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Protein

Tonsoku-like protein

Gene

Tonsl

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Component of the MMS22L-TONSL complex, a complex that stimulates the recombination-dependent repair of stalled or collapsed replication forks. The MMS22L-TONSL complex is required to maintain genome integrity during DNA replication by promoting homologous recombination-mediated repair of replication fork-associated double-strand breaks. It may act by mediating the assembly of RAD51 filaments on ssDNA. Within the complex, may act as a scaffold (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

DNA damage, DNA repair

Names & Taxonomyi

Protein namesi
Recommended name:
Tonsoku-like protein
Alternative name(s):
Inhibitor of kappa B-related protein
Short name:
I-kappa-B-related protein
Short name:
IkappaBR
NF-kappa-B inhibitor-like protein 2
Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 2
Gene namesi
Name:Tonsl
Synonyms:Ikbr, Nfkbil2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 7

Organism-specific databases

RGDi1307483. Tonsl.

Subcellular locationi

  • Cytoplasm By similarity
  • Nucleus By similarity

  • Note: Mainly nuclear. Localizes to DNA damage sites, accumulates at stressed replication forks (By similarity).By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004037751 – 1367Tonsoku-like proteinAdd BLAST1367

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei797Omega-N-methylarginineBy similarity1

Keywords - PTMi

Methylation

Proteomic databases

PaxDbiD4A615.
PRIDEiD4A615.

Expressioni

Gene expression databases

BgeeiENSRNOG00000014703.
GenevisibleiD4A615. RN.

Interactioni

Subunit structurei

Component of the MMS22L-TONSL complex, a complex at least composed of MMS22L and TONSL/NFKBIL2. Interacts with the MCM complex, the FACT complex and the RPA complex. Binds histones (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000019754.

Structurei

3D structure databases

ProteinModelPortaliD4A615.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati27 – 60TPR 1Add BLAST34
Repeati67 – 100TPR 2Add BLAST34
Repeati107 – 147TPR 3Add BLAST41
Repeati162 – 195TPR 4Add BLAST34
Repeati202 – 235TPR 5Add BLAST34
Repeati242 – 275TPR 6Add BLAST34
Repeati311 – 344TPR 7Add BLAST34
Repeati352 – 385TPR 8Add BLAST34
Repeati390 – 424TPR 9Add BLAST35
Repeati528 – 557ANK 1Add BLAST30
Repeati561 – 590ANK 2Add BLAST30
Repeati597 – 626ANK 3Add BLAST30
Repeati1062 – 1086LRR 1Add BLAST25
Repeati1090 – 1118LRR 2Add BLAST29
Repeati1121 – 1144LRR 3Add BLAST24
Repeati1181 – 1205LRR 4Add BLAST25
Repeati1240 – 1263LRR 5Add BLAST24
Repeati1268 – 1293LRR 6Add BLAST26
Repeati1324 – 1347LRR 7Add BLAST24

Domaini

The ANK repeats mediate the interaction with the MCM complex and histones, while the LRR repeats mediate the interaction with MMS22L.By similarity

Sequence similaritiesi

Belongs to the Tonsoku family.Curated
Contains 3 ANK repeats.PROSITE-ProRule annotation
Contains 7 LRR (leucine-rich) repeats.Curated
Contains 9 TPR repeats.Curated

Keywords - Domaini

ANK repeat, Leucine-rich repeat, Repeat, TPR repeat

Phylogenomic databases

eggNOGiKOG0504. Eukaryota.
KOG4308. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00760000119090.
InParanoidiD4A615.
KOiK09257.
OMAiARCYLNI.
OrthoDBiEOG091G015L.
PhylomeDBiD4A615.
TreeFamiTF326440.

Family and domain databases

Gene3Di1.25.40.10. 2 hits.
1.25.40.20. 1 hit.
3.80.10.10. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR006553. Leu-rich_rpt_Cys-con_subtyp.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
[Graphical view]
PfamiPF12796. Ank_2. 1 hit.
PF13516. LRR_6. 3 hits.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 3 hits.
SM00367. LRR_CC. 2 hits.
SM00028. TPR. 6 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
SSF48452. SSF48452. 3 hits.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D4A615-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTLEQELRQL SKAKARAQRN GQLCEEAVCC HQLGELLASH GRFQEALEEH
60 70 80 90 100
QQELHLLESV QDTLGCAVAH RKIGERLAEM ENYSAALKHQ HLYLDLAGSL
110 120 130 140 150
SNHTELQRAW ATIGRTHLDV YDHCQSRDSL LQAQAAFEKS LAIVDEKLEG
160 170 180 190 200
MLTQRELSEM RTRLYLNLGL TCESLQQTAQ CNNYFKKSIF LAEQNHLYED
210 220 230 240 250
LFRARYNLGA IHWRGGQHSQ AMRCLEGARE CARAMKMRFM ESECCMLVSQ
260 270 280 290 300
VLQDLGDFLA AKRALKKAYR LGSQKPNQRV AICQSLKYVL AVVRLQQQLQ
310 320 330 340 350
EAEGNDLQGA MAICEQLGDL FSKADDFPKA SEAYQKQLHF AELLNRPDLE
360 370 380 390 400
LAVIHESLAT TLGDMKDYHK AVHHYEEELR LRKGNALEEA KTWFNIGLAR
410 420 430 440 450
EEAGDAYELL APCFQKAFGC AQQAQRYQLQ RQILQHLYTV QLKLQPQEAR
460 470 480 490 500
DTEIRLQELS MAKDTEEEEE EEEEEEEEAS EALETSEMEL SESEDDADGL
510 520 530 540 550
SQQLEEEEEL QGCVGRRKIN KWNRRNDMGE TLLHRACIEG QLRRVQDLVK
560 570 580 590 600
QGHPLNPRDY CGWTPLHEAC NYGHLEIVRF LLDHGAAVDD PGGQGCDGIT
610 620 630 640 650
PLHDALNCGH FEVAELLIER GASVTLRTRK GLSPLETLQQ WVKLYFRDLD
660 670 680 690 700
LETRQKAASM ERRLQMASSG QASHSSPALQ TIPNNHLFDP ETSPPSSPCP
710 720 730 740 750
KPPSYTPRPP EASPAPAKVF LEETVSAVCR PRKNRHRPAS SSSSSEDDDD
760 770 780 790 800
NTNPCRPSQK RLRHSTQQGE AKTPDPSKSR ETAISSACRA AYQAAIRGVG
810 820 830 840 850
SAQSRRLVPS LPRGSNEVPA PKTALIPEEE FLAEEWLEVD TPLTRSSSSS
860 870 880 890 900
RPSTSISDYE RCPARPRTRA KQSRPASLDG WCTRTKAADA SLTAEPTENS
910 920 930 940 950
SMPRTTGPNK ENCAAGQPLL LVQPPPIRVR VQIQDNLFLI PVPHSDVHSV
960 970 980 990 1000
AWLAEQAAQR YFQTCGLLPR LTLRKDGALL APQDPIPDVL QSNDEVMAEV
1010 1020 1030 1040 1050
TSWDLPPLKD RYRRACQSLG QGEHQQVLQA MEHQSSSPSF SACSLALCQA
1060 1070 1080 1090 1100
QLTPLLRALK LHTALRELRL SGNRLGDPCA TELLATLGTM PNLVLLDLSS
1110 1120 1130 1140 1150
NHLGPEGLRQ LVEGSLGQTA FQNVEELDLS MNPLGDGCAQ ALASLLRTCP
1160 1170 1180 1190 1200
VLRTLRLQAC GFSPSFFLSH QAALGSAFKD AEHLKTLSLS YNTLGAPALA
1210 1220 1230 1240 1250
RVLQSLPTCT LLHLELSSVA ASKSNSSLIE PVIKYLTKEG CALAHLTLSA
1260 1270 1280 1290 1300
NCLSDKAVRE LSRCLPSCPS LTSLDLSANP EVSCAGLEEL LSALQERPQG
1310 1320 1330 1340 1350
LSFFDLSGCS IQGPLNSDLW DKILSQLQEL QLCSKDLTTK DRDTLCQRLP
1360
AGACTLNQGS KLFFKCL
Length:1,367
Mass (Da):151,834
Last modified:April 20, 2010 - v1
Checksum:i417911B44EB11B17
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH473950 Genomic DNA. Translation: EDM15953.1.
RefSeqiNP_001124044.1. NM_001130572.1.
UniGeneiRn.19092.

Genome annotation databases

EnsembliENSRNOT00000019754; ENSRNOP00000019754; ENSRNOG00000014703.
GeneIDi366953.
KEGGirno:366953.
UCSCiRGD:1307483. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH473950 Genomic DNA. Translation: EDM15953.1.
RefSeqiNP_001124044.1. NM_001130572.1.
UniGeneiRn.19092.

3D structure databases

ProteinModelPortaliD4A615.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000019754.

Proteomic databases

PaxDbiD4A615.
PRIDEiD4A615.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000019754; ENSRNOP00000019754; ENSRNOG00000014703.
GeneIDi366953.
KEGGirno:366953.
UCSCiRGD:1307483. rat.

Organism-specific databases

CTDi4796.
RGDi1307483. Tonsl.

Phylogenomic databases

eggNOGiKOG0504. Eukaryota.
KOG4308. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00760000119090.
InParanoidiD4A615.
KOiK09257.
OMAiARCYLNI.
OrthoDBiEOG091G015L.
PhylomeDBiD4A615.
TreeFamiTF326440.

Miscellaneous databases

PROiD4A615.

Gene expression databases

BgeeiENSRNOG00000014703.
GenevisibleiD4A615. RN.

Family and domain databases

Gene3Di1.25.40.10. 2 hits.
1.25.40.20. 1 hit.
3.80.10.10. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR006553. Leu-rich_rpt_Cys-con_subtyp.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
[Graphical view]
PfamiPF12796. Ank_2. 1 hit.
PF13516. LRR_6. 3 hits.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 3 hits.
SM00367. LRR_CC. 2 hits.
SM00028. TPR. 6 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
SSF48452. SSF48452. 3 hits.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTONSL_RAT
AccessioniPrimary (citable) accession number: D4A615
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2011
Last sequence update: April 20, 2010
Last modified: November 2, 2016
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.