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Protein
Submitted name:

Interleukin 7 receptor (Predicted)

Gene

Il7r

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

  1. cytokine receptor activity Source: InterPro

GO - Biological processi

  1. B cell proliferation Source: Ensembl
  2. cell growth Source: Ensembl
  3. cell morphogenesis Source: Ensembl
  4. homeostasis of number of cells Source: Ensembl
  5. immunoglobulin production Source: Ensembl
  6. lymph node development Source: Ensembl
  7. negative regulation of T cell mediated cytotoxicity Source: Ensembl
  8. positive regulation of gene expression Source: Ensembl
  9. positive regulation of T cell differentiation in thymus Source: Ensembl
  10. regulation of cell size Source: Ensembl
  11. T cell differentiation Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

ReceptorImported

Enzyme and pathway databases

ReactomeiREACT_196376. Interleukin-7 signaling.

Names & Taxonomyi

Protein namesi
Submitted name:
Interleukin 7 receptor (Predicted)Imported
Submitted name:
Protein Il7rImported
Gene namesi
Name:Il7rImported
Synonyms:Il7r_predictedImported, LOC100911254
ORF Names:rCG_50960Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi1309776. Il7r.
6493735. LOC100911254.

Subcellular locationi

GO - Cellular componenti

  1. external side of plasma membrane Source: Ensembl
Complete GO annotation...

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00510000048500.
KOiK05072.
OMAiMYEIKVR.
OrthoDBiEOG7SJD5X.
TreeFamiTF336573.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR003961. FN3_dom.
IPR003531. Hempt_rcpt_S_F1_CS.
IPR013783. Ig-like_fold.
[Graphical view]
PfamiPF00041. fn3. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 1 hit.
PROSITEiPS50853. FN3. 1 hit.
PS01355. HEMATOPO_REC_S_F1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D4A3X8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMALGRAFAI VFCLLQAASG ESGNAQDGDL EDAEPDDHSF WCHSQLEVDG
60 70 80 90 100
NQHSLTCAFN DPDIKTTNLE FQICGALLGI DCLTLNKLRE MYFIKTSKFL
110 120 130 140 150
LIGNSSVCVK LGKMDVICKI LDISTIVKPE APSNLKVVYR KEANDFLVTF
160 170 180 190 200
NTSHSTKKYV TALKHDVAYR PERGESNWTH VYLFHTRTTI LQRKLQPKAV
210 220 230 240 250
YEIKVRSIPN HEYFKGFWSE WSPSSTFETP DSKYQGGWDP VLPSIILLSL
260 270 280 290 300
FSMVLLVILA HVLWKKRIKP VVWPSLPDHK KTLEQLCKKP KKNLNVSFNP
310 320 330 340 350
ESFLDCQIHE VNGIQARDEV ESFLQNDLPP RPGELEKQGH RATVHGANWP
360 370 380 390 400
SEISGSTPET FRRESPLRCL ARNLSTCNTP AFLSSRSPDY REGDGNRSHV
410 420 430 440 450
YQDLLPSSRN TNGTVPQPFP LQSGILIPVS QGQPISTSSV LNQEEAYVTM

SSFYQNK
Length:457
Mass (Da):51,533
Last modified:April 20, 2010 - v1
Checksum:i1686221399272672
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH474048 Genomic DNA. Translation: EDL75666.1.
RefSeqiNP_001099888.1. NM_001106418.1.
UniGeneiRn.224662.

Genome annotation databases

EnsembliENSRNOT00000023422; ENSRNOP00000023422; ENSRNOG00000017413.
GeneIDi294797.
KEGGirno:294797.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH474048 Genomic DNA. Translation: EDL75666.1.
RefSeqiNP_001099888.1. NM_001106418.1.
UniGeneiRn.224662.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000023422; ENSRNOP00000023422; ENSRNOG00000017413.
GeneIDi294797.
KEGGirno:294797.

Organism-specific databases

CTDi3575.
RGDi1309776. Il7r.
6493735. LOC100911254.

Phylogenomic databases

GeneTreeiENSGT00510000048500.
KOiK05072.
OMAiMYEIKVR.
OrthoDBiEOG7SJD5X.
TreeFamiTF336573.

Enzyme and pathway databases

ReactomeiREACT_196376. Interleukin-7 signaling.

Miscellaneous databases

NextBioi638592.
PROiD4A3X8.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR003961. FN3_dom.
IPR003531. Hempt_rcpt_S_F1_CS.
IPR013783. Ig-like_fold.
[Graphical view]
PfamiPF00041. fn3. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 1 hit.
PROSITEiPS50853. FN3. 1 hit.
PS01355. HEMATOPO_REC_S_F1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Rat Genome Sequencing Project Consortium
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown NorwayImported.
  2. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BNImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BNImported.
  4. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: Brown NorwayImported.

Entry informationi

Entry nameiD4A3X8_RAT
AccessioniPrimary (citable) accession number: D4A3X8
Entry historyi
Integrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: March 4, 2015
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.