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Protein

Phosphoinositide phospholipase C

Gene

Plcd3

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.UniRule annotationSAAS annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolaseUniRule annotationSAAS annotation, TransducerSAAS annotation
Biological processLipid degradationUniRule annotationSAAS annotation, Lipid metabolism

Enzyme and pathway databases

ReactomeiR-RNO-1855204 Synthesis of IP3 and IP4 in the cytosol

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoinositide phospholipase CUniRule annotation (EC:3.1.4.11UniRule annotation)
Gene namesi
Name:Plcd3Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi1310903 Plcd3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Proteomic databases

PaxDbiD4A978
PRIDEiD4A978

PTM databases

iPTMnetiD4A978
PhosphoSitePlusiD4A978

Expressioni

Gene expression databases

BgeeiENSRNOG00000003033
GenevisibleiD4A978 RN

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000004140

Structurei

3D structure databases

ProteinModelPortaliD4A978
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini336 – 481PI-PLC X-boxInterPro annotationAdd BLAST146
Domaini527 – 643PI-PLC Y-boxInterPro annotationAdd BLAST117
Domaini646 – 751C2InterPro annotationAdd BLAST106

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili497 – 524Sequence analysisAdd BLAST28

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG0169 Eukaryota
ENOG410XPSW LUCA
GeneTreeiENSGT00760000118936
InParanoidiD4A978
KOiK05857
OMAiHELMTLD
OrthoDBiEOG091G02KH
PhylomeDBiD4A978
TreeFamiTF313216

Family and domain databases

Gene3Di2.30.29.30, 1 hit
2.60.40.150, 1 hit
3.20.20.190, 1 hit
InterProiView protein in InterPro
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR011992 EF-hand-dom_pair
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR001192 PI-PLC_fam
IPR028406 PLC-delta3
IPR017946 PLC-like_Pdiesterase_TIM-brl
IPR000909 PLipase_C_PInositol-sp_X_dom
IPR001711 PLipase_C_Pinositol-sp_Y
PANTHERiPTHR10336 PTHR10336, 1 hit
PTHR10336:SF33 PTHR10336:SF33, 1 hit
PfamiView protein in Pfam
PF00168 C2, 1 hit
PF00388 PI-PLC-X, 1 hit
PF00387 PI-PLC-Y, 1 hit
PRINTSiPR00390 PHPHLIPASEC
SMARTiView protein in SMART
SM00239 C2, 1 hit
SM00233 PH, 1 hit
SM00148 PLCXc, 1 hit
SM00149 PLCYc, 1 hit
SUPFAMiSSF47473 SSF47473, 1 hit
SSF51695 SSF51695, 1 hit
PROSITEiView protein in PROSITE
PS50004 C2, 1 hit
PS50007 PIPLC_X_DOMAIN, 1 hit
PS50008 PIPLC_Y_DOMAIN, 1 hit

Sequencei

Sequence statusi: Complete.

D4A978-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLCGGWRRSR RSPEEPRVSA QVAAPLAFLP SPASSDSSTK RPGLRALKKM
60 70 80 90 100
GLTEDEDVQA MLRGSKLLKI RSRTWHKERL YRLQEDGLSV WFQRRIPRAA
110 120 130 140 150
SQHIFFVQHI EAVREGHQSE GLRRFGGAFA PARCLTIAFK GRRKNLDLAA
160 170 180 190 200
PTAEEAQRWV RGLAKLRARL DAMSQRERLD HAHTWIHSYL HRADSDQDSK
210 220 230 240 250
MSFKEIKSLL RMVNVDMNDM YAYRLFKECD HSNNERLEGA EIEAFLRRLL
260 270 280 290 300
KRPELEEIFR RYSGEDRVLS ASELLEFLED QGEDGATLAC AQKLIQTYEL
310 320 330 340 350
NETAKQHELM TLDGFMMYLL SPEGAALNVA HTCVFQDMGQ PLAHYFISSS
360 370 380 390 400
HNTYLTDSQI GGTSSTEAYI RAFTQGCRCV ELDCWEGPGG EPVIYHGHTL
410 420 430 440 450
TSKILFRDVI QAVRDHAFTL SPYPVILSLE NHCGLEQQIV MARHLRNILG
460 470 480 490 500
DMLVTQALDS QNPEELPSPE QLKCRVLVKG KKLPAARNED GRILSDREDE
510 520 530 540 550
DEDEEEAEEA LETAEQRKRA KQISPELSAL VVYCCATRLR TLEPSPGPPQ
560 570 580 590 600
PCKIGSLSER KARKFTREAG TSFVRHNTQQ LTRVYPLGLR MTSANYNPQE
610 620 630 640 650
MWNSGCQLVA LNFQTPGYEM DLNTGRFLIN GQCGYVLKPA YLRQLNTTFD
660 670 680 690 700
PECPGPPRTT LTVQVLTAQQ LPKLNVEKPN SIVDPLVRVE IYGVPEDCAH
710 720 730 740 750
KETDYVLNNG FNPCWEQTLQ FQLRAPELVL VRFVVEDYDT TSPNDFVGQF
760 770 780
TLPLNSLKQG YRHIHLLSKD GASLSPATLF VHIRIENS
Length:788
Mass (Da):89,471
Last modified:April 20, 2010 - v1
Checksum:i13904825D24E8E34
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC107153 Genomic DNA No translation available.
RefSeqiNP_001099315.2, NM_001105845.2
UniGeneiRn.95716

Genome annotation databases

EnsembliENSRNOT00000004140; ENSRNOP00000004140; ENSRNOG00000003033
GeneIDi287745
KEGGirno:287745
UCSCiRGD:1310903 rat

Similar proteinsi

Entry informationi

Entry nameiD4A978_RAT
AccessioniPrimary (citable) accession number: D4A978
Entry historyiIntegrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: May 23, 2018
This is version 76 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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