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D4A978

- D4A978_RAT

UniProt

D4A978 - D4A978_RAT

Protein

Phosphoinositide phospholipase C

Gene

Plcd3

Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 3 out of 5- Protein predictedi
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    • History
      Entry version 46 (01 Oct 2014)
      Sequence version 1 (20 Apr 2010)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.UniRule annotation

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro
    2. phosphatidylinositol phospholipase C activity Source: UniProtKB-EC
    3. signal transducer activity Source: UniProtKB-KW

    GO - Biological processi

    1. angiogenesis Source: Ensembl
    2. intracellular signal transduction Source: InterPro
    3. labyrinthine layer blood vessel development Source: Ensembl
    4. lipid catabolic process Source: UniProtKB-KW
    5. regulation of cell proliferation Source: Ensembl

    Keywords - Molecular functioni

    HydrolaseUniRule annotation, TransducerSAAS annotation

    Keywords - Biological processi

    Lipid degradationUniRule annotation, Lipid metabolism

    Enzyme and pathway databases

    ReactomeiREACT_198661. Synthesis of IP3 and IP4 in the cytosol.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphoinositide phospholipase CUniRule annotation (EC:3.1.4.11UniRule annotation)
    Gene namesi
    Name:Plcd3Imported
    OrganismiRattus norvegicus (Rat)Imported
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 10

    Organism-specific databases

    RGDi1310903. Plcd3.

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: RGD
    2. membrane Source: RGD

    PTM / Processingi

    Proteomic databases

    PRIDEiD4A978.

    Structurei

    3D structure databases

    ProteinModelPortaliD4A978.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains 1 C2 domain.UniRule annotation
    Contains 1 PH domain.UniRule annotation
    Contains 1 PI-PLC X-box domain.UniRule annotation
    Contains 1 PI-PLC Y-box domain.UniRule annotation
    Contains C2 domain.SAAS annotation
    Contains PH domain.SAAS annotation
    Contains PI-PLC X-box domain.SAAS annotation
    Contains PI-PLC Y-box domain.SAAS annotation

    Phylogenomic databases

    GeneTreeiENSGT00740000114979.
    KOiK05857.
    OMAiHWGQTLQ.
    OrthoDBiEOG7V49XT.
    PhylomeDBiD4A978.
    TreeFamiTF313216.

    Family and domain databases

    Gene3Di1.10.238.10. 2 hits.
    2.30.29.30. 1 hit.
    2.60.40.150. 1 hit.
    3.20.20.190. 2 hits.
    InterProiIPR000008. C2_dom.
    IPR011992. EF-hand-dom_pair.
    IPR001849. PH_domain.
    IPR011993. PH_like_dom.
    IPR001192. PI-PLC_fam.
    IPR028406. PLC-delta3.
    IPR017946. PLC-like_Pdiesterase_TIM-brl.
    IPR015359. PLipase_C_EF-hand-like.
    IPR000909. PLipase_C_PInositol-sp_X_dom.
    IPR001711. PLipase_C_Pinositol-sp_Y.
    [Graphical view]
    PANTHERiPTHR10336. PTHR10336. 1 hit.
    PTHR10336:SF33. PTHR10336:SF33. 1 hit.
    PfamiPF00168. C2. 1 hit.
    PF09279. EF-hand_like. 1 hit.
    PF00388. PI-PLC-X. 1 hit.
    PF00387. PI-PLC-Y. 1 hit.
    [Graphical view]
    PRINTSiPR00390. PHPHLIPASEC.
    SMARTiSM00239. C2. 1 hit.
    SM00233. PH. 1 hit.
    SM00148. PLCXc. 1 hit.
    SM00149. PLCYc. 1 hit.
    [Graphical view]
    SUPFAMiSSF49562. SSF49562. 1 hit.
    SSF51695. SSF51695. 1 hit.
    PROSITEiPS50004. C2. 1 hit.
    PS50007. PIPLC_X_DOMAIN. 1 hit.
    PS50008. PIPLC_Y_DOMAIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    D4A978-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLCGGWRRSR RSPEEPRVSA QVAAPLAFLP SPASSDSSTK RPGLRALKKM    50
    GLTEDEDVQA MLRGSKLLKI RSRTWHKERL YRLQEDGLSV WFQRRIPRAA 100
    SQHIFFVQHI EAVREGHQSE GLRRFGGAFA PARCLTIAFK GRRKNLDLAA 150
    PTAEEAQRWV RGLAKLRARL DAMSQRERLD HAHTWIHSYL HRADSDQDSK 200
    MSFKEIKSLL RMVNVDMNDM YAYRLFKECD HSNNERLEGA EIEAFLRRLL 250
    KRPELEEIFR RYSGEDRVLS ASELLEFLED QGEDGATLAC AQKLIQTYEL 300
    NETAKQHELM TLDGFMMYLL SPEGAALNVA HTCVFQDMGQ PLAHYFISSS 350
    HNTYLTDSQI GGTSSTEAYI RAFTQGCRCV ELDCWEGPGG EPVIYHGHTL 400
    TSKILFRDVI QAVRDHAFTL SPYPVILSLE NHCGLEQQIV MARHLRNILG 450
    DMLVTQALDS QNPEELPSPE QLKCRVLVKG KKLPAARNED GRILSDREDE 500
    DEDEEEAEEA LETAEQRKRA KQISPELSAL VVYCCATRLR TLEPSPGPPQ 550
    PCKIGSLSER KARKFTREAG TSFVRHNTQQ LTRVYPLGLR MTSANYNPQE 600
    MWNSGCQLVA LNFQTPGYEM DLNTGRFLIN GQCGYVLKPA YLRQLNTTFD 650
    PECPGPPRTT LTVQVLTAQQ LPKLNVEKPN SIVDPLVRVE IYGVPEDCAH 700
    KETDYVLNNG FNPCWEQTLQ FQLRAPELVL VRFVVEDYDT TSPNDFVGQF 750
    TLPLNSLKQG YRHIHLLSKD GASLSPATLF VHIRIENS 788
    Length:788
    Mass (Da):89,471
    Last modified:April 20, 2010 - v1
    Checksum:i13904825D24E8E34
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR06065667 Genomic DNA. No translation available.
    AABR06065668 Genomic DNA. No translation available.
    RefSeqiNP_001099315.2. NM_001105845.2.
    UniGeneiRn.95716.

    Genome annotation databases

    EnsembliENSRNOT00000004140; ENSRNOP00000004140; ENSRNOG00000003033.
    GeneIDi287745.
    KEGGirno:287745.
    UCSCiRGD:1310903. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR06065667 Genomic DNA. No translation available.
    AABR06065668 Genomic DNA. No translation available.
    RefSeqi NP_001099315.2. NM_001105845.2.
    UniGenei Rn.95716.

    3D structure databases

    ProteinModelPortali D4A978.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi D4A978.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000004140 ; ENSRNOP00000004140 ; ENSRNOG00000003033 .
    GeneIDi 287745.
    KEGGi rno:287745.
    UCSCi RGD:1310903. rat.

    Organism-specific databases

    CTDi 113026.
    RGDi 1310903. Plcd3.

    Phylogenomic databases

    GeneTreei ENSGT00740000114979.
    KOi K05857.
    OMAi HWGQTLQ.
    OrthoDBi EOG7V49XT.
    PhylomeDBi D4A978.
    TreeFami TF313216.

    Enzyme and pathway databases

    Reactomei REACT_198661. Synthesis of IP3 and IP4 in the cytosol.

    Miscellaneous databases

    NextBioi 626929.

    Family and domain databases

    Gene3Di 1.10.238.10. 2 hits.
    2.30.29.30. 1 hit.
    2.60.40.150. 1 hit.
    3.20.20.190. 2 hits.
    InterProi IPR000008. C2_dom.
    IPR011992. EF-hand-dom_pair.
    IPR001849. PH_domain.
    IPR011993. PH_like_dom.
    IPR001192. PI-PLC_fam.
    IPR028406. PLC-delta3.
    IPR017946. PLC-like_Pdiesterase_TIM-brl.
    IPR015359. PLipase_C_EF-hand-like.
    IPR000909. PLipase_C_PInositol-sp_X_dom.
    IPR001711. PLipase_C_Pinositol-sp_Y.
    [Graphical view ]
    PANTHERi PTHR10336. PTHR10336. 1 hit.
    PTHR10336:SF33. PTHR10336:SF33. 1 hit.
    Pfami PF00168. C2. 1 hit.
    PF09279. EF-hand_like. 1 hit.
    PF00388. PI-PLC-X. 1 hit.
    PF00387. PI-PLC-Y. 1 hit.
    [Graphical view ]
    PRINTSi PR00390. PHPHLIPASEC.
    SMARTi SM00239. C2. 1 hit.
    SM00233. PH. 1 hit.
    SM00148. PLCXc. 1 hit.
    SM00149. PLCYc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49562. SSF49562. 1 hit.
    SSF51695. SSF51695. 1 hit.
    PROSITEi PS50004. C2. 1 hit.
    PS50007. PIPLC_X_DOMAIN. 1 hit.
    PS50008. PIPLC_Y_DOMAIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
      Rat Genome Sequencing Project Consortium
      Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
      , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
      Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Brown NorwayImported.
    2. Ensembl
      Submitted (JUL-2011) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: Brown NorwayImported.

    Entry informationi

    Entry nameiD4A978_RAT
    AccessioniPrimary (citable) accession number: D4A978
    Entry historyi
    Integrated into UniProtKB/TrEMBL: April 20, 2010
    Last sequence update: April 20, 2010
    Last modified: October 1, 2014
    This is version 46 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Caution

    The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3