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Protein
Submitted name:

Polycystin 2, transient receptor potential cation channel

Gene

Pkd2

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi761 – 772PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandCalciumPROSITE-ProRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Polycystin 2, transient receptor potential cation channelImported
Submitted name:
Similar to polycystic kidney disease 2 (Predicted)Imported
Gene namesi
Name:Pkd2Imported
Synonyms:RGD1559992_predictedImported
ORF Names:rCG_37877Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 14

Organism-specific databases

RGDi1559992. Pkd2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei222 – 240HelicalSequence analysisAdd BLAST19
Transmembranei419 – 441HelicalSequence analysisAdd BLAST23
Transmembranei461 – 486HelicalSequence analysisAdd BLAST26
Transmembranei507 – 525HelicalSequence analysisAdd BLAST19
Transmembranei554 – 575HelicalSequence analysisAdd BLAST22
Transmembranei595 – 617HelicalSequence analysisAdd BLAST23
Transmembranei657 – 678HelicalSequence analysisAdd BLAST22

Keywords - Cellular componenti

Membrane

PTM / Processingi

PTM databases

iPTMnetiD4A5F1.
PhosphoSitePlusiD4A5F1.

Expressioni

Gene expression databases

BgeeiENSRNOG00000002146.

Interactioni

GO - Molecular functioni

  • alpha-actinin binding Source: RGD
  • ATPase binding Source: Ensembl
  • HLH domain binding Source: Ensembl
  • ion channel binding Source: Ensembl
  • muscle alpha-actinin binding Source: RGD
  • phosphoprotein binding Source: Ensembl
  • protein homodimerization activity Source: Ensembl
  • receptor binding Source: Ensembl

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000002916.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini748 – 783EF-handInterPro annotationAdd BLAST36

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili766 – 790Sequence analysisAdd BLAST25

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG3599. Eukaryota.
ENOG410XTGE. LUCA.
GeneTreeiENSGT00700000104221.
KOiK04986.
OMAiQAWSRDN.
OrthoDBiEOG091G034F.
TreeFamiTF316484.

Family and domain databases

InterProiView protein in InterPro
IPR011992. EF-hand-dom_pair.
IPR002048. EF_hand_dom.
IPR013122. PKD1_2_channel.
IPR003915. PKD_2.
PfamiView protein in Pfam
PF08016. PKD_channel. 1 hit.
PRINTSiPR01433. POLYCYSTIN2.
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiView protein in PROSITE
PS50222. EF_HAND_2. 1 hit.

Sequencei

Sequence statusi: Complete.

D4A5F1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVNSSRVQPQ PPGDPGRSPA PRASGPGRLL AGGAGLAVPG GLREQRGLEI
60 70 80 90 100
EMERIRQAAA RDPPAGASAS PSPPLSSCSR QAWSRDNPGF EAEEDDDDDE
110 120 130 140 150
VEGEEGGMVV EMDVEWRPGS RRPASSSAVS SAGARGRGLG SYRGAAYPSG
160 170 180 190 200
RRRRLEDQGA PCPSPAGGGD PLHRHLPLDG QPPRVAWAER LVRGLRGLWG
210 220 230 240 250
TRLMEESNAN REKYLRSVLR ELVTYLFFLI LLCILTYGMM SSNVYYYTRT
260 270 280 290 300
LSQLFIDTPV SKTEKTNFKT LSSMEDFWKF TEGSFLDGLY WKAQSSNHTQ
310 320 330 340 350
ADNRSFIFYE NLLLGVPRLR QLRVRNGSCS IPQDLRDEIK ECYDVYSVSS
360 370 380 390 400
EDRAPFGPRN GTAWIYTSEK DLNGSSHWGI IATYSGAGYY LDLSRTREET
410 420 430 440 450
AAQLAGLRRN FWLDRGTRAA FIDFSVYNAN INLFCVVRLL VEFPATGGVV
460 470 480 490 500
PSWQFQPVKL IRYVTAFDFF LAACEIIFCF FILYYVVEEI LEIRIHRLNY
510 520 530 540 550
FRSFWNCLDV VIVVLSVVAM MINIYRMSNA EGLLQFLEDQ NSFPNFEHVA
560 570 580 590 600
YWQIQFNNIA AVMVFLVWIK LFKFINFNRT MSQLSTTMSR CAKDLFGFTI
610 620 630 640 650
MFFIIFLAYA QLAYLVFGTQ VDDFSTFQEC IFTQFRIILG DINFAEIEEA
660 670 680 690 700
NRVLGPLYFT TFVFFMFFIL LNMFLAIIND SYSEVKSDLA QQKAEMELSD
710 720 730 740 750
LIRKGCQKAL VKLKLKRNTV DAISESLRQG GGKLNFDELR QDLKGKGHTD
760 770 780 790 800
AEIEAIFTKY DQDGDQELTE REHQQMRDDL EREREDLDLE HSSLPRPMSS
810 820 830 840 850
RSFPRSLDDS EEEDDEDSGH SSRRRGSISS GVSYEEFQVL VRRVDRMEHS
860 870 880 890 900
IGSIVSKIDA VIVKLEIMER AKVKRREVLG RLLDGVAEDA RLGRDSEIHR
910 920 930 940 950
EQMERLVREE LERWESDDAA SQSGHGLGTQ VGLGGQSHPR SSRPPSSQSA
960
EGLEGGGGNG STNAHA
Length:966
Mass (Da):109,093
Last modified:April 20, 2010 - v1
Checksum:i3F4EFB2EF8C64AA7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07072365 Genomic DNA. No translation available.
AC136829 Genomic DNA. No translation available.
CH474022 Genomic DNA. Translation: EDL99486.1.
RefSeqiNP_001178863.1. NM_001191934.1.
UniGeneiRn.198353.

Genome annotation databases

EnsembliENSRNOT00000002916; ENSRNOP00000002916; ENSRNOG00000002146.
GeneIDi498328.
KEGGirno:498328.

Similar proteinsi

Entry informationi

Entry nameiD4A5F1_RAT
AccessioniPrimary (citable) accession number: D4A5F1
Entry historyiIntegrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: October 25, 2017
This is version 73 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported