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Protein
Submitted name:

Phosphatidylinositol 3-kinase catalytic delta polypeptide (Predicted)

Gene

Pik3cd

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

KinaseSAAS annotationImported, Transferase

Enzyme and pathway databases

ReactomeiR-RNO-114604. GPVI-mediated activation cascade.
R-RNO-1257604. PIP3 activates AKT signaling.
R-RNO-1660499. Synthesis of PIPs at the plasma membrane.
R-RNO-392451. G beta:gamma signalling through PI3Kgamma.
R-RNO-512988. Interleukin-3, 5 and GM-CSF signaling.
R-RNO-6811558. PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.
R-RNO-8853659. RET signaling.
R-RNO-912526. Interleukin receptor SHC signaling.
R-RNO-912631. Regulation of signaling by CBL.
R-RNO-983695. Antigen activates B Cell Receptor (BCR) leading to generation of second messengers.

Names & Taxonomyi

Protein namesi
Submitted name:
Phosphatidylinositol 3-kinase catalytic delta polypeptide (Predicted)Imported
Submitted name:
Protein Pik3cdImported
Gene namesi
Name:Pik3cdImported
Synonyms:Pik3cd_predictedImported
ORF Names:rCG_30888Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 5

Organism-specific databases

RGDi1310990. Pik3cd.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Proteomic databases

PeptideAtlasiD4A5Q1.

PTM databases

PhosphoSitePlusiD4A5Q1.

Expressioni

Gene expression databases

BgeeiENSRNOG00000016846.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000061674.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini16 – 105PI3K-ABDInterPro annotationAdd BLAST90
Domaini187 – 278PI3K-RBDInterPro annotationAdd BLAST92
Domaini319 – 476C2 PI3K-typeInterPro annotationAdd BLAST158
Domaini442 – 618PIK helicalInterPro annotationAdd BLAST177
Domaini718 – 944PI3K/PI4KInterPro annotationAdd BLAST227

Sequence similaritiesi

Belongs to the PI3/PI4-kinase family.SAAS annotation

Phylogenomic databases

eggNOGiKOG0904. Eukaryota.
COG5032. LUCA.
GeneTreeiENSGT00760000119110.
KOiK00922.
OMAiDDVADIW.
OrthoDBiEOG091G027R.

Family and domain databases

Gene3Di1.10.1070.11. 1 hit.
1.25.40.70. 1 hit.
2.60.40.150. 1 hit.
InterProiIPR016024. ARM-type_fold.
IPR000008. C2_dom.
IPR011009. Kinase-like_dom.
IPR000403. PI3/4_kinase_cat_dom.
IPR018936. PI3/4_kinase_CS.
IPR003113. PI3K_adapt-bd_dom.
IPR002420. PI3K_C2_dom.
IPR000341. PI3K_Ras-bd_dom.
IPR015433. PI_Kinase.
IPR001263. PInositide-3_kin_accessory_dom.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PANTHERiPTHR10048. PTHR10048. 1 hit.
PfamiPF00454. PI3_PI4_kinase. 1 hit.
PF00792. PI3K_C2. 1 hit.
PF02192. PI3K_p85B. 1 hit.
PF00794. PI3K_rbd. 1 hit.
PF00613. PI3Ka. 1 hit.
[Graphical view]
SMARTiSM00142. PI3K_C2. 1 hit.
SM00143. PI3K_p85B. 1 hit.
SM00144. PI3K_rbd. 1 hit.
SM00145. PI3Ka. 1 hit.
SM00146. PI3Kc. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
SSF49562. SSF49562. 1 hit.
SSF54236. SSF54236. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS00915. PI3_4_KINASE_1. 1 hit.
PS00916. PI3_4_KINASE_2. 1 hit.
PS50290. PI3_4_KINASE_3. 1 hit.
PS51544. PI3K_ABD. 1 hit.
PS51547. PI3K_C2. 1 hit.
PS51546. PI3K_RBD. 1 hit.
PS51545. PIK_HELICAL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D4A5Q1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPPGVDCPME FWTKEESQSV AVDFLLPTGV YLNFPVSRNA NLSTIKQVLW
60 70 80 90 100
HRAQYEPFFH MLSDPEAYVF TCVNQTAEQQ ELEDEQRRLC DIQPFLPVLR
110 120 130 140 150
LVAREGDRVK KLINSQISLL IGKGLHEFDS LRDPEVNDFR TKMRQFCEEA
160 170 180 190 200
AAHRQQLGWV EWLQYSFPLQ LEPSARGWRA GLLHVSNRPL LVNVKFEGSE
210 220 230 240 250
ESFTFQVSTK DMPLALMACA LRKKATVFRQ PLVERPEEYA LQVNGRHEYL
260 270 280 290 300
YGSYPLCHFQ YICSCLHSGL TPHLTMVHSS SILAMRDEQS NPAPQVQKPR
310 320 330 340 350
VKPPPIPAKK PSSVSLWSLE QPFCIELIEG RKVNADERMK LVVQAGLFHG
360 370 380 390 400
NEMLCKTVSS SEVNVCSEPV WKQRLEFDIS ICDLPRMARL CFALYAVVEK
410 420 430 440 450
AKKARSTKKK SKKADCPIAW ANLMLFDYKD QLKTGERCLY MWPSVPDEKG
460 470 480 490 500
ELMNPAGTVR GNPNTESAAA LVIYLPEVAP HPVYFPALEK ILELGRHGER
510 520 530 540 550
GRITEEEMLY LLCSWPELPV LSALELLDFS FPDCYVGSFA IKSLRKLTDD
560 570 580 590 600
ELFQYLLQLV QVLKYESYLD CELTKFLLGR ALANRKIGHF LFWHLRSEMH
610 620 630 640 650
VPSVALRFGL IMEAYCRGST HHMKVLMKQG EALSKLKALN DFVKASSQKT
660 670 680 690 700
TKPQTKEMMH MCMRQETYME ALSHLQSPLD PSTLLEEVCV EQCTFMDSKM
710 720 730 740 750
KPLWIMYSSE KAGGAGSVGI IFKNGDDLRQ DMLTLQMIQL MDFLWKQEGL
760 770 780 790 800
DLRMTPYGCL PTGDRTGLIE VVLHSDTIAN IQLNKSNMAA TAAFNKDALL
810 820 830 840 850
NWLKSKNPGE ALDRAIEEFT LSCAGYCVAT YVLGIGDRHS DNIMIRESGQ
860 870 880 890 900
LFHIDFGHFL GNFKTKFGIN RERVPFILTY DFVHVIQQGK TNNSEKFERF
910 920 930 940
RGYCERAYTI LRRHGLLFLH LFALMRAAGL PELSCSKDIQ TLWH
Length:944
Mass (Da):107,903
Last modified:April 3, 2013 - v2
Checksum:i64E7F064A2DDCAD0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07050474 Genomic DNA. No translation available.
CH473968 Genomic DNA. Translation: EDL81170.1.
RefSeqiNP_001102448.1. NM_001108978.1.
UniGeneiRn.11530.

Genome annotation databases

EnsembliENSRNOT00000066179; ENSRNOP00000061674; ENSRNOG00000016846.
GeneIDi366508.
KEGGirno:366508.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07050474 Genomic DNA. No translation available.
CH473968 Genomic DNA. Translation: EDL81170.1.
RefSeqiNP_001102448.1. NM_001108978.1.
UniGeneiRn.11530.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000061674.

PTM databases

PhosphoSitePlusiD4A5Q1.

Proteomic databases

PeptideAtlasiD4A5Q1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000066179; ENSRNOP00000061674; ENSRNOG00000016846.
GeneIDi366508.
KEGGirno:366508.

Organism-specific databases

CTDi5293.
RGDi1310990. Pik3cd.

Phylogenomic databases

eggNOGiKOG0904. Eukaryota.
COG5032. LUCA.
GeneTreeiENSGT00760000119110.
KOiK00922.
OMAiDDVADIW.
OrthoDBiEOG091G027R.

Enzyme and pathway databases

ReactomeiR-RNO-114604. GPVI-mediated activation cascade.
R-RNO-1257604. PIP3 activates AKT signaling.
R-RNO-1660499. Synthesis of PIPs at the plasma membrane.
R-RNO-392451. G beta:gamma signalling through PI3Kgamma.
R-RNO-512988. Interleukin-3, 5 and GM-CSF signaling.
R-RNO-6811558. PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.
R-RNO-8853659. RET signaling.
R-RNO-912526. Interleukin receptor SHC signaling.
R-RNO-912631. Regulation of signaling by CBL.
R-RNO-983695. Antigen activates B Cell Receptor (BCR) leading to generation of second messengers.

Gene expression databases

BgeeiENSRNOG00000016846.

Family and domain databases

Gene3Di1.10.1070.11. 1 hit.
1.25.40.70. 1 hit.
2.60.40.150. 1 hit.
InterProiIPR016024. ARM-type_fold.
IPR000008. C2_dom.
IPR011009. Kinase-like_dom.
IPR000403. PI3/4_kinase_cat_dom.
IPR018936. PI3/4_kinase_CS.
IPR003113. PI3K_adapt-bd_dom.
IPR002420. PI3K_C2_dom.
IPR000341. PI3K_Ras-bd_dom.
IPR015433. PI_Kinase.
IPR001263. PInositide-3_kin_accessory_dom.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PANTHERiPTHR10048. PTHR10048. 1 hit.
PfamiPF00454. PI3_PI4_kinase. 1 hit.
PF00792. PI3K_C2. 1 hit.
PF02192. PI3K_p85B. 1 hit.
PF00794. PI3K_rbd. 1 hit.
PF00613. PI3Ka. 1 hit.
[Graphical view]
SMARTiSM00142. PI3K_C2. 1 hit.
SM00143. PI3K_p85B. 1 hit.
SM00144. PI3K_rbd. 1 hit.
SM00145. PI3Ka. 1 hit.
SM00146. PI3Kc. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
SSF49562. SSF49562. 1 hit.
SSF54236. SSF54236. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS00915. PI3_4_KINASE_1. 1 hit.
PS00916. PI3_4_KINASE_2. 1 hit.
PS50290. PI3_4_KINASE_3. 1 hit.
PS51544. PI3K_ABD. 1 hit.
PS51547. PI3K_C2. 1 hit.
PS51546. PI3K_RBD. 1 hit.
PS51545. PIK_HELICAL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiD4A5Q1_RAT
AccessioniPrimary (citable) accession number: D4A5Q1
Entry historyi
Integrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 3, 2013
Last modified: November 30, 2016
This is version 66 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.