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Protein

Anoctamin

Gene

Ano1

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

GO - Molecular functioni

  • calcium activated cation channel activity Source: Ensembl
  • intracellular calcium activated chloride channel activity Source: RGD
  • iodide transmembrane transporter activity Source: UniProtKB
  • protein dimerization activity Source: InterPro

GO - Biological processi

  • cellular response to heat Source: InterPro
  • chloride transport Source: UniProtKB
  • iodide transport Source: UniProtKB
  • positive regulation of insulin secretion involved in cellular response to glucose stimulus Source: Ensembl

Enzyme and pathway databases

ReactomeiR-RNO-2672351 Stimuli-sensing channels

Names & Taxonomyi

Protein namesi
Recommended name:
AnoctaminUniRule annotation
Gene namesi
Name:Ano1Imported
Synonyms:Tmem16a_predictedImported
ORF Names:rCG_47753Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi1310786 Ano1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei411 – 435HelicalUniRule annotationAdd BLAST25
Transmembranei488 – 507HelicalUniRule annotationAdd BLAST20
Transmembranei570 – 596HelicalUniRule annotationAdd BLAST27
Transmembranei616 – 640HelicalUniRule annotationAdd BLAST25
Transmembranei660 – 681HelicalUniRule annotationAdd BLAST22
Transmembranei786 – 809HelicalUniRule annotationAdd BLAST24

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PeptideAtlasiD4A915

Expressioni

Gene expression databases

BgeeiENSRNOG00000020865
ExpressionAtlasiD4A915 baseline and differential

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000028329

Structurei

3D structure databases

SMRiD4A915
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini112 – 397Anoct_dimerInterPro annotationAdd BLAST286

Sequence similaritiesi

Belongs to the anoctamin family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

eggNOGiKOG2514 Eukaryota
ENOG410XS4S LUCA
GeneTreeiENSGT00760000119015
KOiK19496
OMAiDPDAECK
OrthoDBiEOG091G01JF
TreeFamiTF314265

Family and domain databases

InterProiView protein in InterPro
IPR032394 Anoct_dimer
IPR007632 Anoctamin
IPR031287 Anoctamin-1
PANTHERiPTHR12308 PTHR12308, 1 hit
PTHR12308:SF13 PTHR12308:SF13, 1 hit
PfamiView protein in Pfam
PF16178 Anoct_dimer, 1 hit
PF04547 Anoctamin, 1 hit

Sequencei

Sequence statusi: Complete.

D4A915-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQDTQDSDIS LEGLTREGAP ADRECQRGPE TIVHEAQDAG TPNSGDATGA
60 70 80 90 100
VDGEREATMR VPEKYSTLPA EDRSVHIVNI CAIEDLGYLP SEGTLLNSLS
110 120 130 140 150
VDPDAECKYG LYFRDGKRKV DYILVYHHKR ASGSRTLARR GLQNDMVLGT
160 170 180 190 200
RSVRQDQPLP GKGSPVDVGS PEAPMDYHED DKRFRREEYE GNLLEAGLEL
210 220 230 240 250
ERDEDTKIHG VGFVKIHAPW HVLCREAEFL KLKMPTKKVY HISETRGLLK
260 270 280 290 300
TINSVLQKIT DPIQPKVAEH RPQTTKRLSY PFSREKQHLF DLTDRDSFFD
310 320 330 340 350
SKTRSTIVYE ILKRTTCTKA KYSMGQGEGR RKDSALLSKR RKCGKYGITS
360 370 380 390 400
LLANGVYSAA YPLHDGDYEG DNVEFNDRKL LYEEWASYGV FYKYQPIDLV
410 420 430 440 450
RKYFGEKVGL YFAWLGAYTQ MLIPASIVGV IVFLYGCATV DENIPSMEMC
460 470 480 490 500
DQRHNITMCP LCDKTCSYWK MSSACATARA SHLFDNPATV FFSVFMALWA
510 520 530 540 550
ATFMEHWKRK QMRLNYRWDL TGFEEEEVSS CDHPRAEYEA RVLEKSLRKE
560 570 580 590 600
SRNKETDKVK LTWRDRFPAY FTNLVSIIFM IAVTFAIVLG VIIYRISTAA
610 620 630 640 650
ALAMNSSPSV RSNIRVTVTA TAVIINLVVI ILLDEVYGCI ARWLTKIEVP
660 670 680 690 700
KTEKSFEERL TFKAFLLKFV NSYTPIFYVA FFKGRFVGRP GDYVYIFRSF
710 720 730 740 750
RMEECAPGGC LMELCIQLSI IMLGKQLIQN NLFEIGIPKM KKFIRYLKLR
760 770 780 790 800
RQSPSDREEY IKRKQRYEVD FNLEPFAGLT PEYMEMIIQF GFVTLFVASF
810 820 830 840 850
PLAPLFALLN NIIEIRLDAK KFVTELRRPV AIRAKDIGIW YNILRGVGKL
860 870 880 890 900
AVIINAFVIS FTSDFIPRLV YLYMYSQNGT MHGFVNHTLS SFNVSDFQNG
910 920 930 940 950
TAPNDPLDLG YEVQICRYKD YREPPWSEHK YDISKDFWAV LAARLAFVIV
960 970 980 990 1000
FQNLVMFMSD FVDWVIPDIP KDISQQIHKE KVLMVELFMR EEQGKQQLLD
1010 1020 1030 1040
TWMEKEKPRD VPCNNHSPTA HPEAGDSSPV PSYEYHGGAL
Length:1,040
Mass (Da):119,352
Last modified:April 20, 2010 - v1
Checksum:i796B03A576DB233E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07072010 Genomic DNA No translation available.
AC095937 Genomic DNA No translation available.
AC110851 Genomic DNA No translation available.
CH473953 Genomic DNA Translation: EDM12245.1
RefSeqiNP_001101034.1, NM_001107564.1
UniGeneiRn.162509

Genome annotation databases

EnsembliENSRNOT00000028329; ENSRNOP00000028329; ENSRNOG00000020865
GeneIDi309135
KEGGirno:309135
UCSCiRGD:1310786 rat

Similar proteinsi

Entry informationi

Entry nameiD4A915_RAT
AccessioniPrimary (citable) accession number: D4A915
Entry historyiIntegrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: May 23, 2018
This is version 74 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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Main funding by: National Institutes of Health