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Protein

Ubiquitin carboxyl-terminal hydrolase

Gene

Usp26

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol proteaseUniRule annotation

Keywords - Biological processi

Ubl conjugation pathwayUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase (EC:3.4.19.12)
Gene namesi
Name:Usp26Imported
ORF Names:rCG_53229Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Chromosome X

Organism-specific databases

RGDi1563443. Usp26.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase C19 family.UniRule annotation
Contains USP domain.SAAS annotation

Phylogenomic databases

GeneTreeiENSGT00440000033542.
KOiK11850.
OMAiDAYDFER.
OrthoDBiEOG7HMS09.
PhylomeDBiD4A5S1.
TreeFamiTF323032.

Family and domain databases

InterProiIPR001394. Peptidase_C19_UCH.
IPR018200. USP_CS.
IPR028889. USP_dom.
[Graphical view]
PfamiPF00443. UCH. 1 hit.
[Graphical view]
PROSITEiPS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D4A5S1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPVLIHAQV QLWSAKAGMS KSRNAFIETF IGKREVKLIL YFSTGKIKAL
60 70 80 90 100
QLYNNIKSVV LRTYGEDQNY LHLTFKNNDF LFVEKLTTMD ARRLKRFLDK
110 120 130 140 150
IYQSNLRAAR RSGERPGDPS TSAQELSSSP PEGHLKASSA CFESAKESEM
160 170 180 190 200
CLFRQLPLLP PSSASLNAVG LLESQFMKRK RFFLGAEKEK QNLKGSTREF
210 220 230 240 250
ETNLVVSISN EKGKERGVRA VEISKAGFGF PFETNYPEEG SVNVRDLNDL
260 270 280 290 300
ITKLFSPLLF ETHYIENGLD WHEYMETFLL DPEKSWQGLP NVGNTCYINV
310 320 330 340 350
VLQSLCSIPL FVNDLFNQGF PWIKPPKDDF NMRLMQLLVL KDIYNARTRQ
360 370 380 390 400
KLLIGITKAL PIFGEVFAAD RQNDAHEFLS LCLVQLKETV QRVNMMWQSE
410 420 430 440 450
NESGDYYLLR EIFANYTSIN RTPVCPVTNN FEFELLSSIF CKACGLTVFK
460 470 480 490 500
REPSRYLSIN IPQGMKDQNM SIQSSLDLFF RAEELEHRCE RCLYNKSVAL
510 520 530 540 550
HKFGRLPRVI IVHLKRYSFS ESRIMNKDEQ HIVISKYLRL SCHCNKNTKP
560 570 580 590 600
PQPLLPNEHV KNLDLLRPLE ELGSEILKLS SNSGRTSRSK VFPTVNIRSD
610 620 630 640 650
KELEVQNGKR VSEVSSGSAQ QEDPGKGANV VRSELTNETE TIKHEKEYVL
660 670 680 690 700
SDLDSGSISE ERSQKCQEAE KCNKEALPQS CPKPSSQEQT ENLGKPAVSH
710 720 730 740 750
TQNGSLSSQG SSDSSKSPGC NDVFDKAKPT SKVEPQKLNQ KEDNIYRLVS
760 770 780 790 800
IINHIGNSPN GGHYINDAFD FRKQSWFTYS DLQVTGIQED LVYKARLSTG
810 820
YVFFYMHNDI FEELLAKEAW STSTSKG
Length:827
Mass (Da):94,128
Last modified:April 20, 2010 - v1
Checksum:i0CDDBE1042A3022C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR06108548 Genomic DNA. No translation available.
AABR06108549 Genomic DNA. No translation available.
AABR06108550 Genomic DNA. No translation available.
AABR06108551 Genomic DNA. No translation available.
AABR06108552 Genomic DNA. No translation available.
AABR06108553 Genomic DNA. No translation available.
CH473991 Genomic DNA. Translation: EDM10949.1.
RefSeqiNP_001100418.1. NM_001106948.1.
XP_008771777.1. XM_008773555.1.
UniGeneiRn.218652.

Genome annotation databases

EnsembliENSRNOT00000047605; ENSRNOP00000047375; ENSRNOG00000029106.
GeneIDi302488.
KEGGirno:302488.
UCSCiRGD:1563443. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR06108548 Genomic DNA. No translation available.
AABR06108549 Genomic DNA. No translation available.
AABR06108550 Genomic DNA. No translation available.
AABR06108551 Genomic DNA. No translation available.
AABR06108552 Genomic DNA. No translation available.
AABR06108553 Genomic DNA. No translation available.
CH473991 Genomic DNA. Translation: EDM10949.1.
RefSeqiNP_001100418.1. NM_001106948.1.
XP_008771777.1. XM_008773555.1.
UniGeneiRn.218652.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000047605; ENSRNOP00000047375; ENSRNOG00000029106.
GeneIDi302488.
KEGGirno:302488.
UCSCiRGD:1563443. rat.

Organism-specific databases

CTDi83844.
RGDi1563443. Usp26.

Phylogenomic databases

GeneTreeiENSGT00440000033542.
KOiK11850.
OMAiDAYDFER.
OrthoDBiEOG7HMS09.
PhylomeDBiD4A5S1.
TreeFamiTF323032.

Miscellaneous databases

NextBioi649707.
PROiD4A5S1.

Family and domain databases

InterProiIPR001394. Peptidase_C19_UCH.
IPR018200. USP_CS.
IPR028889. USP_dom.
[Graphical view]
PfamiPF00443. UCH. 1 hit.
[Graphical view]
PROSITEiPS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Rat Genome Sequencing Project Consortium
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown NorwayImported.
  2. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BNImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BNImported.
  4. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: Brown NorwayImported.

Entry informationi

Entry nameiD4A5S1_RAT
AccessioniPrimary (citable) accession number: D4A5S1
Entry historyi
Integrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: May 27, 2015
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.