ID   D4A858_RAT              Unreviewed;      1141 AA.
AC   D4A858;
DT   20-APR-2010, integrated into UniProtKB/TrEMBL.
DT   25-MAY-2022, sequence version 2.
DT   27-MAR-2024, entry version 86.
DE   SubName: Full=Transforming, acidic coiled-coil containing protein 2 {ECO:0000313|Ensembl:ENSRNOP00000042296.3};
GN   Name=Tacc2 {ECO:0000313|Ensembl:ENSRNOP00000042296.3,
GN   ECO:0000313|RGD:1303004};
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000042296.3, ECO:0000313|Proteomes:UP000002494};
RN   [1] {ECO:0000313|Ensembl:ENSRNOP00000042296.3, ECO:0000313|Proteomes:UP000002494}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000042296.3,
RC   ECO:0000313|Proteomes:UP000002494};
RX   PubMed=15057822; DOI=10.1038/nature02426;
RG   Rat Genome Sequencing Project Consortium;
RA   Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA   Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA   Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA   Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA   Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA   Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA   Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA   Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA   Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA   Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA   Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA   Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA   Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA   Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA   Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA   Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA   Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA   Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA   Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA   Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA   Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA   Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA   Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA   Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA   Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA   Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA   Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA   Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA   Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA   Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA   Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA   Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA   Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA   Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA   Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA   Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA   Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA   Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA   Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA   Mockrin S., Collins F.S.;
RT   "Genome sequence of the Brown Norway rat yields insights into mammalian
RT   evolution.";
RL   Nature 428:493-521(2004).
RN   [2] {ECO:0007829|PubMed:22673903}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=22673903;
RA   Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C.,
RA   Olsen J.V.;
RT   "Quantitative maps of protein phosphorylation sites across 14 different rat
RT   organs and tissues.";
RL   Nat. Commun. 3:876-876(2012).
RN   [3] {ECO:0000313|Ensembl:ENSRNOP00000042296.3}
RP   IDENTIFICATION.
RC   STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000042296.3};
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC   -!- SIMILARITY: Belongs to the TACC family.
CC       {ECO:0000256|ARBA:ARBA00009423}.
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DR   AlphaFoldDB; D4A858; -.
DR   PeptideAtlas; D4A858; -.
DR   Ensembl; ENSRNOT00000047161.5; ENSRNOP00000042296.3; ENSRNOG00000020457.9.
DR   UCSC; RGD:1303004; rat.
DR   AGR; RGD:1303004; -.
DR   RGD; 1303004; Tacc2.
DR   VEuPathDB; HostDB:ENSRNOG00000020457; -.
DR   GeneTree; ENSGT00940000157052; -.
DR   OrthoDB; 5406887at2759; -.
DR   PhylomeDB; D4A858; -.
DR   Proteomes; UP000002494; Chromosome 1.
DR   Bgee; ENSRNOG00000020457; Expressed in skeletal muscle tissue and 20 other cell types or tissues.
DR   ExpressionAtlas; D4A858; baseline and differential.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-KW.
DR   GO; GO:0016922; F:nuclear receptor binding; ISO:RGD.
DR   GO; GO:0019904; F:protein domain specific binding; ISO:RGD.
DR   GO; GO:0030953; P:astral microtubule organization; ISO:RGD.
DR   GO; GO:0008283; P:cell population proliferation; ISO:RGD.
DR   GO; GO:0021987; P:cerebral cortex development; ISO:RGD.
DR   GO; GO:0022027; P:interkinetic nuclear migration; ISO:RGD.
DR   GO; GO:0000226; P:microtubule cytoskeleton organization; ISO:RGD.
DR   GO; GO:0007052; P:mitotic spindle organization; IEA:InterPro.
DR   GO; GO:0022008; P:neurogenesis; ISO:RGD.
DR   GO; GO:0032886; P:regulation of microtubule-based process; ISO:RGD.
DR   Gene3D; 1.20.5.1700; -; 1.
DR   InterPro; IPR039915; TACC.
DR   InterPro; IPR007707; TACC_C.
DR   PANTHER; PTHR13924; TRANSFORMING ACIDIC COILED-COIL CONTAINING PROTEIN 1/2; 1.
DR   PANTHER; PTHR13924:SF11; TRANSFORMING ACIDIC COILED-COIL-CONTAINING PROTEIN 2; 1.
DR   Pfam; PF05010; TACC_C; 1.
DR   Genevisible; D4A858; RN.
PE   1: Evidence at protein level;
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002494}.
FT   DOMAIN          935..1135
FT                   /note="Transforming acidic coiled-coil-containing protein
FT                   C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF05010"
FT   REGION          1..219
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          244..384
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          400..609
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          628..657
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          687..708
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          747..771
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          944..1137
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        1..51
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        70..94
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        147..177
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        256..280
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        296..313
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        331..345
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        361..384
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        531..556
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        567..584
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        637..651
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        689..708
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        753..771
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1141 AA;  123585 MW;  CEB01CADFBF79A32 CRC64;
     MGNENSTSDH QRTSSVQSLR SLQPPGNSQT PQKQGDSPGS GAASIPGTND VIQSAAPEDL
     GHPPLADSSR YGVTVSSVST HLTVQSTSPS AAHASLAPVA SEHAALASAA AGPGVETPTA
     SCQHLAKNIN RSSDSEEAFE TPESTTPVKA PPAPPPPPPE VTPEPEVIEP PAPEEPGCIS
     EPVVVPDGPR SESVEGSPFR PSHSSSAVFD EDKPIASSGT YNLDFDSIEL VDNFQSLEPC
     SADYKGQECK VSTRRKSTES VPPSKTTLSR SLSLQASDFD GASCPGSPEA GTLATDACGT
     GSNSASSTLK RTKKTRPPSL KKKQATKKPT ETPPVKETQQ EPGEESPVPS EEHLAPETKT
     ESATPEGTGC TLSEETSLES AAVPTATCPL TLESVEDVSP LVSGGGRVQN SPPVGRKSVP
     LTTASEAVEV TLPDGGGQED LPAKGLSVRL EFDYSEDKGS WESQQENAPP TKKIGKKPVA
     KMPLRRPKLK KTPEKLDNTP ASPPRSPAEP SDIPIAKGTY TFDIDKWDDP NFNPFSSTSK
     MQESPTLSQQ SYNFDPDACE ESLDPFKASS KTPSSPSKSP ASFEIPASTI EADGDGLNKP
     AKKKKTPLKT MVEDVMSVCS LFDTFRVKKS PKRSPLSDPP SQDPTPAATP EAPPVSTVVH
     ATDEEKLAVT SQKWTCMTVD LDADKQDFPQ PSDLSNFVNE TKFNSPSEEL DYRNSYEIEY
     MEKLGSSLPQ DDDTPKKQAL YLMFDTPQES PVKSPPVRMS DSPTPCSGSS FEDTEALVNA
     TAKLQHPVPR GLASNQEPLL QLPEKSSQKE LEAMALGTPA EAIEITAPEG AFASADALLS
     RLAHPASLCG ALGYLEPDLA EKNPPVFAQK LQEELEFAVM RIEALKLARQ IALASRSRQD
     TKREATHPPD VSISKTTLYS RIGPTEVEKP PGLLFQQPDL DSALQVARAE VIAKEREVSE
     WRDKYEESRR EVVEMRKIVA EYEKTIAQMI EDEQREKSIS HQTVQQLVLE KEQALADLNS
     VEKSLADLFR RYEKMKEVLE GFRKNEEVLK KCAQEYLSRV KKEEQRYQAL KVHAEEKLDR
     ANAEIAQVRG KAQQEQAAYQ ASLRKEQLRV DALERTLEQK NKEIEELTKI CDELIAKMGK
     S
//