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D4A980

- D4A980_RAT

UniProt

D4A980 - D4A980_RAT

Protein
Submitted name:

Protein Malt1

Gene

Malt1

Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 3 out of 5- Protein predictedi
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    • History
      Entry version 36 (01 Oct 2014)
      Sequence version 1 (20 Apr 2010)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. cysteine-type endopeptidase activity Source: InterPro
    2. kinase activator activity Source: Ensembl
    3. signal transducer activity Source: Ensembl
    4. ubiquitin-protein transferase activity Source: Ensembl

    GO - Biological processi

    1. activation of NF-kappaB-inducing kinase activity Source: Ensembl
    2. B-1 B cell differentiation Source: Ensembl
    3. innate immune response Source: Ensembl
    4. nuclear export Source: Ensembl
    5. positive regulation of I-kappaB kinase/NF-kappaB signaling Source: Ensembl
    6. positive regulation of interleukin-2 production Source: Ensembl
    7. positive regulation of NF-kappaB transcription factor activity Source: Ensembl
    8. positive regulation of T cell activation Source: Ensembl
    9. positive regulation of T cell cytokine production Source: Ensembl
    10. protein oligomerization Source: Ensembl
    11. regulation of apoptotic process Source: Ensembl
    12. regulation of T cell receptor signaling pathway Source: Ensembl
    13. response to fungus Source: Ensembl
    14. response to molecule of bacterial origin Source: Ensembl
    15. T cell proliferation Source: Ensembl
    16. T cell receptor signaling pathway Source: Ensembl

    Enzyme and pathway databases

    ReactomeiREACT_197513. FCERI mediated NF-kB activation.
    REACT_199247. Activation of NF-kappaB in B cells.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Protein Malt1Imported
    Gene namesi
    Name:Malt1Imported
    OrganismiRattus norvegicus (Rat)Imported
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 18

    Organism-specific databases

    RGDi1309195. Malt1.

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: Ensembl
    2. nucleus Source: Ensembl
    3. protein complex Source: Ensembl

    Structurei

    3D structure databases

    ProteinModelPortaliD4A980.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    GeneTreeiENSGT00390000018044.
    KOiK07369.
    OMAiMNKEIPN.
    OrthoDBiEOG7673BH.
    PhylomeDBiD4A980.
    TreeFamiTF319744.

    Family and domain databases

    Gene3Di1.10.533.10. 1 hit.
    2.60.40.10. 2 hits.
    3.40.50.1460. 1 hit.
    InterProiIPR029030. Caspase-like_dom.
    IPR011029. DEATH-like_dom.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003598. Ig_sub2.
    IPR011600. Pept_C14_caspase.
    IPR001309. Pept_C14_ICE_p20.
    [Graphical view]
    PfamiPF00656. Peptidase_C14. 1 hit.
    [Graphical view]
    SMARTiSM00408. IGc2. 2 hits.
    [Graphical view]
    SUPFAMiSSF47986. SSF47986. 1 hit.
    PROSITEiPS50208. CASPASE_P20. 1 hit.
    PS50835. IG_LIKE. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    D4A980-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSLWGQPLQA SPPPAVQQPL TASSGPSTAP PAGSTLNRLP EPLLRRLSES    50
    LDRAPEGRGW RQLAELAGSR GRLRLSCLDL EQCSLKVLEP EGSPSLCLLK 100
    LMGEKGCTVP ELSDFLQALE HTEVLQLLNP PGLKITVNPE SKAVLAGQFV 150
    KLCCRATGHP FVQYQWFKMN KEIPYGNSSE LIFNTVHVKD AGFYVCRVNN 200
    NSTFEFSQWS QLDVCDVTEV SDSFQGSLDG VSESKLRICV EPQSQKLAPG 250
    SALLLQCVAI GSPVPHYQWF KDESPLAHET KKHYTVPYVD LEHEGTYWCH 300
    VYNDRDSQDS KKVEIIIGRT DGAVECTEDE LNNLGRPDNK EQTGQPLAKD 350
    KVALLIGNMN YWEHPKLKAP LVDVYELTNL LRQLDFKVVS LLDLTEYEMC 400
    NAVDEFLLLL DKGVYGLLYY AGHGYENFGN SFMVPVDAPN PYRSENCLCV 450
    QNILKLMQEK ETGLNVFLLD MCRKRNDYDD TIPILDALKV TANIVFGYAT 500
    CQGAEAFEIQ HSGLANGIFM KFLKDRLLED KKITVLLDEV AEDMGKCHLT 550
    KGRQALEIRS SLSEKRALTD PIQGAPCSAE ALVRNLQWAK AHELPESMCL 600
    KFQCGVHIQL GFAAEFSNVM IIYTSIVHKP PEIIMCDAYV TDFPLDLDID 650
    PKHANKGTPE ETGSYLVSKE LPKHCLYTRL SSLQKLKEHL IFTVCLSYQY 700
    SGLEDTVEEK QEVSVGKPLI AKLDMHRGLG RKTCLQACPM PDETCHSSTS 750
    TSAGAGHFHS SQDSFHDVYH SQLGNSDSAM PPDRCHCSRT PHAFISNYPP 800
    HHYCQFGRSN VPVETTDEMP FSFSDRLMIS EN 832
    Length:832
    Mass (Da):92,951
    Last modified:April 20, 2010 - v1
    Checksum:i65100297A41CFFE9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR06095569 Genomic DNA. No translation available.
    RefSeqiXP_003751846.1. XM_003751798.2.
    XP_003753105.1. XM_003753057.2.
    UniGeneiRn.86215.

    Genome annotation databases

    EnsembliENSRNOT00000068418; ENSRNOP00000059281; ENSRNOG00000017181.
    GeneIDi307366.
    KEGGirno:307366.
    UCSCiRGD:1309195. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR06095569 Genomic DNA. No translation available.
    RefSeqi XP_003751846.1. XM_003751798.2.
    XP_003753105.1. XM_003753057.2.
    UniGenei Rn.86215.

    3D structure databases

    ProteinModelPortali D4A980.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000068418 ; ENSRNOP00000059281 ; ENSRNOG00000017181 .
    GeneIDi 307366.
    KEGGi rno:307366.
    UCSCi RGD:1309195. rat.

    Organism-specific databases

    CTDi 10892.
    RGDi 1309195. Malt1.

    Phylogenomic databases

    GeneTreei ENSGT00390000018044.
    KOi K07369.
    OMAi MNKEIPN.
    OrthoDBi EOG7673BH.
    PhylomeDBi D4A980.
    TreeFami TF319744.

    Enzyme and pathway databases

    Reactomei REACT_197513. FCERI mediated NF-kB activation.
    REACT_199247. Activation of NF-kappaB in B cells.

    Miscellaneous databases

    NextBioi 657278.
    PROi D4A980.

    Family and domain databases

    Gene3Di 1.10.533.10. 1 hit.
    2.60.40.10. 2 hits.
    3.40.50.1460. 1 hit.
    InterProi IPR029030. Caspase-like_dom.
    IPR011029. DEATH-like_dom.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003598. Ig_sub2.
    IPR011600. Pept_C14_caspase.
    IPR001309. Pept_C14_ICE_p20.
    [Graphical view ]
    Pfami PF00656. Peptidase_C14. 1 hit.
    [Graphical view ]
    SMARTi SM00408. IGc2. 2 hits.
    [Graphical view ]
    SUPFAMi SSF47986. SSF47986. 1 hit.
    PROSITEi PS50208. CASPASE_P20. 1 hit.
    PS50835. IG_LIKE. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
      Rat Genome Sequencing Project Consortium
      Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
      , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
      Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Brown NorwayImported.
    2. Ensembl
      Submitted (JUL-2011) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: Brown NorwayImported.

    Entry informationi

    Entry nameiD4A980_RAT
    AccessioniPrimary (citable) accession number: D4A980
    Entry historyi
    Integrated into UniProtKB/TrEMBL: April 20, 2010
    Last sequence update: April 20, 2010
    Last modified: October 1, 2014
    This is version 36 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Caution

    The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3