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Protein
Submitted name:

Carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase

Gene

Cad

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei252NucleophilePROSITE-ProRule annotation1
Active sitei336PROSITE-ProRule annotation1
Active sitei338PROSITE-ProRule annotation1

GO - Molecular functioni

  • amino acid binding Source: InterPro
  • aspartate carbamoyltransferase activity Source: RGD
  • ATP binding Source: UniProtKB-UniRule
  • carbamoyl-phosphate synthase (ammonia) activity Source: GO_Central
  • carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity Source: RGD
  • dihydroorotase activity Source: RGD
  • enzyme binding Source: Ensembl
  • identical protein binding Source: RGD
  • zinc ion binding Source: Ensembl

GO - Biological processi

  • 'de novo' pyrimidine nucleobase biosynthetic process Source: RGD
  • animal organ regeneration Source: RGD
  • arginine biosynthetic process Source: GO_Central
  • cellular response to drug Source: RGD
  • cellular response to epidermal growth factor stimulus Source: RGD
  • citrulline biosynthetic process Source: RGD
  • drug metabolic process Source: RGD
  • female pregnancy Source: RGD
  • glutamine metabolic process Source: RGD
  • heart development Source: RGD
  • lactation Source: RGD
  • liver development Source: RGD
  • response to amine Source: RGD
  • response to caffeine Source: RGD
  • response to cortisol Source: RGD
  • response to insulin Source: RGD
  • response to starvation Source: RGD
  • response to testosterone Source: RGD
  • urea cycle Source: GO_Central
  • UTP biosynthetic process Source: RGD

Keywordsi

LigandATP-bindingPROSITE-ProRule annotation, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-RNO-500753 Pyrimidine biosynthesis

Names & Taxonomyi

Protein namesi
Submitted name:
Carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotaseImported
Gene namesi
Name:CadImported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 6

Organism-specific databases

RGDi1588606 Cad

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Proteomic databases

PaxDbiD4A8A0
PeptideAtlasiD4A8A0
PRIDEiD4A8A0

PTM databases

iPTMnetiD4A8A0
PhosphoSitePlusiD4A8A0

Expressioni

Gene expression databases

BgeeiENSRNOG00000026474

Interactioni

GO - Molecular functioni

  • enzyme binding Source: Ensembl
  • identical protein binding Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000030030

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini177 – 363Glutamine amidotransferase type-1InterPro annotationAdd BLAST187
Domaini519 – 711ATP-graspInterPro annotationAdd BLAST193
Domaini1052 – 1243ATP-graspInterPro annotationAdd BLAST192

Keywords - Domaini

Glutamine amidotransferasePROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0370 Eukaryota
COG0458 LUCA
COG0505 LUCA
COG0540 LUCA
GeneTreeiENSGT00910000144175
InParanoidiD4A8A0
OMAiNIPCTSM
OrthoDBiEOG091G00DC
TreeFamiTF105604

Family and domain databases

CDDicd01744 GATase1_CPSase, 1 hit
Gene3Di1.10.1030.10, 1 hit
3.30.1490.20, 1 hit
3.40.50.1370, 3 hits
3.40.50.1380, 1 hit
3.40.50.880, 1 hit
3.50.30.20, 1 hit
HAMAPiMF_00001 Asp_carb_tr, 1 hit
MF_01209 CPSase_S_chain, 1 hit
InterProiView protein in InterPro
IPR006680 Amidohydro-rel
IPR006132 Asp/Orn_carbamoyltranf_P-bd
IPR006130 Asp/Orn_carbamoylTrfase
IPR036901 Asp/Orn_carbamoylTrfase_sf
IPR002082 Asp_carbamoyltransf
IPR006131 Asp_carbamoyltransf_Asp/Orn-bd
IPR011761 ATP-grasp
IPR013815 ATP_grasp_subdomain_1
IPR006275 CarbamoylP_synth_lsu
IPR005480 CarbamoylP_synth_lsu_oligo
IPR036897 CarbamoylP_synth_lsu_oligo_sf
IPR006274 CarbamoylP_synth_ssu
IPR002474 CarbamoylP_synth_ssu_N
IPR036480 CarbP_synth_ssu_N_sf
IPR005479 CbamoylP_synth_lsu-like_ATP-bd
IPR005483 CbamoylP_synth_lsu_CPSase_dom
IPR029062 Class_I_gatase-like
IPR035686 CPSase_GATase1
IPR002195 Dihydroorotase_CS
IPR017926 GATASE
IPR011059 Metal-dep_hydrolase_composite
IPR032466 Metal_Hydrolase
IPR011607 MGS-like_dom
IPR036914 MGS-like_dom_sf
IPR016185 PreATP-grasp_dom_sf
PfamiView protein in Pfam
PF01979 Amidohydro_1, 1 hit
PF02786 CPSase_L_D2, 2 hits
PF02787 CPSase_L_D3, 1 hit
PF00988 CPSase_sm_chain, 1 hit
PF00117 GATase, 1 hit
PF02142 MGS, 1 hit
PF00185 OTCace, 1 hit
PF02729 OTCace_N, 1 hit
PRINTSiPR00100 AOTCASE
PR00101 ATCASE
PR00098 CPSASE
SMARTiView protein in SMART
SM01096 CPSase_L_D3, 1 hit
SM01097 CPSase_sm_chain, 1 hit
SM00851 MGS, 1 hit
SUPFAMiSSF48108 SSF48108, 1 hit
SSF51338 SSF51338, 1 hit
SSF51556 SSF51556, 1 hit
SSF52021 SSF52021, 1 hit
SSF52317 SSF52317, 1 hit
SSF52335 SSF52335, 1 hit
SSF52440 SSF52440, 2 hits
SSF53671 SSF53671, 1 hit
TIGRFAMsiTIGR00670 asp_carb_tr, 1 hit
TIGR01369 CPSaseII_lrg, 1 hit
TIGR01368 CPSaseIIsmall, 1 hit
PROSITEiView protein in PROSITE
PS50975 ATP_GRASP, 2 hits
PS00097 CARBAMOYLTRANSFERASE, 1 hit
PS00866 CPSASE_1, 2 hits
PS00867 CPSASE_2, 2 hits
PS00482 DIHYDROOROTASE_1, 1 hit
PS00483 DIHYDROOROTASE_2, 1 hit
PS51273 GATASE_TYPE_1, 1 hit

Sequencei

Sequence statusi: Complete.

D4A8A0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAALVLEDGS VLQGRPFGAA VSTAGEVVFQ TGMVGYPEAL TDPSYKAQIL
60 70 80 90 100
VLTYPLIGNY GIPSDEEDEF GLSKWFESSE IHVAGLVVGE CCPTPSHWSA
110 120 130 140 150
TCTLHEWLQQ HGIPGLQGVD TRELTKKLRE QGSLLGKLVQ KGTEPSALPF
160 170 180 190 200
VDPNARPLAP EVSIKTPRVF NAGGAPRIFA VDCGLKYNQI RCLCQLGAEV
210 220 230 240 250
TVVPWNHELD SRKYDGLFLS NGPGDPASYP GVVSTLNRVL SEPNPRPVFG
260 270 280 290 300
ICLGHQLLAL AIGAKTYKMR YGNRGHNQPC LLVGTGRCFL TSQNHGFAVD
310 320 330 340 350
ADSLPAGWAP LFTNANDCSN EGIVHDNLPF FSVQFHPEHR AGPSDMELLF
360 370 380 390 400
DVFLETVRDT VAGNAEGRTV RERLAQRLCP PELPIPGSGL PPPRKVLILG
410 420 430 440 450
SGGLSIGQAG EFDYSGSQAI KALKEENIQT LLINPNIATV QTSQGLADKV
460 470 480 490 500
YFLPITPHYV TQVIRNERPD GILLTFGGQT ALNCGVELTK AGVLARYGVR
510 520 530 540 550
VLGTPVETIE LTEDRRAFAA RMAEIGEHVA PSEAANSLEQ AQAAAERLGY
560 570 580 590 600
PVLVRAAFAL GGLGSGFAST KEELSALVAP AFAHTSQVLI DKSLKGWKEI
610 620 630 640 650
EYEVVRDAYG NCVTVCNMEN LDPLGIHTGE SIVVAPSQTL NDREYQLLRR
660 670 680 690 700
TAIKVTQHLG IVGECNVQYA LNPESEQYYI IEVNARLSRS SALASKATGY
710 720 730 740 750
PLAYVAAKLA LGIPLPELRN SVTGGTAAFE PSLDYCVVKI PRWDLSKFLR
760 770 780 790 800
VSTKIGSCMK SVGEVMGIGR SFEEAFQKAL RMVDENCVGF DHTVKPVSDV
810 820 830 840 850
ELETPTDKRI FVVAAALWAG YSVERLYELT RIDCWFLHRM KRIVTHAKLL
860 870 880 890 900
EQHRGRPLPQ DLLHQAKCLG FSDKQIALAV LSTELVVRKL RQELGICPAV
910 920 930 940 950
KQIDTVAAEW PAQTNYLYLT YWGNTHDLDF RTPHVLVLGS GVYRIGSSVE
960 970 980 990 1000
FDWCAVGCIQ QLRKMGYKTI MVNYNPETVS TDYDMCDRLY FDEISFEVVM
1010 1020 1030 1040 1050
DIYELENPEG VILSMGGQLP NNMAMALHRQ QCRVLGTSPE AIDSAENRFK
1060 1070 1080 1090 1100
FSRLLDTIGI SQPQWRELSD LESARQFCQT VGYPCVVRPS YVLSGAAMNV
1110 1120 1130 1140 1150
AYTDGDLERF LSSAAAVSKE HPVVISKFIQ EAKEIDVDAV ACDGIVSAIA
1160 1170 1180 1190 1200
ISEHVENAGV HSGDATLVTP PQDITPKTLE RIKAIVHAVG QELQVTGPFN
1210 1220 1230 1240 1250
LQLIAKDDQL KVIECNVRVS RSFPFVSKTL GVDLVALATR IIMGEKVESV
1260 1270 1280 1290 1300
GLMTGSGVVG VKVPQFSFSR LAGADVVLGV EMTSTGEVAG FGESRCEAYL
1310 1320 1330 1340 1350
KAMLSTGFKI PKKNILLTIG SYKNKSELLP TVRLLESLGY SLYASLGTAD
1360 1370 1380 1390 1400
FYTEHGVKVT AVDWHFEEAV DGECPPQRSI LDQLAENHFE LVINLSMRGA
1410 1420 1430 1440 1450
GGRRLSSFVT KGYRTRRLAA DFSVPLIIDI KCTKLFVEAL GQIGPAPPLK
1460 1470 1480 1490 1500
VHVDCMTSQK LVRLPGLIDV HVHLREPGGT HKEDFASGTA AALAGGVTMV
1510 1520 1530 1540 1550
CAMPNTRPPI IDAPALALAQ KLAEAGARCD FTLFLGASSE NAGTLGAVAG
1560 1570 1580 1590 1600
SAAGLKLYLN ETFSELRLDS VAQWMEHFET WPSHLPIVAH AERQSVAAVL
1610 1620 1630 1640 1650
MAQLTRRSVH ICHVARKEEI LLIKTAKAQG LPVTCEVAPH HLFLNREDLE
1660 1670 1680 1690 1700
RLGPGKGEVR PELGSREDME ALWENMAVID CFASDHAPHT LEEKCGPKPP
1710 1720 1730 1740 1750
PGFPGLETML PLLLTAVSEG RLSLDDLLQR LHHNPRRIFH LPLQEDTYVE
1760 1770 1780 1790 1800
VDLEHEWTVP SHMPFSKAHW TPFEGQKVKG TVRRVVLRGE VAYIDGQVLV
1810 1820 1830 1840 1850
PPGYGQDVRK WPQGAVPQPP PPTPTTTEIT TTPERPRRVI PGLPDGRFHL
1860 1870 1880 1890 1900
PPRIHRASDP GLPAEEPKEK PPRKVAESEL IGTPDGPCYP VPPVPRQASP
1910 1920 1930 1940 1950
QNLGSSGLLH PQMSPLLHSL VGQHILSVKQ FTKDQMSHLF NVAHTLRMMV
1960 1970 1980 1990 2000
QKERSLDILK GKVMASMFYE VSTRTSSSFA AAMARLGGAV LSFSEATSSV
2010 2020 2030 2040 2050
QKGESLADSV QTMSCYADVV VLRHPQPGAV ELAAKHCRRP VINAGDGVGE
2060 2070 2080 2090 2100
HPTQALLDIF TIREELGTVN GMTITMVGDL KHGRTVHSLA CLLTQYRVSL
2110 2120 2130 2140 2150
RYVAPPSLRM PSSVWDFVAS RGTKQEEFES IEEALPDTDV LYMTRIQKER
2160 2170 2180 2190 2200
FGSSQEYEAC FGQFILTPHI MTRAKKKMVV MHPMPRVNEI SVEVDSDPRA
2210 2220
AYFRQAENGM YIRMALLATV LGRF
Length:2,224
Mass (Da):243,371
Last modified:April 3, 2013 - v2
Checksum:i36877361B53D2F4E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07073211 Genomic DNA No translation available.

Genome annotation databases

EnsembliENSRNOT00000039709; ENSRNOP00000030030; ENSRNOG00000026474

Similar proteinsi

Entry informationi

Entry nameiD4A8A0_RAT
AccessioniPrimary (citable) accession number: D4A8A0
Entry historyiIntegrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 3, 2013
Last modified: May 23, 2018
This is version 79 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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Main funding by: National Institutes of Health