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Protein
Submitted name:

CD3 antigen, epsilon polypeptide (Predicted)

Gene

Cd3e

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-RNO-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
R-RNO-202424. Downstream TCR signaling.
R-RNO-202427. Phosphorylation of CD3 and TCR zeta chains.
R-RNO-202430. Translocation of ZAP-70 to Immunological synapse.
R-RNO-202433. Generation of second messenger molecules.
R-RNO-389948. PD-1 signaling.

Names & Taxonomyi

Protein namesi
Submitted name:
CD3 antigen, epsilon polypeptide (Predicted)Imported
Submitted name:
Protein Cd3eImported
Gene namesi
Name:Cd3eImported
Synonyms:Cd3e_predictedImported
ORF Names:rCG_58471Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 8

Organism-specific databases

RGDi1309222. Cd3e.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei104 – 128HelicalSequence analysisAdd BLAST25

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_500816128621 – 188Sequence analysisAdd BLAST168

PTM databases

PhosphoSitePlusiD4A5M2.

Expressioni

Gene expression databases

BgeeiENSRNOG00000016069.
ExpressionAtlasiD4A5M2. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000047591.

Structurei

3D structure databases

ProteinModelPortaliD4A5M2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 88Ig-like (immunoglobulin-like)InterPro annotationAdd BLAST59

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG410IYD1. Eukaryota.
ENOG41123JN. LUCA.
GeneTreeiENSGT00510000048592.
KOiK06451.
OMAiQRGQNKE.
OrthoDBiEOG091G0PKE.
PhylomeDBiD4A5M2.
TreeFamiTF335892.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR015484. CD3_esu/gsu/dsu.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003598. Ig_sub2.
IPR003110. Phos_immunorcpt_sig_ITAM.
[Graphical view]
PANTHERiPTHR10570. PTHR10570. 1 hit.
PfamiPF02189. ITAM. 1 hit.
[Graphical view]
SMARTiSM00408. IGc2. 1 hit.
SM00077. ITAM. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS51055. ITAM_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D4A5M2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQWNAFWSIL GLSLLAVGTC QEEYEVSISG TSVELTCPLE NEDNLKWEKN
60 70 80 90 100
DKVLPDKNEK HLVLEDFSEV KDSGYYVCYT ESSRKNTYLY LKARVCENCM
110 120 130 140 150
EVDLTAVSII IIVDICITLG LLMVVYYWSK KRKAKAKPVT RGTGTGGRPR
160 170 180
GKAQGQNKER PPPVPNPDYE PIRKGQRDLY SGLNQRAV
Length:188
Mass (Da):21,312
Last modified:April 20, 2010 - v1
Checksum:iB1CF3214AB4A0ABC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC136866 Genomic DNA. No translation available.
CH473975 Genomic DNA. Translation: EDL95346.1.
RefSeqiNP_001101610.1. NM_001108140.1.
UniGeneiRn.96221.

Genome annotation databases

EnsembliENSRNOT00000047291; ENSRNOP00000047591; ENSRNOG00000016069.
GeneIDi315609.
KEGGirno:315609.
UCSCiRGD:1309222. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC136866 Genomic DNA. No translation available.
CH473975 Genomic DNA. Translation: EDL95346.1.
RefSeqiNP_001101610.1. NM_001108140.1.
UniGeneiRn.96221.

3D structure databases

ProteinModelPortaliD4A5M2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000047591.

PTM databases

PhosphoSitePlusiD4A5M2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000047291; ENSRNOP00000047591; ENSRNOG00000016069.
GeneIDi315609.
KEGGirno:315609.
UCSCiRGD:1309222. rat.

Organism-specific databases

CTDi916.
RGDi1309222. Cd3e.

Phylogenomic databases

eggNOGiENOG410IYD1. Eukaryota.
ENOG41123JN. LUCA.
GeneTreeiENSGT00510000048592.
KOiK06451.
OMAiQRGQNKE.
OrthoDBiEOG091G0PKE.
PhylomeDBiD4A5M2.
TreeFamiTF335892.

Enzyme and pathway databases

ReactomeiR-RNO-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
R-RNO-202424. Downstream TCR signaling.
R-RNO-202427. Phosphorylation of CD3 and TCR zeta chains.
R-RNO-202430. Translocation of ZAP-70 to Immunological synapse.
R-RNO-202433. Generation of second messenger molecules.
R-RNO-389948. PD-1 signaling.

Gene expression databases

BgeeiENSRNOG00000016069.
ExpressionAtlasiD4A5M2. baseline and differential.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR015484. CD3_esu/gsu/dsu.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003598. Ig_sub2.
IPR003110. Phos_immunorcpt_sig_ITAM.
[Graphical view]
PANTHERiPTHR10570. PTHR10570. 1 hit.
PfamiPF02189. ITAM. 1 hit.
[Graphical view]
SMARTiSM00408. IGc2. 1 hit.
SM00077. ITAM. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS51055. ITAM_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiD4A5M2_RAT
AccessioniPrimary (citable) accession number: D4A5M2
Entry historyi
Integrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: November 30, 2016
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.