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D4AA88

- D4AA88_RAT

UniProt

D4AA88 - D4AA88_RAT

Protein
Submitted name:

Protein Tp73

Gene

Tp73

Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 5 out of 5- Protein inferred from homologyi
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    • History
      Entry version 41 (01 Oct 2014)
      Sequence version 1 (20 Apr 2010)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. chromatin binding Source: RefGenome
    2. damaged DNA binding Source: RefGenome
    3. double-stranded DNA binding Source: RefGenome
    4. p53 binding Source: RefGenome
    5. sequence-specific DNA binding Source: RGD
    6. sequence-specific DNA binding transcription factor activity Source: RefGenome
    7. transcription regulatory region DNA binding Source: Ensembl

    GO - Biological processi

    1. activation of MAPK activity Source: RGD
    2. cell cycle arrest Source: Ensembl
    3. cellular response to UV Source: RefGenome
    4. cerebrospinal fluid secretion Source: Ensembl
    5. digestive tract morphogenesis Source: Ensembl
    6. DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator Source: RefGenome
    7. hippocampus development Source: Ensembl
    8. inflammatory response Source: Ensembl
    9. intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator Source: RefGenome
    10. kidney development Source: RGD
    11. mitotic G1 DNA damage checkpoint Source: RefGenome
    12. negative regulation of JUN kinase activity Source: RefGenome
    13. negative regulation of neuron apoptotic process Source: RefGenome
    14. negative regulation of neuron differentiation Source: RGD
    15. negative regulation of transcription from RNA polymerase II promoter Source: RefGenome
    16. neuron development Source: Ensembl
    17. positive regulation of apoptotic process Source: RGD
    18. positive regulation of cell size Source: Ensembl
    19. positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator Source: Ensembl
    20. positive regulation of oligodendrocyte differentiation Source: RGD
    21. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
    22. post-embryonic development Source: Ensembl
    23. protein tetramerization Source: InterPro
    24. release of cytochrome c from mitochondria Source: Ensembl
    25. response to gamma radiation Source: RefGenome
    26. response to organonitrogen compound Source: RGD
    27. response to X-ray Source: RefGenome

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Protein Tp73Imported
    Submitted name:
    Transformation related protein 73 (Predicted)Imported
    Gene namesi
    Name:Tp73Imported
    Synonyms:Trp73_predictedImported
    ORF Names:rCG_31420Imported
    OrganismiRattus norvegicus (Rat)Imported
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 5

    Organism-specific databases

    RGDi1307083. Tp73.

    Subcellular locationi

    GO - Cellular componenti

    1. chromatin Source: RGD
    2. cytosol Source: RefGenome
    3. nucleus Source: RGD
    4. transcription factor complex Source: RefGenome

    Keywords - Cellular componenti

    NucleusUniRule annotation

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the p53 family.UniRule annotation

    Phylogenomic databases

    GeneTreeiENSGT00390000015092.
    KOiK10148.
    OMAiNEGQSAP.
    OrthoDBiEOG7JQBNW.
    TreeFamiTF106101.

    Family and domain databases

    Gene3Di1.10.150.50. 1 hit.
    2.60.40.720. 1 hit.
    4.10.170.10. 1 hit.
    InterProiIPR008967. p53-like_TF_DNA-bd.
    IPR012346. p53/RUNT-type_TF_DNA-bd.
    IPR011615. p53_DNA-bd.
    IPR010991. p53_tetrameristn.
    IPR002117. p53_tumour_suppressor.
    IPR001660. SAM.
    IPR013761. SAM/pointed.
    IPR011510. SAM_2.
    [Graphical view]
    PANTHERiPTHR11447. PTHR11447. 1 hit.
    PfamiPF00870. P53. 1 hit.
    PF07710. P53_tetramer. 1 hit.
    PF07647. SAM_2. 1 hit.
    [Graphical view]
    PRINTSiPR00386. P53SUPPRESSR.
    SMARTiSM00454. SAM. 1 hit.
    [Graphical view]
    SUPFAMiSSF47719. SSF47719. 1 hit.
    SSF47769. SSF47769. 1 hit.
    SSF49417. SSF49417. 1 hit.
    PROSITEiPS00348. P53. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    D4AA88-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSSPRQLDAY ATALPLQATG PPAPLPKSTD PSRAQVQPRM SNGVGEMAQS    50
    SSSSSSSSTF EHLWSSLEPD STYFDLPQPS QGNSEATGSE ESNMDVFHLQ 100
    GMTSSVMAQF NLLSSAMDQM GSRAAPASPY TPEHAASAPT HSPYAQPSST 150
    FDTMSPAPVI PSNTDYPGPH HFEVTFQQSS TAKSATWTYS PLLKKLYCQI 200
    AKTCPIQIKV STPPPPGTAI RAMPVYKKAE HVTDIVKRCP NHELGRDFNE 250
    GQSAPASHLI RVEGNNLSQY VDDPVTGRQS VVVPYEPPQV GTEFTTILYN 300
    FMCNSSCVGG MNRRPILVII TLETRDGQVL GRRSFEGRIC ACPGRDRKAD 350
    EDHYREQQAL NESTTKNGAA SKRAFKQSPP AIPALGTNVK KRRHGDEDMF 400
    YMHVRGRENF EILMKVKESL ELMELVPQPL VDSYRQQQQQ QLLQRPSHLQ 450
    PPSYGPVLSP MNKVHGGVNK LPSVNQLVGQ PPPHSSAAGP NLGSMGSGIL 500
    NSHSHSMPAN GEMNGGHSSQ TMVSGSHCTP PPPYHADPSL VSFLTGLGCP 550
    NCIECFTSQG LQSIYHLQNL TIEDLGALKI PDQYRMTIWR GLQDLKQSHD 600
    CGQQLLRSSS NAATISIGGS GELQRQRVME AVHFRVRHTI TIPNRGGAGG 650
    VTGPDEWADF GFDLPDCKSR KQPIKEEFTE TESH 684
    Length:684
    Mass (Da):74,579
    Last modified:April 20, 2010 - v1
    Checksum:i5DD54931B07B269B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR06041235 Genomic DNA. No translation available.
    AABR06041236 Genomic DNA. No translation available.
    AABR06041237 Genomic DNA. No translation available.
    AABR06041238 Genomic DNA. No translation available.
    AABR06041239 Genomic DNA. No translation available.
    AABR06041240 Genomic DNA. No translation available.
    CH473968 Genomic DNA. Translation: EDL81259.1.
    RefSeqiNP_001102166.1. NM_001108696.1.
    UniGeneiRn.103860.

    Genome annotation databases

    EnsembliENSRNOT00000055398; ENSRNOP00000052265; ENSRNOG00000024707.
    GeneIDi362675.
    KEGGirno:362675.
    UCSCiRGD:1307083. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR06041235 Genomic DNA. No translation available.
    AABR06041236 Genomic DNA. No translation available.
    AABR06041237 Genomic DNA. No translation available.
    AABR06041238 Genomic DNA. No translation available.
    AABR06041239 Genomic DNA. No translation available.
    AABR06041240 Genomic DNA. No translation available.
    CH473968 Genomic DNA. Translation: EDL81259.1 .
    RefSeqi NP_001102166.1. NM_001108696.1.
    UniGenei Rn.103860.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000055398 ; ENSRNOP00000052265 ; ENSRNOG00000024707 .
    GeneIDi 362675.
    KEGGi rno:362675.
    UCSCi RGD:1307083. rat.

    Organism-specific databases

    CTDi 7161.
    RGDi 1307083. Tp73.

    Phylogenomic databases

    GeneTreei ENSGT00390000015092.
    KOi K10148.
    OMAi NEGQSAP.
    OrthoDBi EOG7JQBNW.
    TreeFami TF106101.

    Miscellaneous databases

    NextBioi 680833.

    Family and domain databases

    Gene3Di 1.10.150.50. 1 hit.
    2.60.40.720. 1 hit.
    4.10.170.10. 1 hit.
    InterProi IPR008967. p53-like_TF_DNA-bd.
    IPR012346. p53/RUNT-type_TF_DNA-bd.
    IPR011615. p53_DNA-bd.
    IPR010991. p53_tetrameristn.
    IPR002117. p53_tumour_suppressor.
    IPR001660. SAM.
    IPR013761. SAM/pointed.
    IPR011510. SAM_2.
    [Graphical view ]
    PANTHERi PTHR11447. PTHR11447. 1 hit.
    Pfami PF00870. P53. 1 hit.
    PF07710. P53_tetramer. 1 hit.
    PF07647. SAM_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00386. P53SUPPRESSR.
    SMARTi SM00454. SAM. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47719. SSF47719. 1 hit.
    SSF47769. SSF47769. 1 hit.
    SSF49417. SSF49417. 1 hit.
    PROSITEi PS00348. P53. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
      Rat Genome Sequencing Project Consortium
      Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
      , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
      Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Brown NorwayImported.
    2. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: BNImported.
    3. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: BNImported.
    4. Ensembl
      Submitted (JUL-2011) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: Brown NorwayImported.

    Entry informationi

    Entry nameiD4AA88_RAT
    AccessioniPrimary (citable) accession number: D4AA88
    Entry historyi
    Integrated into UniProtKB/TrEMBL: April 20, 2010
    Last sequence update: April 20, 2010
    Last modified: October 1, 2014
    This is version 41 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3