CH473968 Genomic DNA. Translation: EDL81259.1.
IPI	IPI00869594.
RefSeq	NP_001102166.1. NM_001108696.1.
UniGene	Rn.103860.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000055398; ENSRNOP00000052265; ENSRNOG00000024707.
GeneID	362675.
KEGG	rno:362675.
UCSC	RGD:1307083. rat.
Organism-specific databases
CTD	7161.
RGD	1307083. Tp73.
Phylogenomic databases
GeneTree	ENSGT00390000015092.
KO	K10148.
OrthoDB	EOG4P5K8S.
Family and domain databases
Gene3D	1.10.150.50. 1 hit. 2.60.40.720. 1 hit. 4.10.170.10. 1 hit.
InterPro	IPR008967. p53-like_TF_DNA-bd. IPR012346. p53/RUNT-type_TF_DNA-bd. IPR011615. p53_DNA-bd. IPR010991. p53_tetrameristn. IPR002117. p53_tumour_suppressor. IPR001660. SAM. IPR013761. SAM/pointed. IPR011510. SAM_2. [Graphical view]
PANTHER	PTHR11447. PTHR11447. 1 hit.
Pfam	PF00870. P53. 1 hit. PF07710. P53_tetramer. 1 hit. PF07647. SAM_2. 1 hit. [Graphical view]
PRINTS	PR00386. P53SUPPRESSR.
SMART	SM00454. SAM. 1 hit. [Graphical view]
SUPFAM	SSF49417. P53_like_DNA_bnd. 1 hit. SSF47719. p53_tetrameristn. 1 hit. SSF47769. SAM_homology. 1 hit.
PROSITE	PS00348. P53. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	680833.

Entry information

Entry name

D4AA88_RAT

Accession

Primary (citable) accession number: D4AA88

Entry history

Integrated into UniProtKB/TrEMBL:	April 20, 2010
Last sequence update:	April 20, 2010
Last modified:	May 1, 2013
This is version 33 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)