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Protein

Phosphoinositide phospholipase C

Gene

Plcd3

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

HydrolaseUniRule annotation, TransducerSAAS annotation

Keywords - Biological processi

Lipid degradationUniRule annotation, Lipid metabolism

Enzyme and pathway databases

ReactomeiREACT_337837. Synthesis of IP3 and IP4 in the cytosol.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoinositide phospholipase CUniRule annotation (EC:3.1.4.11UniRule annotation)
Gene namesi
Name:Plcd3Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi1310903. Plcd3.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: RGD
  • membrane Source: RGD
Complete GO annotation...

PTM / Processingi

Proteomic databases

PRIDEiD4A978.

Expressioni

Gene expression databases

GenevisibleiD4A978. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000004140.

Structurei

3D structure databases

ProteinModelPortaliD4A978.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 C2 domain.UniRule annotation
Contains 1 PH domain.UniRule annotation
Contains 1 PI-PLC X-box domain.UniRule annotation
Contains 1 PI-PLC Y-box domain.UniRule annotation

Phylogenomic databases

GeneTreeiENSGT00760000118936.
InParanoidiD4A978.
KOiK05857.
OMAiNTQQLTR.
OrthoDBiEOG7V49XT.
PhylomeDBiD4A978.
TreeFamiTF313216.

Family and domain databases

Gene3Di1.10.238.10. 2 hits.
2.30.29.30. 1 hit.
2.60.40.150. 1 hit.
3.20.20.190. 2 hits.
InterProiIPR000008. C2_dom.
IPR011992. EF-hand-dom_pair.
IPR011993. PH-like_dom.
IPR001849. PH_domain.
IPR001192. PI-PLC_fam.
IPR028406. PLC-delta3.
IPR017946. PLC-like_Pdiesterase_TIM-brl.
IPR015359. PLipase_C_EF-hand-like.
IPR000909. PLipase_C_PInositol-sp_X_dom.
IPR001711. PLipase_C_Pinositol-sp_Y.
[Graphical view]
PANTHERiPTHR10336. PTHR10336. 1 hit.
PTHR10336:SF33. PTHR10336:SF33. 1 hit.
PfamiPF00168. C2. 1 hit.
PF09279. EF-hand_like. 1 hit.
PF00388. PI-PLC-X. 1 hit.
PF00387. PI-PLC-Y. 1 hit.
[Graphical view]
PRINTSiPR00390. PHPHLIPASEC.
SMARTiSM00239. C2. 1 hit.
SM00233. PH. 1 hit.
SM00148. PLCXc. 1 hit.
SM00149. PLCYc. 1 hit.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 1 hit.
SSF51695. SSF51695. 1 hit.
PROSITEiPS50004. C2. 1 hit.
PS50007. PIPLC_X_DOMAIN. 1 hit.
PS50008. PIPLC_Y_DOMAIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D4A978-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLCGGWRRSR RSPEEPRVSA QVAAPLAFLP SPASSDSSTK RPGLRALKKM
60 70 80 90 100
GLTEDEDVQA MLRGSKLLKI RSRTWHKERL YRLQEDGLSV WFQRRIPRAA
110 120 130 140 150
SQHIFFVQHI EAVREGHQSE GLRRFGGAFA PARCLTIAFK GRRKNLDLAA
160 170 180 190 200
PTAEEAQRWV RGLAKLRARL DAMSQRERLD HAHTWIHSYL HRADSDQDSK
210 220 230 240 250
MSFKEIKSLL RMVNVDMNDM YAYRLFKECD HSNNERLEGA EIEAFLRRLL
260 270 280 290 300
KRPELEEIFR RYSGEDRVLS ASELLEFLED QGEDGATLAC AQKLIQTYEL
310 320 330 340 350
NETAKQHELM TLDGFMMYLL SPEGAALNVA HTCVFQDMGQ PLAHYFISSS
360 370 380 390 400
HNTYLTDSQI GGTSSTEAYI RAFTQGCRCV ELDCWEGPGG EPVIYHGHTL
410 420 430 440 450
TSKILFRDVI QAVRDHAFTL SPYPVILSLE NHCGLEQQIV MARHLRNILG
460 470 480 490 500
DMLVTQALDS QNPEELPSPE QLKCRVLVKG KKLPAARNED GRILSDREDE
510 520 530 540 550
DEDEEEAEEA LETAEQRKRA KQISPELSAL VVYCCATRLR TLEPSPGPPQ
560 570 580 590 600
PCKIGSLSER KARKFTREAG TSFVRHNTQQ LTRVYPLGLR MTSANYNPQE
610 620 630 640 650
MWNSGCQLVA LNFQTPGYEM DLNTGRFLIN GQCGYVLKPA YLRQLNTTFD
660 670 680 690 700
PECPGPPRTT LTVQVLTAQQ LPKLNVEKPN SIVDPLVRVE IYGVPEDCAH
710 720 730 740 750
KETDYVLNNG FNPCWEQTLQ FQLRAPELVL VRFVVEDYDT TSPNDFVGQF
760 770 780
TLPLNSLKQG YRHIHLLSKD GASLSPATLF VHIRIENS
Length:788
Mass (Da):89,471
Last modified:April 20, 2010 - v1
Checksum:i13904825D24E8E34
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC107153 Genomic DNA. No translation available.
RefSeqiNP_001099315.2. NM_001105845.2.
UniGeneiRn.95716.

Genome annotation databases

EnsembliENSRNOT00000004140; ENSRNOP00000004140; ENSRNOG00000003033.
GeneIDi287745.
KEGGirno:287745.
UCSCiRGD:1310903. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC107153 Genomic DNA. No translation available.
RefSeqiNP_001099315.2. NM_001105845.2.
UniGeneiRn.95716.

3D structure databases

ProteinModelPortaliD4A978.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000004140.

Proteomic databases

PRIDEiD4A978.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000004140; ENSRNOP00000004140; ENSRNOG00000003033.
GeneIDi287745.
KEGGirno:287745.
UCSCiRGD:1310903. rat.

Organism-specific databases

CTDi113026.
RGDi1310903. Plcd3.

Phylogenomic databases

GeneTreeiENSGT00760000118936.
InParanoidiD4A978.
KOiK05857.
OMAiNTQQLTR.
OrthoDBiEOG7V49XT.
PhylomeDBiD4A978.
TreeFamiTF313216.

Enzyme and pathway databases

ReactomeiREACT_337837. Synthesis of IP3 and IP4 in the cytosol.

Miscellaneous databases

NextBioi626929.

Gene expression databases

GenevisibleiD4A978. RN.

Family and domain databases

Gene3Di1.10.238.10. 2 hits.
2.30.29.30. 1 hit.
2.60.40.150. 1 hit.
3.20.20.190. 2 hits.
InterProiIPR000008. C2_dom.
IPR011992. EF-hand-dom_pair.
IPR011993. PH-like_dom.
IPR001849. PH_domain.
IPR001192. PI-PLC_fam.
IPR028406. PLC-delta3.
IPR017946. PLC-like_Pdiesterase_TIM-brl.
IPR015359. PLipase_C_EF-hand-like.
IPR000909. PLipase_C_PInositol-sp_X_dom.
IPR001711. PLipase_C_Pinositol-sp_Y.
[Graphical view]
PANTHERiPTHR10336. PTHR10336. 1 hit.
PTHR10336:SF33. PTHR10336:SF33. 1 hit.
PfamiPF00168. C2. 1 hit.
PF09279. EF-hand_like. 1 hit.
PF00388. PI-PLC-X. 1 hit.
PF00387. PI-PLC-Y. 1 hit.
[Graphical view]
PRINTSiPR00390. PHPHLIPASEC.
SMARTiSM00239. C2. 1 hit.
SM00233. PH. 1 hit.
SM00148. PLCXc. 1 hit.
SM00149. PLCYc. 1 hit.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 1 hit.
SSF51695. SSF51695. 1 hit.
PROSITEiPS50004. C2. 1 hit.
PS50007. PIPLC_X_DOMAIN. 1 hit.
PS50008. PIPLC_Y_DOMAIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Rat Genome Sequencing Project Consortium
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown NorwayImported.
  2. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: Brown NorwayImported.
  3. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiD4A978_RAT
AccessioniPrimary (citable) accession number: D4A978
Entry historyi
Integrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: July 22, 2015
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.