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D4A978

- D4A978_RAT

UniProt

D4A978 - D4A978_RAT

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Protein

Phosphoinositide phospholipase C

Gene

Plcd3

Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 3 out of 5- Protein predictedi

Functioni

Catalytic activityi

1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.UniRule annotation

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
  2. phosphatidylinositol phospholipase C activity Source: UniProtKB-EC
  3. signal transducer activity Source: UniProtKB-KW

GO - Biological processi

  1. angiogenesis Source: Ensembl
  2. intracellular signal transduction Source: InterPro
  3. labyrinthine layer blood vessel development Source: Ensembl
  4. lipid catabolic process Source: UniProtKB-KW
  5. regulation of cell proliferation Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

HydrolaseUniRule annotation, TransducerSAAS annotation

Keywords - Biological processi

Lipid degradationUniRule annotation, Lipid metabolism

Enzyme and pathway databases

ReactomeiREACT_198661. Synthesis of IP3 and IP4 in the cytosol.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoinositide phospholipase CUniRule annotation (EC:3.1.4.11UniRule annotation)
Gene namesi
Name:Plcd3Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 10

Organism-specific databases

RGDi1310903. Plcd3.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: RGD
  2. membrane Source: RGD
Complete GO annotation...

PTM / Processingi

Proteomic databases

PRIDEiD4A978.

Structurei

3D structure databases

ProteinModelPortaliD4A978.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 C2 domain.UniRule annotation
Contains 1 PH domain.UniRule annotation
Contains 1 PI-PLC X-box domain.UniRule annotation
Contains 1 PI-PLC Y-box domain.UniRule annotation
Contains C2 domain.SAAS annotation
Contains Cdomain.SAAS annotation
Contains PH domain.SAAS annotation
Contains PI-PLC X-box domain.SAAS annotation
Contains PI-PLC Y-box domain.SAAS annotation

Phylogenomic databases

GeneTreeiENSGT00760000118936.
InParanoidiD4A978.
KOiK05857.
OMAiHWGQTLQ.
OrthoDBiEOG7V49XT.
PhylomeDBiD4A978.
TreeFamiTF313216.

Family and domain databases

Gene3Di1.10.238.10. 2 hits.
2.30.29.30. 1 hit.
2.60.40.150. 1 hit.
3.20.20.190. 2 hits.
InterProiIPR000008. C2_dom.
IPR011992. EF-hand-dom_pair.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR001192. PI-PLC_fam.
IPR028406. PLC-delta3.
IPR017946. PLC-like_Pdiesterase_TIM-brl.
IPR015359. PLipase_C_EF-hand-like.
IPR000909. PLipase_C_PInositol-sp_X_dom.
IPR001711. PLipase_C_Pinositol-sp_Y.
[Graphical view]
PANTHERiPTHR10336. PTHR10336. 1 hit.
PTHR10336:SF33. PTHR10336:SF33. 1 hit.
PfamiPF00168. C2. 1 hit.
PF09279. EF-hand_like. 1 hit.
PF00388. PI-PLC-X. 1 hit.
PF00387. PI-PLC-Y. 1 hit.
[Graphical view]
PRINTSiPR00390. PHPHLIPASEC.
SMARTiSM00239. C2. 1 hit.
SM00233. PH. 1 hit.
SM00148. PLCXc. 1 hit.
SM00149. PLCYc. 1 hit.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 1 hit.
SSF51695. SSF51695. 1 hit.
PROSITEiPS50004. C2. 1 hit.
PS50007. PIPLC_X_DOMAIN. 1 hit.
PS50008. PIPLC_Y_DOMAIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D4A978-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLCGGWRRSR RSPEEPRVSA QVAAPLAFLP SPASSDSSTK RPGLRALKKM
60 70 80 90 100
GLTEDEDVQA MLRGSKLLKI RSRTWHKERL YRLQEDGLSV WFQRRIPRAA
110 120 130 140 150
SQHIFFVQHI EAVREGHQSE GLRRFGGAFA PARCLTIAFK GRRKNLDLAA
160 170 180 190 200
PTAEEAQRWV RGLAKLRARL DAMSQRERLD HAHTWIHSYL HRADSDQDSK
210 220 230 240 250
MSFKEIKSLL RMVNVDMNDM YAYRLFKECD HSNNERLEGA EIEAFLRRLL
260 270 280 290 300
KRPELEEIFR RYSGEDRVLS ASELLEFLED QGEDGATLAC AQKLIQTYEL
310 320 330 340 350
NETAKQHELM TLDGFMMYLL SPEGAALNVA HTCVFQDMGQ PLAHYFISSS
360 370 380 390 400
HNTYLTDSQI GGTSSTEAYI RAFTQGCRCV ELDCWEGPGG EPVIYHGHTL
410 420 430 440 450
TSKILFRDVI QAVRDHAFTL SPYPVILSLE NHCGLEQQIV MARHLRNILG
460 470 480 490 500
DMLVTQALDS QNPEELPSPE QLKCRVLVKG KKLPAARNED GRILSDREDE
510 520 530 540 550
DEDEEEAEEA LETAEQRKRA KQISPELSAL VVYCCATRLR TLEPSPGPPQ
560 570 580 590 600
PCKIGSLSER KARKFTREAG TSFVRHNTQQ LTRVYPLGLR MTSANYNPQE
610 620 630 640 650
MWNSGCQLVA LNFQTPGYEM DLNTGRFLIN GQCGYVLKPA YLRQLNTTFD
660 670 680 690 700
PECPGPPRTT LTVQVLTAQQ LPKLNVEKPN SIVDPLVRVE IYGVPEDCAH
710 720 730 740 750
KETDYVLNNG FNPCWEQTLQ FQLRAPELVL VRFVVEDYDT TSPNDFVGQF
760 770 780
TLPLNSLKQG YRHIHLLSKD GASLSPATLF VHIRIENS
Length:788
Mass (Da):89,471
Last modified:April 20, 2010 - v1
Checksum:i13904825D24E8E34
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AABR06065667 Genomic DNA. No translation available.
AABR06065668 Genomic DNA. No translation available.
RefSeqiNP_001099315.2. NM_001105845.2.
UniGeneiRn.95716.

Genome annotation databases

EnsembliENSRNOT00000004140; ENSRNOP00000004140; ENSRNOG00000003033.
GeneIDi287745.
KEGGirno:287745.
UCSCiRGD:1310903. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AABR06065667 Genomic DNA. No translation available.
AABR06065668 Genomic DNA. No translation available.
RefSeqi NP_001099315.2. NM_001105845.2.
UniGenei Rn.95716.

3D structure databases

ProteinModelPortali D4A978.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi D4A978.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000004140 ; ENSRNOP00000004140 ; ENSRNOG00000003033 .
GeneIDi 287745.
KEGGi rno:287745.
UCSCi RGD:1310903. rat.

Organism-specific databases

CTDi 113026.
RGDi 1310903. Plcd3.

Phylogenomic databases

GeneTreei ENSGT00760000118936.
InParanoidi D4A978.
KOi K05857.
OMAi HWGQTLQ.
OrthoDBi EOG7V49XT.
PhylomeDBi D4A978.
TreeFami TF313216.

Enzyme and pathway databases

Reactomei REACT_198661. Synthesis of IP3 and IP4 in the cytosol.

Miscellaneous databases

NextBioi 626929.

Family and domain databases

Gene3Di 1.10.238.10. 2 hits.
2.30.29.30. 1 hit.
2.60.40.150. 1 hit.
3.20.20.190. 2 hits.
InterProi IPR000008. C2_dom.
IPR011992. EF-hand-dom_pair.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR001192. PI-PLC_fam.
IPR028406. PLC-delta3.
IPR017946. PLC-like_Pdiesterase_TIM-brl.
IPR015359. PLipase_C_EF-hand-like.
IPR000909. PLipase_C_PInositol-sp_X_dom.
IPR001711. PLipase_C_Pinositol-sp_Y.
[Graphical view ]
PANTHERi PTHR10336. PTHR10336. 1 hit.
PTHR10336:SF33. PTHR10336:SF33. 1 hit.
Pfami PF00168. C2. 1 hit.
PF09279. EF-hand_like. 1 hit.
PF00388. PI-PLC-X. 1 hit.
PF00387. PI-PLC-Y. 1 hit.
[Graphical view ]
PRINTSi PR00390. PHPHLIPASEC.
SMARTi SM00239. C2. 1 hit.
SM00233. PH. 1 hit.
SM00148. PLCXc. 1 hit.
SM00149. PLCYc. 1 hit.
[Graphical view ]
SUPFAMi SSF49562. SSF49562. 1 hit.
SSF51695. SSF51695. 1 hit.
PROSITEi PS50004. C2. 1 hit.
PS50007. PIPLC_X_DOMAIN. 1 hit.
PS50008. PIPLC_Y_DOMAIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Rat Genome Sequencing Project Consortium
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown NorwayImported.
  2. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: Brown NorwayImported.

Entry informationi

Entry nameiD4A978_RAT
AccessioniPrimary (citable) accession number: D4A978
Entry historyi
Integrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: October 29, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3