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Protein
Submitted name:

Polycystic kidney disease 2-like 2 (Predicted)

Gene

Pkd2l2

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
Polycystic kidney disease 2-like 2 (Predicted)Imported
Submitted name:
Polycystin 2-like 2, transient receptor potential cation channelImported
Gene namesi
Name:Pkd2l2Imported
Synonyms:Pkd2l2_predictedImported
ORF Names:rCG_49521Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 18

Organism-specific databases

RGDi1310272. Pkd2l2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei32 – 51HelicalSequence analysisAdd BLAST20
Transmembranei277 – 297HelicalSequence analysisAdd BLAST21
Transmembranei318 – 346HelicalSequence analysisAdd BLAST29
Transmembranei366 – 387HelicalSequence analysisAdd BLAST22
Transmembranei407 – 429HelicalSequence analysisAdd BLAST23
Transmembranei469 – 490HelicalSequence analysisAdd BLAST22

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

BgeeiENSRNOG00000025489.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000030483.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini77 – 497PKD_channelInterPro annotationAdd BLAST421

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG3599. Eukaryota.
ENOG410XTGE. LUCA.
GeneTreeiENSGT00700000104221.
KOiK04991.
OMAiIKEHANR.
OrthoDBiEOG091G034F.
TreeFamiTF316484.

Family and domain databases

InterProiView protein in InterPro
IPR013122. PKD1_2_channel.
IPR003915. PKD_2.
PfamiView protein in Pfam
PF08016. PKD_channel. 1 hit.
PRINTSiPR01433. POLYCYSTIN2.

Sequencei

Sequence statusi: Complete.

D4A828-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEATWWHRG GTSKHDLHYR REAEVNTTLE ELLLYFIFLI NLCILTFGTV
60 70 80 90 100
NPHMYYLNKV MSSLFVDTSL PDDERSSFRS IRSITEFWKF MEGPLVEGLY
110 120 130 140 150
WDSWYGNTQL DSVKNSSLIY YENILLGVPR VRQLRVRNST CQVYPAFQSL
160 170 180 190 200
ASDCYNKYTA ENEDFSDFGL KHDPEWRHSA PSSTAPWHWG FVGVYRDGGY
210 220 230 240 250
MVTLSKSKSE TKAKLADLRQ NNWIGRGTRA VFIDFSLYNA NVNLFCIIRL
260 270 280 290 300
LAEFPATGGI LTSWQFYSVK LIRYVSYYDH FIASCEIIFC IFLLVFITQE
310 320 330 340 350
LRKLNEFKSA YFRSVWNWIE LLLLVLCFLA VSFYAYCNVQ CFLLLGQLLR
360 370 380 390 400
STESYPDFYF LAYWHIYYNN IIAITIFFAW IKIFKFISFN ETMSQLSSTL
410 420 430 440 450
SRCMKDIVGF AIMFFIIFFA YAQLAFLVFG SQVDDFSTFQ NSIFAQFRIV
460 470 480 490 500
LGDFNFAGIQ QANWILGPIY FITFIFFVFF VLLNMFLAII NDTYSEVKAD
510 520 530 540 550
YSIGRRPDFE LGSIIKKSCF NILEKLRLRK AQNNEDKKMK TSVDLAQARK
560 570 580 590 600
EGFDESEIQE ARQMKRWKER LEKKYYSTEI QDDYQPVTQQ EFRELFLYAV
610 620
ELEKELHYLS LKLNQVMRKL H
Length:621
Mass (Da):73,300
Last modified:April 20, 2010 - v1
Checksum:i28F88ADDB67585CD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07031690 Genomic DNA. No translation available.
AABR07031691 Genomic DNA. No translation available.
CH473974 Genomic DNA. Translation: EDL76225.1.
RefSeqiNP_001099626.1. NM_001106156.1.
XP_008770248.1. XM_008772026.1.
UniGeneiRn.207191.

Genome annotation databases

EnsembliENSRNOT00000037690; ENSRNOP00000030483; ENSRNOG00000025489.
GeneIDi291683.
KEGGirno:291683.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07031690 Genomic DNA. No translation available.
AABR07031691 Genomic DNA. No translation available.
CH473974 Genomic DNA. Translation: EDL76225.1.
RefSeqiNP_001099626.1. NM_001106156.1.
XP_008770248.1. XM_008772026.1.
UniGeneiRn.207191.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000030483.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000037690; ENSRNOP00000030483; ENSRNOG00000025489.
GeneIDi291683.
KEGGirno:291683.

Organism-specific databases

CTDi27039.
RGDi1310272. Pkd2l2.

Phylogenomic databases

eggNOGiKOG3599. Eukaryota.
ENOG410XTGE. LUCA.
GeneTreeiENSGT00700000104221.
KOiK04991.
OMAiIKEHANR.
OrthoDBiEOG091G034F.
TreeFamiTF316484.

Gene expression databases

BgeeiENSRNOG00000025489.

Family and domain databases

InterProiView protein in InterPro
IPR013122. PKD1_2_channel.
IPR003915. PKD_2.
PfamiView protein in Pfam
PF08016. PKD_channel. 1 hit.
PRINTSiPR01433. POLYCYSTIN2.
ProtoNetiSearch...

Entry informationi

Entry nameiD4A828_RAT
AccessioniPrimary (citable) accession number: D4A828
Entry historyiIntegrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: May 10, 2017
This is version 54 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.