Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

Caspase recruitment domain family, member 15 (Predicted)

Gene

Nod2

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • muramyl dipeptide binding Source: RGD

GO - Biological processi

  • cellular response to organic cyclic compound Source: RGD
  • positive regulation of cell proliferation Source: RGD
  • positive regulation of dendritic cell cytokine production Source: RGD
  • regulation of apoptotic process Source: InterPro
  • response to muramyl dipeptide Source: RGD
  • response to nutrient Source: RGD
Complete GO annotation...

Keywords - Ligandi

ATP-bindingSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-RNO-168638. NOD1/2 Signaling Pathway.
R-RNO-445989. TAK1 activates NFkB by phosphorylation and activation of IKKs complex.
R-RNO-446652. Interleukin-1 signaling.
R-RNO-450302. activated TAK1 mediates p38 MAPK activation.
R-RNO-450321. JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1.

Names & Taxonomyi

Protein namesi
Submitted name:
Caspase recruitment domain family, member 15 (Predicted)Imported
Submitted name:
Protein Nod2Imported
Gene namesi
Name:Nod2Imported
Synonyms:Card15_predictedImported
ORF Names:rCG_63140Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 19

Organism-specific databases

RGDi1306368. Nod2.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: RGD
Complete GO annotation...

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000061463.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 8282CARDInterPro annotationAdd
BLAST
Domaini107 – 19185CARDInterPro annotationAdd
BLAST
Domaini266 – 402137NACHTInterPro annotationAdd
BLAST

Sequence similaritiesi

Contains NACHT domain.SAAS annotation

Keywords - Domaini

RepeatSAAS annotation

Phylogenomic databases

eggNOGiKOG4308. Eukaryota.
ENOG410ZBX3. LUCA.
GeneTreeiENSGT00840000129782.
KOiK10165.
OMAiTDGCARS.
OrthoDBiEOG7P5T07.

Family and domain databases

Gene3Di1.10.533.10. 2 hits.
3.80.10.10. 1 hit.
InterProiIPR001315. CARD.
IPR011029. DEATH-like_dom.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR007111. NACHT_NTPase.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00619. CARD. 2 hits.
PF13516. LRR_6. 2 hits.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 2 hits.
SSF52540. SSF52540. 1 hit.
PROSITEiPS50209. CARD. 2 hits.
PS50837. NACHT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D4A5W3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCSQEDFQAQ RSQLVALLVS GSLEGFESIL DWLLSWDVLS REDYEGLSLP
60 70 80 90 100
GQPLSHSARR LLDTVCNKGV WGCQKLFEAV QEAQANSHTF ELQGCWDVHS
110 120 130 140 150
LHPTRDLQSH RPAIVRRLCS HVEAILELAR DEGFLSQYEC EEIRLPIFTS
160 170 180 190 200
SQRARRLLDL AAVKANGLAA FLLQHVRKLP ASLSLPYEAA ECQKFTAKLR
210 220 230 240 250
TMVSAQSRFL STYDGSENLC LEDIYTENTL ELRTEVGTAG ALQKSPATLG
260 270 280 290 300
LEELFGTHGH LNKDADTILV VGEAGSGKST LLQRLHLLWA SGQNFREFLF
310 320 330 340 350
IFPFSCRQLQ CMTKPLSLRT LLFEHCCWPD VGQDDVFQFL LDHPDRVLLT
360 370 380 390 400
FDGLDEFKFR FTDRERHCSP LDPTSVQTLL FNLLQGNLLK NACKVLTSRP
410 420 430 440 450
DAVSALLRKF VRTECHLKGF SEEGIKLYLR KHHREPGVAD RLIHLIQATS
460 470 480 490 500
ALHGLCHLPV FSWMVSRCHR ELLLQNRGFP TTSTDMYLLI LQHFLLHASP
510 520 530 540 550
PDSFPLGLGP GLLQSRLSTL LHLGHLALQG LAMSCYVFSA QQLQAAQVDS
560 570 580 590 600
EDISLGFLVR AQSVVPGSKA PLEFLHITFQ CFFAAFYLAV SADTSAASLK
610 620 630 640 650
HLFSCGRPGN SLLLRLLPNL CIQGSRVKGG QAALLQKAEP HNLQITAAFL
660 670 680 690 700
AGLLSQQHRD LLAACQVPER VLLQRQARAR SCLAHSLREH FHSIPPAVPG
710 720 730 740 750
ETKSMHAMPG FIWLIRSLYE MQEVQLAREA VRRLDIGHLK LTFCRVGPAE
760 770 780 790 800
CAALAFVLQH LQRPVALQLD HNSVGDVGVE QLLPCLGVCT ALYLRDNNIS
810 820 830 840 850
DRGARTLVEC ALRCEQLQKL ALFNNKLTDG CASSVAKLLA HKQNFLSLRV
860 870 880 890 900
GNNHITAAGA EVLAQGLKSN TSLQFLGFWG NSVGDKGSQA LAEVVADHQR
910 920 930
LKWLSLVGNN IGSVGAHALA LMLEKNKSLE EL
Length:932
Mass (Da):103,398
Last modified:April 20, 2010 - v1
Checksum:iC0A7A4271FF7DEA9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07043075 Genomic DNA. No translation available.
AABR07043076 Genomic DNA. No translation available.
CH474037 Genomic DNA. Translation: EDL87529.1.
RefSeqiNP_001099642.1. NM_001106172.1.
UniGeneiRn.218600.

Genome annotation databases

EnsembliENSRNOT00000065103; ENSRNOP00000061463; ENSRNOG00000014124.
GeneIDi291912.
KEGGirno:291912.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07043075 Genomic DNA. No translation available.
AABR07043076 Genomic DNA. No translation available.
CH474037 Genomic DNA. Translation: EDL87529.1.
RefSeqiNP_001099642.1. NM_001106172.1.
UniGeneiRn.218600.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000061463.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000065103; ENSRNOP00000061463; ENSRNOG00000014124.
GeneIDi291912.
KEGGirno:291912.

Organism-specific databases

CTDi64127.
RGDi1306368. Nod2.

Phylogenomic databases

eggNOGiKOG4308. Eukaryota.
ENOG410ZBX3. LUCA.
GeneTreeiENSGT00840000129782.
KOiK10165.
OMAiTDGCARS.
OrthoDBiEOG7P5T07.

Enzyme and pathway databases

ReactomeiR-RNO-168638. NOD1/2 Signaling Pathway.
R-RNO-445989. TAK1 activates NFkB by phosphorylation and activation of IKKs complex.
R-RNO-446652. Interleukin-1 signaling.
R-RNO-450302. activated TAK1 mediates p38 MAPK activation.
R-RNO-450321. JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1.

Family and domain databases

Gene3Di1.10.533.10. 2 hits.
3.80.10.10. 1 hit.
InterProiIPR001315. CARD.
IPR011029. DEATH-like_dom.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR007111. NACHT_NTPase.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00619. CARD. 2 hits.
PF13516. LRR_6. 2 hits.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 2 hits.
SSF52540. SSF52540. 1 hit.
PROSITEiPS50209. CARD. 2 hits.
PS50837. NACHT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Rat Genome Sequencing Project Consortium
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown NorwayImported.
  2. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BNImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BNImported.
  4. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: Brown NorwayImported.

Entry informationi

Entry nameiD4A5W3_RAT
AccessioniPrimary (citable) accession number: D4A5W3
Entry historyi
Integrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: July 6, 2016
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.