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Protein
Submitted name:

Transformation related protein 73 (Predicted)

Gene

Tp73

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-RNO-6804759 Regulation of TP53 Activity through Association with Co-factors
R-RNO-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs

Names & Taxonomyi

Protein namesi
Submitted name:
Transformation related protein 73 (Predicted)Imported
Submitted name:
Tumor protein p73Imported
Gene namesi
Name:Tp73Imported
Synonyms:Trp73_predictedImported
ORF Names:rCG_31420Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 5

Organism-specific databases

RGDi1307083 Tp73

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusUniRule annotation

Expressioni

Gene expression databases

BgeeiENSRNOG00000024707

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000052265

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini532 – 598SAMInterPro annotationAdd BLAST67

Sequence similaritiesi

Belongs to the p53 family.UniRule annotation

Phylogenomic databases

eggNOGiENOG410IGE4 Eukaryota
ENOG410XV9W LUCA
GeneTreeiENSGT00390000015092
KOiK10148
OMAiCIEYFTS
OrthoDBiEOG091G0XY5
TreeFamiTF106101

Family and domain databases

CDDicd08367 P53, 1 hit
cd09571 SAM_tumor-p73, 1 hit
Gene3Di2.60.40.720, 1 hit
4.10.170.10, 1 hit
InterProiView protein in InterPro
IPR008967 p53-like_TF_DNA-bd
IPR012346 p53/RUNT-type_TF_DNA-bd_sf
IPR011615 p53_DNA-bd
IPR036674 p53_tetramer_sf
IPR010991 p53_tetrameristn
IPR002117 p53_tumour_suppressor
IPR001660 SAM
IPR013761 SAM/pointed_sf
IPR032646 Tp73
IPR037612 Tumour-p73_SAM
PANTHERiPTHR11447 PTHR11447, 1 hit
PTHR11447:SF21 PTHR11447:SF21, 1 hit
PfamiView protein in Pfam
PF00870 P53, 1 hit
PF07710 P53_tetramer, 1 hit
PF07647 SAM_2, 1 hit
PRINTSiPR00386 P53SUPPRESSR
SMARTiView protein in SMART
SM00454 SAM, 1 hit
SUPFAMiSSF47719 SSF47719, 1 hit
SSF47769 SSF47769, 1 hit
SSF49417 SSF49417, 1 hit
PROSITEiView protein in PROSITE
PS00348 P53, 1 hit

Sequencei

Sequence statusi: Complete.

D4AA88-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSPRQLDAY ATALPLQATG PPAPLPKSTD PSRAQVQPRM SNGVGEMAQS
60 70 80 90 100
SSSSSSSSTF EHLWSSLEPD STYFDLPQPS QGNSEATGSE ESNMDVFHLQ
110 120 130 140 150
GMTSSVMAQF NLLSSAMDQM GSRAAPASPY TPEHAASAPT HSPYAQPSST
160 170 180 190 200
FDTMSPAPVI PSNTDYPGPH HFEVTFQQSS TAKSATWTYS PLLKKLYCQI
210 220 230 240 250
AKTCPIQIKV STPPPPGTAI RAMPVYKKAE HVTDIVKRCP NHELGRDFNE
260 270 280 290 300
GQSAPASHLI RVEGNNLSQY VDDPVTGRQS VVVPYEPPQV GTEFTTILYN
310 320 330 340 350
FMCNSSCVGG MNRRPILVII TLETRDGQVL GRRSFEGRIC ACPGRDRKAD
360 370 380 390 400
EDHYREQQAL NESTTKNGAA SKRAFKQSPP AIPALGTNVK KRRHGDEDMF
410 420 430 440 450
YMHVRGRENF EILMKVKESL ELMELVPQPL VDSYRQQQQQ QLLQRPSHLQ
460 470 480 490 500
PPSYGPVLSP MNKVHGGVNK LPSVNQLVGQ PPPHSSAAGP NLGSMGSGIL
510 520 530 540 550
NSHSHSMPAN GEMNGGHSSQ TMVSGSHCTP PPPYHADPSL VSFLTGLGCP
560 570 580 590 600
NCIECFTSQG LQSIYHLQNL TIEDLGALKI PDQYRMTIWR GLQDLKQSHD
610 620 630 640 650
CGQQLLRSSS NAATISIGGS GELQRQRVME AVHFRVRHTI TIPNRGGAGG
660 670 680
VTGPDEWADF GFDLPDCKSR KQPIKEEFTE TESH
Length:684
Mass (Da):74,579
Last modified:April 20, 2010 - v1
Checksum:i5DD54931B07B269B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07050620 Genomic DNA No translation available.
CH473968 Genomic DNA Translation: EDL81259.1
RefSeqiNP_001102166.1, NM_001108696.1
UniGeneiRn.103860

Genome annotation databases

EnsembliENSRNOT00000055398; ENSRNOP00000052265; ENSRNOG00000024707
GeneIDi362675
KEGGirno:362675
UCSCiRGD:1307083 rat

Similar proteinsi

Entry informationi

Entry nameiD4AA88_RAT
AccessioniPrimary (citable) accession number: D4AA88
Entry historyiIntegrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: May 23, 2018
This is version 72 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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