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Protein
Submitted name:

Transformation related protein 73 (Predicted)

Gene

Tp73

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-RNO-6804759. Regulation of TP53 Activity through Association with Co-factors.
R-RNO-8939236. RUNX1 regulates transcription of genes involved in differentiation of HSCs.

Names & Taxonomyi

Protein namesi
Submitted name:
Transformation related protein 73 (Predicted)Imported
Submitted name:
Tumor protein p73Imported
Gene namesi
Name:Tp73Imported
Synonyms:Trp73_predictedImported
ORF Names:rCG_31420Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 5

Organism-specific databases

RGDi1307083. Tp73.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusUniRule annotation

Expressioni

Gene expression databases

BgeeiENSRNOG00000024707.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000052265.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini532 – 598SAMInterPro annotationAdd BLAST67

Sequence similaritiesi

Belongs to the p53 family.UniRule annotation

Phylogenomic databases

eggNOGiENOG410IGE4. Eukaryota.
ENOG410XV9W. LUCA.
GeneTreeiENSGT00390000015092.
KOiK10148.
OMAiCIEYFTS.
OrthoDBiEOG091G0XY5.
TreeFamiTF106101.

Family and domain databases

CDDicd08367. P53. 1 hit.
Gene3Di2.60.40.720. 1 hit.
4.10.170.10. 1 hit.
InterProiView protein in InterPro
IPR008967. p53-like_TF_DNA-bd.
IPR012346. p53/RUNT-type_TF_DNA-bd_sf.
IPR011615. p53_DNA-bd.
IPR036674. p53_tetramer_sf.
IPR010991. p53_tetrameristn.
IPR002117. p53_tumour_suppressor.
IPR001660. SAM.
IPR013761. SAM/pointed_sf.
IPR032646. Tp73.
PANTHERiPTHR11447. PTHR11447. 1 hit.
PTHR11447:SF21. PTHR11447:SF21. 1 hit.
PfamiView protein in Pfam
PF00870. P53. 1 hit.
PF07710. P53_tetramer. 1 hit.
PF07647. SAM_2. 1 hit.
PRINTSiPR00386. P53SUPPRESSR.
SMARTiView protein in SMART
SM00454. SAM. 1 hit.
SUPFAMiSSF47719. SSF47719. 1 hit.
SSF47769. SSF47769. 1 hit.
SSF49417. SSF49417. 1 hit.
PROSITEiView protein in PROSITE
PS00348. P53. 1 hit.

Sequencei

Sequence statusi: Complete.

D4AA88-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSPRQLDAY ATALPLQATG PPAPLPKSTD PSRAQVQPRM SNGVGEMAQS
60 70 80 90 100
SSSSSSSSTF EHLWSSLEPD STYFDLPQPS QGNSEATGSE ESNMDVFHLQ
110 120 130 140 150
GMTSSVMAQF NLLSSAMDQM GSRAAPASPY TPEHAASAPT HSPYAQPSST
160 170 180 190 200
FDTMSPAPVI PSNTDYPGPH HFEVTFQQSS TAKSATWTYS PLLKKLYCQI
210 220 230 240 250
AKTCPIQIKV STPPPPGTAI RAMPVYKKAE HVTDIVKRCP NHELGRDFNE
260 270 280 290 300
GQSAPASHLI RVEGNNLSQY VDDPVTGRQS VVVPYEPPQV GTEFTTILYN
310 320 330 340 350
FMCNSSCVGG MNRRPILVII TLETRDGQVL GRRSFEGRIC ACPGRDRKAD
360 370 380 390 400
EDHYREQQAL NESTTKNGAA SKRAFKQSPP AIPALGTNVK KRRHGDEDMF
410 420 430 440 450
YMHVRGRENF EILMKVKESL ELMELVPQPL VDSYRQQQQQ QLLQRPSHLQ
460 470 480 490 500
PPSYGPVLSP MNKVHGGVNK LPSVNQLVGQ PPPHSSAAGP NLGSMGSGIL
510 520 530 540 550
NSHSHSMPAN GEMNGGHSSQ TMVSGSHCTP PPPYHADPSL VSFLTGLGCP
560 570 580 590 600
NCIECFTSQG LQSIYHLQNL TIEDLGALKI PDQYRMTIWR GLQDLKQSHD
610 620 630 640 650
CGQQLLRSSS NAATISIGGS GELQRQRVME AVHFRVRHTI TIPNRGGAGG
660 670 680
VTGPDEWADF GFDLPDCKSR KQPIKEEFTE TESH
Length:684
Mass (Da):74,579
Last modified:April 20, 2010 - v1
Checksum:i5DD54931B07B269B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07050620 Genomic DNA. No translation available.
CH473968 Genomic DNA. Translation: EDL81259.1.
RefSeqiNP_001102166.1. NM_001108696.1.
UniGeneiRn.103860.

Genome annotation databases

EnsembliENSRNOT00000055398; ENSRNOP00000052265; ENSRNOG00000024707.
GeneIDi362675.
KEGGirno:362675.
UCSCiRGD:1307083. rat.

Similar proteinsi

Entry informationi

Entry nameiD4AA88_RAT
AccessioniPrimary (citable) accession number: D4AA88
Entry historyiIntegrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: November 22, 2017
This is version 68 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported