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Protein
Submitted name:

CD3 antigen, epsilon polypeptide (Predicted)

Gene

Cd3e

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: -Protein predictedi

Functioni

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-RNO-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-RNO-202424 Downstream TCR signaling
R-RNO-202427 Phosphorylation of CD3 and TCR zeta chains
R-RNO-202430 Translocation of ZAP-70 to Immunological synapse
R-RNO-202433 Generation of second messenger molecules
R-RNO-389948 PD-1 signaling

Names & Taxonomyi

Protein namesi
Submitted name:
CD3 antigen, epsilon polypeptide (Predicted)Imported
Submitted name:
CD3e moleculeImported
Gene namesi
Name:Cd3eImported
Synonyms:Cd3e_predictedImported
ORF Names:rCG_58471Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 8

Organism-specific databases

RGDi1309222 Cd3e

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei104 – 128HelicalSequence analysisAdd BLAST25

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_501408784621 – 188Sequence analysisAdd BLAST168

Expressioni

Gene expression databases

BgeeiENSRNOG00000016069

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000047591

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 88Ig-likeInterPro annotationAdd BLAST59

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG410IYD1 Eukaryota
ENOG41123JN LUCA
GeneTreeiENSGT00510000048592
KOiK06451
OMAiQRGQNKE
OrthoDBiEOG091G0PKE
TreeFamiTF335892

Family and domain databases

Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR015484 CD3_esu/gsu/dsu
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003598 Ig_sub2
IPR003110 Phos_immunorcpt_sig_ITAM
PANTHERiPTHR10570 PTHR10570, 1 hit
PfamiView protein in Pfam
PF02189 ITAM, 1 hit
SMARTiView protein in SMART
SM00408 IGc2, 1 hit
SM00077 ITAM, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS51055 ITAM_1, 1 hit

Sequencei

Sequence statusi: Complete.

D4A5M2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQWNAFWSIL GLSLLAVGTC QEEYEVSISG TSVELTCPLE NEDNLKWEKN
60 70 80 90 100
DKVLPDKNEK HLVLEDFSEV KDSGYYVCYT ESSRKNTYLY LKARVCENCM
110 120 130 140 150
EVDLTAVSII IIVDICITLG LLMVVYYWSK KRKAKAKPVT RGTGTGGRPR
160 170 180
GKAQGQNKER PPPVPNPDYE PIRKGQRDLY SGLNQRAV
Length:188
Mass (Da):21,312
Last modified:April 20, 2010 - v1
Checksum:iB1CF3214AB4A0ABC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC136866 Genomic DNA No translation available.
CH473975 Genomic DNA Translation: EDL95346.1
RefSeqiNP_001101610.1, NM_001108140.1
UniGeneiRn.96221

Genome annotation databases

EnsembliENSRNOT00000047291; ENSRNOP00000047591; ENSRNOG00000016069
GeneIDi315609
KEGGirno:315609
UCSCiRGD:1309222 rat

Similar proteinsi

Entry informationi

Entry nameiD4A5M2_RAT
AccessioniPrimary (citable) accession number: D4A5M2
Entry historyiIntegrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: March 28, 2018
This is version 76 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health