ID   D4A604_RAT              Unreviewed;       599 AA.
AC   D4A604;
DT   20-APR-2010, integrated into UniProtKB/TrEMBL.
DT   25-MAY-2022, sequence version 3.
DT   27-MAR-2024, entry version 81.
DE   SubName: Full=Phosphatidylinositol glycan anchor biosynthesis, class T {ECO:0000313|Ensembl:ENSRNOP00000019761.7};
GN   Name=Pigt {ECO:0000313|Ensembl:ENSRNOP00000019761.7,
GN   ECO:0000313|RGD:1307156};
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000019761.7, ECO:0000313|Proteomes:UP000002494};
RN   [1] {ECO:0000313|Ensembl:ENSRNOP00000019761.7, ECO:0000313|Proteomes:UP000002494}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000019761.7,
RC   ECO:0000313|Proteomes:UP000002494};
RX   PubMed=15057822; DOI=10.1038/nature02426;
RG   Rat Genome Sequencing Project Consortium;
RA   Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA   Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA   Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA   Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA   Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA   Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA   Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA   Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA   Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA   Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA   Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA   Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA   Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA   Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA   Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA   Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA   Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA   Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA   Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA   Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA   Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA   Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA   Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA   Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA   Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA   Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA   Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA   Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA   Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA   Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA   Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA   Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA   Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA   Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA   Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA   Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA   Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA   Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA   Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA   Mockrin S., Collins F.S.;
RT   "Genome sequence of the Brown Norway rat yields insights into mammalian
RT   evolution.";
RL   Nature 428:493-521(2004).
RN   [2] {ECO:0000313|Ensembl:ENSRNOP00000019761.7}
RP   IDENTIFICATION.
RC   STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000019761.7};
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   RefSeq; XP_006235594.1; XM_006235532.3.
DR   AlphaFoldDB; D4A604; -.
DR   STRING; 10116.ENSRNOP00000019761; -.
DR   jPOST; D4A604; -.
DR   PaxDb; 10116-ENSRNOP00000019761; -.
DR   PeptideAtlas; D4A604; -.
DR   Ensembl; ENSRNOT00000019761.7; ENSRNOP00000019761.7; ENSRNOG00000014690.7.
DR   GeneID; 296360; -.
DR   UCSC; RGD:1307156; rat.
DR   AGR; RGD:1307156; -.
DR   CTD; 51604; -.
DR   RGD; 1307156; Pigt.
DR   VEuPathDB; HostDB:ENSRNOG00000014690; -.
DR   eggNOG; KOG2407; Eukaryota.
DR   GeneTree; ENSGT00390000018558; -.
DR   HOGENOM; CLU_021459_2_0_1; -.
DR   InParanoid; D4A604; -.
DR   TreeFam; TF105921; -.
DR   Reactome; R-RNO-162791; Attachment of GPI anchor to uPAR.
DR   Proteomes; UP000002494; Chromosome 3.
DR   Bgee; ENSRNOG00000014690; Expressed in ovary and 19 other cell types or tissues.
DR   GO; GO:0005737; C:cytoplasm; ISO:RGD.
DR   GO; GO:0031410; C:cytoplasmic vesicle; ISO:RGD.
DR   GO; GO:0042765; C:GPI-anchor transamidase complex; ISO:RGD.
DR   GO; GO:0016255; P:attachment of GPI anchor to protein; ISO:RGD.
DR   GO; GO:0051402; P:neuron apoptotic process; ISO:RGD.
DR   GO; GO:0030182; P:neuron differentiation; ISO:RGD.
DR   InterPro; IPR007245; PIG-T.
DR   PANTHER; PTHR12959:SF11; GPI TRANSAMIDASE COMPONENT PIG-T; 1.
DR   PANTHER; PTHR12959; GPI TRANSAMIDASE COMPONENT PIG-T-RELATED; 1.
DR   Pfam; PF04113; Gpi16; 2.
PE   1: Evidence at protein level;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0007829|PeptideAtlas:D4A604};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002494};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        547..568
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
SQ   SEQUENCE   599 AA;  67574 MW;  C40E585382E91937 CRC64;
     MATFSGRRRC WEAEAAAGMA AAMPLGLSLL LLVLVGQGCC GRVEGPRDSL REELVITPLP
     SGDVAATFQF RTRWDSDLQR EGVSHYRLFP KALGQLISKY SLRELHLSFT QGFWRTRYWG
     PPFLQAPSGA ELWVWFQDTV TDVDKSWKEL SNVLSGIFCA SLNFIDSTNT VTPTASFKPL
     GLANDTDHYF LRYAVLPREV VCTENLTPWK KLLPCSSKAG LSVLLKADRL FHTSYHSQAV
     HIRPICRNAH CTSISWELRQ TLSVVFDAFI TGQGKKDWSL FRMFSRTLTE ACPLASQSLV
     YVDITGYSQD NETLEVSPPP TSTYQDVILG TRKTYAVYDL FDTAMINNSR NLNIQLKWKR
     PPDNAEALPV PFLHAQRYVS GYGLQKGELS TLLYNSHPYR AFPVLLLDAV PWYLRLYVHT
     LTITSKGKDN KPSYIHYQPA QDRQQPHLLE MLIQLPANSV TKVSIQFERA LLKWTEYTPD
     PNHGFYVSPS VLSALVPSMV AAKPVDWEES PLFNTLFPVS DGSSYFVRLY TEPLLVNLPT
     PDFSMPYNVI CLTCTVVAVC YGSFYNLLTR TFHIEEPKSG GLAKRLANLI RRARGVPPL
//