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Protein

Zinc finger FYVE domain-containing protein 26

Gene

Zfyve26

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Phosphatidylinositol 3-phosphate-binding protein required for the abcission step in cytokinesis: recruited to the midbody during cytokinesis and acts as a regulator of abcission. May also be required for efficient homologous recombination DNA double-strand break repair (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri1815 – 187561FYVE-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, DNA damage, DNA repair

Keywords - Ligandi

Lipid-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger FYVE domain-containing protein 26
Gene namesi
Name:Zfyve26
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1307820. Zfyve26.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 25422542Zinc finger FYVE domain-containing protein 26PRO_0000408352Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei612 – 6121PhosphoserineCombined sources
Modified residuei616 – 6161PhosphoserineCombined sources
Modified residuei1739 – 17391PhosphoserineBy similarity
Modified residuei1783 – 17831PhosphoserineBy similarity
Modified residuei1785 – 17851PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiD4A8G9.
PRIDEiD4A8G9.

PTM databases

iPTMnetiD4A8G9.

Interactioni

Subunit structurei

Interacts with AP5Z1, AP5B1, AP5S1 and SPG11. Interacts with TTC19 and KIF13A (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000016380.

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili866 – 89126Sequence analysisAdd
BLAST
Coiled coili1495 – 152228Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi752 – 78029Arg-richAdd
BLAST

Domaini

The FYVE-type zinc finger mediates binding to phosphatidylinositol 3-phosphate and recruitment to the midbody during cytokinesis.By similarity

Sequence similaritiesi

Belongs to the ZFYVE26 family.Curated
Contains 1 FYVE-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri1815 – 187561FYVE-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiKOG1811. Eukaryota.
ENOG410XRV7. LUCA.
InParanoidiD4A8G9.
KOiK19027.
PhylomeDBiD4A8G9.
TreeFamiTF324517.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR028730. ZFYVE26.
IPR000306. Znf_FYVE.
IPR017455. Znf_FYVE-rel.
IPR011011. Znf_FYVE_PHD.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PANTHERiPTHR22835:SF279. PTHR22835:SF279. 2 hits.
PfamiPF01363. FYVE. 1 hit.
[Graphical view]
SMARTiSM00064. FYVE. 1 hit.
[Graphical view]
SUPFAMiSSF57903. SSF57903. 1 hit.
PROSITEiPS50178. ZF_FYVE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D4A8G9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSYPFGKEET TTEKQLFEFF CECLRRGDWE LAQACVPQLQ RGQGEIPQKV
60 70 80 90 100
EDILQALVQC PILLRCGPDI NPQRLAWLWL LVLEKWLPPE KKLLSTVFRR
110 120 130 140 150
KLEFLFLSED LQGGIPETIL KELFETLAQG PAGCTSDRSQ RWESGAPQLS
160 170 180 190 200
PEAVSMLWNL LKQAPGPAQA LLELLLEERH SASLCHSSLQ KSLLDLIRKA
210 220 230 240 250
LQTLRDPASQ PAGVTDAVCG ALQALCCTAE LPEGEWHVLC EELLETCRTE
260 270 280 290 300
GSPLKEERLL GCLLHKAGRS LLSLYGHTYA EKVAERPPKA SLSGKDHPDP
310 320 330 340 350
ERAMLALFST PDPAHAWKMA FFYCLSNNKH FLEQILVTAL TLLKEEDFPS
360 370 380 390 400
LGYLLDREFR PLSHLLVLLG WTHCQSLESA KRLLQTLYRN QDQGHDELLR
410 420 430 440 450
DACEGLWAHL EVLEWCVQQS SSLIPKRELL CHLHGGDSHS VLYSLHHLTN
460 470 480 490 500
LPALREEEVL KLLQKVPTKD LQGEHDTHDA SVPEHLSQCQ SLTLYQGFCA
510 520 530 540 550
MKYAVYALCV NSHQHSQCPD CRDSASSEEL ALVEPGRDSL PSPGASHLFP
560 570 580 590 600
TYLARCRQYL QRIPDSLCLE ILENIFSLLL ITSADLHPEP HLPEDYAEDD
610 620 630 640 650
DIEGKGPWGL WSPSESPQHI AATERRSERA SMGPRDLAPT GPGCPKGEPK
660 670 680 690 700
DNSPGPHTHS FLDLKHFTSS LSGFLADEFA IGAFLSLIQE QLNELSSHRT
710 720 730 740 750
PEETELLEDQ SCWAARDGLQ GRLHRFSKVL SEAQWRYKVV TSNQSSEEQP
760 770 780 790 800
SRRYRPTAKR HSSLRRGRRT RRTRADGRER GSNPSLEGTS SELSTSTSEG
810 820 830 840 850
SLSAVSGQVE ADNRFQPQPQ SSIIPMMFSP PESLLASCIL RGNFAEAHQV
860 870 880 890 900
VLMFNLKSSP SAGELMFVER YQEVIQELAR VEHKIENQNS DGGNNTVRRT
910 920 930 940 950
GSGRSTLQAI GSAAAAGMVF YSISDVTDKL LSPSEDPIPT LQEDFWINAA
960 970 980 990 1000
LTETNTPLRG VLEDLSPPAM AAFDLACCQC QLWKTCKQLL ETAERRLSSS
1010 1020 1030 1040 1050
LEGRGRRLDQ VVLNPDGMRG FPFVLQQISK ILSYPLTVTG LTKSETLEER
1060 1070 1080 1090 1100
GGGAPRCSIS ELLQMCWPSL TEDCIASHTS LSQQLDQALQ SLREALTLSE
1110 1120 1130 1140 1150
PKSTPLTCLV EQAAQKAPEA EAHPVHIQSQ LLQKTLGKQT LAGPRQTDYV
1160 1170 1180 1190 1200
GAFFSYCSSL AKVLLRSLSS DPDNVEVKVG NPFVLLQQSS SQLVSHLLLE
1210 1220 1230 1240 1250
RQVPPDRLAA LLAQEHLNLS VPQVIVSCCC EPLTLCLSRQ SQQASSLTAH
1260 1270 1280 1290 1300
LGMLAQGHAS HLLDGLPLSV LGSPRPSENP SAERKSDSSP KDSLPAFTAS
1310 1320 1330 1340 1350
ALAFLKSRSK ILAMVACLRA SRGTKVSRPS LSWKELRGRR EAPLTAEKVA
1360 1370 1380 1390 1400
QECEHLLEQF PVFEAALLAN WEPLQQASES RPSLAASLCG QARLSTVLLG
1410 1420 1430 1440 1450
LHSTLAQDVV TEAFEEALVA RDWPRALQLI DVYGQDSDDL SSVRDSVLTC
1460 1470 1480 1490 1500
ATVCDKEGWQ YLFPVKDASL RSQLALRFVD KWPLESCLEI LAYCVSDMAV
1510 1520 1530 1540 1550
PEELKSELQR KLTELRVYQK ILGLQDPPVW CDWQTLRSCC AEDPSTVMDM
1560 1570 1580 1590 1600
MLGSQEYELC EEWGCLYPIP REHLVSLHHK HLLYLLERRE YEKALQLLQR
1610 1620 1630 1640 1650
IPDPTMCLEV TERSLDQHPS LATSHFLANY LTSHFYGELT TDRHHEIQAL
1660 1670 1680 1690 1700
YMGSKVLLTL PEQHRASYAH LSSSPLLMLE QLLMNMKVDW ATTAVQTLQQ
1710 1720 1730 1740 1750
LLAGQDIGFT LDEVDSLLSR YAGKALDLPY PLREKRSDSM IHLQEPVHQA
1760 1770 1780 1790 1800
SDPETLSRSS SAEFSAAAAA PAPAAPGSAL VCSPSPKERA FPQTQPPLEF
1810 1820 1830 1840 1850
VPPETPPARD QWVPDETESM CMVCCREHFT MFNRRHHCRR CGRLVCGSCS
1860 1870 1880 1890 1900
TKKMVVEGCR ENPTRVCDQC YSYYNKDAPE ESPCQSEVPD SAKNESPSYS
1910 1920 1930 1940 1950
AVVRIPKATE VEWILSLNEE ENELVRSEFY YEQAPSASLC IAILNLHRDS
1960 1970 1980 1990 2000
IACGHQLIEH CCRLSRGLTN PEVDAGLLID IMKQLLFSAK MMFVKAGQSQ
2010 2020 2030 2040 2050
DLALCDSYIS KVDVLHILVA AAYRHMPSLD QILQPASVTR LRNQLLEAEY
2060 2070 2080 2090 2100
YQLGVEVSTK TGLDSTGAWH AWGMACLKAG NLTAAREKFS RCLKPPLDLN
2110 2120 2130 2140 2150
QLSHGSRLVQ DVVEYLESTV RPLVSLQDDD YFATLRELEA TLRTQSLFLE
2160 2170 2180 2190 2200
AIPDGKIMNN TYYQECLFYL HNYSTNLAII SFYMRHNCLR EALLHLLNKE
2210 2220 2230 2240 2250
SPAEVFIEGI FQPSYKSGKL HTLENLLESI DPTLESWGAY LIAACQHLQK
2260 2270 2280 2290 2300
KNYYHILYEL QQFMKDQVRA AMTCIRFFSH KAKSYTELGE KLSWLLKAKD
2310 2320 2330 2340 2350
HLKIYLQENS RSSGRKKTTF FRKKMAAADV SRHMNTLQLQ MEVTRFLHRC
2360 2370 2380 2390 2400
ESARTSQITT LPLPTLFGNN HMKMEVACQV MLGGKNVEDG FGIAFRVLQD
2410 2420 2430 2440 2450
FQLDAAVTYC RAARQLVEKE KYGEIRQLLK CVSESGMAAK SDGDTILLNC
2460 2470 2480 2490 2500
LEAFKRIPPQ ELEGLIQAIH SDDNKVRAYL TCCKLRSAYL IAVKQEHTQA
2510 2520 2530 2540
AALVQQVQQA AKSSGDSVVQ DICAQWLLTS HSRGAHGSGS RK
Length:2,542
Mass (Da):284,215
Last modified:April 20, 2010 - v1
Checksum:i3128C41C447CBD11
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH473947 Genomic DNA. Translation: EDM03727.1.
RefSeqiNP_001101508.1. NM_001108038.1.
UniGeneiRn.16048.

Genome annotation databases

GeneIDi314265.
KEGGirno:314265.
UCSCiRGD:1307820. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH473947 Genomic DNA. Translation: EDM03727.1.
RefSeqiNP_001101508.1. NM_001108038.1.
UniGeneiRn.16048.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000016380.

PTM databases

iPTMnetiD4A8G9.

Proteomic databases

PaxDbiD4A8G9.
PRIDEiD4A8G9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi314265.
KEGGirno:314265.
UCSCiRGD:1307820. rat.

Organism-specific databases

CTDi23503.
RGDi1307820. Zfyve26.

Phylogenomic databases

eggNOGiKOG1811. Eukaryota.
ENOG410XRV7. LUCA.
InParanoidiD4A8G9.
KOiK19027.
PhylomeDBiD4A8G9.
TreeFamiTF324517.

Miscellaneous databases

PROiD4A8G9.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR028730. ZFYVE26.
IPR000306. Znf_FYVE.
IPR017455. Znf_FYVE-rel.
IPR011011. Znf_FYVE_PHD.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PANTHERiPTHR22835:SF279. PTHR22835:SF279. 2 hits.
PfamiPF01363. FYVE. 1 hit.
[Graphical view]
SMARTiSM00064. FYVE. 1 hit.
[Graphical view]
SUPFAMiSSF57903. SSF57903. 1 hit.
PROSITEiPS50178. ZF_FYVE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown Norway.
  2. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-612 AND SER-616, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiZFY26_RAT
AccessioniPrimary (citable) accession number: D4A8G9
Secondary accession number(s): D3ZB97, D3ZBA4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 3, 2011
Last sequence update: April 20, 2010
Last modified: June 8, 2016
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.