ID   CL004_RAT               Reviewed;         552 AA.
AC   D4A770;
DT   04-FEB-2015, integrated into UniProtKB/Swiss-Prot.
DT   20-APR-2010, sequence version 1.
DT   27-MAR-2024, entry version 68.
DE   RecName: Full=Protein C12orf4 homolog;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Brown Norway;
RX   PubMed=15057822; DOI=10.1038/nature02426;
RA   Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA   Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA   Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA   Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA   Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA   Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA   Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA   Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA   Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA   Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA   Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA   Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA   Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA   Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA   Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA   Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA   Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA   Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA   Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA   Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA   Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA   Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA   Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA   Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA   Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA   Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA   Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA   Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA   Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA   Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA   Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA   Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA   Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA   Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA   Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA   Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA   Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA   Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA   Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA   Mockrin S., Collins F.S.;
RT   "Genome sequence of the Brown Norway rat yields insights into mammalian
RT   evolution.";
RL   Nature 428:493-521(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Brown Norway;
RA   Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   SUBCELLULAR LOCATION, IDENTIFICATION BY MASS SPECTROMETRY, AND FUNCTION.
RX   PubMed=25122211; DOI=10.1371/journal.pone.0104998;
RA   Mazuc E., Guglielmi L., Bec N., Parez V., Hahn C.S., Mollevi C.,
RA   Parrinello H., Desvignes J.P., Larroque C., Jupp R., Dariavach P.,
RA   Martineau P.;
RT   "In-cell intrabody selection from a diverse human library identifies
RT   C12orf4 protein as a new player in rodent mast cell degranulation.";
RL   PLoS ONE 9:E104998-E104998(2014).
CC   -!- FUNCTION: Plays a role in mast cell degranulation.
CC       {ECO:0000269|PubMed:25122211}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:25122211}.
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DR   EMBL; AABR06033849; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AABR06033850; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AABR06033851; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH473964; EDM01821.1; -; Genomic_DNA.
DR   RefSeq; NP_001100093.1; NM_001106623.1.
DR   AlphaFoldDB; D4A770; -.
DR   STRING; 10116.ENSRNOP00000074196; -.
DR   PhosphoSitePlus; D4A770; -.
DR   PaxDb; 10116-ENSRNOP00000026838; -.
DR   PeptideAtlas; D4A770; -.
DR   Ensembl; ENSRNOT00000089513.2; ENSRNOP00000074196.1; ENSRNOG00000055036.2.
DR   Ensembl; ENSRNOT00055018284; ENSRNOP00055014693; ENSRNOG00055010812.
DR   Ensembl; ENSRNOT00060028997; ENSRNOP00060023348; ENSRNOG00060016960.
DR   Ensembl; ENSRNOT00065057611; ENSRNOP00065047413; ENSRNOG00065033519.
DR   GeneID; 297607; -.
DR   KEGG; rno:297607; -.
DR   UCSC; RGD:1311164; rat.
DR   AGR; RGD:1311164; -.
DR   CTD; 297607; -.
DR   RGD; 1311164; RGD1311164.
DR   eggNOG; KOG4506; Eukaryota.
DR   GeneTree; ENSGT00390000010229; -.
DR   HOGENOM; CLU_036084_0_0_1; -.
DR   InParanoid; D4A770; -.
DR   OMA; LMHRIMS; -.
DR   OrthoDB; 5482447at2759; -.
DR   PhylomeDB; D4A770; -.
DR   TreeFam; TF314243; -.
DR   PRO; PR:D4A770; -.
DR   Proteomes; UP000002494; Chromosome 4.
DR   Proteomes; UP000234681; Chromosome 4.
DR   Bgee; ENSRNOG00000055036; Expressed in cerebellum and 19 other cell types or tissues.
DR   GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
DR   GO; GO:0043304; P:regulation of mast cell degranulation; IDA:UniProtKB.
DR   InterPro; IPR019311; DUF2362.
DR   PANTHER; PTHR16525:SF0; PROTEIN C12ORF4; 1.
DR   PANTHER; PTHR16525; UNCHARACTERIZED; 1.
DR   Pfam; PF10154; DUF2362; 1.
DR   Genevisible; D4A770; RN.
PE   1: Evidence at protein level;
KW   Cytoplasm; Phosphoprotein; Reference proteome.
FT   CHAIN           1..552
FT                   /note="Protein C12orf4 homolog"
FT                   /id="PRO_0000431922"
FT   MOD_RES         79
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q91YN0"
SQ   SEQUENCE   552 AA;  63619 MW;  1E928892A77E3A85 CRC64;
     MKKNRERFSS KEREFVYKFQ IGSERLELRV PLRFPVDENA SHLHGRLMLL HSLPCFIEND
     LKEALARFIE EESLRDHDSD AEACLEAVKS GEVDLHQLAS TWAKAYAETT LEHARPEEPN
     WDEDFADVYH DLIHSPASET LLNLEHNYFV SISELIGERD VELKKLRERQ GIEMEKVMQE
     LGKSLTDQDV NSLAAQHFES QQDLENKWSN ELKQSTAIQK QEYQEWVIKL HQDLKNPNNS
     SLSEEIKVQP SQFRESADAA GRIYEEQRKL EESFTIHLGA QLKTMHNLRL LRADMLDFCK
     HKRTQGSGVK LHRLQTALSL YSTSLCGLVL LVDNRINSYS GIKRDFATVC QECTDFHFPR
     IEEQLEVVQQ VALYARTQRR SKCKEARDSG NQNGGSDEKS KNAERNYLNI LPGEFYITRH
     SNLSEIHVAF HLCVDDNVKS GNITARDPAI MGLRNILKVC CTHDITTISI PLLLVHDMSE
     EMTIPWCLRR AELVFKCVKG FMMEMASWDG GISRTVQFLV PQSISEEMFY QLSNMLPQIF
     RVSSTLTLTS KH
//