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Protein

Tetratricopeptide repeat protein 19, mitochondrial

Gene

Ttc19

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Required for the preservation of the structural and functional integrity of mitochondrial respiratory complex III by allowing the physiological turnover of the Rieske protein UQCRFS1. Involved in the clearance of UQCRFS1 N-terminal fragments, which are produced upon incorporation into the complex III and whose presence is detrimental for its catalytic activity.By similarity

GO - Biological processi

Keywordsi

Biological processCell cycle, Cell division, Electron transport, Respiratory chain, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Tetratricopeptide repeat protein 19, mitochondrial
Short name:
TPR repeat protein 19
Gene namesi
Name:Ttc19
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi1582808 Ttc19

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 52MitochondrionSequence analysisAdd BLAST52
ChainiPRO_000040835453 – 365Tetratricopeptide repeat protein 19, mitochondrialAdd BLAST313

Proteomic databases

PaxDbiD4A6D7
PeptideAtlasiD4A6D7
PRIDEiD4A6D7

Expressioni

Gene expression databases

BgeeiENSRNOG00000002977
GenevisibleiD4A6D7 RN

Interactioni

Subunit structurei

Binds to the mature mitochondrial complex III dimer, after the incorporation of the Rieske protein UQCRFS1. Interacts with UQCRC1 and UQCRFS1 (By similarity). Interacts with ZFYVE26 and CHMP4B.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000054591

Structurei

3D structure databases

SMRiD4A6D7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati127 – 160TPR 1Add BLAST34
Repeati170 – 203TPR 2Add BLAST34
Repeati220 – 260TPR 3Add BLAST41
Repeati269 – 302TPR 4Add BLAST34
Repeati308 – 341TPR 5Add BLAST34

Sequence similaritiesi

Belongs to the TTC19 family.Curated

Keywords - Domaini

Repeat, TPR repeat, Transit peptide

Phylogenomic databases

eggNOGiKOG1840 Eukaryota
COG0457 LUCA
GeneTreeiENSGT00390000009194
InParanoidiD4A6D7
KOiK18169
OMAiGMKQEDN
OrthoDBiEOG091G0AH0
PhylomeDBiD4A6D7
TreeFamiTF314010

Family and domain databases

Gene3Di1.25.40.10, 2 hits
InterProiView protein in InterPro
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat
SMARTiView protein in SMART
SM00028 TPR, 4 hits
SUPFAMiSSF48452 SSF48452, 1 hit
PROSITEiView protein in PROSITE
PS50293 TPR_REGION, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: D4A6D7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MFRLLRWRLG RTLLRAAGRR CGGCTARLLP ERAGDAGPGA ERLRTRGAPA
60 70 80 90 100
RGHRVLPLLA ALAWFSRTAA AEEQPGEDAT DEAEAEIIQL LKRAKLSIMK
110 120 130 140 150
DEPEAAELIL HDALRLAYES DNKKAITYTY DLMANLAFIR GQLENAEQLF
160 170 180 190 200
KATMSYLLGG GMKQEDNAIV EISLKLANIY AAQNKQEFAL AGYEFCISTL
210 220 230 240 250
EGKIEREKEL AEDIMSEERA NTYLLLGMCL DSCARYLLFS KQLSQAQRMY
260 270 280 290 300
EKALQICQEI QGERHPQTIV LMSDLATALD AQGHFDDAYI YMQRASDLAR
310 320 330 340 350
EINHPELHMV LSNLAAILIH RERYTQAKEI YQEALKQAEL KRDEFSVQHI
360
REELAELSRK SRLLT
Length:365
Mass (Da):41,333
Last modified:April 20, 2010 - v1
Checksum:i1F0E4B560F9097FD
GO
Isoform 2 (identifier: D4A6D7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     133-145: Missing.

Show »
Length:352
Mass (Da):39,875
Checksum:i66B1789E65B59F6B
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_041059133 – 145Missing in isoform 2. CuratedAdd BLAST13

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH473948 Genomic DNA Translation: EDM04701.1
CH473948 Genomic DNA Translation: EDM04702.1
RefSeqiNP_001103114.1, NM_001109644.1 [D4A6D7-2]
XP_006246592.1, XM_006246530.3 [D4A6D7-1]
UniGeneiRn.216288

Genome annotation databases

EnsembliENSRNOT00000057777; ENSRNOP00000054591; ENSRNOG00000002977 [D4A6D7-2]
GeneIDi691506
KEGGirno:691506
UCSCiRGD:1582808 rat [D4A6D7-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiTTC19_RAT
AccessioniPrimary (citable) accession number: D4A6D7
Secondary accession number(s): D4A3Z0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 3, 2011
Last sequence update: April 20, 2010
Last modified: May 23, 2018
This is version 54 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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