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D4AA88 (D4AA88_RAT) Unreviewed, UniProtKB/TrEMBL

Last modified July 9, 2014. Version 39. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein names

Transformation related protein 73 (Predicted) EMBL EDL81259.1
Gene names
Name:Tp73 RGD 1307083 Ensembl ENSRNOP00000052265
Synonyms:Trp73_predicted EMBL EDL81259.1
ORF Names:rCG_31420 EMBL EDL81259.1
OrganismRattus norvegicus (Rat) [Reference proteome] Ensembl ENSRNOP00000052265
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length684 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Sequence similarities

Belongs to the p53 family. RuleBase RU003401

Ontologies

Keywords
   Cellular componentNucleus RuleBase RU003401
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processDNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator

Inferred from Biological aspect of Ancestor. Source: RefGenome

activation of MAPK activity

Inferred from mutant phenotype PubMed 17353261. Source: RGD

cell cycle arrest

Inferred from electronic annotation. Source: Ensembl

cellular response to UV

Inferred from Biological aspect of Ancestor. Source: RefGenome

cerebrospinal fluid secretion

Inferred from electronic annotation. Source: Ensembl

digestive tract morphogenesis

Inferred from electronic annotation. Source: Ensembl

hippocampus development

Inferred from electronic annotation. Source: Ensembl

inflammatory response

Inferred from electronic annotation. Source: Ensembl

intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

Inferred from Biological aspect of Ancestor. Source: RefGenome

kidney development

Inferred from expression pattern PubMed 15805112. Source: RGD

mitotic G1 DNA damage checkpoint

Inferred from Biological aspect of Ancestor. Source: RefGenome

negative regulation of JUN kinase activity

Inferred from Biological aspect of Ancestor. Source: RefGenome

negative regulation of neuron apoptotic process

Inferred from Biological aspect of Ancestor. Source: RefGenome

negative regulation of neuron differentiation

Inferred from mutant phenotype PubMed 17353261. Source: RGD

negative regulation of transcription from RNA polymerase II promoter

Inferred from Biological aspect of Ancestor. Source: RefGenome

neuron development

Inferred from electronic annotation. Source: Ensembl

positive regulation of apoptotic process

Inferred from mutant phenotype PubMed 15716325. Source: RGD

positive regulation of cell size

Inferred from electronic annotation. Source: Ensembl

positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

Inferred from electronic annotation. Source: Ensembl

positive regulation of oligodendrocyte differentiation

Inferred from mutant phenotype PubMed 14960496. Source: RGD

positive regulation of transcription from RNA polymerase II promoter

Inferred from electronic annotation. Source: Ensembl

post-embryonic development

Inferred from electronic annotation. Source: Ensembl

protein tetramerization

Inferred from electronic annotation. Source: InterPro

release of cytochrome c from mitochondria

Inferred from electronic annotation. Source: Ensembl

response to X-ray

Inferred from Biological aspect of Ancestor. Source: RefGenome

response to gamma radiation

Inferred from Biological aspect of Ancestor. Source: RefGenome

response to organonitrogen compound

Inferred from expression pattern PubMed 14587038. Source: RGD

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentchromatin

Inferred from direct assay PubMed 15805112. Source: RGD

cytosol

Inferred from Biological aspect of Ancestor. Source: RefGenome

nucleus

Inferred from direct assay PubMed 15805112. Source: RGD

transcription factor complex

Inferred from Biological aspect of Ancestor. Source: RefGenome

   Molecular_functionchromatin binding

Inferred from Biological aspect of Ancestor. Source: RefGenome

damaged DNA binding

Inferred from Biological aspect of Ancestor. Source: RefGenome

double-stranded DNA binding

Inferred from Biological aspect of Ancestor. Source: RefGenome

p53 binding

Inferred from Biological aspect of Ancestor. Source: RefGenome

sequence-specific DNA binding

Inferred from direct assay PubMed 15805112. Source: RGD

sequence-specific DNA binding transcription factor activity

Inferred from Biological aspect of Ancestor. Source: RefGenome

transcription regulatory region DNA binding

Inferred from electronic annotation. Source: Ensembl

Complete GO annotation...

Sequences

Sequence LengthMass (Da)Tools
D4AA88 [UniParc].

Last modified April 20, 2010. Version 1.
Checksum: 5DD54931B07B269B

FASTA68474,579
        10         20         30         40         50         60 
MSSPRQLDAY ATALPLQATG PPAPLPKSTD PSRAQVQPRM SNGVGEMAQS SSSSSSSSTF 

        70         80         90        100        110        120 
EHLWSSLEPD STYFDLPQPS QGNSEATGSE ESNMDVFHLQ GMTSSVMAQF NLLSSAMDQM 

       130        140        150        160        170        180 
GSRAAPASPY TPEHAASAPT HSPYAQPSST FDTMSPAPVI PSNTDYPGPH HFEVTFQQSS 

       190        200        210        220        230        240 
TAKSATWTYS PLLKKLYCQI AKTCPIQIKV STPPPPGTAI RAMPVYKKAE HVTDIVKRCP 

       250        260        270        280        290        300 
NHELGRDFNE GQSAPASHLI RVEGNNLSQY VDDPVTGRQS VVVPYEPPQV GTEFTTILYN 

       310        320        330        340        350        360 
FMCNSSCVGG MNRRPILVII TLETRDGQVL GRRSFEGRIC ACPGRDRKAD EDHYREQQAL 

       370        380        390        400        410        420 
NESTTKNGAA SKRAFKQSPP AIPALGTNVK KRRHGDEDMF YMHVRGRENF EILMKVKESL 

       430        440        450        460        470        480 
ELMELVPQPL VDSYRQQQQQ QLLQRPSHLQ PPSYGPVLSP MNKVHGGVNK LPSVNQLVGQ 

       490        500        510        520        530        540 
PPPHSSAAGP NLGSMGSGIL NSHSHSMPAN GEMNGGHSSQ TMVSGSHCTP PPPYHADPSL 

       550        560        570        580        590        600 
VSFLTGLGCP NCIECFTSQG LQSIYHLQNL TIEDLGALKI PDQYRMTIWR GLQDLKQSHD 

       610        620        630        640        650        660 
CGQQLLRSSS NAATISIGGS GELQRQRVME AVHFRVRHTI TIPNRGGAGG VTGPDEWADF 

       670        680 
GFDLPDCKSR KQPIKEEFTE TESH 

« Hide

References

« Hide 'large scale' references
[1]"Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
Rat Genome Sequencing Project Consortium
Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M. expand/collapse author list , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Brown Norway Ensembl ENSRNOP00000052265.
[2]"Gene and alternative splicing annotation with AIR."
Florea L., Di Francesco V., Miller J., Turner R., Yao A., Harris M., Walenz B., Mobarry C., Merkulov G.V., Charlab R., Dew I., Deng Z., Istrail S., Li P., Sutton G.
Genome Res. 15:54-66(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: BN EMBL EDL81259.1.
[3]Mural R.J., Li P.W., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S.H., Dew I., Evans C.A., Ferriera S., Flanigan M., Fosler C., Glodek A., Gu Z., Holt R.A., Jennings D., Kraft C.L., Lu F. expand/collapse author list , Nguyen T., Nusskern D.R., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Wang Z., Woodage T., Zheng X.H., Zhong F.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: BN EMBL EDL81259.1.
[4]Ensembl
Submitted (JUL-2011) to UniProtKB
Cited for: IDENTIFICATION.
Strain: Brown Norway Ensembl ENSRNOP00000052265.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AABR06041235 Genomic DNA. No translation available.
AABR06041236 Genomic DNA. No translation available.
AABR06041237 Genomic DNA. No translation available.
AABR06041238 Genomic DNA. No translation available.
AABR06041239 Genomic DNA. No translation available.
AABR06041240 Genomic DNA. No translation available.
CH473968 Genomic DNA. Translation: EDL81259.1.
RefSeqNP_001102166.1. NM_001108696.1.
UniGeneRn.103860.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000055398; ENSRNOP00000052265; ENSRNOG00000024707.
GeneID362675.
KEGGrno:362675.
UCSCRGD:1307083. rat.

Organism-specific databases

CTD7161.
RGD1307083. Tp73.

Phylogenomic databases

GeneTreeENSGT00390000015092.
KOK10148.
OMANEGQSAP.
OrthoDBEOG7JQBNW.
PhylomeDBD4AA88.
TreeFamTF106101.

Family and domain databases

Gene3D1.10.150.50. 1 hit.
2.60.40.720. 1 hit.
4.10.170.10. 1 hit.
InterProIPR008967. p53-like_TF_DNA-bd.
IPR012346. p53/RUNT-type_TF_DNA-bd.
IPR011615. p53_DNA-bd.
IPR010991. p53_tetrameristn.
IPR002117. p53_tumour_suppressor.
IPR001660. SAM.
IPR013761. SAM/pointed.
IPR011510. SAM_2.
[Graphical view]
PANTHERPTHR11447. PTHR11447. 1 hit.
PfamPF00870. P53. 1 hit.
PF07710. P53_tetramer. 1 hit.
PF07647. SAM_2. 1 hit.
[Graphical view]
PRINTSPR00386. P53SUPPRESSR.
SMARTSM00454. SAM. 1 hit.
[Graphical view]
SUPFAMSSF47719. SSF47719. 1 hit.
SSF47769. SSF47769. 1 hit.
SSF49417. SSF49417. 1 hit.
PROSITEPS00348. P53. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio680833.

Entry information

Entry nameD4AA88_RAT
AccessionPrimary (citable) accession number: D4AA88
Entry history
Integrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: July 9, 2014
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)