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Protein
Submitted name:

Cytoplasmic FMR1 interacting protein 1 (Predicted)

Gene

Cyfip1

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • protein complex binding Source: Ensembl
  • Rac GTPase binding Source: Ensembl
  • RNA 7-methylguanosine cap binding Source: RGD

GO - Biological processi

  • axon extension Source: Ensembl
  • cellular response to insulin stimulus Source: RGD
  • cognition Source: Ensembl
  • dendrite extension Source: Ensembl
  • lamellipodium assembly Source: Ensembl
  • modification of synaptic structure Source: Ensembl
  • negative regulation of synaptic vesicle recycling Source: RGD
  • positive regulation of Arp2/3 complex-mediated actin nucleation Source: Ensembl
  • positive regulation of axon extension Source: RGD
  • positive regulation of axonogenesis Source: RGD
  • positive regulation of dendrite development Source: RGD
  • positive regulation of neurotrophin TRK receptor signaling pathway Source: Ensembl
  • positive regulation of ruffle assembly Source: RGD
  • Rac protein signal transduction Source: Ensembl
  • regulation of translation Source: Ensembl
  • response to electrical stimulus Source: RGD

Enzyme and pathway databases

ReactomeiR-RNO-2029482. Regulation of actin dynamics for phagocytic cup formation.
R-RNO-4420097. VEGFA-VEGFR2 Pathway.
R-RNO-5663213. RHO GTPases Activate WASPs and WAVEs.
R-RNO-6798695. Neutrophil degranulation.

Names & Taxonomyi

Protein namesi
Submitted name:
Cytoplasmic FMR1 interacting protein 1 (Predicted)Imported
Submitted name:
Cytoplasmic FMR1-interacting protein 1Imported
Gene namesi
Name:Cyfip1Imported
Synonyms:Cyfip1_predictedImported
ORF Names:rCG_45119Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi1310332. Cyfip1.

Subcellular locationi

GO - Cellular componenti

  • axonal growth cone Source: RGD
  • central region of growth cone Source: RGD
  • cytoplasm Source: RGD
  • dendritic growth cone Source: RGD
  • dendritic spine Source: SynGO
  • excitatory synapse Source: RGD
  • extracellular exosome Source: Ensembl
  • filopodium tip Source: RGD
  • focal adhesion Source: Ensembl
  • lamellipodium Source: Ensembl
  • mRNA cap binding complex Source: Ensembl
  • neuronal cell body Source: RGD
  • perinuclear region of cytoplasm Source: Ensembl
  • peripheral region of growth cone Source: RGD
  • SCAR complex Source: Ensembl
  • terminal bouton Source: RGD

Expressioni

Gene expression databases

BgeeiENSRNOG00000011945.
ExpressionAtlasiD4A8H8. baseline and differential.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000016376.

Family & Domainsi

Phylogenomic databases

eggNOGiKOG3534. Eukaryota.
ENOG410XPKW. LUCA.
GeneTreeiENSGT00500000044831.
KOiK05749.
OMAiNDIVQYP.
OrthoDBiEOG091G0105.
TreeFamiTF312925.

Family and domain databases

InterProiView protein in InterPro
IPR008081. Cytoplasmic_FMR1-int.
IPR009828. DUF1394.
PANTHERiPTHR12195. PTHR12195. 1 hit.
PfamiView protein in Pfam
PF07159. DUF1394. 1 hit.
PF05994. FragX_IP. 1 hit.
PIRSFiPIRSF008153. FMR1_interacting. 1 hit.
PRINTSiPR01698. CYTOFMRPINTP.

Sequencei

Sequence statusi: Complete.

D4A8H8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAQVTLEDA LSNVDLLEEL PLPDQQPCIE PPPSSLLYQP NFNTNFEDRN
60 70 80 90 100
AFVTGIARYI EQATVHSSMN EMLEEGQEYA VMLYTWRSCS RAIPQVKCNE
110 120 130 140 150
QPNRVEIYEK TVEVLEPEVT KLMNFMYFQR NAIERFCGEV RRLCHAERRK
160 170 180 190 200
DFVSEAYLIT LGKFINMFAV LDELKNMKCS VKNDHSAYKR AAQFLRKMAD
210 220 230 240 250
PQSIQESQNL SMFLANHNKI TQSLQQQLEV ISGYEELLAD IVNLCVDYYE
260 270 280 290 300
NRMYLTPSEK HMLLKVMGFG LYLMDGSVSN IYKLDAKKRI NLSKIDKYFK
310 320 330 340 350
QLQVVPLFGD MQIELARYIK TSAHYEENKS RWTCTSSSSS PQYNICEQMI
360 370 380 390 400
QIREDHMRFI SELARYSNSE VVTGSGRQEA QKTDAEYRKL FDLALQGLQL
410 420 430 440 450
LSQWSAHVME VYSWKLVHPT DKYSNKDCPD NAEEYERATR YNYTTEEKFA
460 470 480 490 500
LVEVIAMIKG LQVLMGRMES VFNHAIRHTV YAALQDFSQV TLREPLRQAI
510 520 530 540 550
KKKKNVIQSV LQAIRKTVCD WETGHEPFND PALRGEKDPK SGFDIKVPRR
560 570 580 590 600
AVGPSSTQLY MVRTMLESLI ADKSGSKKTL RSSLEGPTIL DIEKFHRESF
610 620 630 640 650
FYTHLINFSE TLQQCCDLSQ LWFREFFLEL TMGRRIQFPI EMSMPWILTD
660 670 680 690 700
HILETKEASM MEYVLYSLDL YNDSAHYALT KFNKQFLYDE IEAEVNLCFD
710 720 730 740 750
QFVYKLADQI FAYYKVMAGS LLLDKRLRSE CKNQGATIHL PPSNRYETLL
760 770 780 790 800
KQRHVQLLGR SIDLNRLITQ RVSAAMYKSL ELAIGRFESE DLTSVVELDG
810 820 830 840 850
LLEINRMTHK LLSRYLTLDS FDAMFREANH NVSAPYGRIT LHVFWELNYD
860 870 880 890 900
FLPNYCYNGS TNRFVRTVLP FSQEFQRDKQ PNAQPQYLHG SKALNLAYSS
910 920 930 940 950
IYGSYRNFVG PPHFQVICRL LGYQGIAVVM EELLKVVKSL LQGTILQYVK
960 970 980 990 1000
TLMEVMPKIC RLPRHEYGSP GILEFFHHQL KDIVEYAELK TVCFQNLREV
1010 1020 1030 1040 1050
GNAVLFCLLI EQSLSLEEVC DLLHAAPFQN ILPRVHVKEG ERVDAKMKRL
1060 1070 1080 1090 1100
ESKYAPLHLV PLIERLGTPQ QIAIAREGDL LTKERLCCGL SMFEVILTRI
1110 1120 1130 1140 1150
RTFLDDPIWR GPLPSNGVMH VDECVEFHRL WSAMQFVYCI PVGTHEFTVE
1160 1170 1180 1190 1200
QCFGDGLHWA GCMIIVLLGQ QRRFAVLDFC YHLLKVQKHD GKDEIIKNVP
1210 1220 1230 1240 1250
LKKMVERIRK FQILNDEIIT ILDKYLKSGD GESTPVEHVR CFQPPIHQSL

ASS
Length:1,253
Mass (Da):145,257
Last modified:April 20, 2010 - v1
Checksum:i8FFA98BE785322D9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07003539 Genomic DNA. No translation available.
CH474036 Genomic DNA. Translation: EDL86460.1.
RefSeqiNP_001100987.1. NM_001107517.1.
UniGeneiRn.143776.

Genome annotation databases

EnsembliENSRNOT00000016376; ENSRNOP00000016376; ENSRNOG00000011945.
GeneIDi308666.
KEGGirno:308666.
UCSCiRGD:1310332. rat.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiD4A8H8_RAT
AccessioniPrimary (citable) accession number: D4A8H8
Entry historyiIntegrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: July 5, 2017
This is version 58 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported