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D4A5S1

- D4A5S1_RAT

UniProt

D4A5S1 - D4A5S1_RAT

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Protein
Ubiquitin carboxyl-terminal hydrolase
Gene
Usp26, rCG_53229
Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).UniRule annotation

GO - Molecular functioni

  1. cysteine-type peptidase activity Source: UniProtKB-KW
  2. ubiquitinyl hydrolase activity Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. protein deubiquitination Source: Ensembl
  2. ubiquitin-dependent protein catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol proteaseUniRule annotation

Keywords - Biological processi

Ubl conjugation pathwayUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolaseUniRule annotation (EC:3.4.19.12UniRule annotation)
Gene namesi
Name:Usp26Imported
ORF Names:rCG_53229Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome X

Organism-specific databases

RGDi1563443. Usp26.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: Ensembl
Complete GO annotation...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase C19 family.UniRule annotation
Contains USP domain.SAAS annotations

Phylogenomic databases

GeneTreeiENSGT00440000033542.
KOiK11850.
OMAiDAYDFER.
OrthoDBiEOG7HMS09.
TreeFamiTF323032.

Family and domain databases

InterProiIPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
[Graphical view]
PfamiPF00443. UCH. 1 hit.
[Graphical view]
PROSITEiPS00972. UCH_2_1. 1 hit.
PS00973. UCH_2_2. 1 hit.
PS50235. UCH_2_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D4A5S1-1 [UniParc]FASTAAdd to Basket

« Hide

MDPVLIHAQV QLWSAKAGMS KSRNAFIETF IGKREVKLIL YFSTGKIKAL    50
QLYNNIKSVV LRTYGEDQNY LHLTFKNNDF LFVEKLTTMD ARRLKRFLDK 100
IYQSNLRAAR RSGERPGDPS TSAQELSSSP PEGHLKASSA CFESAKESEM 150
CLFRQLPLLP PSSASLNAVG LLESQFMKRK RFFLGAEKEK QNLKGSTREF 200
ETNLVVSISN EKGKERGVRA VEISKAGFGF PFETNYPEEG SVNVRDLNDL 250
ITKLFSPLLF ETHYIENGLD WHEYMETFLL DPEKSWQGLP NVGNTCYINV 300
VLQSLCSIPL FVNDLFNQGF PWIKPPKDDF NMRLMQLLVL KDIYNARTRQ 350
KLLIGITKAL PIFGEVFAAD RQNDAHEFLS LCLVQLKETV QRVNMMWQSE 400
NESGDYYLLR EIFANYTSIN RTPVCPVTNN FEFELLSSIF CKACGLTVFK 450
REPSRYLSIN IPQGMKDQNM SIQSSLDLFF RAEELEHRCE RCLYNKSVAL 500
HKFGRLPRVI IVHLKRYSFS ESRIMNKDEQ HIVISKYLRL SCHCNKNTKP 550
PQPLLPNEHV KNLDLLRPLE ELGSEILKLS SNSGRTSRSK VFPTVNIRSD 600
KELEVQNGKR VSEVSSGSAQ QEDPGKGANV VRSELTNETE TIKHEKEYVL 650
SDLDSGSISE ERSQKCQEAE KCNKEALPQS CPKPSSQEQT ENLGKPAVSH 700
TQNGSLSSQG SSDSSKSPGC NDVFDKAKPT SKVEPQKLNQ KEDNIYRLVS 750
IINHIGNSPN GGHYINDAFD FRKQSWFTYS DLQVTGIQED LVYKARLSTG 800
YVFFYMHNDI FEELLAKEAW STSTSKG 827
Length:827
Mass (Da):94,128
Last modified:April 20, 2010 - v1
Checksum:i0CDDBE1042A3022C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AABR06108548 Genomic DNA. No translation available.
AABR06108549 Genomic DNA. No translation available.
AABR06108550 Genomic DNA. No translation available.
AABR06108551 Genomic DNA. No translation available.
AABR06108552 Genomic DNA. No translation available.
AABR06108553 Genomic DNA. No translation available.
CH473991 Genomic DNA. Translation: EDM10949.1.
RefSeqiNP_001100418.1. NM_001106948.1.
XP_006257637.1. XM_006257575.1.
UniGeneiRn.218652.

Genome annotation databases

EnsembliENSRNOT00000047605; ENSRNOP00000047375; ENSRNOG00000029106.
GeneIDi302488.
KEGGirno:302488.
UCSCiRGD:1563443. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AABR06108548 Genomic DNA. No translation available.
AABR06108549 Genomic DNA. No translation available.
AABR06108550 Genomic DNA. No translation available.
AABR06108551 Genomic DNA. No translation available.
AABR06108552 Genomic DNA. No translation available.
AABR06108553 Genomic DNA. No translation available.
CH473991 Genomic DNA. Translation: EDM10949.1 .
RefSeqi NP_001100418.1. NM_001106948.1.
XP_006257637.1. XM_006257575.1.
UniGenei Rn.218652.

3D structure databases

ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000047605 ; ENSRNOP00000047375 ; ENSRNOG00000029106 .
GeneIDi 302488.
KEGGi rno:302488.
UCSCi RGD:1563443. rat.

Organism-specific databases

CTDi 83844.
RGDi 1563443. Usp26.

Phylogenomic databases

GeneTreei ENSGT00440000033542.
KOi K11850.
OMAi DAYDFER.
OrthoDBi EOG7HMS09.
TreeFami TF323032.

Miscellaneous databases

NextBioi 649707.
PROi D4A5S1.

Family and domain databases

InterProi IPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
[Graphical view ]
Pfami PF00443. UCH. 1 hit.
[Graphical view ]
PROSITEi PS00972. UCH_2_1. 1 hit.
PS00973. UCH_2_2. 1 hit.
PS50235. UCH_2_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Rat Genome Sequencing Project Consortium
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown NorwayImported.
  2. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BNImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BNImported.
  4. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: Brown NorwayImported.

Entry informationi

Entry nameiD4A5S1_RAT
AccessioniPrimary (citable) accession number: D4A5S1
Entry historyi
Integrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: September 3, 2014
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

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