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Protein

G-protein coupled receptor 183

Gene

Gpr183

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

G-protein coupled receptor expressed in lymphocytes that acts as a chemotactic receptor for B-cells, T-cells, splenic dendritic cells, monocytes/macrophages and astrocytes (By similarity). Receptor for oxysterol 7-alpha,25-dihydroxycholesterol (7-alpha,25-OHC) and other related oxysterols (By similarity). Mediates cell positioning and movement of a number of cells by binding the 7-alpha,25-OHC ligand that forms a chemotactic gradient (By similarity). Binding of 7-alpha,25-OHC mediates the correct localization of B-cells during humoral immune responses (By similarity). Guides B-cell movement along the B-cell zone-T-cell zone boundary and later to interfollicular and outer follicular regions (By similarity). Its specific expression during B-cell maturation helps position B-cells appropriately for mounting T-dependent antibody responses (By similarity). Collaborates with CXCR5 to mediate B-cell migration; probably by forming a heterodimer with CXCR5 that affects the interaction between of CXCL13 and CXCR5 (By similarity). Also acts as a chemotactic receptor for some T-cells upon binding to 7-alpha,25-OHC ligand (By similarity). Promotes follicular helper T (Tfh) cells differentiation by positioning activated T-cells at the follicle-T-zone interface, promoting contact of newly activated CD4 T-cells with activated dendritic cells and exposing them to Tfh-cell-promoting inducible costimulator (ICOS) ligand (By similarity). Expression in splenic dendritic cells is required for their homeostasis, localization and ability to induce B- and T-cell responses: GPR183 acts as a chemotactic receptor in dendritic cells that mediates the accumulation of CD4+ dendritic cells in bridging channels (By similarity). Regulates migration of astrocytes and is involved in communication between astrocytes and macrophages (By similarity). Promotes osteoclast precursor migration to bone surfaces (By similarity). Signals constitutively through G(i)-alpha, but not G(s)-alpha or G(q)-alpha (By similarity). Signals constitutively also via MAPK1/3 (ERK1/2) (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei83Oxysterol agonistBy similarity1
Binding sitei108Oxysterol agonistBy similarity1
Binding sitei112Oxysterol agonistBy similarity1
Binding sitei256Oxysterol agonistBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processAdaptive immunity, Immunity

Enzyme and pathway databases

ReactomeiR-RNO-373076 Class A/1 (Rhodopsin-like receptors)
R-RNO-418594 G alpha (i) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
G-protein coupled receptor 183
Alternative name(s):
Epstein-Barr virus-induced G-protein coupled receptor 2
Short name:
EBI2
Short name:
EBV-induced G-protein coupled receptor 2
Gene namesi
Name:Gpr183
Synonyms:Ebi2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 15

Organism-specific databases

RGDi1598095 Gpr183

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 32ExtracellularSequence analysisAdd BLAST32
Transmembranei33 – 53Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini54 – 68CytoplasmicSequence analysisAdd BLAST15
Transmembranei69 – 89Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini90 – 101ExtracellularSequence analysisAdd BLAST12
Transmembranei102 – 122Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini123 – 143CytoplasmicSequence analysisAdd BLAST21
Transmembranei144 – 164Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini165 – 190ExtracellularSequence analysisAdd BLAST26
Transmembranei191 – 211Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini212 – 240CytoplasmicSequence analysisAdd BLAST29
Transmembranei241 – 261Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini262 – 287ExtracellularSequence analysisAdd BLAST26
Transmembranei288 – 308Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini309 – 357CytoplasmicSequence analysisAdd BLAST49

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004188841 – 357G-protein coupled receptor 183Add BLAST357

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi4N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi100 ↔ 177PROSITE-ProRule annotation
Modified residuei324PhosphoserineBy similarity1
Modified residuei345PhosphoserineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiD4A7K7

PTM databases

iPTMnetiD4A7K7
PhosphoSitePlusiD4A7K7

Expressioni

Gene expression databases

BgeeiENSRNOG00000025094

Interactioni

Subunit structurei

Homodimer and heterodimer. Heterodimerizes with CXCR5; leading to modulate the interaction between of CXCL13 and CXCR5.By similarity

Structurei

3D structure databases

ProteinModelPortaliD4A7K7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni122 – 130Interaction with G proteinsBy similarity9

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IEQQ Eukaryota
ENOG4110QC8 LUCA
GeneTreeiENSGT00910000144002
InParanoidiD4A7K7
KOiK04305
OMAiTTCMEYP
OrthoDBiEOG091G0B23
PhylomeDBiD4A7K7
TreeFamiTF350009

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

D4A7K7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANNFTTPLA ASHGNNCDLY AHHSTARILM PLHYSLVFII GLVGNLLALV
60 70 80 90 100
VIVQNRKKIN STTLYSMNLV ISDILFTTAL PTRIVYYALG FDWRIGDALC
110 120 130 140 150
RITALLFYIN TYAGVNFMTC LSIDRFFAVV HPLRYNKIKR IEYAKGICVF
160 170 180 190 200
VWILVFAQTL PLLLKPMSKQ EADKTTCMEY PNFEGTASLP WILLGACLLG
210 220 230 240 250
YVLPLAIILL CYSQICCKLF RTAKQNPLTE KSGVNKKALN TIILIIGVFV
260 270 280 290 300
LCFTPYHVAI MQHMVKTLYA PGALGCGVRH SFQISLHFTV CLMNFNCCMD
310 320 330 340 350
PFIYFFACKG YKRKVMKMLK RQVSVSISSA VRSAPEENSR EMTESQMMIH

SKASNGR
Length:357
Mass (Da):40,227
Last modified:April 20, 2010 - v1
Checksum:iF14C3483B1825553
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR03095075 Genomic DNA No translation available.
CH473951 Genomic DNA Translation: EDM02572.1
RefSeqiNP_001102856.1, NM_001109386.1
UniGeneiRn.179130

Genome annotation databases

EnsembliENSRNOT00000034560; ENSRNOP00000035137; ENSRNOG00000025094
GeneIDi679975
KEGGirno:679975

Similar proteinsi

Entry informationi

Entry nameiGP183_RAT
AccessioniPrimary (citable) accession number: D4A7K7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 5, 2012
Last sequence update: April 20, 2010
Last modified: May 23, 2018
This is version 66 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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