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Protein

Cysteine and histidine-rich domain-containing protein 1

Gene

Chordc1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Regulates centrosome duplication, probably by inhibiting the kinase activity of ROCK2. Proposed to act as co-chaperone for HSP90. May play a role in the regulation of NOD1 via a HSP90 chaperone complex. In vitro, has intrinsic chaperone activity. This function may be achieved by inhibiting association of ROCK2 with NPM1. Involved in stress response. Prevents tumorigenesis (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi5 – 51Zinc 1PROSITE-ProRule annotation
Metal bindingi10 – 101Zinc 1PROSITE-ProRule annotation
Metal bindingi24 – 241Zinc 1PROSITE-ProRule annotation
Metal bindingi27 – 271Zinc 2PROSITE-ProRule annotation
Metal bindingi42 – 421Zinc 2PROSITE-ProRule annotation
Metal bindingi43 – 431Zinc 2PROSITE-ProRule annotation
Metal bindingi59 – 591Zinc 2PROSITE-ProRule annotation
Metal bindingi64 – 641Zinc 1PROSITE-ProRule annotation
Metal bindingi157 – 1571Zinc 3PROSITE-ProRule annotation
Metal bindingi162 – 1621Zinc 3PROSITE-ProRule annotation
Metal bindingi176 – 1761Zinc 3PROSITE-ProRule annotation
Metal bindingi179 – 1791Zinc 4PROSITE-ProRule annotation
Metal bindingi194 – 1941Zinc 4PROSITE-ProRule annotation
Metal bindingi195 – 1951Zinc 4PROSITE-ProRule annotation
Metal bindingi211 – 2111Zinc 4PROSITE-ProRule annotation
Metal bindingi216 – 2161Zinc 3PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

Stress response

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Cysteine and histidine-rich domain-containing protein 1
Alternative name(s):
CHORD domain-containing protein 1
Short name:
CHP-1
Morgana
Gene namesi
Name:Chordc1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 8

Organism-specific databases

RGDi1304679. Chordc1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 331330Cysteine and histidine-rich domain-containing protein 1PRO_0000402802Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei47 – 471PhosphothreonineBy similarity
Modified residuei51 – 511PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiD4A4T9.
PRIDEiD4A4T9.

PTM databases

iPTMnetiD4A4T9.

Expressioni

Gene expression databases

GenevisibleiD4A4T9. RN.

Interactioni

Subunit structurei

Interacts with HSP90AA1, HSP90AB1, PPP5C, ROCK1 and ROCK2.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000030171.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini5 – 6460CHORD 1PROSITE-ProRule annotationAdd
BLAST
Domaini157 – 21660CHORD 2PROSITE-ProRule annotationAdd
BLAST
Domaini227 – 31690CSPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni2 – 7776Interaction with PPP5CBy similarityAdd
BLAST
Regioni65 – 316252Interaction with HSP90AA1 and HSP90AB1By similarityAdd
BLAST

Sequence similaritiesi

Contains 2 CHORD domains.PROSITE-ProRule annotation
Contains 1 CS domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG1667. Eukaryota.
ENOG410XPV6. LUCA.
GeneTreeiENSGT00390000005180.
InParanoidiD4A4T9.
KOiK16729.
OMAiCCQKRTS.
OrthoDBiEOG7X6M0X.
PhylomeDBiD4A4T9.
TreeFamiTF105394.

Family and domain databases

Gene3Di2.60.40.790. 1 hit.
InterProiIPR007051. CHORD_dom.
IPR007052. CS_dom.
IPR008978. HSP20-like_chaperone.
[Graphical view]
PfamiPF04968. CHORD. 2 hits.
PF04969. CS. 1 hit.
[Graphical view]
SUPFAMiSSF49764. SSF49764. 1 hit.
PROSITEiPS51401. CHORD. 2 hits.
PS51203. CS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

D4A4T9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALLCYNRGC GQRFDPEANA DDACTYHPGV PVFHDALKGW SCCKRRTTDF
60 70 80 90 100
SDFLSIVGCT KGRHNSEKPP EPVKPEVKTT EKKELSELKP KFQEHIIQAP
110 120 130 140 150
KPVEAIKRPS PDEPMTNLEL KISASLKQAL DKLKLSSGNE EDKKEEDSDE
160 170 180 190 200
IKIGTSCKNG GCSKTYQGLQ SLEEVCVYHS GVPIFHEGMK YWSCCRRKTS
210 220 230 240 250
DFNTFLAQEG CTRGKHVWTK KDAGKKVVPC RHDWHQTGGE VTISVYAKNS
260 270 280 290 300
LPELSQVEAN STLLNVHIVF EGEKEFHQNV KLWGVIDVKR SYVTMTATKI
310 320 330
EITMRKAEPM QWASLELPTT KKQEKQKDIA D
Length:331
Mass (Da):37,362
Last modified:April 20, 2010 - v1
Checksum:i88100248DC1061C5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH473993 Genomic DNA. Translation: EDL78419.1.
RefSeqiNP_001101598.1. NM_001108128.1.
UniGeneiRn.6136.

Genome annotation databases

EnsembliENSRNOT00000030569; ENSRNOP00000030171; ENSRNOG00000026643.
GeneIDi315447.
KEGGirno:315447.
UCSCiRGD:1304679. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH473993 Genomic DNA. Translation: EDL78419.1.
RefSeqiNP_001101598.1. NM_001108128.1.
UniGeneiRn.6136.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000030171.

PTM databases

iPTMnetiD4A4T9.

Proteomic databases

PaxDbiD4A4T9.
PRIDEiD4A4T9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000030569; ENSRNOP00000030171; ENSRNOG00000026643.
GeneIDi315447.
KEGGirno:315447.
UCSCiRGD:1304679. rat.

Organism-specific databases

CTDi26973.
RGDi1304679. Chordc1.

Phylogenomic databases

eggNOGiKOG1667. Eukaryota.
ENOG410XPV6. LUCA.
GeneTreeiENSGT00390000005180.
InParanoidiD4A4T9.
KOiK16729.
OMAiCCQKRTS.
OrthoDBiEOG7X6M0X.
PhylomeDBiD4A4T9.
TreeFamiTF105394.

Miscellaneous databases

PROiD4A4T9.

Gene expression databases

GenevisibleiD4A4T9. RN.

Family and domain databases

Gene3Di2.60.40.790. 1 hit.
InterProiIPR007051. CHORD_dom.
IPR007052. CS_dom.
IPR008978. HSP20-like_chaperone.
[Graphical view]
PfamiPF04968. CHORD. 2 hits.
PF04969. CS. 1 hit.
[Graphical view]
SUPFAMiSSF49764. SSF49764. 1 hit.
PROSITEiPS51401. CHORD. 2 hits.
PS51203. CS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown Norway.

Entry informationi

Entry nameiCHRD1_RAT
AccessioniPrimary (citable) accession number: D4A4T9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2011
Last sequence update: April 20, 2010
Last modified: June 8, 2016
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.