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D4A8G7

- D4A8G7_RAT

UniProt

D4A8G7 - D4A8G7_RAT

Protein
Submitted name:

Protein Snw1

Gene

Snw1

Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 3 out of 5- Protein predictedi
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    • History
      Entry version 37 (01 Oct 2014)
      Sequence version 1 (20 Apr 2010)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. protein binding Source: RGD
    2. transcription coactivator activity Source: Ensembl
    3. transcription corepressor activity Source: Ensembl

    GO - Biological processi

    1. cellular response to retinoic acid Source: Ensembl
    2. intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator Source: Ensembl
    3. mRNA splicing, via spliceosome Source: InterPro
    4. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
    5. positive regulation by host of viral transcription Source: Ensembl
    6. positive regulation of histone H3-K4 methylation Source: Ensembl
    7. positive regulation of mRNA splicing, via spliceosome Source: Ensembl
    8. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
    9. positive regulation of transforming growth factor beta receptor signaling pathway Source: Ensembl
    10. positive regulation of vitamin D receptor signaling pathway Source: Ensembl
    11. regulation of retinoic acid receptor signaling pathway Source: Ensembl
    12. retinoic acid receptor signaling pathway Source: Ensembl

    Enzyme and pathway databases

    ReactomeiREACT_198659. NOTCH1 Intracellular Domain Regulates Transcription.
    REACT_198750. Constitutive Signaling by NOTCH1 PEST Domain Mutants.
    REACT_198752. Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Protein Snw1Imported
    Submitted name:
    Similar to Nuclear protein SkiP (Ski-interacting protein) (Predicted)Imported
    Gene namesi
    Name:Snw1Imported
    Synonyms:RGD1561926_predictedImported
    ORF Names:rCG_20602Imported
    OrganismiRattus norvegicus (Rat)Imported
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 6

    Organism-specific databases

    RGDi1561926. Snw1.

    Subcellular locationi

    GO - Cellular componenti

    1. catalytic step 2 spliceosome Source: Ensembl
    2. chromatin Source: RGD
    3. nuclear matrix Source: Ensembl
    4. positive transcription elongation factor complex b Source: Ensembl
    5. SMAD3-SMAD4 protein complex Source: Ensembl

    Interactioni

    Protein-protein interaction databases

    DIPiDIP-60964N.

    Family & Domainsi

    Phylogenomic databases

    GeneTreeiENSGT00390000010423.
    KOiK06063.
    OMAiAYNVYDK.
    OrthoDBiEOG72JWFX.
    TreeFamiTF300782.

    Family and domain databases

    InterProiIPR017862. SKI-int_prot_SKIP.
    IPR004015. SKI-int_prot_SKIP_SNW-dom.
    [Graphical view]
    PANTHERiPTHR12096. PTHR12096. 1 hit.
    PfamiPF02731. SKIP_SNW. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    D4A8G7-1 [UniParc]FASTAAdd to Basket

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    MALTSFLPAP TQLSQDQLEA EERARSQRSR QTSLVSSRRE PPPYGYRKGW    50
    IPRLLEDFGD GGAFPEIHVA QYPLDMGRKK KMSNALAIQV DPEGKIKYDA 100
    IARQGQSKDK VIYSKYTDLV PKEVMNADDP DLQRPDEEAI KEITEKTRVA 150
    LEKSVSQKVA AAMPVRAADK LAPAQYIRYT PSQQGVAFNS GAKQRVIRMV 200
    EMQKDPMEPP RFKINKKIPR GPPSPPAPVM HSPSRKMTVK EQQEWKIPPC 250
    ISNWKNAKGY TIPLDKRLAA DGRGLQTVHI NENFAKLAEA LYIADRKARE 300
    AVEMRAQVER KMAQKEKEKH EEKLREMAQK ARERRAGIKT HVEKEDGEAR 350
    ERDEIRHDRR KERQHDRNLS RAAPDKRSKL QRNENRDISE VIALGVPNPR 400
    TSNEVQYDQR LFNQSKGMDS GFAGGEDEIY NVYDQAWRGG KDMAQSIYRP 450
    SKNLDKDMYG DDLETRIKTN RFVPDKEFSG SDGRKRGREG PVQFEEDPFG 500
    LDKFLEEAKQ HGGSKRPSDS SRPKEHEHEG KKRRKE 536
    Length:536
    Mass (Da):61,463
    Last modified:April 20, 2010 - v1
    Checksum:i668801CC6323E44D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR06045456 Genomic DNA. No translation available.
    CH473982 Genomic DNA. Translation: EDL81657.1.
    RefSeqiNP_001102749.1. NM_001109279.1.
    UniGeneiRn.220230.

    Genome annotation databases

    EnsembliENSRNOT00000057807; ENSRNOP00000054619; ENSRNOG00000037998.
    GeneIDi500695.
    KEGGirno:500695.
    UCSCiRGD:1561926. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR06045456 Genomic DNA. No translation available.
    CH473982 Genomic DNA. Translation: EDL81657.1 .
    RefSeqi NP_001102749.1. NM_001109279.1.
    UniGenei Rn.220230.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-60964N.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000057807 ; ENSRNOP00000054619 ; ENSRNOG00000037998 .
    GeneIDi 500695.
    KEGGi rno:500695.
    UCSCi RGD:1561926. rat.

    Organism-specific databases

    CTDi 22938.
    RGDi 1561926. Snw1.

    Phylogenomic databases

    GeneTreei ENSGT00390000010423.
    KOi K06063.
    OMAi AYNVYDK.
    OrthoDBi EOG72JWFX.
    TreeFami TF300782.

    Enzyme and pathway databases

    Reactomei REACT_198659. NOTCH1 Intracellular Domain Regulates Transcription.
    REACT_198750. Constitutive Signaling by NOTCH1 PEST Domain Mutants.
    REACT_198752. Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.

    Miscellaneous databases

    NextBioi 707018.

    Family and domain databases

    InterProi IPR017862. SKI-int_prot_SKIP.
    IPR004015. SKI-int_prot_SKIP_SNW-dom.
    [Graphical view ]
    PANTHERi PTHR12096. PTHR12096. 1 hit.
    Pfami PF02731. SKIP_SNW. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
      Rat Genome Sequencing Project Consortium
      Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
      , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
      Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Brown NorwayImported.
    2. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: BNImported.
    3. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: BNImported.
    4. Ensembl
      Submitted (JUL-2011) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: Brown NorwayImported.

    Entry informationi

    Entry nameiD4A8G7_RAT
    AccessioniPrimary (citable) accession number: D4A8G7
    Entry historyi
    Integrated into UniProtKB/TrEMBL: April 20, 2010
    Last sequence update: April 20, 2010
    Last modified: October 1, 2014
    This is version 37 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3