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D4A978

- D4A978_RAT

UniProt

D4A978 - D4A978_RAT

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Protein

Phosphoinositide phospholipase C

Gene
Plcd3
Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein predictedi

Functioni

Catalytic activityi

1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.UniRule annotation

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
  2. phosphatidylinositol phospholipase C activity Source: InterPro
  3. signal transducer activity Source: UniProtKB-KW

GO - Biological processi

  1. angiogenesis Source: Ensembl
  2. intracellular signal transduction Source: InterPro
  3. labyrinthine layer blood vessel development Source: Ensembl
  4. lipid metabolic process Source: InterPro
  5. regulation of cell proliferation Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

HydrolaseUniRule annotation, TransducerSAAS annotations

Keywords - Biological processi

Lipid degradationUniRule annotation, Lipid metabolism

Enzyme and pathway databases

ReactomeiREACT_198661. Synthesis of IP3 and IP4 in the cytosol.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoinositide phospholipase CUniRule annotation (EC:3.1.4.11UniRule annotation)
Gene namesi
Name:Plcd3Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 10

Organism-specific databases

RGDi1310903. Plcd3.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: RGD
  2. membrane Source: RGD
Complete GO annotation...

PTM / Processingi

Proteomic databases

PRIDEiD4A978.

Structurei

3D structure databases

ProteinModelPortaliD4A978.

Family & Domainsi

Sequence similaritiesi

Contains 1 C2 domain.UniRule annotation
Contains 1 PH domain.UniRule annotation
Contains 1 PI-PLC X-box domain.UniRule annotation
Contains 1 PI-PLC Y-box domain.UniRule annotation
Contains C2 domain.SAAS annotations
Contains Cdomain.SAAS annotations
Contains PH domain.SAAS annotations
Contains PI-PLC X-box domain.SAAS annotations
Contains PI-PLC Y-box domain.SAAS annotations

Phylogenomic databases

GeneTreeiENSGT00740000114979.
KOiK05857.
OMAiHWGQTLQ.
OrthoDBiEOG7V49XT.
PhylomeDBiD4A978.
TreeFamiTF313216.

Family and domain databases

Gene3Di1.10.238.10. 2 hits.
2.30.29.30. 1 hit.
2.60.40.150. 1 hit.
3.20.20.190. 2 hits.
InterProiIPR000008. C2_dom.
IPR011992. EF-hand-dom_pair.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR001192. PI-PLC_fam.
IPR028406. PLC-delta3.
IPR017946. PLC-like_Pdiesterase_TIM-brl.
IPR015359. PLipase_C_EF-hand-like.
IPR000909. PLipase_C_PInositol-sp_X_dom.
IPR001711. PLipase_C_Pinositol-sp_Y.
[Graphical view]
PANTHERiPTHR10336. PTHR10336. 1 hit.
PTHR10336:SF33. PTHR10336:SF33. 1 hit.
PfamiPF00168. C2. 1 hit.
PF09279. EF-hand_like. 1 hit.
PF00388. PI-PLC-X. 1 hit.
PF00387. PI-PLC-Y. 1 hit.
[Graphical view]
PRINTSiPR00390. PHPHLIPASEC.
SMARTiSM00239. C2. 1 hit.
SM00233. PH. 1 hit.
SM00148. PLCXc. 1 hit.
SM00149. PLCYc. 1 hit.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 1 hit.
SSF51695. SSF51695. 1 hit.
PROSITEiPS50004. C2. 1 hit.
PS50007. PIPLC_X_DOMAIN. 1 hit.
PS50008. PIPLC_Y_DOMAIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D4A978-1 [UniParc]FASTAAdd to Basket

« Hide

MLCGGWRRSR RSPEEPRVSA QVAAPLAFLP SPASSDSSTK RPGLRALKKM    50
GLTEDEDVQA MLRGSKLLKI RSRTWHKERL YRLQEDGLSV WFQRRIPRAA 100
SQHIFFVQHI EAVREGHQSE GLRRFGGAFA PARCLTIAFK GRRKNLDLAA 150
PTAEEAQRWV RGLAKLRARL DAMSQRERLD HAHTWIHSYL HRADSDQDSK 200
MSFKEIKSLL RMVNVDMNDM YAYRLFKECD HSNNERLEGA EIEAFLRRLL 250
KRPELEEIFR RYSGEDRVLS ASELLEFLED QGEDGATLAC AQKLIQTYEL 300
NETAKQHELM TLDGFMMYLL SPEGAALNVA HTCVFQDMGQ PLAHYFISSS 350
HNTYLTDSQI GGTSSTEAYI RAFTQGCRCV ELDCWEGPGG EPVIYHGHTL 400
TSKILFRDVI QAVRDHAFTL SPYPVILSLE NHCGLEQQIV MARHLRNILG 450
DMLVTQALDS QNPEELPSPE QLKCRVLVKG KKLPAARNED GRILSDREDE 500
DEDEEEAEEA LETAEQRKRA KQISPELSAL VVYCCATRLR TLEPSPGPPQ 550
PCKIGSLSER KARKFTREAG TSFVRHNTQQ LTRVYPLGLR MTSANYNPQE 600
MWNSGCQLVA LNFQTPGYEM DLNTGRFLIN GQCGYVLKPA YLRQLNTTFD 650
PECPGPPRTT LTVQVLTAQQ LPKLNVEKPN SIVDPLVRVE IYGVPEDCAH 700
KETDYVLNNG FNPCWEQTLQ FQLRAPELVL VRFVVEDYDT TSPNDFVGQF 750
TLPLNSLKQG YRHIHLLSKD GASLSPATLF VHIRIENS 788
Length:788
Mass (Da):89,471
Last modified:April 20, 2010 - v1
Checksum:i13904825D24E8E34
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AABR06065667 Genomic DNA. No translation available.
AABR06065668 Genomic DNA. No translation available.
RefSeqiNP_001099315.2. NM_001105845.2.
UniGeneiRn.95716.

Genome annotation databases

EnsembliENSRNOT00000004140; ENSRNOP00000004140; ENSRNOG00000003033.
GeneIDi287745.
KEGGirno:287745.
UCSCiRGD:1310903. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AABR06065667 Genomic DNA. No translation available.
AABR06065668 Genomic DNA. No translation available.
RefSeqi NP_001099315.2. NM_001105845.2.
UniGenei Rn.95716.

3D structure databases

ProteinModelPortali D4A978.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi D4A978.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000004140 ; ENSRNOP00000004140 ; ENSRNOG00000003033 .
GeneIDi 287745.
KEGGi rno:287745.
UCSCi RGD:1310903. rat.

Organism-specific databases

CTDi 113026.
RGDi 1310903. Plcd3.

Phylogenomic databases

GeneTreei ENSGT00740000114979.
KOi K05857.
OMAi HWGQTLQ.
OrthoDBi EOG7V49XT.
PhylomeDBi D4A978.
TreeFami TF313216.

Enzyme and pathway databases

Reactomei REACT_198661. Synthesis of IP3 and IP4 in the cytosol.

Miscellaneous databases

NextBioi 626929.

Family and domain databases

Gene3Di 1.10.238.10. 2 hits.
2.30.29.30. 1 hit.
2.60.40.150. 1 hit.
3.20.20.190. 2 hits.
InterProi IPR000008. C2_dom.
IPR011992. EF-hand-dom_pair.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR001192. PI-PLC_fam.
IPR028406. PLC-delta3.
IPR017946. PLC-like_Pdiesterase_TIM-brl.
IPR015359. PLipase_C_EF-hand-like.
IPR000909. PLipase_C_PInositol-sp_X_dom.
IPR001711. PLipase_C_Pinositol-sp_Y.
[Graphical view ]
PANTHERi PTHR10336. PTHR10336. 1 hit.
PTHR10336:SF33. PTHR10336:SF33. 1 hit.
Pfami PF00168. C2. 1 hit.
PF09279. EF-hand_like. 1 hit.
PF00388. PI-PLC-X. 1 hit.
PF00387. PI-PLC-Y. 1 hit.
[Graphical view ]
PRINTSi PR00390. PHPHLIPASEC.
SMARTi SM00239. C2. 1 hit.
SM00233. PH. 1 hit.
SM00148. PLCXc. 1 hit.
SM00149. PLCYc. 1 hit.
[Graphical view ]
SUPFAMi SSF49562. SSF49562. 1 hit.
SSF51695. SSF51695. 1 hit.
PROSITEi PS50004. C2. 1 hit.
PS50007. PIPLC_X_DOMAIN. 1 hit.
PS50008. PIPLC_Y_DOMAIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Rat Genome Sequencing Project Consortium
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown NorwayImported.
  2. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: Brown NorwayImported.

Entry informationi

Entry nameiD4A978_RAT
AccessioniPrimary (citable) accession number: D4A978
Entry historyi
Integrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: September 3, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

Similar proteinsi