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Protein
Submitted name:

Phosphatidylinositol 3-kinase catalytic delta polypeptide (Predicted)

Gene

Pik3cd

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinasePROSITE-ProRule annotationSAAS annotationImported, Transferase
LigandATP-bindingSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-RNO-114604 GPVI-mediated activation cascade
R-RNO-1257604 PIP3 activates AKT signaling
R-RNO-1660499 Synthesis of PIPs at the plasma membrane
R-RNO-392451 G beta:gamma signalling through PI3Kgamma
R-RNO-512988 Interleukin-3, 5 and GM-CSF signaling
R-RNO-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-RNO-8853659 RET signaling
R-RNO-912526 Interleukin receptor SHC signaling
R-RNO-912631 Regulation of signaling by CBL
R-RNO-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers

Names & Taxonomyi

Protein namesi
Submitted name:
Phosphatidylinositol 3-kinase catalytic delta polypeptide (Predicted)Imported
Submitted name:
Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit deltaImported
Gene namesi
Name:Pik3cdImported
Synonyms:Pik3cd_predictedImported
ORF Names:rCG_30888Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 5

Organism-specific databases

RGDi1310990 Pik3cd

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Proteomic databases

PeptideAtlasiD4A5Q1

Expressioni

Gene expression databases

BgeeiENSRNOG00000016846

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000061674

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini16 – 105PI3K-ABDInterPro annotationAdd BLAST90
Domaini187 – 278PI3K-RBDInterPro annotationAdd BLAST92
Domaini319 – 476C2 PI3K-typeInterPro annotationAdd BLAST158
Domaini442 – 618PIK helicalInterPro annotationAdd BLAST177
Domaini718 – 944PI3K/PI4KInterPro annotationAdd BLAST227

Sequence similaritiesi

Belongs to the PI3/PI4-kinase family.PROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG0904 Eukaryota
COG5032 LUCA
GeneTreeiENSGT00760000119110
KOiK00922
OMAiQCTFMDS
OrthoDBiEOG091G027R

Family and domain databases

Gene3Di1.10.1070.111 hit
2.60.40.1501 hit
InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR035892 C2_domain_sf
IPR011009 Kinase-like_dom_sf
IPR000403 PI3/4_kinase_cat_dom
IPR036940 PI3/4_kinase_cat_sf
IPR018936 PI3/4_kinase_CS
IPR003113 PI3K_adapt-bd_dom
IPR002420 PI3K_C2_dom
IPR000341 PI3K_Ras-bd_dom
IPR008290 PI3K_Vps34
IPR015433 PI_Kinase
IPR001263 PInositide-3_kin_accessory_dom
IPR029071 Ubiquitin-like_domsf
PANTHERiPTHR10048 PTHR10048, 2 hits
PfamiView protein in Pfam
PF00454 PI3_PI4_kinase, 1 hit
PF00792 PI3K_C2, 1 hit
PF02192 PI3K_p85B, 1 hit
PF00794 PI3K_rbd, 1 hit
PF00613 PI3Ka, 1 hit
PIRSFiPIRSF000587 PI3K_Vps34, 3 hits
SMARTiView protein in SMART
SM00142 PI3K_C2, 1 hit
SM00143 PI3K_p85B, 1 hit
SM00144 PI3K_rbd, 1 hit
SM00145 PI3Ka, 1 hit
SM00146 PI3Kc, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
SSF54236 SSF54236, 1 hit
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00915 PI3_4_KINASE_1, 1 hit
PS00916 PI3_4_KINASE_2, 1 hit
PS50290 PI3_4_KINASE_3, 1 hit
PS51544 PI3K_ABD, 1 hit
PS51547 PI3K_C2, 1 hit
PS51546 PI3K_RBD, 1 hit
PS51545 PIK_HELICAL, 1 hit

Sequencei

Sequence statusi: Complete.

D4A5Q1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPPGVDCPME FWTKEESQSV AVDFLLPTGV YLNFPVSRNA NLSTIKQVLW
60 70 80 90 100
HRAQYEPFFH MLSDPEAYVF TCVNQTAEQQ ELEDEQRRLC DIQPFLPVLR
110 120 130 140 150
LVAREGDRVK KLINSQISLL IGKGLHEFDS LRDPEVNDFR TKMRQFCEEA
160 170 180 190 200
AAHRQQLGWV EWLQYSFPLQ LEPSARGWRA GLLHVSNRPL LVNVKFEGSE
210 220 230 240 250
ESFTFQVSTK DMPLALMACA LRKKATVFRQ PLVERPEEYA LQVNGRHEYL
260 270 280 290 300
YGSYPLCHFQ YICSCLHSGL TPHLTMVHSS SILAMRDEQS NPAPQVQKPR
310 320 330 340 350
VKPPPIPAKK PSSVSLWSLE QPFCIELIEG RKVNADERMK LVVQAGLFHG
360 370 380 390 400
NEMLCKTVSS SEVNVCSEPV WKQRLEFDIS ICDLPRMARL CFALYAVVEK
410 420 430 440 450
AKKARSTKKK SKKADCPIAW ANLMLFDYKD QLKTGERCLY MWPSVPDEKG
460 470 480 490 500
ELMNPAGTVR GNPNTESAAA LVIYLPEVAP HPVYFPALEK ILELGRHGER
510 520 530 540 550
GRITEEEMLY LLCSWPELPV LSALELLDFS FPDCYVGSFA IKSLRKLTDD
560 570 580 590 600
ELFQYLLQLV QVLKYESYLD CELTKFLLGR ALANRKIGHF LFWHLRSEMH
610 620 630 640 650
VPSVALRFGL IMEAYCRGST HHMKVLMKQG EALSKLKALN DFVKASSQKT
660 670 680 690 700
TKPQTKEMMH MCMRQETYME ALSHLQSPLD PSTLLEEVCV EQCTFMDSKM
710 720 730 740 750
KPLWIMYSSE KAGGAGSVGI IFKNGDDLRQ DMLTLQMIQL MDFLWKQEGL
760 770 780 790 800
DLRMTPYGCL PTGDRTGLIE VVLHSDTIAN IQLNKSNMAA TAAFNKDALL
810 820 830 840 850
NWLKSKNPGE ALDRAIEEFT LSCAGYCVAT YVLGIGDRHS DNIMIRESGQ
860 870 880 890 900
LFHIDFGHFL GNFKTKFGIN RERVPFILTY DFVHVIQQGK TNNSEKFERF
910 920 930 940
RGYCERAYTI LRRHGLLFLH LFALMRAAGL PELSCSKDIQ TLWH
Length:944
Mass (Da):107,903
Last modified:April 3, 2013 - v2
Checksum:i64E7F064A2DDCAD0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07050474 Genomic DNA No translation available.
CH473968 Genomic DNA Translation: EDL81170.1
RefSeqiNP_001102448.1, NM_001108978.1
UniGeneiRn.11530

Genome annotation databases

EnsembliENSRNOT00000066179; ENSRNOP00000061674; ENSRNOG00000016846
GeneIDi366508
KEGGirno:366508

Similar proteinsi

Entry informationi

Entry nameiD4A5Q1_RAT
AccessioniPrimary (citable) accession number: D4A5Q1
Entry historyiIntegrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 3, 2013
Last modified: April 25, 2018
This is version 81 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported