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Protein

Transcription factor E2F7

Gene

E2f7

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Atypical E2F transcription factor that participates in various processes such as angiogenesis, polyploidization of specialized cells and DNA damage response. Mainly acts as a transcription repressor that binds DNA independently of DP proteins and specifically recognizes the E2 recognition site 5'-TTTC[CG]CGC-3'. Directly represses transcription of classical E2F transcription factors such as E2F1. Acts as a regulator of S-phase by recognizing and binding the E2-related site 5'-TTCCCGCC-3' and mediating repression of G1/S-regulated genes. Plays a key role in polyploidization of cells in placenta and liver by regulating the endocycle, probably by repressing genes promoting cytokinesis and antagonizing action of classical E2F proteins (E2F1, E2F2 and/or E2F3). Required for placental development by promoting polyploidization of trophoblast giant cells. Also involved in DNA damage response: up-regulated by p53/TP53 following genotoxic stress and acts as a downstream effector of p53/TP53-dependent repression by mediating repression of indirect p53/TP53 target genes involved in DNA replication. Acts as a promoter of sprouting angiogenesis, possibly by acting as a transcription activator: associates with HIF1A, recognizes and binds the VEGFA promoter, which is different from canonical E2 recognition site, and activates expression of the VEGFA gene. Acts as a negative regulator of keratinocyte differentiation (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi143 – 212Sequence analysisAdd BLAST70
DNA bindingi283 – 368Sequence analysisAdd BLAST86

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding, Repressor
Biological processCell cycle, DNA damage, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor E2F7
Short name:
E2F-7
Gene namesi
Name:E2f7
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1310258 E2f7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004207051 – 902Transcription factor E2F7Add BLAST902

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei96PhosphoserineBy similarity1
Modified residuei411PhosphoserineBy similarity1
Modified residuei832PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiD4A4D7
PRIDEiD4A4D7

Interactioni

Subunit structurei

Homodimer and heterodimer: mainly forms homodimers and, to a lesser extent, heterodimers with E2F8. Dimerization is important for DNA-binding. Interacts with HIF1A (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000030798

Structurei

3D structure databases

SMRiD4A4D7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

In contrast to classical members of the E2F transcription factor, atypical members contain 2 DNA-binding domains and regulate transcription in a DP-independent manner. Both DNA-binding domains are required for DNA-binding and are proposed to form an intramolecular structure that is similar to the winged helix structure of the E2F-DP heterodimer (By similarity).By similarity

Sequence similaritiesi

Belongs to the E2F/DP family.Curated

Phylogenomic databases

eggNOGiKOG2578 Eukaryota
ENOG4111IGY LUCA
InParanoidiD4A4D7
PhylomeDBiD4A4D7
TreeFamiTF105567

Family and domain databases

Gene3Di1.10.10.10, 2 hits
InterProiView protein in InterPro
IPR015633 E2F
IPR003316 E2F_WHTH_DNA-bd_dom
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PANTHERiPTHR12081 PTHR12081, 1 hit
PfamiView protein in Pfam
PF02319 E2F_TDP, 2 hits
SMARTiView protein in SMART
SM01372 E2F_TDP, 2 hits
SUPFAMiSSF46785 SSF46785, 2 hits

Sequencei

Sequence statusi: Complete.

D4A4D7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEVNCLTLKD LISPRQTRLD FAVEDAETAQ KENIFVDRSR MTPKTPMKNE
60 70 80 90 100
PIDLSKQRIF TPERSPITPV KLVDRQPQVE PWTPTANLKM LISAASPDIR
110 120 130 140 150
DREKKKELFR PIENKGDAFV NSLQLDVVGD SAVDDYEKRR PSRKQKSLGL
160 170 180 190 200
LCQKFLARYP SYPLSTEKTT ISLDEVAVSL GVERRRIYDI VNVLESLHLV
210 220 230 240 250
SRVAKNQYGW HGRHSLPKTL RTLQRLGEEQ KYEEQMACLQ QKELDLMEYR
260 270 280 290 300
FGERRKDGSP DPRDQHLLDF SESDYPSSSA NSRKDKSLRI MSQKFVMLFL
310 320 330 340 350
VSKTKIVTLD VAAKILIEES QDTPDHSKFK TKVRRLYDIA NVLTSLALIK
360 370 380 390 400
KVHVTEERGR KPAFKWIGPV DFSSIDEELL DVSASVLPEL KKETYGQIRV
410 420 430 440 450
CAKERLARYG SFNTVQTSEK IQRKVNSEPS SPQGGKQGPA YSLEIGSLAA
460 470 480 490 500
IYRQKVEDSS QGEAFVNKRA APPASVLDPT LPVDSEYCVK PLAQPVFSVA
510 520 530 540 550
QTDLQAFSAQ NGLNGQVGVP VPSAASDAET LKSALLASQP LVYVPSTSLF
560 570 580 590 600
MLYGSVQEAL SPESRSEEDG SGSDVPADLS LAPTAQKRLC EERNPLEDDE
610 620 630 640 650
PAVKRQSREF EDSPLSLVMP KKPSNSTDLA FPVTTGNGRA TPLEDACVKG
660 670 680 690 700
QLPAAEDASG RAVPNGFIAS ECGNPSRNPD TEKSSNDNEI TKDPSLLQYL
710 720 730 740 750
YVQSPAGLNG FNMLLPGGQT PHAVAPSSAA MPSFGVPCMF LPSPGLGPFP
760 770 780 790 800
VLYSPAIPGP ISSAPGTLPN TGPMNFGLST LASASHLLIS PAAMVNPKSS
810 820 830 840 850
TLPSADPQLR CQPPLNPNPV MPGSHGVIHP ESPGYMRHPV SMVKAEQSPA
860 870 880 890 900
PATPKSIQRR HRETFFKTPG SLGDPAFRRE RNQSRNTSSA QRRLEISSSG

PD
Length:902
Mass (Da):99,029
Last modified:April 20, 2010 - v1
Checksum:iF48A0A0D3A961013
GO

Sequence databases

RefSeqiXP_006241382.1, XM_006241320.2
XP_006241383.1, XM_006241321.2
UniGeneiRn.211183

Genome annotation databases

GeneIDi314818
UCSCiRGD:1310258 rat

Similar proteinsi

Entry informationi

Entry nameiE2F7_RAT
AccessioniPrimary (citable) accession number: D4A4D7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2013
Last sequence update: April 20, 2010
Last modified: March 28, 2018
This is version 58 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health