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Protein
Submitted name:

Protein Snw1

Gene

Snw1

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

  1. poly(A) RNA binding Source: Ensembl
  2. transcription coactivator activity Source: Ensembl
  3. transcription corepressor activity Source: Ensembl

GO - Biological processi

  1. cellular response to retinoic acid Source: Ensembl
  2. intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator Source: Ensembl
  3. mRNA splicing, via spliceosome Source: InterPro
  4. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
  5. positive regulation by host of viral transcription Source: Ensembl
  6. positive regulation of histone H3-K4 methylation Source: Ensembl
  7. positive regulation of mRNA splicing, via spliceosome Source: Ensembl
  8. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  9. positive regulation of transforming growth factor beta receptor signaling pathway Source: Ensembl
  10. positive regulation of vitamin D receptor signaling pathway Source: Ensembl
  11. regulation of retinoic acid receptor signaling pathway Source: Ensembl
  12. retinoic acid receptor signaling pathway Source: Ensembl
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_198659. NOTCH1 Intracellular Domain Regulates Transcription.
REACT_198750. Constitutive Signaling by NOTCH1 PEST Domain Mutants.
REACT_198752. Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.
REACT_263583. Notch-HLH transcription pathway.

Names & Taxonomyi

Protein namesi
Submitted name:
Protein Snw1Imported
Submitted name:
Similar to Nuclear protein SkiP (Ski-interacting protein) (Predicted)Imported
Gene namesi
Name:Snw1Imported
Synonyms:RGD1561926_predictedImported
ORF Names:rCG_20602Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 6

Organism-specific databases

RGDi1561926. Snw1.

Subcellular locationi

GO - Cellular componenti

  1. catalytic step 2 spliceosome Source: Ensembl
  2. chromatin Source: RGD
  3. nuclear matrix Source: Ensembl
  4. positive transcription elongation factor complex b Source: Ensembl
  5. SMAD3-SMAD4 protein complex Source: Ensembl
Complete GO annotation...

Interactioni

Protein-protein interaction databases

DIPiDIP-60964N.

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00390000010423.
KOiK06063.
OMAiAPPYGQR.
OrthoDBiEOG72JWFX.
TreeFamiTF300782.

Family and domain databases

InterProiIPR017862. SKI-int_prot_SKIP.
IPR004015. SKI-int_prot_SKIP_SNW-dom.
[Graphical view]
PANTHERiPTHR12096. PTHR12096. 1 hit.
PfamiPF02731. SKIP_SNW. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D4A8G7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MALTSFLPAP TQLSQDQLEA EERARSQRSR QTSLVSSRRE PPPYGYRKGW
60 70 80 90 100
IPRLLEDFGD GGAFPEIHVA QYPLDMGRKK KMSNALAIQV DPEGKIKYDA
110 120 130 140 150
IARQGQSKDK VIYSKYTDLV PKEVMNADDP DLQRPDEEAI KEITEKTRVA
160 170 180 190 200
LEKSVSQKVA AAMPVRAADK LAPAQYIRYT PSQQGVAFNS GAKQRVIRMV
210 220 230 240 250
EMQKDPMEPP RFKINKKIPR GPPSPPAPVM HSPSRKMTVK EQQEWKIPPC
260 270 280 290 300
ISNWKNAKGY TIPLDKRLAA DGRGLQTVHI NENFAKLAEA LYIADRKARE
310 320 330 340 350
AVEMRAQVER KMAQKEKEKH EEKLREMAQK ARERRAGIKT HVEKEDGEAR
360 370 380 390 400
ERDEIRHDRR KERQHDRNLS RAAPDKRSKL QRNENRDISE VIALGVPNPR
410 420 430 440 450
TSNEVQYDQR LFNQSKGMDS GFAGGEDEIY NVYDQAWRGG KDMAQSIYRP
460 470 480 490 500
SKNLDKDMYG DDLETRIKTN RFVPDKEFSG SDGRKRGREG PVQFEEDPFG
510 520 530
LDKFLEEAKQ HGGSKRPSDS SRPKEHEHEG KKRRKE
Length:536
Mass (Da):61,463
Last modified:April 20, 2010 - v1
Checksum:i668801CC6323E44D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR06045456 Genomic DNA. No translation available.
CH473982 Genomic DNA. Translation: EDL81657.1.
RefSeqiNP_001102749.1. NM_001109279.1.
UniGeneiRn.220230.

Genome annotation databases

EnsembliENSRNOT00000057807; ENSRNOP00000054619; ENSRNOG00000037998.
GeneIDi500695.
KEGGirno:500695.
UCSCiRGD:1561926. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR06045456 Genomic DNA. No translation available.
CH473982 Genomic DNA. Translation: EDL81657.1.
RefSeqiNP_001102749.1. NM_001109279.1.
UniGeneiRn.220230.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-60964N.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000057807; ENSRNOP00000054619; ENSRNOG00000037998.
GeneIDi500695.
KEGGirno:500695.
UCSCiRGD:1561926. rat.

Organism-specific databases

CTDi22938.
RGDi1561926. Snw1.

Phylogenomic databases

GeneTreeiENSGT00390000010423.
KOiK06063.
OMAiAPPYGQR.
OrthoDBiEOG72JWFX.
TreeFamiTF300782.

Enzyme and pathway databases

ReactomeiREACT_198659. NOTCH1 Intracellular Domain Regulates Transcription.
REACT_198750. Constitutive Signaling by NOTCH1 PEST Domain Mutants.
REACT_198752. Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.
REACT_263583. Notch-HLH transcription pathway.

Miscellaneous databases

NextBioi707018.

Family and domain databases

InterProiIPR017862. SKI-int_prot_SKIP.
IPR004015. SKI-int_prot_SKIP_SNW-dom.
[Graphical view]
PANTHERiPTHR12096. PTHR12096. 1 hit.
PfamiPF02731. SKIP_SNW. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Rat Genome Sequencing Project Consortium
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown NorwayImported.
  2. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BNImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BNImported.
  4. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: Brown NorwayImported.

Entry informationi

Entry nameiD4A8G7_RAT
AccessioniPrimary (citable) accession number: D4A8G7
Entry historyi
Integrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: February 4, 2015
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.