Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Adhesion G-protein coupled receptor F2

Gene

Adgrf2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Orphan receptor.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Adhesion G-protein coupled receptor F2
Alternative name(s):
G-protein coupled receptor 111
G-protein coupled receptor PGR20
Gene namesi
Name:Adgrf2
Synonyms:Gpr111, Pgr20
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1306718. Adgrf2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini26 – 386ExtracellularCuratedAdd BLAST361
Transmembranei387 – 407Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini408 – 422CytoplasmicCuratedAdd BLAST15
Transmembranei423 – 443Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini444 – 465ExtracellularCuratedAdd BLAST22
Transmembranei466 – 486Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini487 – 493CytoplasmicCurated7
Transmembranei494 – 514Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini515 – 541ExtracellularCuratedAdd BLAST27
Transmembranei542 – 562Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini563 – 586CytoplasmicCuratedAdd BLAST24
Transmembranei587 – 607Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini608 – 610ExtracellularCurated3
Transmembranei611 – 631Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini632 – 638CytoplasmicCurated7

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000043322926 – 638Adhesion G-protein coupled receptor F2Sequence analysisAdd BLAST613

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi155N-linked (GlcNAc...)Sequence analysis1
Glycosylationi219N-linked (GlcNAc...)Sequence analysis1
Glycosylationi248N-linked (GlcNAc...)Sequence analysis1
Glycosylationi293N-linked (GlcNAc...)Sequence analysis1
Glycosylationi311N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiD4A3T6.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000035606.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini326 – 376GPSPROSITE-ProRule annotationAdd BLAST51

Sequence similaritiesi

Contains 1 GPS domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4193. Eukaryota.
ENOG410XSD2. LUCA.
InParanoidiD4A3T6.
OrthoDBiEOG091G03WY.
PhylomeDBiD4A3T6.
TreeFamiTF316380.

Family and domain databases

InterProiIPR017981. GPCR_2-like.
IPR000832. GPCR_2_secretin-like.
IPR000203. GPS.
[Graphical view]
PfamiPF00002. 7tm_2. 1 hit.
PF01825. GPS. 1 hit.
[Graphical view]
PRINTSiPR00249. GPCRSECRETIN.
SMARTiSM00303. GPS. 1 hit.
[Graphical view]
PROSITEiPS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
PS50221. GPS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

D4A3T6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MISARWLYCL VLLLATESCR LFCQAASKSK ENVMPRPHDV CDGVCKNNAS
60 70 80 90 100
PCFQSCPPNS EGNMKFACKA KRWHKVTETC HTLNAHSIFE EDKELYSVQS
110 120 130 140 150
SESTIRTHMF NSGLKTITDT LMEKCPKDLS CVIRGIEKSP RIPGNIAVVV
160 170 180 190 200
QLLHNISTTL TKGVDEEKMQ SYSAMANHIL NSKSISNWTF IQDRNSSCVL
210 220 230 240 250
LQSINSFASN LFMKGHLINI SHVFIHTLGT VVPRNSLGKN FTFSMRVNDT
260 270 280 290 300
SDKVTGRILL TTEELQKVPS AFQVISIAFP TLGAILEASL LENMTVNGLV
310 320 330 340 350
LSVILPKELK NISLIFEKIR KSGERKSQCV GWHSLESRWD RRACKMIQEN
360 370 380 390 400
SRQAICRCQP NKFFTSFSIL MSPNTVESPV LTYITYIGLG ISICSLIICL
410 420 430 440 450
AIEALVWSQV TKTEISYLRH LCIANIAVTL LMADVWFIVA SFLSGPIVHH
460 470 480 490 500
NGCVTATFFV HFFYLSVFFW MLAKALLILY GILIVFHTLP KSCLVASLFT
510 520 530 540 550
VGYGCPLVIA VITLAVTEPG KGYLRPEACW LNWDMTKALL AFVVPALAIV
560 570 580 590 600
VVNLITVTLV IIKTQRAAVG SSMFQEVRAI VRICKNIAIL TPLLGLTWGF
610 620 630
GIATVVAGHS LAFHIIFSLL NALQVSPDAM IESEWRGC
Length:638
Mass (Da):70,830
Last modified:April 20, 2010 - v1
Checksum:i8613B71433D5A694
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR06058952 Genomic DNA. No translation available.

Genome annotation databases

UCSCiRGD:1306718. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR06058952 Genomic DNA. No translation available.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000035606.

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PaxDbiD4A3T6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiRGD:1306718. rat.

Organism-specific databases

RGDi1306718. Adgrf2.

Phylogenomic databases

eggNOGiKOG4193. Eukaryota.
ENOG410XSD2. LUCA.
InParanoidiD4A3T6.
OrthoDBiEOG091G03WY.
PhylomeDBiD4A3T6.
TreeFamiTF316380.

Miscellaneous databases

PROiD4A3T6.

Family and domain databases

InterProiIPR017981. GPCR_2-like.
IPR000832. GPCR_2_secretin-like.
IPR000203. GPS.
[Graphical view]
PfamiPF00002. 7tm_2. 1 hit.
PF01825. GPS. 1 hit.
[Graphical view]
PRINTSiPR00249. GPCRSECRETIN.
SMARTiSM00303. GPS. 1 hit.
[Graphical view]
PROSITEiPS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
PS50221. GPS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAGRF2_RAT
AccessioniPrimary (citable) accession number: D4A3T6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 24, 2015
Last sequence update: April 20, 2010
Last modified: October 5, 2016
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Most adhesion GPCRs undergo autoproteolysis at the GPS domain. ADGRF2 is not autoproteolyzed at the GPS motif because of the lack of a consensus catalytic triad sequence within GPS domain.By similarity

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.