ID   D4A7V6_RAT              Unreviewed;      1962 AA.
AC   D4A7V6;
DT   20-APR-2010, integrated into UniProtKB/TrEMBL.
DT   20-APR-2010, sequence version 1.
DT   27-MAR-2024, entry version 94.
DE   SubName: Full=Caspase 8 associated protein 2 {ECO:0000313|Ensembl:ENSRNOP00000009227.4};
GN   Name=Casp8ap2 {ECO:0000313|Ensembl:ENSRNOP00000009227.4,
GN   ECO:0000313|RGD:1305771};
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000009227.4, ECO:0000313|Proteomes:UP000002494};
RN   [1] {ECO:0000313|Ensembl:ENSRNOP00000009227.4, ECO:0000313|Proteomes:UP000002494}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000009227.4,
RC   ECO:0000313|Proteomes:UP000002494};
RX   PubMed=15057822; DOI=10.1038/nature02426;
RG   Rat Genome Sequencing Project Consortium;
RA   Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA   Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA   Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA   Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA   Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA   Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA   Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA   Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA   Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA   Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA   Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA   Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA   Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA   Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA   Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA   Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA   Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA   Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA   Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA   Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA   Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA   Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA   Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA   Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA   Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA   Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA   Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA   Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA   Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA   Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA   Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA   Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA   Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA   Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA   Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA   Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA   Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA   Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA   Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA   Mockrin S., Collins F.S.;
RT   "Genome sequence of the Brown Norway rat yields insights into mammalian
RT   evolution.";
RL   Nature 428:493-521(2004).
RN   [2] {ECO:0007829|PubMed:16641100}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=16641100; DOI=10.1073/pnas.0600895103;
RA   Hoffert J.D., Pisitkun T., Wang G., Shen R.F., Knepper M.A.;
RT   "Quantitative phosphoproteomics of vasopressin-sensitive renal cells:
RT   regulation of aquaporin-2 phosphorylation at two sites.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:7159-7164(2006).
RN   [3] {ECO:0007829|PubMed:22673903}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=22673903;
RA   Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C.,
RA   Olsen J.V.;
RT   "Quantitative maps of protein phosphorylation sites across 14 different rat
RT   organs and tissues.";
RL   Nat. Commun. 3:876-876(2012).
RN   [4] {ECO:0000313|Ensembl:ENSRNOP00000009227.4}
RP   IDENTIFICATION.
RC   STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000009227.4};
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   RefSeq; NP_001101391.1; NM_001107921.1.
DR   RefSeq; XP_006238035.1; XM_006237973.3.
DR   RefSeq; XP_006238036.1; XM_006237974.2.
DR   RefSeq; XP_006238037.1; XM_006237975.3.
DR   RefSeq; XP_008761842.1; XM_008763620.2.
DR   AlphaFoldDB; D4A7V6; -.
DR   SMR; D4A7V6; -.
DR   STRING; 10116.ENSRNOP00000009227; -.
DR   PhosphoSitePlus; D4A7V6; -.
DR   PaxDb; 10116-ENSRNOP00000009227; -.
DR   Ensembl; ENSRNOT00000009228.7; ENSRNOP00000009227.4; ENSRNOG00000006487.8.
DR   GeneID; 313128; -.
DR   KEGG; rno:313128; -.
DR   UCSC; RGD:1305771; rat.
DR   AGR; RGD:1305771; -.
DR   CTD; 9994; -.
DR   RGD; 1305771; Casp8ap2.
DR   eggNOG; ENOG502QQGD; Eukaryota.
DR   GeneTree; ENSGT00620000088063; -.
DR   HOGENOM; CLU_001861_0_0_1; -.
DR   OMA; RMESPCK; -.
DR   OrthoDB; 4254504at2759; -.
DR   TreeFam; TF332487; -.
DR   Reactome; R-RNO-3899300; SUMOylation of transcription cofactors.
DR   PRO; PR:D4A7V6; -.
DR   Proteomes; UP000002494; Chromosome 5.
DR   Bgee; ENSRNOG00000006487; Expressed in thymus and 19 other cell types or tissues.
DR   GO; GO:0005737; C:cytoplasm; IDA:ARUK-UCL.
DR   GO; GO:0005739; C:mitochondrion; ISO:RGD.
DR   GO; GO:0005634; C:nucleus; IDA:ARUK-UCL.
DR   GO; GO:0016605; C:PML body; ISO:RGD.
DR   GO; GO:0008656; F:cysteine-type endopeptidase activator activity involved in apoptotic process; ISO:RGD.
DR   GO; GO:0042802; F:identical protein binding; ISO:RGD.
DR   GO; GO:0002020; F:protease binding; ISO:RGD.
DR   GO; GO:0032184; F:SUMO polymer binding; ISO:RGD.
DR   GO; GO:0003714; F:transcription corepressor activity; ISO:RGD.
DR   GO; GO:0071260; P:cellular response to mechanical stimulus; ISO:RGD.
DR   GO; GO:0008625; P:extrinsic apoptotic signaling pathway via death domain receptors; ISO:RGD.
DR   GO; GO:0036337; P:Fas signaling pathway; ISO:RGD.
DR   Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR   InterPro; IPR039674; FLASH.
DR   PANTHER; PTHR15489:SF2; CASP8-ASSOCIATED PROTEIN 2; 1.
DR   PANTHER; PTHR15489; CASPASE 8 ASSOCIATED PROTEIN 2; 1.
DR   Pfam; PF21227; Myb_DNA-binding_7; 1.
PE   1: Evidence at protein level;
KW   Reference proteome {ECO:0000313|Proteomes:UP000002494}.
SQ   SEQUENCE   1962 AA;  219690 MW;  76B0A27867A59CD1 CRC64;
     MAADDDNGDG TGLFDVCPAS PLKNNDEGSL DIYAGLDSTV SDSTARSCVS FRNCLDLYEE
     ILTEEGTAKE ATYSDLQIEY GKCQQQMKDL MKRFKEIQTQ NLNLKNENQS LKKNISALIK
     TARVEINRKD EEINHLHQRL SEFPHFRNNH KTARTKDSRS KSPHLDNCSK TDHGVKSDVQ
     KDIHPNTSQP NLEKEGKSHS EAQNSLHLST GIEKHCTNNV WSRSPYQVSE GNSNEDNRRG
     RNGVRHSQGS RGTDRTQKDL NSSCNDGEPR DKEAASRLHG NPEKHGSSEA RAENKISEIK
     SSTGLGNKSE RSASSWEKET SRERPHTRVE PQNDKNLERQ NERLQNTHRK ELQSQDKAER
     KGDVKFKPAG EEQGHRGRVD RALPPHSKND MKYYGFNKYH PEERRGREDG KRDRGMSSHG
     FQDRRCSSSL SSNRNSKYPH SKEVSVAHQW ENTPFKAERH RTEDRRKRER ENKEESRHVK
     SDKKSPPEHL QRTHKDTKKS TANGKRQTEQ KHGKGPVSTS ELSKGTDNRE CTMKVENGPN
     EAKGKDLKLS FMEKLNLTLS PAKKQPVCQD NEHQIIGVPK PSGVCDSQSL EKTETVACLP
     SVSEQDREEP KSELPEPKEA LSATSQPRTS IPENKVKEEN RLLFKSVENT VPCELLACGT
     EISFPAPVEI EQARCLVQSM EVEETCAGAR AAASVVMRVL PEHASEDFSQ ELGTKRHDDI
     NSCDISEGGK KKVVLSPKAA AASESHLEPV VEEPSISPVN CSGDNNPKLE PSLEERPKVE
     NKSSPLEPCL PKEMFVPSPQ KTELIDHKID TGESNSVYQD DDNSVLSIDF NNLRPIPEPI
     SPLNSPVRPV SKVLSMESSC TIPLYDSSHK DEFPSNSTLS TFKSQSDLNK ENEKPVPKLD
     KCSEAESCKN LSVDELEEGE IRSDDEESVA QKRLEKSARP RTSTEVPPGK ISPGSRRSTV
     HVHKDNGRTV VKLPRDRITW SQRSNESRPS NTERKSKTMS ISSLEKILPL ILAPSSVWEV
     MHMLRLLGKH VRKNYMKFKI KFSLTQFHRI IESAILSFTS LIRYLDLSKI CKSVSTLQKS
     LCDVIESNLK QVKKNGIVDR LFEQQQTDMK KKLWKFVDEQ LDYLFEKLKK ILLKFCDSVK
     HENDSSEGKL GKKYKERAQH SNCQKKKMDN KEIRREKVLK SENTVNFKSS LGCEKFEEKH
     QDQNKTNTTT VKHDVKRTFS TCTDNNTKNS ECKEQFLGMN CPSTPRPGET EGNVEEGTPA
     AQHACVKSER GFEILTEQQA SSLTFNLVSD AQMGEIFKSL LQGSDLLDTG GTEKAEWELK
     TPEKQLLESL KCESAPACTT EELVSEAASL CPKVISDDNW SLLSSEKGPS LSSGLSLPVH
     PDVLDENCMF EVSSNLALSK DNVYSSEKSK PCISSILLED LAVSLTVPSP LKSDGHLSFL
     KPEVLSTSTP EEVISAHFSE DALLEEEDAS EQDIHLALES DNSSSKSSCS SWTSRSVASG
     FQYHPNLPMH AVIMEKSNDH FIVKIRRATP STSPGLKHGM VAEESLTPLP RTGKEADGAA
     EKEPTLFQST VLNPVQDLEN SDKSIDKSKP THEDQNSIVQ TQVPDIYEFL KDASNKVVHC
     DQVVDDCFKL HQVWEPKVSE SLQELPSMEK NAHSVDDHLP NTHIDLTKDP ATETKSLELM
     DVTVLDIDHL EHSKPNLDQD AQITCTSLQH DAVDAFIDLT HDVSNESKNE SNEPVLTVEG
     VGCQVICIDD DNHKEGKVGK VNSSLECTVE ETCIDLTSES AGSFEVKRHT LKSEPPSKSD
     CLELPETLGN GHKKRKNSPA VSHSSQKKQR KDMDLSSEKT KRLSPNSDRT GDAHRKHGSK
     KREPAVSDTS LSSEVNPEVK GSTAPLATFP GSLSAKNVIK KKGEIIVSWT RNDDREILLE
     CQKRMPSLKT FTHLAVKLNK NPNQVSERFQ QLKKLFEKSK CR
//