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D4A5S1

- D4A5S1_RAT

UniProt

D4A5S1 - D4A5S1_RAT

Protein

Ubiquitin carboxyl-terminal hydrolase

Gene

Usp26

Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 39 (01 Oct 2014)
      Sequence version 1 (20 Apr 2010)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).UniRule annotation

    GO - Molecular functioni

    1. cysteine-type peptidase activity Source: UniProtKB-KW
    2. ubiquitinyl hydrolase activity Source: InterPro

    GO - Biological processi

    1. protein deubiquitination Source: Ensembl
    2. ubiquitin-dependent protein catabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Protease, Thiol proteaseUniRule annotation

    Keywords - Biological processi

    Ubl conjugation pathwayUniRule annotation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ubiquitin carboxyl-terminal hydrolaseUniRule annotation (EC:3.4.19.12UniRule annotation)
    Gene namesi
    Name:Usp26Imported
    ORF Names:rCG_53229Imported
    OrganismiRattus norvegicus (Rat)Imported
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome X

    Organism-specific databases

    RGDi1563443. Usp26.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: Ensembl

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase C19 family.UniRule annotation
    Contains USP domain.SAAS annotation

    Phylogenomic databases

    GeneTreeiENSGT00440000033542.
    KOiK11850.
    OMAiDAYDFER.
    OrthoDBiEOG7HMS09.
    TreeFamiTF323032.

    Family and domain databases

    InterProiIPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR028889. UCH/PAN2.
    [Graphical view]
    PfamiPF00443. UCH. 1 hit.
    [Graphical view]
    PROSITEiPS00972. UCH_2_1. 1 hit.
    PS00973. UCH_2_2. 1 hit.
    PS50235. UCH_2_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    D4A5S1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDPVLIHAQV QLWSAKAGMS KSRNAFIETF IGKREVKLIL YFSTGKIKAL    50
    QLYNNIKSVV LRTYGEDQNY LHLTFKNNDF LFVEKLTTMD ARRLKRFLDK 100
    IYQSNLRAAR RSGERPGDPS TSAQELSSSP PEGHLKASSA CFESAKESEM 150
    CLFRQLPLLP PSSASLNAVG LLESQFMKRK RFFLGAEKEK QNLKGSTREF 200
    ETNLVVSISN EKGKERGVRA VEISKAGFGF PFETNYPEEG SVNVRDLNDL 250
    ITKLFSPLLF ETHYIENGLD WHEYMETFLL DPEKSWQGLP NVGNTCYINV 300
    VLQSLCSIPL FVNDLFNQGF PWIKPPKDDF NMRLMQLLVL KDIYNARTRQ 350
    KLLIGITKAL PIFGEVFAAD RQNDAHEFLS LCLVQLKETV QRVNMMWQSE 400
    NESGDYYLLR EIFANYTSIN RTPVCPVTNN FEFELLSSIF CKACGLTVFK 450
    REPSRYLSIN IPQGMKDQNM SIQSSLDLFF RAEELEHRCE RCLYNKSVAL 500
    HKFGRLPRVI IVHLKRYSFS ESRIMNKDEQ HIVISKYLRL SCHCNKNTKP 550
    PQPLLPNEHV KNLDLLRPLE ELGSEILKLS SNSGRTSRSK VFPTVNIRSD 600
    KELEVQNGKR VSEVSSGSAQ QEDPGKGANV VRSELTNETE TIKHEKEYVL 650
    SDLDSGSISE ERSQKCQEAE KCNKEALPQS CPKPSSQEQT ENLGKPAVSH 700
    TQNGSLSSQG SSDSSKSPGC NDVFDKAKPT SKVEPQKLNQ KEDNIYRLVS 750
    IINHIGNSPN GGHYINDAFD FRKQSWFTYS DLQVTGIQED LVYKARLSTG 800
    YVFFYMHNDI FEELLAKEAW STSTSKG 827
    Length:827
    Mass (Da):94,128
    Last modified:April 20, 2010 - v1
    Checksum:i0CDDBE1042A3022C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR06108548 Genomic DNA. No translation available.
    AABR06108549 Genomic DNA. No translation available.
    AABR06108550 Genomic DNA. No translation available.
    AABR06108551 Genomic DNA. No translation available.
    AABR06108552 Genomic DNA. No translation available.
    AABR06108553 Genomic DNA. No translation available.
    CH473991 Genomic DNA. Translation: EDM10949.1.
    RefSeqiNP_001100418.1. NM_001106948.1.
    XP_006257637.1. XM_006257575.1.
    UniGeneiRn.218652.

    Genome annotation databases

    EnsembliENSRNOT00000047605; ENSRNOP00000047375; ENSRNOG00000029106.
    GeneIDi302488.
    KEGGirno:302488.
    UCSCiRGD:1563443. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR06108548 Genomic DNA. No translation available.
    AABR06108549 Genomic DNA. No translation available.
    AABR06108550 Genomic DNA. No translation available.
    AABR06108551 Genomic DNA. No translation available.
    AABR06108552 Genomic DNA. No translation available.
    AABR06108553 Genomic DNA. No translation available.
    CH473991 Genomic DNA. Translation: EDM10949.1 .
    RefSeqi NP_001100418.1. NM_001106948.1.
    XP_006257637.1. XM_006257575.1.
    UniGenei Rn.218652.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000047605 ; ENSRNOP00000047375 ; ENSRNOG00000029106 .
    GeneIDi 302488.
    KEGGi rno:302488.
    UCSCi RGD:1563443. rat.

    Organism-specific databases

    CTDi 83844.
    RGDi 1563443. Usp26.

    Phylogenomic databases

    GeneTreei ENSGT00440000033542.
    KOi K11850.
    OMAi DAYDFER.
    OrthoDBi EOG7HMS09.
    TreeFami TF323032.

    Miscellaneous databases

    NextBioi 649707.
    PROi D4A5S1.

    Family and domain databases

    InterProi IPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR028889. UCH/PAN2.
    [Graphical view ]
    Pfami PF00443. UCH. 1 hit.
    [Graphical view ]
    PROSITEi PS00972. UCH_2_1. 1 hit.
    PS00973. UCH_2_2. 1 hit.
    PS50235. UCH_2_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
      Rat Genome Sequencing Project Consortium
      Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
      , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
      Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Brown NorwayImported.
    2. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: BNImported.
    3. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: BNImported.
    4. Ensembl
      Submitted (JUL-2011) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: Brown NorwayImported.

    Entry informationi

    Entry nameiD4A5S1_RAT
    AccessioniPrimary (citable) accession number: D4A5S1
    Entry historyi
    Integrated into UniProtKB/TrEMBL: April 20, 2010
    Last sequence update: April 20, 2010
    Last modified: October 1, 2014
    This is version 39 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3