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D4A3X8

- D4A3X8_RAT

UniProt

D4A3X8 - D4A3X8_RAT

Protein
Submitted name:

Interleukin 7 receptor (Predicted)

Gene

Il7r

Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 2 out of 5- Protein predictedi
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    • History
      Entry version 37 (01 Oct 2014)
      Sequence version 1 (20 Apr 2010)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. cytokine receptor activity Source: InterPro

    GO - Biological processi

    1. B cell proliferation Source: Ensembl
    2. cell growth Source: Ensembl
    3. cell morphogenesis Source: Ensembl
    4. homeostasis of number of cells Source: Ensembl
    5. immunoglobulin production Source: Ensembl
    6. lymph node development Source: Ensembl
    7. negative regulation of T cell mediated cytotoxicity Source: Ensembl
    8. positive regulation of gene expression Source: Ensembl
    9. positive regulation of T cell differentiation in thymus Source: Ensembl
    10. regulation of cell size Source: Ensembl
    11. T cell differentiation Source: Ensembl

    Keywords - Molecular functioni

    ReceptorImported

    Enzyme and pathway databases

    ReactomeiREACT_196376. Interleukin-7 signaling.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Interleukin 7 receptor (Predicted)Imported
    Submitted name:
    Protein LOC100911254Imported
    Gene namesi
    Name:Il7rImported
    Synonyms:Il7r_predictedImported, LOC100911254Imported
    ORF Names:rCG_50960Imported
    OrganismiRattus norvegicus (Rat)Imported
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi1309776. Il7r.
    6493735. LOC100911254.

    Subcellular locationi

    GO - Cellular componenti

    1. external side of plasma membrane Source: Ensembl

    Family & Domainsi

    Phylogenomic databases

    GeneTreeiENSGT00510000048500.
    KOiK05072.
    OMAiMYEIKVR.
    OrthoDBiEOG7SJD5X.
    TreeFamiTF336573.

    Family and domain databases

    Gene3Di2.60.40.10. 1 hit.
    InterProiIPR003961. Fibronectin_type3.
    IPR003531. Hempt_rcpt_S_F1_CS.
    IPR013783. Ig-like_fold.
    [Graphical view]
    PfamiPF00041. fn3. 1 hit.
    [Graphical view]
    SUPFAMiSSF49265. SSF49265. 1 hit.
    PROSITEiPS50853. FN3. 1 hit.
    PS01355. HEMATOPO_REC_S_F1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    D4A3X8-1 [UniParc]FASTAAdd to Basket

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    MMALGRAFAI VFCLLQAASG ESGNAQDGDL EDAEPDDHSF WCHSQLEVDG    50
    NQHSLTCAFN DPDIKTTNLE FQICGALLGI DCLTLNKLRE MYFIKTSKFL 100
    LIGNSSVCVK LGKMDVICKI LDISTIVKPE APSNLKVVYR KEANDFLVTF 150
    NTSHSTKKYV TALKHDVAYR PERGESNWTH VYLFHTRTTI LQRKLQPKAV 200
    YEIKVRSIPN HEYFKGFWSE WSPSSTFETP DSKYQGGWDP VLPSIILLSL 250
    FSMVLLVILA HVLWKKRIKP VVWPSLPDHK KTLEQLCKKP KKNLNVSFNP 300
    ESFLDCQIHE VNGIQARDEV ESFLQNDLPP RPGELEKQGH RATVHGANWP 350
    SEISGSTPET FRRESPLRCL ARNLSTCNTP AFLSSRSPDY REGDGNRSHV 400
    YQDLLPSSRN TNGTVPQPFP LQSGILIPVS QGQPISTSSV LNQEEAYVTM 450
    SSFYQNK 457
    Length:457
    Mass (Da):51,533
    Last modified:April 20, 2010 - v1
    Checksum:i1686221399272672
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH474048 Genomic DNA. Translation: EDL75666.1.
    RefSeqiNP_001099888.1. NM_001106418.1.
    UniGeneiRn.224662.

    Genome annotation databases

    EnsembliENSRNOT00000023422; ENSRNOP00000023422; ENSRNOG00000017413.
    GeneIDi294797.
    KEGGirno:294797.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH474048 Genomic DNA. Translation: EDL75666.1 .
    RefSeqi NP_001099888.1. NM_001106418.1.
    UniGenei Rn.224662.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000023422 ; ENSRNOP00000023422 ; ENSRNOG00000017413 .
    GeneIDi 294797.
    KEGGi rno:294797.

    Organism-specific databases

    CTDi 3575.
    RGDi 1309776. Il7r.
    6493735. LOC100911254.

    Phylogenomic databases

    GeneTreei ENSGT00510000048500.
    KOi K05072.
    OMAi MYEIKVR.
    OrthoDBi EOG7SJD5X.
    TreeFami TF336573.

    Enzyme and pathway databases

    Reactomei REACT_196376. Interleukin-7 signaling.

    Miscellaneous databases

    NextBioi 638592.
    PROi D4A3X8.

    Family and domain databases

    Gene3Di 2.60.40.10. 1 hit.
    InterProi IPR003961. Fibronectin_type3.
    IPR003531. Hempt_rcpt_S_F1_CS.
    IPR013783. Ig-like_fold.
    [Graphical view ]
    Pfami PF00041. fn3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49265. SSF49265. 1 hit.
    PROSITEi PS50853. FN3. 1 hit.
    PS01355. HEMATOPO_REC_S_F1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
      Rat Genome Sequencing Project Consortium
      Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
      , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
      Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Brown NorwayImported.
    2. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: BNImported.
    3. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: BNImported.
    4. Ensembl
      Submitted (JUL-2011) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: Brown NorwayImported.

    Entry informationi

    Entry nameiD4A3X8_RAT
    AccessioniPrimary (citable) accession number: D4A3X8
    Entry historyi
    Integrated into UniProtKB/TrEMBL: April 20, 2010
    Last sequence update: April 20, 2010
    Last modified: October 1, 2014
    This is version 37 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3