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Protein

Tetratricopeptide repeat protein 19, mitochondrial

Gene

Ttc19

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Mitochondrial protein required for formation of the mitochondrial complex III.By similarity

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Tetratricopeptide repeat protein 19, mitochondrial
Short name:
TPR repeat protein 19
Gene namesi
Name:Ttc19
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi1582808. Ttc19.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 52MitochondrionSequence analysisAdd BLAST52
ChainiPRO_000040835453 – 365Tetratricopeptide repeat protein 19, mitochondrialAdd BLAST313

Proteomic databases

PaxDbiD4A6D7.
PeptideAtlasiD4A6D7.
PRIDEiD4A6D7.

Expressioni

Gene expression databases

BgeeiENSRNOG00000002977.
GenevisibleiD4A6D7. RN.

Interactioni

Subunit structurei

Interacts with UQCRC1 and UQCRFS1.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000054591.

Structurei

3D structure databases

SMRiD4A6D7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati127 – 160TPR 1Add BLAST34
Repeati170 – 203TPR 2Add BLAST34
Repeati220 – 260TPR 3Add BLAST41
Repeati269 – 302TPR 4Add BLAST34
Repeati308 – 341TPR 5Add BLAST34

Sequence similaritiesi

Belongs to the TTC19 family.Curated

Keywords - Domaini

Repeat, TPR repeat, Transit peptide

Phylogenomic databases

eggNOGiKOG1840. Eukaryota.
COG0457. LUCA.
GeneTreeiENSGT00390000009194.
InParanoidiD4A6D7.
KOiK18169.
OMAiGRGGSMY.
OrthoDBiEOG091G0AH0.
PhylomeDBiD4A6D7.
TreeFamiTF314010.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
1.25.40.10. 1 hit.
InterProiView protein in InterPro
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
IPR011991. WHTH_DNA-bd_dom.
PfamiView protein in Pfam
PF13374. TPR_10. 1 hit.
SMARTiView protein in SMART
SM00028. TPR. 4 hits.
SUPFAMiSSF48452. SSF48452. 1 hit.
PROSITEiView protein in PROSITE
PS50293. TPR_REGION. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: D4A6D7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MFRLLRWRLG RTLLRAAGRR CGGCTARLLP ERAGDAGPGA ERLRTRGAPA
60 70 80 90 100
RGHRVLPLLA ALAWFSRTAA AEEQPGEDAT DEAEAEIIQL LKRAKLSIMK
110 120 130 140 150
DEPEAAELIL HDALRLAYES DNKKAITYTY DLMANLAFIR GQLENAEQLF
160 170 180 190 200
KATMSYLLGG GMKQEDNAIV EISLKLANIY AAQNKQEFAL AGYEFCISTL
210 220 230 240 250
EGKIEREKEL AEDIMSEERA NTYLLLGMCL DSCARYLLFS KQLSQAQRMY
260 270 280 290 300
EKALQICQEI QGERHPQTIV LMSDLATALD AQGHFDDAYI YMQRASDLAR
310 320 330 340 350
EINHPELHMV LSNLAAILIH RERYTQAKEI YQEALKQAEL KRDEFSVQHI
360
REELAELSRK SRLLT
Length:365
Mass (Da):41,333
Last modified:April 20, 2010 - v1
Checksum:i1F0E4B560F9097FD
GO
Isoform 2 (identifier: D4A6D7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     133-145: Missing.

Show »
Length:352
Mass (Da):39,875
Checksum:i66B1789E65B59F6B
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_041059133 – 145Missing in isoform 2. CuratedAdd BLAST13

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH473948 Genomic DNA. Translation: EDM04701.1.
CH473948 Genomic DNA. Translation: EDM04702.1.
RefSeqiNP_001103114.1. NM_001109644.1. [D4A6D7-2]
XP_006246592.1. XM_006246530.3. [D4A6D7-1]
UniGeneiRn.216288.

Genome annotation databases

EnsembliENSRNOT00000057777; ENSRNOP00000054591; ENSRNOG00000002977. [D4A6D7-2]
GeneIDi691506.
KEGGirno:691506.
UCSCiRGD:1582808. rat. [D4A6D7-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH473948 Genomic DNA. Translation: EDM04701.1.
CH473948 Genomic DNA. Translation: EDM04702.1.
RefSeqiNP_001103114.1. NM_001109644.1. [D4A6D7-2]
XP_006246592.1. XM_006246530.3. [D4A6D7-1]
UniGeneiRn.216288.

3D structure databases

SMRiD4A6D7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000054591.

Proteomic databases

PaxDbiD4A6D7.
PeptideAtlasiD4A6D7.
PRIDEiD4A6D7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000057777; ENSRNOP00000054591; ENSRNOG00000002977. [D4A6D7-2]
GeneIDi691506.
KEGGirno:691506.
UCSCiRGD:1582808. rat. [D4A6D7-1]

Organism-specific databases

CTDi54902.
RGDi1582808. Ttc19.

Phylogenomic databases

eggNOGiKOG1840. Eukaryota.
COG0457. LUCA.
GeneTreeiENSGT00390000009194.
InParanoidiD4A6D7.
KOiK18169.
OMAiGRGGSMY.
OrthoDBiEOG091G0AH0.
PhylomeDBiD4A6D7.
TreeFamiTF314010.

Miscellaneous databases

PROiPR:D4A6D7.

Gene expression databases

BgeeiENSRNOG00000002977.
GenevisibleiD4A6D7. RN.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
1.25.40.10. 1 hit.
InterProiView protein in InterPro
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
IPR011991. WHTH_DNA-bd_dom.
PfamiView protein in Pfam
PF13374. TPR_10. 1 hit.
SMARTiView protein in SMART
SM00028. TPR. 4 hits.
SUPFAMiSSF48452. SSF48452. 1 hit.
PROSITEiView protein in PROSITE
PS50293. TPR_REGION. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiTTC19_RAT
AccessioniPrimary (citable) accession number: D4A6D7
Secondary accession number(s): D4A3Z0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 3, 2011
Last sequence update: April 20, 2010
Last modified: May 10, 2017
This is version 49 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.