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D4A980

- D4A980_RAT

UniProt

D4A980 - D4A980_RAT

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Protein
Submitted name:

Protein Malt1

Gene

Malt1

Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 3 out of 5- Protein predictedi

Functioni

GO - Molecular functioni

  1. cysteine-type endopeptidase activity Source: InterPro
  2. kinase activator activity Source: Ensembl
  3. signal transducer activity Source: Ensembl
  4. ubiquitin-protein transferase activity Source: Ensembl

GO - Biological processi

  1. activation of NF-kappaB-inducing kinase activity Source: Ensembl
  2. B-1 B cell differentiation Source: Ensembl
  3. innate immune response Source: Ensembl
  4. nuclear export Source: Ensembl
  5. positive regulation of I-kappaB kinase/NF-kappaB signaling Source: Ensembl
  6. positive regulation of interleukin-2 production Source: Ensembl
  7. positive regulation of NF-kappaB transcription factor activity Source: Ensembl
  8. positive regulation of T cell activation Source: Ensembl
  9. positive regulation of T cell cytokine production Source: Ensembl
  10. protein oligomerization Source: Ensembl
  11. regulation of apoptotic process Source: Ensembl
  12. regulation of T cell receptor signaling pathway Source: Ensembl
  13. response to fungus Source: Ensembl
  14. response to molecule of bacterial origin Source: Ensembl
  15. T cell proliferation Source: Ensembl
  16. T cell receptor signaling pathway Source: Ensembl
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_197513. FCERI mediated NF-kB activation.
REACT_199247. Activation of NF-kappaB in B cells.

Names & Taxonomyi

Protein namesi
Submitted name:
Protein Malt1Imported
Gene namesi
Name:Malt1Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 18

Organism-specific databases

RGDi1309195. Malt1.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: Ensembl
  2. nucleolus Source: Ensembl
  3. protein complex Source: Ensembl
Complete GO annotation...

Expressioni

Gene expression databases

ExpressionAtlasiD4A980. baseline.

Structurei

3D structure databases

ProteinModelPortaliD4A980.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00390000018044.
InParanoidiD4A980.
KOiK07369.
OMAiMNKEIPN.
OrthoDBiEOG7673BH.
PhylomeDBiD4A980.
TreeFamiTF319744.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
2.60.40.10. 2 hits.
3.40.50.1460. 1 hit.
InterProiIPR029030. Caspase-like_dom.
IPR011029. DEATH-like_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003598. Ig_sub2.
IPR011600. Pept_C14_caspase.
IPR001309. Pept_C14_ICE_p20.
[Graphical view]
PfamiPF00656. Peptidase_C14. 1 hit.
[Graphical view]
SMARTiSM00408. IGc2. 2 hits.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
PROSITEiPS50208. CASPASE_P20. 1 hit.
PS50835. IG_LIKE. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D4A980 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSLWGQPLQA SPPPAVQQPL TASSGPSTAP PAGSTLNRLP EPLLRRLSES
60 70 80 90 100
LDRAPEGRGW RQLAELAGSR GRLRLSCLDL EQCSLKVLEP EGSPSLCLLK
110 120 130 140 150
LMGEKGCTVP ELSDFLQALE HTEVLQLLNP PGLKITVNPE SKAVLAGQFV
160 170 180 190 200
KLCCRATGHP FVQYQWFKMN KEIPYGNSSE LIFNTVHVKD AGFYVCRVNN
210 220 230 240 250
NSTFEFSQWS QLDVCDVTEV SDSFQGSLDG VSESKLRICV EPQSQKLAPG
260 270 280 290 300
SALLLQCVAI GSPVPHYQWF KDESPLAHET KKHYTVPYVD LEHEGTYWCH
310 320 330 340 350
VYNDRDSQDS KKVEIIIGRT DGAVECTEDE LNNLGRPDNK EQTGQPLAKD
360 370 380 390 400
KVALLIGNMN YWEHPKLKAP LVDVYELTNL LRQLDFKVVS LLDLTEYEMC
410 420 430 440 450
NAVDEFLLLL DKGVYGLLYY AGHGYENFGN SFMVPVDAPN PYRSENCLCV
460 470 480 490 500
QNILKLMQEK ETGLNVFLLD MCRKRNDYDD TIPILDALKV TANIVFGYAT
510 520 530 540 550
CQGAEAFEIQ HSGLANGIFM KFLKDRLLED KKITVLLDEV AEDMGKCHLT
560 570 580 590 600
KGRQALEIRS SLSEKRALTD PIQGAPCSAE ALVRNLQWAK AHELPESMCL
610 620 630 640 650
KFQCGVHIQL GFAAEFSNVM IIYTSIVHKP PEIIMCDAYV TDFPLDLDID
660 670 680 690 700
PKHANKGTPE ETGSYLVSKE LPKHCLYTRL SSLQKLKEHL IFTVCLSYQY
710 720 730 740 750
SGLEDTVEEK QEVSVGKPLI AKLDMHRGLG RKTCLQACPM PDETCHSSTS
760 770 780 790 800
TSAGAGHFHS SQDSFHDVYH SQLGNSDSAM PPDRCHCSRT PHAFISNYPP
810 820 830
HHYCQFGRSN VPVETTDEMP FSFSDRLMIS EN
Length:832
Mass (Da):92,951
Last modified:April 20, 2010 - v1
Checksum:i65100297A41CFFE9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AABR06095569 Genomic DNA. No translation available.
RefSeqiXP_003751846.1. XM_003751798.3.
XP_003753105.1. XM_003753057.3.
UniGeneiRn.86215.

Genome annotation databases

EnsembliENSRNOT00000068418; ENSRNOP00000059281; ENSRNOG00000017181.
GeneIDi307366.
KEGGirno:307366.
UCSCiRGD:1309195. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AABR06095569 Genomic DNA. No translation available.
RefSeqi XP_003751846.1. XM_003751798.3.
XP_003753105.1. XM_003753057.3.
UniGenei Rn.86215.

3D structure databases

ProteinModelPortali D4A980.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000068418 ; ENSRNOP00000059281 ; ENSRNOG00000017181 .
GeneIDi 307366.
KEGGi rno:307366.
UCSCi RGD:1309195. rat.

Organism-specific databases

CTDi 10892.
RGDi 1309195. Malt1.

Phylogenomic databases

GeneTreei ENSGT00390000018044.
InParanoidi D4A980.
KOi K07369.
OMAi MNKEIPN.
OrthoDBi EOG7673BH.
PhylomeDBi D4A980.
TreeFami TF319744.

Enzyme and pathway databases

Reactomei REACT_197513. FCERI mediated NF-kB activation.
REACT_199247. Activation of NF-kappaB in B cells.

Miscellaneous databases

NextBioi 657278.
PROi D4A980.

Gene expression databases

ExpressionAtlasi D4A980. baseline.

Family and domain databases

Gene3Di 1.10.533.10. 1 hit.
2.60.40.10. 2 hits.
3.40.50.1460. 1 hit.
InterProi IPR029030. Caspase-like_dom.
IPR011029. DEATH-like_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003598. Ig_sub2.
IPR011600. Pept_C14_caspase.
IPR001309. Pept_C14_ICE_p20.
[Graphical view ]
Pfami PF00656. Peptidase_C14. 1 hit.
[Graphical view ]
SMARTi SM00408. IGc2. 2 hits.
[Graphical view ]
SUPFAMi SSF47986. SSF47986. 1 hit.
PROSITEi PS50208. CASPASE_P20. 1 hit.
PS50835. IG_LIKE. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Rat Genome Sequencing Project Consortium
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown NorwayImported.
  2. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: Brown NorwayImported.

Entry informationi

Entry nameiD4A980_RAT
AccessioniPrimary (citable) accession number: D4A980
Entry historyi
Integrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: October 29, 2014
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3