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Protein

Probable G-protein coupled receptor 158

Gene

Gpr158

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Orphan receptor.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Probable G-protein coupled receptor 158
Gene namesi
Name:Gpr158
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1305841. Gpr158.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini25 – 417ExtracellularSequence analysisAdd BLAST393
Transmembranei418 – 438HelicalSequence analysisAdd BLAST21
Topological domaini439 – 451CytoplasmicSequence analysisAdd BLAST13
Transmembranei452 – 472HelicalSequence analysisAdd BLAST21
Topological domaini473 – 480ExtracellularSequence analysis8
Transmembranei481 – 501HelicalSequence analysisAdd BLAST21
Topological domaini502 – 528CytoplasmicSequence analysisAdd BLAST27
Transmembranei529 – 549HelicalSequence analysisAdd BLAST21
Topological domaini550 – 579ExtracellularSequence analysisAdd BLAST30
Transmembranei580 – 600HelicalSequence analysisAdd BLAST21
Topological domaini601 – 613CytoplasmicSequence analysisAdd BLAST13
Transmembranei614 – 634HelicalSequence analysisAdd BLAST21
Topological domaini635 – 643ExtracellularSequence analysis9
Transmembranei644 – 664HelicalSequence analysisAdd BLAST21
Topological domaini665 – 1202CytoplasmicSequence analysisAdd BLAST538

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000041836225 – 1202Probable G-protein coupled receptor 158Add BLAST1178

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi98N-linked (GlcNAc...)Sequence analysis1
Glycosylationi143N-linked (GlcNAc...)Sequence analysis1
Glycosylationi215N-linked (GlcNAc...)Sequence analysis1
Glycosylationi274N-linked (GlcNAc...)Sequence analysis1
Glycosylationi333N-linked (GlcNAc...)Sequence analysis1
Modified residuei694PhosphoserineBy similarity1
Modified residuei705PhosphoserineBy similarity1
Modified residuei708PhosphoserineBy similarity1
Cross-linki774Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Modified residuei865PhosphoserineBy similarity1
Modified residuei946PhosphoserineBy similarity1
Modified residuei1061PhosphoserineBy similarity1
Modified residuei1076PhosphoserineCombined sources1

Keywords - PTMi

Glycoprotein, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiD4A6L0.
PRIDEiD4A6L0.

PTM databases

iPTMnetiD4A6L0.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000038884.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4418. Eukaryota.
ENOG410XXEC. LUCA.
InParanoidiD4A6L0.
PhylomeDBiD4A6L0.
TreeFamiTF319114.

Family and domain databases

InterProiIPR017978. GPCR_3_C.
[Graphical view]
PfamiPF00003. 7tm_3. 1 hit.
[Graphical view]
PROSITEiPS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

D4A6L0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGAMAYSLLL CLLLAHLGLG EVGASLDPSE RPDSSRERTS RGKQHGQQLP
60 70 80 90 100
RASAPDPSIP WSRSTDGTIL AQKLAEEVPM DVASYLYTGD FHQLKRANCS
110 120 130 140 150
GRYELAGLPG KSPSLASSHP SLHGALDTLT HATNFLNMML QSNKSREQTV
160 170 180 190 200
QDDLQWYQAL VRSLLEGEPS ISRAAITFST ESLSTPAPQV FLQATREESR
210 220 230 240 250
ILLQDLSSSA HHLANATLET EWFHGLRRKW RPHLHRRGSN QGPRGLGHSW
260 270 280 290 300
RRRDGLGGDR SHVKWSPPFL ECENGSYKPG WLVTLSAAFY GLQPNLVPEF
310 320 330 340 350
RGVMKVDINL QKVDIDQCSS DGWFSGTHKC HLNNSECMPI KGLGFVLGAY
360 370 380 390 400
QCVCKAGFYH PRVFSVNNFQ RRGPDHHFSG STKDVSEEAH VCLPCREGCP
410 420 430 440 450
FCADDRPCFV QEDKYLRLAI ISFQALCMLL DFVSMLVVYH FRKAKSIRAS
460 470 480 490 500
GLILLETILF GSLLLYFPVV ILYFEPSTFR CILLRWVRLL GFATVYGTVT
510 520 530 540 550
LKLHRVLKVF LSRTAQRIPY MTGGRVMRML AVIVLVVFWF LVGWTSSMCQ
560 570 580 590 600
NLERDILLVG QGQTSDNLTF NMCLIDRWDY MTAVAEFLFL LWGIYLCYAV
610 620 630 640 650
RTVPSAFHEP RYMAVAVHNE LIITAIFHTI RFVLASRLQP DWMLMLYFAH
660 670 680 690 700
THLTVTVTIG LLLIPKFSHS SNNPRDDIAT EAYEDELDMG RSGSYLNSSI
710 720 730 740 750
NSAWSEHSLD PEDIRDELKK LYAQLEIYKR KKMITNNPHL QKKRCSKKGL
760 770 780 790 800
GRSIMRRITE IPETVSRQCS KEDKEGTDHS AAKGTGLVRK NPTESSGNTG
810 820 830 840 850
RPKEESLKNR VFSLKKSHST YDHVRDQTDE SSSLPTESQE EEVTENSTLE
860 870 880 890 900
SLSSKKLTQK VKEDSEAEST ESVPLVCKSA SAHNLSSEKK PGHPRTSMLQ
910 920 930 940 950
KSLSVIASAK EKTLGLAGKT QTLVMEDRAK SQKPQPKDRE TNRKYSNSDN
960 970 980 990 1000
TETNPNSNHT EELRKPQKSG IMKQQRVNLP TANPDASSST TQIKDNFDIG
1010 1020 1030 1040 1050
EVCPWEVYDL TPGPVPSEPK AQKHVSIAAS EVEQNPASFS KEKSHHKPKA
1060 1070 1080 1090 1100
AEGLYQANHK SIDKTEVCPW ESHGQSPLED ENRLISKTPV LPGRAREENG
1110 1120 1130 1140 1150
SQLYTTNMCA GQYEELPPKA VASKVENENL NQMGDQEKQT SSSVDIIPGS
1160 1170 1180 1190 1200
CISSNNSPQP LTSRAEVCPW EFEPLEQPNA ERIVALPASS ALSASKIPGP

RK
Length:1,202
Mass (Da):134,459
Last modified:April 20, 2010 - v1
Checksum:i939666F82DFED1DD
GO

Sequence databases

UniGeneiRn.146822.

Genome annotation databases

UCSCiRGD:1305841. rat.

Cross-referencesi

Sequence databases

UniGeneiRn.146822.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000038884.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiD4A6L0.

Proteomic databases

PaxDbiD4A6L0.
PRIDEiD4A6L0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiRGD:1305841. rat.

Organism-specific databases

RGDi1305841. Gpr158.

Phylogenomic databases

eggNOGiKOG4418. Eukaryota.
ENOG410XXEC. LUCA.
InParanoidiD4A6L0.
PhylomeDBiD4A6L0.
TreeFamiTF319114.

Miscellaneous databases

PROiD4A6L0.

Family and domain databases

InterProiIPR017978. GPCR_3_C.
[Graphical view]
PfamiPF00003. 7tm_3. 1 hit.
[Graphical view]
PROSITEiPS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGP158_RAT
AccessioniPrimary (citable) accession number: D4A6L0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2012
Last sequence update: April 20, 2010
Last modified: July 6, 2016
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.