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Protein

Protein C12orf4 homolog

Gene
N/A
Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in mast cell degranulation.1 Publication

GO - Biological processi

  • regulation of mast cell degranulation Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Protein C12orf4 homolog
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Unassembled WGS sequence

Organism-specific databases

RGDi1311164. RGD1311164.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 552552Protein C12orf4 homologPRO_0000431922Add
BLAST

Expressioni

Gene expression databases

GenevisibleiD4A770. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000026838.

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00390000010229.
OMAiEMEKVMQ.
OrthoDBiEOG741Z1Z.
PhylomeDBiD4A770.
TreeFamiTF314243.

Family and domain databases

InterProiIPR019311. DUF2362.
[Graphical view]
PANTHERiPTHR16525. PTHR16525. 1 hit.
PfamiPF10154. DUF2362. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D4A770-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKNRERFSS KEREFVYKFQ IGSERLELRV PLRFPVDENA SHLHGRLMLL
60 70 80 90 100
HSLPCFIEND LKEALARFIE EESLRDHDSD AEACLEAVKS GEVDLHQLAS
110 120 130 140 150
TWAKAYAETT LEHARPEEPN WDEDFADVYH DLIHSPASET LLNLEHNYFV
160 170 180 190 200
SISELIGERD VELKKLRERQ GIEMEKVMQE LGKSLTDQDV NSLAAQHFES
210 220 230 240 250
QQDLENKWSN ELKQSTAIQK QEYQEWVIKL HQDLKNPNNS SLSEEIKVQP
260 270 280 290 300
SQFRESADAA GRIYEEQRKL EESFTIHLGA QLKTMHNLRL LRADMLDFCK
310 320 330 340 350
HKRTQGSGVK LHRLQTALSL YSTSLCGLVL LVDNRINSYS GIKRDFATVC
360 370 380 390 400
QECTDFHFPR IEEQLEVVQQ VALYARTQRR SKCKEARDSG NQNGGSDEKS
410 420 430 440 450
KNAERNYLNI LPGEFYITRH SNLSEIHVAF HLCVDDNVKS GNITARDPAI
460 470 480 490 500
MGLRNILKVC CTHDITTISI PLLLVHDMSE EMTIPWCLRR AELVFKCVKG
510 520 530 540 550
FMMEMASWDG GISRTVQFLV PQSISEEMFY QLSNMLPQIF RVSSTLTLTS

KH
Length:552
Mass (Da):63,619
Last modified:April 20, 2010 - v1
Checksum:i1E928892A77E3A85
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR06033849 Genomic DNA. No translation available.
AABR06033850 Genomic DNA. No translation available.
AABR06033851 Genomic DNA. No translation available.
CH473964 Genomic DNA. Translation: EDM01821.1.
RefSeqiNP_001100093.1. NM_001106623.1.
UniGeneiRn.225116.

Genome annotation databases

EnsembliENSRNOT00000089513; ENSRNOP00000074196; ENSRNOG00000055036.
GeneIDi297607.
KEGGirno:297607.
UCSCiRGD:1311164. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR06033849 Genomic DNA. No translation available.
AABR06033850 Genomic DNA. No translation available.
AABR06033851 Genomic DNA. No translation available.
CH473964 Genomic DNA. Translation: EDM01821.1.
RefSeqiNP_001100093.1. NM_001106623.1.
UniGeneiRn.225116.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000026838.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000089513; ENSRNOP00000074196; ENSRNOG00000055036.
GeneIDi297607.
KEGGirno:297607.
UCSCiRGD:1311164. rat.

Organism-specific databases

CTDi297607.
RGDi1311164. RGD1311164.

Phylogenomic databases

GeneTreeiENSGT00390000010229.
OMAiEMEKVMQ.
OrthoDBiEOG741Z1Z.
PhylomeDBiD4A770.
TreeFamiTF314243.

Miscellaneous databases

NextBioi642503.

Gene expression databases

GenevisibleiD4A770. RN.

Family and domain databases

InterProiIPR019311. DUF2362.
[Graphical view]
PANTHERiPTHR16525. PTHR16525. 1 hit.
PfamiPF10154. DUF2362. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown Norway.
  2. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown Norway.
  3. "In-cell intrabody selection from a diverse human library identifies C12orf4 protein as a new player in rodent mast cell degranulation."
    Mazuc E., Guglielmi L., Bec N., Parez V., Hahn C.S., Mollevi C., Parrinello H., Desvignes J.P., Larroque C., Jupp R., Dariavach P., Martineau P.
    PLoS ONE 9:E104998-E104998(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, IDENTIFICATION BY MASS SPECTROMETRY, FUNCTION.

Entry informationi

Entry nameiCL004_RAT
AccessioniPrimary (citable) accession number: D4A770
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 4, 2015
Last sequence update: April 20, 2010
Last modified: July 22, 2015
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.