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D4A980

- D4A980_RAT

UniProt

D4A980 - D4A980_RAT

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Protein
Submitted name: Protein Malt1
Gene
Malt1
Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein predictedi

Functioni

GO - Molecular functioni

  1. cysteine-type endopeptidase activity Source: InterPro
  2. kinase activator activity Source: Ensembl
  3. signal transducer activity Source: Ensembl
  4. ubiquitin-protein transferase activity Source: Ensembl

GO - Biological processi

  1. B-1 B cell differentiation Source: Ensembl
  2. T cell proliferation Source: Ensembl
  3. T cell receptor signaling pathway Source: Ensembl
  4. activation of NF-kappaB-inducing kinase activity Source: Ensembl
  5. innate immune response Source: Ensembl
  6. nuclear export Source: Ensembl
  7. positive regulation of I-kappaB kinase/NF-kappaB signaling Source: Ensembl
  8. positive regulation of NF-kappaB transcription factor activity Source: Ensembl
  9. positive regulation of T cell activation Source: Ensembl
  10. positive regulation of T cell cytokine production Source: Ensembl
  11. positive regulation of interleukin-2 production Source: Ensembl
  12. protein oligomerization Source: Ensembl
  13. regulation of T cell receptor signaling pathway Source: Ensembl
  14. regulation of apoptotic process Source: Ensembl
  15. response to fungus Source: Ensembl
  16. response to molecule of bacterial origin Source: Ensembl
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_197513. FCERI mediated NF-kB activation.
REACT_199247. Activation of NF-kappaB in B cells.

Names & Taxonomyi

Protein namesi
Submitted name:
Protein Malt1Imported
Gene namesi
Name:Malt1Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 18

Organism-specific databases

RGDi1309195. Malt1.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: Ensembl
  2. nucleus Source: Ensembl
  3. protein complex Source: Ensembl
Complete GO annotation...

Structurei

3D structure databases

ProteinModelPortaliD4A980.

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00390000018044.
KOiK07369.
OMAiMNKEIPN.
OrthoDBiEOG7673BH.
PhylomeDBiD4A980.
TreeFamiTF319744.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
2.60.40.10. 2 hits.
3.40.50.1460. 1 hit.
InterProiIPR029030. Caspase-like_dom.
IPR011029. DEATH-like_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003598. Ig_sub2.
IPR011600. Pept_C14_caspase.
IPR001309. Pept_C14_ICE_p20.
[Graphical view]
PfamiPF00656. Peptidase_C14. 1 hit.
[Graphical view]
SMARTiSM00408. IGc2. 2 hits.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
PROSITEiPS50208. CASPASE_P20. 1 hit.
PS50835. IG_LIKE. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D4A980-1 [UniParc]FASTAAdd to Basket

« Hide

MSLWGQPLQA SPPPAVQQPL TASSGPSTAP PAGSTLNRLP EPLLRRLSES    50
LDRAPEGRGW RQLAELAGSR GRLRLSCLDL EQCSLKVLEP EGSPSLCLLK 100
LMGEKGCTVP ELSDFLQALE HTEVLQLLNP PGLKITVNPE SKAVLAGQFV 150
KLCCRATGHP FVQYQWFKMN KEIPYGNSSE LIFNTVHVKD AGFYVCRVNN 200
NSTFEFSQWS QLDVCDVTEV SDSFQGSLDG VSESKLRICV EPQSQKLAPG 250
SALLLQCVAI GSPVPHYQWF KDESPLAHET KKHYTVPYVD LEHEGTYWCH 300
VYNDRDSQDS KKVEIIIGRT DGAVECTEDE LNNLGRPDNK EQTGQPLAKD 350
KVALLIGNMN YWEHPKLKAP LVDVYELTNL LRQLDFKVVS LLDLTEYEMC 400
NAVDEFLLLL DKGVYGLLYY AGHGYENFGN SFMVPVDAPN PYRSENCLCV 450
QNILKLMQEK ETGLNVFLLD MCRKRNDYDD TIPILDALKV TANIVFGYAT 500
CQGAEAFEIQ HSGLANGIFM KFLKDRLLED KKITVLLDEV AEDMGKCHLT 550
KGRQALEIRS SLSEKRALTD PIQGAPCSAE ALVRNLQWAK AHELPESMCL 600
KFQCGVHIQL GFAAEFSNVM IIYTSIVHKP PEIIMCDAYV TDFPLDLDID 650
PKHANKGTPE ETGSYLVSKE LPKHCLYTRL SSLQKLKEHL IFTVCLSYQY 700
SGLEDTVEEK QEVSVGKPLI AKLDMHRGLG RKTCLQACPM PDETCHSSTS 750
TSAGAGHFHS SQDSFHDVYH SQLGNSDSAM PPDRCHCSRT PHAFISNYPP 800
HHYCQFGRSN VPVETTDEMP FSFSDRLMIS EN 832
Length:832
Mass (Da):92,951
Last modified:April 20, 2010 - v1
Checksum:i65100297A41CFFE9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AABR06095569 Genomic DNA. No translation available.
RefSeqiXP_003751846.1. XM_003751798.2.
XP_003753105.1. XM_003753057.2.
UniGeneiRn.86215.

Genome annotation databases

EnsembliENSRNOT00000068418; ENSRNOP00000059281; ENSRNOG00000017181.
GeneIDi307366.
KEGGirno:307366.
UCSCiRGD:1309195. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AABR06095569 Genomic DNA. No translation available.
RefSeqi XP_003751846.1. XM_003751798.2.
XP_003753105.1. XM_003753057.2.
UniGenei Rn.86215.

3D structure databases

ProteinModelPortali D4A980.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000068418 ; ENSRNOP00000059281 ; ENSRNOG00000017181 .
GeneIDi 307366.
KEGGi rno:307366.
UCSCi RGD:1309195. rat.

Organism-specific databases

CTDi 10892.
RGDi 1309195. Malt1.

Phylogenomic databases

GeneTreei ENSGT00390000018044.
KOi K07369.
OMAi MNKEIPN.
OrthoDBi EOG7673BH.
PhylomeDBi D4A980.
TreeFami TF319744.

Enzyme and pathway databases

Reactomei REACT_197513. FCERI mediated NF-kB activation.
REACT_199247. Activation of NF-kappaB in B cells.

Miscellaneous databases

NextBioi 657278.
PROi D4A980.

Family and domain databases

Gene3Di 1.10.533.10. 1 hit.
2.60.40.10. 2 hits.
3.40.50.1460. 1 hit.
InterProi IPR029030. Caspase-like_dom.
IPR011029. DEATH-like_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003598. Ig_sub2.
IPR011600. Pept_C14_caspase.
IPR001309. Pept_C14_ICE_p20.
[Graphical view ]
Pfami PF00656. Peptidase_C14. 1 hit.
[Graphical view ]
SMARTi SM00408. IGc2. 2 hits.
[Graphical view ]
SUPFAMi SSF47986. SSF47986. 1 hit.
PROSITEi PS50208. CASPASE_P20. 1 hit.
PS50835. IG_LIKE. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Rat Genome Sequencing Project Consortium
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown NorwayImported.
  2. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: Brown NorwayImported.

Entry informationi

Entry nameiD4A980_RAT
AccessioniPrimary (citable) accession number: D4A980
Entry historyi
Integrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: September 3, 2014
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

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