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Protein

G-protein coupled receptor 183

Gene

Gpr183

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Protein inferred from homologyi

Functioni

G-protein coupled receptor expressed in lymphocytes that acts as a chemotactic receptor for B-cells, T-cells, splenic dendritic cells, monocytes/macrophages and astrocytes (By similarity). Receptor for oxysterol 7-alpha,25-dihydroxycholesterol (7-alpha,25-OHC) and other related oxysterols (By similarity). Mediates cell positioning and movement of a number of cells by binding the 7-alpha,25-OHC ligand that forms a chemotactic gradient (By similarity). Binding of 7-alpha,25-OHC mediates the correct localization of B-cells during humoral immune responses (By similarity). Guides B-cell movement along the B-cell zone-T-cell zone boundary and later to interfollicular and outer follicular regions (By similarity). Its specific expression during B-cell maturation helps position B-cells appropriately for mounting T-dependent antibody responses (By similarity). Collaborates with CXCR5 to mediate B-cell migration; probably by forming a heterodimer with CXCR5 that affects the interaction between of CXCL13 and CXCR5 (By similarity). Also acts as a chemotactic receptor for some T-cells upon binding to 7-alpha,25-OHC ligand (By similarity). Promotes follicular helper T (Tfh) cells differentiation by positioning activated T-cells at the follicle-T-zone interface, promoting contact of newly activated CD4 T-cells with activated dendritic cells and exposing them to Tfh-cell-promoting inducible costimulator (ICOS) ligand (By similarity). Expression in splenic dendritic cells is required for their homeostasis, localization and ability to induce B- and T-cell responses: GPR183 acts as a chemotactic receptor in dendritic cells that mediates the accumulation of CD4+ dendritic cells in bridging channels (By similarity). Regulates migration of astrocytes and is involved in communication between astrocytes and macrophages (By similarity). Promotes osteoclast precursor migration to bone surfaces (By similarity). Signals constitutively through G(i)-alpha, but not G(s)-alpha or G(q)-alpha (By similarity). Signals constitutively also via MAPK1/3 (ERK1/2) (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei83Oxysterol agonistBy similarity1
Binding sitei108Oxysterol agonistBy similarity1
Binding sitei112Oxysterol agonistBy similarity1
Binding sitei256Oxysterol agonistBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Adaptive immunity, Immunity

Names & Taxonomyi

Protein namesi
Recommended name:
G-protein coupled receptor 183
Alternative name(s):
Epstein-Barr virus-induced G-protein coupled receptor 2
Short name:
EBI2
Short name:
EBV-induced G-protein coupled receptor 2
Gene namesi
Name:Gpr183
Synonyms:Ebi2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 15

Organism-specific databases

RGDi1598095. Gpr183.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 32ExtracellularSequence analysisAdd BLAST32
Transmembranei33 – 53Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini54 – 68CytoplasmicSequence analysisAdd BLAST15
Transmembranei69 – 89Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini90 – 101ExtracellularSequence analysisAdd BLAST12
Transmembranei102 – 122Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini123 – 143CytoplasmicSequence analysisAdd BLAST21
Transmembranei144 – 164Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini165 – 190ExtracellularSequence analysisAdd BLAST26
Transmembranei191 – 211Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini212 – 240CytoplasmicSequence analysisAdd BLAST29
Transmembranei241 – 261Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini262 – 287ExtracellularSequence analysisAdd BLAST26
Transmembranei288 – 308Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini309 – 357CytoplasmicSequence analysisAdd BLAST49

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004188841 – 357G-protein coupled receptor 183Add BLAST357

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi4N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi100 ↔ 177PROSITE-ProRule annotation
Modified residuei324PhosphoserineBy similarity1
Modified residuei345PhosphoserineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiD4A7K7.

PTM databases

iPTMnetiD4A7K7.
PhosphoSitePlusiD4A7K7.

Expressioni

Gene expression databases

BgeeiENSRNOG00000025094.

Interactioni

Subunit structurei

Homodimer and heterodimer. Heterodimerizes with CXCR5; leading to modulate the interaction between of CXCL13 and CXCR5.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000035137.

Structurei

3D structure databases

ProteinModelPortaliD4A7K7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni122 – 130Interaction with G proteinsBy similarity9

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IEQQ. Eukaryota.
ENOG4110QC8. LUCA.
GeneTreeiENSGT00760000118784.
InParanoidiD4A7K7.
KOiK04305.
OMAiRSAPEEN.
OrthoDBiEOG091G0B23.
PhylomeDBiD4A7K7.
TreeFamiTF350009.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D4A7K7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANNFTTPLA ASHGNNCDLY AHHSTARILM PLHYSLVFII GLVGNLLALV
60 70 80 90 100
VIVQNRKKIN STTLYSMNLV ISDILFTTAL PTRIVYYALG FDWRIGDALC
110 120 130 140 150
RITALLFYIN TYAGVNFMTC LSIDRFFAVV HPLRYNKIKR IEYAKGICVF
160 170 180 190 200
VWILVFAQTL PLLLKPMSKQ EADKTTCMEY PNFEGTASLP WILLGACLLG
210 220 230 240 250
YVLPLAIILL CYSQICCKLF RTAKQNPLTE KSGVNKKALN TIILIIGVFV
260 270 280 290 300
LCFTPYHVAI MQHMVKTLYA PGALGCGVRH SFQISLHFTV CLMNFNCCMD
310 320 330 340 350
PFIYFFACKG YKRKVMKMLK RQVSVSISSA VRSAPEENSR EMTESQMMIH

SKASNGR
Length:357
Mass (Da):40,227
Last modified:April 20, 2010 - v1
Checksum:iF14C3483B1825553
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR03095075 Genomic DNA. No translation available.
CH473951 Genomic DNA. Translation: EDM02572.1.
RefSeqiNP_001102856.1. NM_001109386.1.
UniGeneiRn.179130.

Genome annotation databases

EnsembliENSRNOT00000034560; ENSRNOP00000035137; ENSRNOG00000025094.
GeneIDi679975.
KEGGirno:679975.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR03095075 Genomic DNA. No translation available.
CH473951 Genomic DNA. Translation: EDM02572.1.
RefSeqiNP_001102856.1. NM_001109386.1.
UniGeneiRn.179130.

3D structure databases

ProteinModelPortaliD4A7K7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000035137.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiD4A7K7.
PhosphoSitePlusiD4A7K7.

Proteomic databases

PaxDbiD4A7K7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000034560; ENSRNOP00000035137; ENSRNOG00000025094.
GeneIDi679975.
KEGGirno:679975.

Organism-specific databases

CTDi1880.
RGDi1598095. Gpr183.

Phylogenomic databases

eggNOGiENOG410IEQQ. Eukaryota.
ENOG4110QC8. LUCA.
GeneTreeiENSGT00760000118784.
InParanoidiD4A7K7.
KOiK04305.
OMAiRSAPEEN.
OrthoDBiEOG091G0B23.
PhylomeDBiD4A7K7.
TreeFamiTF350009.

Miscellaneous databases

PROiD4A7K7.

Gene expression databases

BgeeiENSRNOG00000025094.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGP183_RAT
AccessioniPrimary (citable) accession number: D4A7K7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 5, 2012
Last sequence update: April 20, 2010
Last modified: November 2, 2016
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.