Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

CD3 antigen, epsilon polypeptide (Predicted)

Gene

Cd3e

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-RNO-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
R-RNO-202424. Downstream TCR signaling.
R-RNO-202427. Phosphorylation of CD3 and TCR zeta chains.
R-RNO-202430. Translocation of ZAP-70 to Immunological synapse.
R-RNO-202433. Generation of second messenger molecules.
R-RNO-389948. PD-1 signaling.

Names & Taxonomyi

Protein namesi
Submitted name:
CD3 antigen, epsilon polypeptide (Predicted)Imported
Submitted name:
CD3e moleculeImported
Gene namesi
Name:Cd3eImported
Synonyms:Cd3e_predictedImported
ORF Names:rCG_58471Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 8

Organism-specific databases

RGDi1309222. Cd3e.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei104 – 128HelicalSequence analysisAdd BLAST25

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_501082969921 – 188Sequence analysisAdd BLAST168

PTM databases

PhosphoSitePlusiD4A5M2.

Expressioni

Gene expression databases

BgeeiENSRNOG00000016069.
ExpressionAtlasiD4A5M2. baseline and differential.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000047591.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 88Ig-likeInterPro annotationAdd BLAST59

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG410IYD1. Eukaryota.
ENOG41123JN. LUCA.
GeneTreeiENSGT00510000048592.
KOiK06451.
OMAiQRGQNKE.
OrthoDBiEOG091G0PKE.
TreeFamiTF335892.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiView protein in InterPro
IPR015484. CD3_esu/gsu/dsu.
IPR007110. Ig-like_dom.
IPR036179. Ig-like_dom_sf.
IPR013783. Ig-like_fold.
IPR003598. Ig_sub2.
IPR003110. Phos_immunorcpt_sig_ITAM.
PANTHERiPTHR10570. PTHR10570. 1 hit.
PfamiView protein in Pfam
PF02189. ITAM. 1 hit.
SMARTiView protein in SMART
SM00408. IGc2. 1 hit.
SM00077. ITAM. 1 hit.
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiView protein in PROSITE
PS50835. IG_LIKE. 1 hit.
PS51055. ITAM_1. 1 hit.

Sequencei

Sequence statusi: Complete.

D4A5M2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQWNAFWSIL GLSLLAVGTC QEEYEVSISG TSVELTCPLE NEDNLKWEKN
60 70 80 90 100
DKVLPDKNEK HLVLEDFSEV KDSGYYVCYT ESSRKNTYLY LKARVCENCM
110 120 130 140 150
EVDLTAVSII IIVDICITLG LLMVVYYWSK KRKAKAKPVT RGTGTGGRPR
160 170 180
GKAQGQNKER PPPVPNPDYE PIRKGQRDLY SGLNQRAV
Length:188
Mass (Da):21,312
Last modified:April 20, 2010 - v1
Checksum:iB1CF3214AB4A0ABC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC136866 Genomic DNA. No translation available.
CH473975 Genomic DNA. Translation: EDL95346.1.
RefSeqiNP_001101610.1. NM_001108140.1.
UniGeneiRn.96221.

Genome annotation databases

EnsembliENSRNOT00000047291; ENSRNOP00000047591; ENSRNOG00000016069.
GeneIDi315609.
KEGGirno:315609.
UCSCiRGD:1309222. rat.

Similar proteinsi

Entry informationi

Entry nameiD4A5M2_RAT
AccessioniPrimary (citable) accession number: D4A5M2
Entry historyiIntegrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: October 25, 2017
This is version 71 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported