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D4AA88

- D4AA88_RAT

UniProt

D4AA88 - D4AA88_RAT

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Protein
Submitted name:

Protein Tp73

Gene

Tp73

Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 5 out of 5- Protein inferred from homologyi

Functioni

GO - Molecular functioni

  1. chromatin binding Source: RefGenome
  2. damaged DNA binding Source: RefGenome
  3. double-stranded DNA binding Source: RefGenome
  4. p53 binding Source: RefGenome
  5. sequence-specific DNA binding Source: RGD
  6. sequence-specific DNA binding transcription factor activity Source: RefGenome
  7. transcription regulatory region DNA binding Source: Ensembl

GO - Biological processi

  1. activation of MAPK activity Source: RGD
  2. cell cycle arrest Source: Ensembl
  3. cellular response to UV Source: RefGenome
  4. cerebrospinal fluid secretion Source: Ensembl
  5. digestive tract morphogenesis Source: Ensembl
  6. DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator Source: RefGenome
  7. hippocampus development Source: Ensembl
  8. inflammatory response Source: Ensembl
  9. intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator Source: RefGenome
  10. kidney development Source: RGD
  11. mitotic G1 DNA damage checkpoint Source: RefGenome
  12. negative regulation of JUN kinase activity Source: RefGenome
  13. negative regulation of neuron apoptotic process Source: RefGenome
  14. negative regulation of neuron differentiation Source: RGD
  15. negative regulation of transcription from RNA polymerase II promoter Source: RefGenome
  16. neuron development Source: Ensembl
  17. positive regulation of apoptotic process Source: RGD
  18. positive regulation of cell size Source: Ensembl
  19. positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator Source: Ensembl
  20. positive regulation of oligodendrocyte differentiation Source: RGD
  21. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  22. post-embryonic development Source: Ensembl
  23. protein tetramerization Source: InterPro
  24. release of cytochrome c from mitochondria Source: Ensembl
  25. response to drug Source: RGD
  26. response to gamma radiation Source: RefGenome
  27. response to organonitrogen compound Source: RGD
  28. response to X-ray Source: RefGenome
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Protein Tp73Imported
Submitted name:
Transformation related protein 73 (Predicted)Imported
Gene namesi
Name:Tp73Imported
Synonyms:Trp73_predictedImported
ORF Names:rCG_31420Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 5

Organism-specific databases

RGDi1307083. Tp73.

Subcellular locationi

GO - Cellular componenti

  1. chromatin Source: RGD
  2. cytoplasm Source: RGD
  3. cytosol Source: RefGenome
  4. nucleus Source: RGD
  5. transcription factor complex Source: RefGenome
Complete GO annotation...

Keywords - Cellular componenti

NucleusUniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the p53 family.UniRule annotation

Phylogenomic databases

GeneTreeiENSGT00390000015092.
KOiK10148.
OMAiNEGQSAP.
OrthoDBiEOG7JQBNW.
TreeFamiTF106101.

Family and domain databases

Gene3Di1.10.150.50. 1 hit.
2.60.40.720. 1 hit.
4.10.170.10. 1 hit.
InterProiIPR008967. p53-like_TF_DNA-bd.
IPR012346. p53/RUNT-type_TF_DNA-bd.
IPR011615. p53_DNA-bd.
IPR010991. p53_tetrameristn.
IPR002117. p53_tumour_suppressor.
IPR001660. SAM.
IPR013761. SAM/pointed.
IPR011510. SAM_2.
[Graphical view]
PANTHERiPTHR11447. PTHR11447. 1 hit.
PfamiPF00870. P53. 1 hit.
PF07710. P53_tetramer. 1 hit.
PF07647. SAM_2. 1 hit.
[Graphical view]
PRINTSiPR00386. P53SUPPRESSR.
SMARTiSM00454. SAM. 1 hit.
[Graphical view]
SUPFAMiSSF47719. SSF47719. 1 hit.
SSF47769. SSF47769. 1 hit.
SSF49417. SSF49417. 1 hit.
PROSITEiPS00348. P53. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D4AA88-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSSPRQLDAY ATALPLQATG PPAPLPKSTD PSRAQVQPRM SNGVGEMAQS
60 70 80 90 100
SSSSSSSSTF EHLWSSLEPD STYFDLPQPS QGNSEATGSE ESNMDVFHLQ
110 120 130 140 150
GMTSSVMAQF NLLSSAMDQM GSRAAPASPY TPEHAASAPT HSPYAQPSST
160 170 180 190 200
FDTMSPAPVI PSNTDYPGPH HFEVTFQQSS TAKSATWTYS PLLKKLYCQI
210 220 230 240 250
AKTCPIQIKV STPPPPGTAI RAMPVYKKAE HVTDIVKRCP NHELGRDFNE
260 270 280 290 300
GQSAPASHLI RVEGNNLSQY VDDPVTGRQS VVVPYEPPQV GTEFTTILYN
310 320 330 340 350
FMCNSSCVGG MNRRPILVII TLETRDGQVL GRRSFEGRIC ACPGRDRKAD
360 370 380 390 400
EDHYREQQAL NESTTKNGAA SKRAFKQSPP AIPALGTNVK KRRHGDEDMF
410 420 430 440 450
YMHVRGRENF EILMKVKESL ELMELVPQPL VDSYRQQQQQ QLLQRPSHLQ
460 470 480 490 500
PPSYGPVLSP MNKVHGGVNK LPSVNQLVGQ PPPHSSAAGP NLGSMGSGIL
510 520 530 540 550
NSHSHSMPAN GEMNGGHSSQ TMVSGSHCTP PPPYHADPSL VSFLTGLGCP
560 570 580 590 600
NCIECFTSQG LQSIYHLQNL TIEDLGALKI PDQYRMTIWR GLQDLKQSHD
610 620 630 640 650
CGQQLLRSSS NAATISIGGS GELQRQRVME AVHFRVRHTI TIPNRGGAGG
660 670 680
VTGPDEWADF GFDLPDCKSR KQPIKEEFTE TESH
Length:684
Mass (Da):74,579
Last modified:April 20, 2010 - v1
Checksum:i5DD54931B07B269B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AABR06041235 Genomic DNA. No translation available.
AABR06041236 Genomic DNA. No translation available.
AABR06041237 Genomic DNA. No translation available.
AABR06041238 Genomic DNA. No translation available.
AABR06041239 Genomic DNA. No translation available.
AABR06041240 Genomic DNA. No translation available.
CH473968 Genomic DNA. Translation: EDL81259.1.
RefSeqiNP_001102166.1. NM_001108696.1.
UniGeneiRn.103860.

Genome annotation databases

EnsembliENSRNOT00000055398; ENSRNOP00000052265; ENSRNOG00000024707.
GeneIDi362675.
KEGGirno:362675.
UCSCiRGD:1307083. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AABR06041235 Genomic DNA. No translation available.
AABR06041236 Genomic DNA. No translation available.
AABR06041237 Genomic DNA. No translation available.
AABR06041238 Genomic DNA. No translation available.
AABR06041239 Genomic DNA. No translation available.
AABR06041240 Genomic DNA. No translation available.
CH473968 Genomic DNA. Translation: EDL81259.1 .
RefSeqi NP_001102166.1. NM_001108696.1.
UniGenei Rn.103860.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000055398 ; ENSRNOP00000052265 ; ENSRNOG00000024707 .
GeneIDi 362675.
KEGGi rno:362675.
UCSCi RGD:1307083. rat.

Organism-specific databases

CTDi 7161.
RGDi 1307083. Tp73.

Phylogenomic databases

GeneTreei ENSGT00390000015092.
KOi K10148.
OMAi NEGQSAP.
OrthoDBi EOG7JQBNW.
TreeFami TF106101.

Miscellaneous databases

NextBioi 680833.

Family and domain databases

Gene3Di 1.10.150.50. 1 hit.
2.60.40.720. 1 hit.
4.10.170.10. 1 hit.
InterProi IPR008967. p53-like_TF_DNA-bd.
IPR012346. p53/RUNT-type_TF_DNA-bd.
IPR011615. p53_DNA-bd.
IPR010991. p53_tetrameristn.
IPR002117. p53_tumour_suppressor.
IPR001660. SAM.
IPR013761. SAM/pointed.
IPR011510. SAM_2.
[Graphical view ]
PANTHERi PTHR11447. PTHR11447. 1 hit.
Pfami PF00870. P53. 1 hit.
PF07710. P53_tetramer. 1 hit.
PF07647. SAM_2. 1 hit.
[Graphical view ]
PRINTSi PR00386. P53SUPPRESSR.
SMARTi SM00454. SAM. 1 hit.
[Graphical view ]
SUPFAMi SSF47719. SSF47719. 1 hit.
SSF47769. SSF47769. 1 hit.
SSF49417. SSF49417. 1 hit.
PROSITEi PS00348. P53. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Rat Genome Sequencing Project Consortium
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown NorwayImported.
  2. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BNImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BNImported.
  4. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: Brown NorwayImported.

Entry informationi

Entry nameiD4AA88_RAT
AccessioniPrimary (citable) accession number: D4AA88
Entry historyi
Integrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: October 29, 2014
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3