ID   D4A871_RAT              Unreviewed;       578 AA.
AC   D4A871;
DT   20-APR-2010, integrated into UniProtKB/TrEMBL.
DT   22-JUL-2015, sequence version 3.
DT   27-MAR-2024, entry version 77.
DE   SubName: Full=Leiomodin 3 {ECO:0000313|Ensembl:ENSRNOP00000042274.5};
GN   Name=Lmod3 {ECO:0000313|Ensembl:ENSRNOP00000042274.5,
GN   ECO:0000313|RGD:1564924};
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000042274.5, ECO:0000313|Proteomes:UP000002494};
RN   [1] {ECO:0000313|Ensembl:ENSRNOP00000042274.5, ECO:0000313|Proteomes:UP000002494}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000042274.5,
RC   ECO:0000313|Proteomes:UP000002494};
RX   PubMed=15057822; DOI=10.1038/nature02426;
RG   Rat Genome Sequencing Project Consortium;
RA   Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA   Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA   Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA   Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA   Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA   Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA   Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA   Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA   Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA   Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA   Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA   Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA   Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA   Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA   Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA   Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA   Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA   Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA   Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA   Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA   Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA   Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA   Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA   Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA   Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA   Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA   Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA   Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA   Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA   Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA   Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA   Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA   Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA   Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA   Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA   Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA   Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA   Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA   Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA   Mockrin S., Collins F.S.;
RT   "Genome sequence of the Brown Norway rat yields insights into mammalian
RT   evolution.";
RL   Nature 428:493-521(2004).
RN   [2] {ECO:0000313|Ensembl:ENSRNOP00000042274.5}
RP   IDENTIFICATION.
RC   STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000042274.5};
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   RefSeq; XP_006237034.1; XM_006236972.3.
DR   RefSeq; XP_006237035.1; XM_006236973.3.
DR   RefSeq; XP_575617.4; XM_575617.7.
DR   AlphaFoldDB; D4A871; -.
DR   SMR; D4A871; -.
DR   STRING; 10116.ENSRNOP00000042274; -.
DR   PaxDb; 10116-ENSRNOP00000042274; -.
DR   Ensembl; ENSRNOT00000047453.6; ENSRNOP00000042274.5; ENSRNOG00000032443.6.
DR   GeneID; 500267; -.
DR   KEGG; rno:500267; -.
DR   AGR; RGD:1564924; -.
DR   CTD; 56203; -.
DR   RGD; 1564924; Lmod3.
DR   eggNOG; KOG3735; Eukaryota.
DR   GeneTree; ENSGT00940000159731; -.
DR   HOGENOM; CLU_031052_4_1_1; -.
DR   InParanoid; D4A871; -.
DR   OMA; GMWERLG; -.
DR   OrthoDB; 2883785at2759; -.
DR   TreeFam; TF315841; -.
DR   Proteomes; UP000002494; Chromosome 4.
DR   Bgee; ENSRNOG00000032443; Expressed in skeletal muscle tissue and 4 other cell types or tissues.
DR   GO; GO:0031672; C:A band; ISO:RGD.
DR   GO; GO:0005737; C:cytoplasm; ISO:RGD.
DR   GO; GO:0005856; C:cytoskeleton; IBA:GO_Central.
DR   GO; GO:0031430; C:M band; ISO:RGD.
DR   GO; GO:0030016; C:myofibril; IBA:GO_Central.
DR   GO; GO:0005865; C:striated muscle thin filament; ISO:RGD.
DR   GO; GO:0003785; F:actin monomer binding; ISO:RGD.
DR   GO; GO:0005523; F:tropomyosin binding; ISO:RGD.
DR   GO; GO:0007015; P:actin filament organization; IBA:GO_Central.
DR   GO; GO:0045010; P:actin nucleation; ISO:RGD.
DR   GO; GO:0006936; P:muscle contraction; IBA:GO_Central.
DR   GO; GO:0030239; P:myofibril assembly; IBA:GO_Central.
DR   GO; GO:0051694; P:pointed-end actin filament capping; IEA:InterPro.
DR   GO; GO:0048743; P:positive regulation of skeletal muscle fiber development; ISO:RGD.
DR   GO; GO:0048741; P:skeletal muscle fiber development; ISO:RGD.
DR   GO; GO:0030240; P:skeletal muscle thin filament assembly; ISO:RGD.
DR   GO; GO:0006941; P:striated muscle contraction; ISO:RGD.
DR   Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR004934; TMOD.
DR   PANTHER; PTHR10901:SF3; LEIOMODIN-3; 1.
DR   PANTHER; PTHR10901; TROPOMODULIN; 1.
DR   Pfam; PF03250; Tropomodulin; 1.
DR   SUPFAM; SSF52047; RNI-like; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002494}.
FT   REGION          1..21
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          46..67
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          93..113
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          129..230
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          404..441
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        141..175
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        189..205
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        208..230
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   578 AA;  66090 MW;  7B636A5F8C113471 CRC64;
     MSEHSGNSDQ EDTLSEELDE DEILANLSPE ELKELQSEME VMAPDPHLPV GMIQKDQTDK
     APTGNFDHKS LVDYMYLQKA SRRMLEDERV PVSFVQSEEN TQKQHEVREK GIASMPQFLK
     EKLNSEILAK KRQSNGSNNV QETEDDEDEE DEEDEEDDED EDEGEEGDED EEDGDGEQAN
     RGKNEAKEQV HNNASICQQP ATRAMEEQKA TRAMEEQKDT AETKGKGAKK IAKLDPKKLA
     LDTSFLKVSA RPSGNQTDLD GSLRRVRQND PDMKELNLNN IENIPKEMLL DFVNAMKKNK
     HIKSFSLANV GADESVAFAL ANMLRENRSI TTLNIESNFI TGKGIVAIMR CLQFNETLTE
     LRFHNQRHML GHHAEMEISR LLKANNTLLK MGYHFELPGP RMVVTNLLTR NQDKRRQKRQ
     EEQQQQQLKE QRKLIAMLEN GLGLPPGMWE RLGGPMPDPR MQEFFQPSPG RSLAAQEVPF
     GARKEMIKNP PQPPQYKTDP DSFRVVKLKR IQRKSRMPEA RESQEKTNLK DVIKTLKPVP
     RNRPPPLVEI TPRDQLLNDI RHSNVAYLKP VQLPKELA
//